Atropine increases sevoflurane potency in cortical but not spinal networks during cholinergic overstimulation

Toxicology

Volumn 268, Issue 1-2, 2010, Pages 98-103

  Drexler, Berthold ^a   Antkowiak, Bernd ^a   Thiermann, Horst ^b   Grasshoff, Christian ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b BUNDESWEHR INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (Germany)

Author keywords

Acetylcholine; Anaesthesia; Atropine; Cortex; Sevoflurane; Spinal cord

Indexed keywords

ACETYLCHOLINE; ANESTHETIC AGENT; ATROPINE; SEVOFLURANE;

ACTION POTENTIAL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CHOLINERGIC STIMULATION; CONTROLLED STUDY; DRUG POTENCY; DRUG POTENTIATION; EMBRYO; FEMALE; GENERAL ANESTHESIA; MOUSE; NEOCORTEX; NEWBORN; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD; TISSUE SLICE;

ACETYLCHOLINE; ANIMALS; ATROPINE; DRUG SYNERGISM; METHYL ETHERS; MICE; NEOCORTEX; PHOSPHORIC ACID ESTERS; SPINAL CORD;

MUS;

EID: 73749085170     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2009.12.005     Document Type: Article

References (28)

1. Antkowiak B., and Helfrich-Förster C. Effects of small concentrations of volatile anesthetics on action potential firing of neocortical neurons in vitro. Anesthesiology 88 (1998) 1592-1602
2. Baker D.J. Management of casualties from terrorist chemical and biological attack: a key role for the anaesthetist. Br. J. Anaesth. 89 (2002) 211-214
3. Ben Abraham R., Rudick V., and Weinbroum A.A. Practical guidelines for acute care of victims of bioterrorism: conventional injuries and concomitant nerve agent intoxication. Anesthesiology 97 (2002) 989-1004
4. Braschler U.F., Iannone A., Spenger C., Streit J., and Lüscher H.-R. A modified roller tube technique for organotypic cocultures of embryonic rat spinal cord, sensory ganglia and skeletal muscle. J. Neurosci. Methods 29 (1989) 121-129
5. Campagna J.A., Miller K.W., and Forman S.A. Mechanisms of actions of inhaled anesthetics. N. Engl. J. Med. 348 (2003) 2110-2124
6. Cosar A., and Kenar L. An anesthesiological approach to nerve agent victims. Mil. Med. 171 (2006) 7-11
7. De Jong R.H. Nerve gas terrorism: a grim challenge to anesthesiologists. Anesth. Analg. 96 (2003) 819-825 (table)
8. Fiset P., Paus T., Daloze T., Plourde G., Meuret P., Bonhomme V., Hajj-Ali N., Backman S.B., and Evans A.C. Brain mechanisms of propofol-induced loss of consciousness in humans: a positron emission tomographic study. J. Neurosci. 19 (1999) 5506-5513
9. Franks N.P., and Lieb W.R. Molecular and cellular mechanisms of general anaesthesia. Nature 367 (1994) 607-614
10. Gähwiler B.H. Organotypic monolayer cultures of nervous tissue. J. Neurosci. Methods 4 (1981) 329-342
11. Grasshoff C., and Antkowiak B. Propofol and sevoflurane depress spinal neurons in vitro via different molecular targets. Anesthesiology 101 (2004) 1167-1176
12. Grasshoff C., Drexler B., and Antkowiak B. Effects of cholinergic overstimulation on isoflurane potency and efficacy in cortical and spinal networks. Toxicology 229 (2007) 206-213
13. Grasshoff C., Drexler B., Hentschke H., Thiermann H., and Antkowiak B. Cholinergic modulation of sevoflurane potency in cortical and spinal networks in vitro. Anesthesiology 106 (2007) 1147-1155
14. Grasshoff C., Rudolph M., and Antkowiak B. Molecular and systemic mechanisms of general anaesthesia: the 'multi-site and multiple mechanisms' concept. Curr. Opin. Anaesthesiol. 18 (2005) 386-391
15. Grasshoff C., Thiermann H., and Antkowiak B. Anaesthesia in patients suffering from organophosphorus intoxication-interactions between general anaesthetics and acetylcholine in cortical networks in vitro. Toxicology 233 (2007) 214-222
16. Gredell J.A., Turnquist P.A., MacIver M.B., and Pearce R.A. Determination of diffusion and partition coefficients of propofol in rat brain tissue: implications for studies of drug action in vitro. Br. J. Anaesth. 93 (2004) 810-817
17. Hashimoto T., Shu H., and Kuriyama K. Muscarinic M1 receptor mediated inhibition of GABA release from rat cerebral cortex. Neurochem. Int. 24 (1994) 389-394
18. Hentschke H., Schwarz C., and Antkowiak B. Neocortex is the major target of sedative concentrations of volatile anaesthetics: strong depression of firing rates and increase of GABA receptor-mediated inhibition. Eur. J. Neurosci. 21 (2005) 93-102
19. Lallement G., Denoyer M., Collet A., Pernot-Marino I., Baubichon D., Monmaur P., and Blanchet G. Changes in hippocampal acetylcholine and glutamate extracellular levels during soman-induced seizures: influence of septal cholinoceptive cells. Neurosci. Lett. 139 (1992) 104-107
20. Meuret P., Backman S.B., Bonhomme V., Plourde G., and Fiset P. Physostigmine reverses propofol-induced unconsciousness and attenuation of the auditory steady state response and bispectral index in human volunteers. Anesthesiology 93 (2000) 708-717
21. Plourde G., Chartrand D., Fiset P., Font S., and Backman S.B. Antagonism of sevoflurane anaesthesia by physostigmine: effects on the auditory steady-state response and bispectral index. Br. J. Anaesth. 91 (2003) 583-586
22. Rudolph U., and Antkowiak B. Molecular and neuronal substrates for general anaesthetics. Nat. Rev. Neurosci. 5 (2004) 709-720
23. Sonner J.M., Antognini J.F., Dutton R.C., Flood P., Gray A.T., Harris R.A., Homanics G.E., Kendig J., Orser B., Raines D.E., Rampil I.J., Trudell J., Vissel B., and Eger E.I. Inhaled anesthetics and immobility: mechanisms, mysteries, and minimum alveolar anesthetic concentration. Anesth. Analg. 97 (2003) 718-740
24. Thiermann H., Mast U., Klimmek R., Eyer P., Hibler A., Pfab R., Felgenhauer N., and Zilker T. Cholinesterase status, pharmacokinetics and laboratory findings during obidoxime therapy in organophosphate poisoned patients. Hum. Exp. Toxicol. 16 (1997) 473-480
25. Thiermann H., Szinicz L., Eyer F., Worek F., Eyer P., Felgenhauer N., and Zilker T. Modern strategies in therapy of organophosphate poisoning. Toxicol. Lett. 107 (1999) 233-239
26. Thiermann H., Worek F., Eyer P., Eyer F., Felgenhauer N., and Zilker T. Obidoxime in acute organophosphate poisoning: 2-PK/PD relationships. Clin. Toxicol. (Phila) 47 (2009) 807-813
27. Tonduli L.S., Testylier G., Marino I.P., and Lallement G. Triggering of soman-induced seizures in rats: multiparametric analysis with special correlation between enzymatic, neurochemical and electrophysiological data. J. Neurosci. Res. 58 (1999) 464-473
28. White S.M. Chemical and biological weapons. Implications for anaesthesia and intensive care. Br. J. Anaesth. 89 (2002) 306-324