Synthesis and cytotoxicity of cis-dichloroplatinum (II) complexes of (1S,3S)-1,2,3,4-tetrahydroisoquinolines

European Journal of Medicinal Chemistry

Volumn 46, Issue 1, 2011, Pages 356-363

  Xu, Geng ^a   Yan, Zheng ^a   Wang, Nan ^a   Liu, Zhanzhu ^a  

^a PEKING UNION MEDICAL COLLEGE   (China)

Author keywords

Antitumor activity; cis Dichloroplatinum (II) complexes; Synthesis; Tetrahydroisoquinolines

Indexed keywords

CISPLATIN; CISPLATIN DERIVATIVE; METYL 4 [(6,7 DIMETHOXY 1 PHENYL 1,2,3,4 TETRAHYDRO 3 ISOQUINOLINYL)METHYLAMINO]BENZOATE DICHLOROPLATINATE; METYL 4 [[1 (4 CHLOROPHENYL) 6,7 DIMETHOXY 1,2,3,4 TETRAHYDRO 3 ISOQUINOLINYL]METHYLAMINO]BENZOATE DICHLOROPLATINATE; METYL 4 [[6,7 DIMETHOXY 1 (4 METHOXYPHENYL) 1,2,3,4 TETRAHYDRO 3 ISOQUINOLINYL]METHYLAMINO]BENZOATE DICHLOROPLATINATE; N (4 CHLOROPHENYL) N (6,7 DIMETHOXY 1 PHENYL 1,2,3,4 TETRAHYDRO 3 ISOQUINOLINYL)METHYLAMINE DICHLOROPLATINATE; N (4 CHLOROPHENYL) N [1 (4 CHLOROPHENYL) 6,7 DIMETHOXY 1,2,3,4 TETRAHYDRO 3 ISOQUINOLINYL]METHYLAMINE DICHLOROPLATINATE; N (4 CHLOROPHENYL) N [6,7 DIMETHOXY 1 (4 METHOXYPHENYL) 1,2,3,4 TETRAHYDRO 3 ISOQUINOLINYL]METHYLAMINE DICHLOROPLATINATE; N (6,7 DIMETHOXY 1 PHENYL 1,2,3,4 TETRAHYDRO 3 ISOQUINOLINYL)METHYL N (4 METHOXYPHENYL)AMINE DICHLOROPLATINATE; N (6,7 DIMETHOXY 1 PHENYL 1,2,3,4 TETRAHYDRO 3 ISOQUINOLINYL)METHYL N (4 METHYLPHENYL)AMINE DICHLOROPLATINATE; N (6,7 DIMETHOXY 1 PHENYL 1,2,3,4 TETRAHYDRO 3 ISOQUINOLINYL)METHYL N [4 (TRIFLUOROMETHYL)PHENYL]AMINE DICHLOROPLATINATE; N (6,7 DIMETHOXY 1 PHENYL 1,2,3,4 TETRAHYDRO 3 ISOQUINOLINYL)METHYL N PHENYLAMINE DICHLOROPLATINATE; N [1 (4 CHLOROPHENYL) 6,7 DIMETHOXY 1,2,3,4 TETRAHYDRO 3 ISOQUINOLINYL]METHYL N (4 METHOXYPHENYL)AMINE DICHLOROPLATINATE; N [1 (4 CHLOROPHENYL) 6,7 DIMETHOXY 1,2,3,4 TETRAHYDRO 3 ISOQUINOLINYL]METHYL N (4 METHYLPHENYL)AMINE DICHLOROPLATINATE; N [1 (4 CHLOROPHENYL) 6,7 DIMETHOXY 1,2,3,4 TETRAHYDRO 3 ISOQUINOLINYL]METHYL N [4 (TRIFLUOROMETHYL)PHENYL]AMINE DICHLOROPLATINATE; N [1 (4 CHLOROPHENYL) 6,7 DIMETHOXY 1,2,3,4 TETRAHYDRO 3 ISOQUINOLINYL]METHYL N PHENYLAMINE DICHLOROPLATINATE; N [6,7 DIMETHOXY 1 (4 METHOXYPHENYL) 1,2,3,4 N TETRAHYDRO 3 ISOQUINOLINYL]METHYL N [4 (TRIFLUOROMETHYL)PHENYL]AMINE DICHLOROPLATINATE; N [6,7 DIMETHOXY 1 (4 METHOXYPHENYL) 1,2,3,4 TETRAHYDRO 3 ISOQUINOLINYL]METHYL N (4 METHOXYPHENYL)AMINE DICHLOROPLATINATE; N [6,7 DIMETHOXY 1 (4 METHOXYPHENYL) 1,2,3,4 TETRAHYDRO 3 ISOQUINOLINYL]METHYL N (4 METHYLPHENYL)AMINE DICHLOROPLATINATE; N [6,7 DIMETHOXY 1 (4 METHOXYPHENYL) 1,2,3,4 TETRAHYDRO 3 ISOQUINOLINYL]METHYL N PHENYLAMINE DICHLOROPLATINATE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; HUMANS; INHIBITORY CONCENTRATION 50; ORGANOPLATINUM COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROISOQUINOLINES;

EID: 78650516527     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.11.025     Document Type: Article

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