Interactions between atropine and etomidate in cortical and spinal networks during cholinergic crisis

Toxicology Letters

Volumn 198, Issue 3, 2010, Pages 342-347

  Drexler, Berthold ^a   Antkowiak, Bernd ^a   Thiermann, Horst ^b   Seeger, Thomas ^b   Grasshoff, Christian ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b BUNDESWEHR INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (Germany)

Author keywords

Acetylcholine; Anaesthesia; Atropine; Cortex; Etomidate; Spinal cord

Indexed keywords

ATROPINE; ETOMIDATE; ORGANOPHOSPHORUS COMPOUND; ACETYLCHOLINE; INTRAVENOUS ANESTHETIC AGENT; MUSCARINIC RECEPTOR BLOCKING AGENT;

ACTION POTENTIAL; ANESTHESIA INDUCTION; ANIMAL TISSUE; ARTICLE; BRAIN REGION; BRAIN SLICE; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DISEASE SEVERITY; GENERAL ANESTHESIA; HEMODYNAMICS; IMMOBILIZATION; IN VITRO STUDY; INTOXICATION; INTRAVENOUS ANESTHESIA; MOUSE; NEOCORTEX; NERVE CELL INHIBITION; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD; UNCONSCIOUSNESS; ANIMAL; DRUG EFFECTS; DRUG INTERACTION; FEMALE; METABOLISM; NERVE CELL; NERVE CELL NETWORK; PREGNANCY;

ACETYLCHOLINE; ACTION POTENTIALS; ANESTHETICS, INTRAVENOUS; ANIMALS; ATROPINE; DRUG INTERACTIONS; ETOMIDATE; FEMALE; MICE; MUSCARINIC ANTAGONISTS; NEOCORTEX; NERVE NET; NEURONS; PREGNANCY; SPINAL CORD; IN VITRO TECHNIQUES;

EID: 78650519784     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2010.07.016     Document Type: Article

References (34)

1. A receptor. Anesthesiology 1999, 91:500-511.
2. Antkowiak B., Helfrich-Förster C. Effects of small concentrations of volatile anesthetics on action potential firing of neocortical neurons in vitro. Anesthesiology 1998, 88:1592-1602.
3. Arbous M.S., Grobbee D.E., van Kleef J.W., de Lange J.J., Spoormans H.H., Touw P., Werner F.M., Meursing A.E. Mortality associated with anaesthesia: a qualitative analysis to identify risk factors. Anaesthesia 2001, 56:1141-1153.
4. Ben Abraham R., Rudick V., Weinbroum A.A. Practical guidelines for acute care of victims of bioterrorism: conventional injuries and concomitant nerve agent intoxication. Anesthesiology 2002, 97:989-1004.
5. Benkwitz C., Liao M., Laster M.J., Sonner J.M., Eger E.I., Pearce R.A. Determination of the EC50 amnesic concentration of etomidate and its diffusion profile in brain tissue: implications for in vitro studies. Anesthesiology 2007, 106:114-123.
6. Bergen J.M., Smith D.C. A review of etomidate for rapid sequence intubation in the emergency department. J. Emerg. Med. 1997, 15:221-230.
7. Braschler U.F., Iannone A., Spenger C., Streit J., Lüscher H.-R. A modified roller tube technique for organotypic cocultures of embryonic rat spinal cord, sensory ganglia and skeletal muscle. J. Neurosci. Methods 1989, 29:121-129.
8. Campagna J.A., Miller K.W., Forman S.A. Mechanisms of actions of inhaled anesthetics. N. Engl. J. Med. 2003, 348:2110-2124.
9. Cosar A., Kenar L. An anesthesiological approach to nerve agent victims. Mil. Med. 2006, 171:7-11.
10. De Jong R.H. Nerve gas terrorism: a grim challenge to anesthesiologists. Anesth. Analg. 2003, 96:819-825.
11. Dewer Y.M.E. Organophosphorus poisoning and therapeutic agents: clinical profile. Pestic. Saf. News 2002, 5(3).
12. Dickinson R., Awaiz S., Whittington M.A., Lieb W.R., Franks N.P. The effects of general anaesthetics on carbachol-evoked gamma oscillations in the rat hippocampus in vitro. Neuropharmacology 2003, 44:864-872.
13. Drexler B., Antkowiak B., Thiermann H., Grasshoff C. Atropine increases sevoflurane potency in cortical but not spinal networks during cholinergic overstimulation. Toxicology 2010, 268:98-103.
14. Eddleston M., Buckley N.A., Eyer P., Dawson A.H. Management of acute organophosphorus pesticide poisoning. Lancet 2008, 371:597-607.
15. Eyer F., Worek F., Eyer P., Felgenhauer N., Haberkorn M., Zilker T., Thiermann H. Obidoxime in acute organophosphate poisoning. 1. Clinical effectiveness. Clin. Toxicol. (Phila.) 2009, 47:798-806.
16. Fiset P., Paus T., Daloze T., Plourde G., Meuret P., Bonhomme V., Hajj-Ali N., Backman S.B., Evans A.C. Brain mechanisms of propofol-induced loss of consciousness in humans: a positron emission tomographic study. J. Neurosci. 1999, 19:5506-5513.
17. Franks N.P. Molecular targets underlying general anaesthesia. Br. J. Pharmacol. 2006, 147(Suppl. 1):S72-S81.
18. Gähwiler B.H. Organotypic monolayer cultures of nervous tissue. J. Neurosci. Methods 1981, 4:329-342.
19. Grasshoff C., Antkowiak B. Propofol and sevoflurane depress spinal neurons in vitro via different molecular targets. Anesthesiology 2004, 101:1167-1176.
20. Grasshoff C., Drexler B., Antkowiak B. Effects of cholinergic overstimulation on isoflurane potency and efficacy in cortical and spinal networks. Toxicology 2007, 229:206-213.
21. Grasshoff C., Drexler B., Hentschke H., Thiermann H., Antkowiak B. Cholinergic modulation of sevoflurane potency in cortical and spinal networks in vitro. Anesthesiology 2007, 106:1147-1155.
22. Grasshoff C., Jurd R., Rudolph U., Antkowiak B. Modulation of presynaptic beta3-containing GABAA receptors limits the immobilizing actions of GABAergic anesthetics. Mol. Pharmacol. 2007, 72:780-787.
23. Grasshoff C., Rudolph M., Antkowiak B. Molecular and systemic mechanisms of general anaesthesia: the 'multi-site and multiple mechanisms' concept. Cur. Opin. Anaesthesiol. 2005, 18:386-391.
24. Gredell J.A., Turnquist P.A., MacIver M.B., Pearce R.A. Determination of diffusion and partition coefficients of propofol in rat brain tissue: implications for studies of drug action in vitro. Br. J. Anaesth. 2004, 93:810-817.
25. Gunnell D., Eddleston M., Phillips M.R., Konradsen F. The global distribution of fatal pesticide self-poisoning: systematic review. BMC Public Health 2007, 7:357.
26. Hentschke H., Schwarz C., Antkowiak B. Neocortex is the major target of sedative concentrations of volatile anaesthetics: strong depression of firing rates and increase of GABA receptor-mediated inhibition. Eur. J. Neurosci. 2005, 21:93-102.
27. Lallement G., Denoyer M., Collet A., Pernot-Marino I., Baubichon D., Monmaur P., Blanchet G. Changes in hippocampal acetylcholine and glutamate extracellular levels during soman-induced seizures: influence of septal cholinoceptive cells. Neurosci. Lett. 1992, 139:104-107.
28. Motulsky H.J., Ransnas L.A. Fitting curves to data using nonlinear regression: a practical and nonmathematical review. FASEB J. 1987, 1:365-374.
29. Murray H., Marik P.E. Etomidate for endotracheal intubation in sepsis: acknowledging the good while accepting the bad. Chest 2005, 127:707-709.
30. Rudolph U., Antkowiak B. Molecular and neuronal substrates for general anaesthetics. Nat. Rev. Neurosci. 2004, 5:709-720.
31. Sonner J.M., Antognini J.F., Dutton R.C., Flood P., Gray A.T., Harris R.A., Homanics G.E., Kendig J., Orser B., Raines D.E., Rampil I.J., Trudell J., Vissel B., Eger E.I. Inhaled anesthetics and immobility: mechanisms, mysteries, and minimum alveolar anesthetic concentration. Anesth. Analg. 2003, 97:718-740.
32. Thiermann H., Worek F., Eyer P., Eyer F., Felgenhauer N., Zilker T. Obidoxime in acute organophosphate poisoning. 2. PK/PD relationships. Clin. Toxicol. (Phila.) 2009, 47:807-813.
33. Tonduli L.S., Testylier G., Marino I.P., Lallement G. Triggering of soman-induced seizures in rats: multiparametric analysis with special correlation between enzymatic, neurochemical and electrophysiological data. J. Neurosci. Res. 1999, 58:464-473.
34. Yanagisawa N., Morita H., Nakajima T. Sarin experiences in Japan: acute toxicity and long-term effects. J. Neurol. Sci. 2006, 249:76-85.