A novel Nudix hydrolase for oxidized purine nucleoside triphosphates encoded by ORFYLR151c (PCD1 gene) in Saccharomyces cerevisiae

Nucleic Acids Research

Volumn 32, Issue 18, 2004, Pages 5339-5348

  Nunoshiba, Tatsuo ^c   Ishida, Rikiya ^c   Sasaki, Michi ^c   Iwai, Shigenori ^a   Nakabeppu, Yusaku ^b   Yamamoto, Kazuo ^c  

^a OSAKA UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIHYDRO 2 HYDROXY 2' DEOXYADENOSINE TRIPHOSPHATE; 7,8 DIHYDRO 8 OXO 2' DEOXYGUANOSINE TRIPHOSPHATE; ADENINE; CYTOSINE; GUANINE; HYBRID PROTEIN; HYDROLASE; INORGANIC PYROPHOSPHATASE; NUCLEOSIDE TRIPHOSPHATE; NUDIX HYDROLASE; THYMINE; UNCLASSIFIED DRUG; 2 HYDROXYDEOXYADENOSINE TRIPHOSPHATE; 2-HYDROXYDEOXYADENOSINE TRIPHOSPHATE; 8 OXODEOXYGUANOSINE TRIPHOSPHATE; 8-OXODEOXYGUANOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE; DEOXYGUANOSINE PHOSPHATE; DRUG DERIVATIVE; ESCHERICHIA COLI PROTEIN; MUTT PROTEIN, E COLI; NUDIX HYDROLASES; PHOSPHATASE; PURINE NUCLEOTIDE; RECOMBINANT PROTEIN; SODIUM CHLORIDE;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BIOCHEMISTRY; CONTROLLED STUDY; ENZYME ACTIVITY; ESCHERICHIA COLI; FREQUENCY ANALYSIS; GENE EXPRESSION; HUMAN; MOUSE; MUTAGENESIS; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; OPEN READING FRAME; PRIORITY JOURNAL; PSEUDOMONAS; PSEUDOMONAS VULGARIS; RAT; SACCHAROMYCES CEREVISIAE; SEQUENCE DATABASE; WILD TYPE; ENZYMOLOGY; GENE REPRESSION; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR GENETICS; MUTATION; PH; SEQUENCE ALIGNMENT;

ESCHERICHIA COLI; PSEUDOMONAS; SACCHAROMYCES CEREVISIAE;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; DEOXYGUANINE NUCLEOTIDES; ESCHERICHIA COLI PROTEINS; HYDROGEN-ION CONCENTRATION; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHORIC MONOESTER HYDROLASES; PURINE NUCLEOTIDES; PYROPHOSPHATASES; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SEQUENCE ALIGNMENT; SODIUM CHLORIDE; SUPPRESSION, GENETIC;

EID: 6044242268     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkh868     Document Type: Article

References (39)

1. Fridovich,I. (1983) Superoxide radical: an endogenous toxicant. Annu. Rev. Pharmacol. Toxicol., 23, 239-257.
2. Kappus,H. and Sies,H. (1981) Toxic drug effects associated with oxygen metabolism: redox cycling and lipid peroxidation. Experimentia, 37, 1233-1358.
3. Farr,S.B. and Kogoma,T. (1991) Oxidative stress responses in Escherichia coli and Salmonella typhimurium. Microbiol. Rev., 55, 561-585.
4. Ames,B.N., Shigenaga,M.K. and Hagan,T.M. (1993) Oxidants, antioxidants, and the degenerative diseases of aging. Proc. Natl Acad. Sci. USA, 90, 7915-7922.
5. Demple,B. and Harrison,L. (1994) Repair of oxidative damage to DNA: enzymology and biology. Annu. Rev. Biochem., 63, 915-948.
6. Imlay,JA. and Linn,S. (1988) DNA damage and oxygen radical toxicity. Science, 240, 1302-1309.
7. Shibutani,S., Takeshita,M. and Grollman,A.P. (1991) Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG. Nature, 349, 431-434.
8. Maki,H. and Sekiguchi,M. (1992) MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis. Nature, 355, 273-275.
9. Cheng,K.C., Cahill,D.S., Kasai,H., Nishimura,S. and Loeb,L.A. (1992) 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions. J. Biol. Chem., 267, 166-172.
10. Michaels,M. and Miller,J.H. (1992) The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine). J. Bacteriol., 174, 6321-6325.
11. Bailly,V., Verly,W.G., O'Connor,T. and Laval,J. (1989) Mechanism of DNA strand nicking at apurinic/apyrimidinic sites by Escherichia coli [formamidopyrimidine] DNA glycosylase. Biochem J. 262, 581-589.
12. Michaels,M.L., Cruz,C., Grollman,A.P. and Miller,J.H. (1992) Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNA. Proc. Natl Acad. Sci. USA 89, 7022-7025.
13. Au,K.G., Clark,S., Miller,J.H. and Modrich,P. (1989) Escherichia coli mutY gene encodes an adenine glycosylase active on G-A mispairs. Proc. Natl Acad. Sci. USA, 86, 8877-8881.
14. Tajiri,T., Maki,H. and Sekiguchi,M. (1995) Functional cooperation of MutT, MutM and MutY proteins in preventing mutations caused by spontaneous oxidation of guanine nucleotide in Escherichia coli. Mutat. Res., 336, 257-267.
15. Nunoshiba,T., Watanabe,T., Nakabeppu,Y. and Yamamoto,K. (2002) Mutagenic target for hydroxyl radicals generated in Escherichia coli mutant deficient in Mn- and Fe-superoxide dismutases and Fur, a repressor for iron-uptake systems. DNA Repair, 1, 411-418.
16. Nunoshiba,T., Obata,F., Boss,A.C., Oikawa,S., Mori,T., Kawanishi,S. and Yamamoto,K. (1999) Role of iron and superoxide for generation of hydroxyl radical, oxidative DNA lesions, and mutagenesis in Escherichia coli. J. Biol. Chem., 274, 34832-34837.
17. Watanabe,T., van Geldorp,G., Najrana,T., Yamamura,E., Nunoshiba,T. and Yamamoto,K. (2001) Miscoding and misincorporation of 8-oxo-guanine during leading and lagging strand synthesis in Escherichia coli. Mol. Gen. Genet., 264, 836-841.
18. Lu,A.L., Li,X., Gu,Y., Wright,P.M. and Chang,D.Y. (2001) Repair of oxidative DNA damage: mechanisms and functions. Cell Biochem. Biophys., 35, 141-170.
19. Nakabeppu,Y. (2001) Regulation of intracellular localization of human MTH1, OGG1, and MYH proteins for repair of oxidative DNA damage. Prog. Nucleic Acid Res. Mol. Biol., 68, 75-94.
20. Kobayashi,M., Ohara-Nemoto,Y., Kaneko,M., Hayakawa,H., Sekiguchi,M. and Yamamoto,K. (1998) Potential of Escherichia coli GTP cyclohydrolase II for hydrolyzing 8-oxo-dGTP, a mutagenic substrate for DNA synthesis. J. Biol. Chem., 273, 26394-26399.
21. Cupples,C.G. and Miller,J.H. (1989) A set of lacZ mutations in Escherichia coli that allow rapid detection of each of the six base substitutions. Proc. Natl Acad. Sci. USA, 86, 5345-5349.
22. Ramotar,D., Kim,C., Lillis,R. and Demple,B. (1993) Intracellular localization of the Apn1 DNA repair enzyme of Saccharomyces cerevisiae. Nuclear transport signals and biological role. J. Biol. Chem., 268, 20533-20539.
23. Nunoshiba,T. and Yamamoto,K. (1999) Role of glutathione on acrolein-induced cytotoxicity and mutagenicity in Escherichia coli. Mutat. Res., 442, 1-8.
24. Bessman,M.J., Frick,D.N. and O'Handley,S.F. (1996) The MutT proteins or 'Nudix' hydrolases, a family of versatile, widely distributed, 'housecleaning' enzymes. J. Biol. Chem., 271, 25059-25062.
25. Yakushiji,H., Maraboeuf,F., Takahashi,M., Deng,Z.S., Kawabata,S., Nakabeppu,Y. and Sekiguchi,M. (1997) Biochemical and physicochemical characterization of normal and variant forms of human MTH1 protein with antimutagenic activity. Mutat. Res., 384, 181-194.
26. Jurczyk,S.C., Kodra,J.T., Park,J.H., Benner,S.A. and Battersby,T.R. (1999) Synthesis of 2-deoxyisoguanosine 5-triphosphate and 2-deoxy-5-methylisocytidine 5-triphosphate. Helv. Chim. Acta, 82, 1005-1015.
27. Fujikawa,K., Kamiya,H., Yakushiji,H., Fujii,Y., Nakabeppu,Y. and Kasai,H. (1999) The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein. J. Biol. Chem., 274, 18201-18205.
28. Fujii,Y., Shimokawa,H., Sekiguchi,M. and Nakabeppu,Y. (1999) Functional significance of the conserved residues for the 23-residue module among MTH1 and MutT family proteins. J. Biol. Chem., 274, 38251-38259.
29. Sakai,Y., Furuichi,M., Takahashi,M., Mishima,M., Iwai,S., Shirakawa,M. and Nakabeppu,Y. (2002) A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1. J. Biol. Chem., 277, 8579-8587.
30. Bruner,S.D., Nash,H.M., Lane,W.S. and Verdine,G.L. (1998) Repair of oxidatively damaged guanine in Saccharomyces cerevisiae by an alternative pathway. Curr. Biol., 8, 393-403.
31. Earley,M.C. and Crouse,G.F. (1998) The role of mismatch repair in the prevention of base pair mutations in Saccharomyces cerevisiae. Proc. Natl Acad. Sci. USA, 95, 15487-15491.
32. Yang,Y., Karthikeyan,R., Mack,S.E., Vonarx,E.J. and Kunz,B.A. (1999) Analysis of yeast pms1, msh2, and mlh1 imitators points to differences in mismatch correction efficiencies between prokaryotic and eukaryotic cells. Mol. Gen. Genet., 261, 777-787.
33. Egashira,A., Yamauchi,K., Yoshiyama,K., Kawate,H., Katsuki,M., Sekiguchi,M., Sugimachi,K., Maki,H. and Tsuzuki,T. (2002) Mutational specificity of mice defective in the MTH1 and/or the MSH2 genes. DNA Repair, 3, 881-893.
34. Shimokawa,H., Fujii,Y., Furuichi,M., Sekiguchi,M. and Nakabeppu,Y. (2000) Functional significance of conserved residues in the phosphohydrolase module of Escherichia coli MutT protein. Nucleic Acids Res., 28, 3240-3249.
35. Harris,T.K., Wu,G., Massiah,M.A. and Mildvan,A.S. (2000) Mutational, kinetic, and NMR studies of the roles of conserved glutamate residues and of lysine-39 in the mechanism of the MutT pyrophosphohydrolase. Biochemistry, 39, 1655-1674.
36. Cartwright,J.L., Gasmi,L., Spiller,D.G. and McLennan,A.G. (2000) The Saccharomyces cerevisiae PCD1 gene encodes a peroxisomal nudix hydrolase active toward coenzyme A and its derivatives. J. Biol. Chem., 275, 32925-32930.
37. Taddei,F., Hayakawa,H., Bouton,M., Cirinesi,A., Matie,I., Sekiguchi,M. and Radman,M. (1977) Counteraction by MutT protein of transcriptional errors caused by oxidative damage. Science, 278, 128-130.
38. Fujikawa,K., Kamiya,H., Yakushiji,H., Nakabeppu,Y. and Kasai,H. (2001) Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP. Nucleic Acids Res., 29, 449-454.
39. Ishibashi,T., Hayakawa,H. and Sekiguchi,M. (2003) A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides. EMBO Rep., 4, 479-483.