Evidence of the formation of direct covalent adducts of primaquine, 2-tert-butylprimaquine (NP-96) and monohydroxy metabolite of NP-96 with glutathione and N-acetylcysteine

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 1, 2011, Pages 1-7

  Garg, Amit ^a   Prasad, Bhagwat ^a   Takwani, Hardik ^a   Jain, Meenakshi ^a   Jain, Rahul ^a   Singh, Saranjit ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

Glutathione; LC MS; N Acetylcysteine; NP 96; Primaquine; Reactive metabolite

Indexed keywords

GLUTATHIONES; LC-MS; N-ACETYLCYSTEINE; NP-96; PRIMAQUINE; REACTIVE METABOLITES;

ACETONITRILE; AMINES; AMMONIUM COMPOUNDS; BIOMOLECULES; METABOLISM;

METABOLITES;

2 TERT BUTYLPRIMAQUINE; ACETONITRILE; ACETYLCYSTEINE; AMMONIUM ACETATE; GLUTATHIONE; METHEMOGLOBIN; PARACETAMOL; PRIMAQUINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; COVALENT BOND; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MASS SPECTROMETRY; METABOLITE; NONHUMAN; PRIORITY JOURNAL; RAT;

ACETYLCYSTEINE; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GLUTATHIONE; HUMANS; MICROSOMES, LIVER; PRIMAQUINE; RATS; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 78650521002     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.10.029     Document Type: Article

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