Susceptibility to the cytogenetic effects of dichloromethane is related to the glutathione S-transferase theta phenotype

Toxicology Letters

Volumn 199, Issue 3, 2010, Pages 218-224

  Olvera Bello, Alejandra E ^a   Estrada Muñiz, Elizabet ^a   Elizondo, Guillermo ^a   Vega, Libia ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

Cell cycle arrest; DNA damage; Glutathione S transferase polymorphisms; Methylene chloride; Peripheral blood mononuclear cells

Indexed keywords

DICHLOROMETHANE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE THETA; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BIOTRANSFORMATION; CARCINOGENICITY; CELL LEVEL; CELL PROLIFERATION; CYTOGENETICS; DNA DAMAGE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MALE; MITOSIS INDEX; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; SISTER CHROMATID EXCHANGE;

ANIMALIA;

EID: 78650516045     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2010.09.002     Document Type: Article

References (39)

1. Alexandrie A.K., Rannug A., Juronen E., Tasa G., Warholm M. Detection and characterization of a novel functional polymorphism in the GSTT1 gene. Pharmacogenetics 2002, 12:613-619.
2. ATSDR Agency for Toxic Substances and Disease Registry. Toxical Profiles for Methylene Chloride, ATSDR 205-93-0606 September, 2000.
3. Bogaards J.J., van Ommen B., van Bladeren P.J. Interindividual differences in the in vitro conjugation of methylene chloride with glutathione by cytosolic glutathione S-transferase in 22 human liver samples. Biochem. Pharmacol. 1993, 45:2166-2169.
4. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
5. Bruhn C., Brockmoller J., Kerb R., Roots I., Borchert H.H. Concordance between enzyme activity and genotype of glutathione S-transferase theta (GSTT1). Biochem. Pharmacol. 1998, 56:1189-1193.
6. Casanova M., Bell D.A., Heck H.D. Dichloromethane metabolism to formaldehyde and reaction of formaldehyde with nucleic acids in hepatocytes of rodents and humans with and without glutathione S-transferase T1 and M1 genes. Fundam. Appl. Toxicol. 1997, 37:168-180.
7. Ceschi M., Sun C.L., Van Den Berg D., Koh W.P., Yu M.C., Probst-Hensch N. The effect of cyclin D1 (CCND1) G870A-polymorphism on breast cancer risk is modified by oxidative stress among Chinese women in Singapore. Carcinogenesis 2005, 26:1457-1464.
8. Chakova N.N., Mikhalenko E.P., Polonetskaya S.N., Chebotareva N.V., Demidchik Y.E., Zhilko A.A., Kvitko O.V., Krupnova E.V. GST polymorphism and cytogenetic changes in lung tissues of lung cancer patients. Cytol. Genet. 2009, 43:38-41.
9. El-Masri H.A., Bell D.A., Portier C.J. Effects of glutathione transferase theta polymorphism on the risk estimates of dichloromethane to humans. Toxicol. Appl. Pharmacol. 1999, 158:221-230.
10. Evans M.V., Caldwell J.C. Evaluation of two different metabolic hypotheses for dichloromethane toxicity using physiologically based pharmacokinetic modeling for in vivo inhalation gas uptake data exposure in female B6C3F1 mice. Toxicol. Appl. Pharmacol. 2010, 244:280-290.
11. Gargas M.L., Clewell H.J., Andersen M.E. Metabolism of inhaled dihalomethanes in vivo: differentiation of kinetic constants for two independent pathways. Toxicol. Appl. Pharmacol. 1986, 82:211-223.
12. Gonsebatt M.E., Vega L., Herrera L.A., Montero R., Rojas E., Cebrian M.E., Ostrosky-Wegman P. Inorganic arsenic effects on human lymphocyte stimulation and proliferation. Mutat. Res. 1992, 283:91-95.
13. Green T. Methylene chloride induced mouse liver and lung tumours: an overview of the role of mechanistic studies in human safety assessment. Hum. Exp. Toxicol. 1997, 16:3-13.
14. Guengerich F.P., McCormick W.A., Wheeler J.B. Analysis of the kinetic mechanism of haloalkane conjugation by mammalian theta-class glutathione transferases. Chem. Res. Toxicol. 2003, 16:1493-1499.
15. Hallier E., Schroder K.R., Asmuth K., Dommermuth A., Aust B., Goergens H.W. Metabolism of dichloromethane (methylene chloride) to formaldehyde in human erythrocytes: influence of polymorphism of glutathione transferase theta (GST-T1). Arch. Toxicol. 1994, 68:423-427.
16. Hu Y., Kabler S.L., Tennant A.H., Townsend A.J., Kligerman A.D. Induction of DNA-protein crosslinks by dichloromethane in V79 cell line transfected with the murine glutathione-S-transferase theta 1 gene. Mutat. Res. 2006, 607:231-239.
17. IARC, Monographs, International Agency for Research on Cancer Methylene Chloride 1993, p. 71.
18. Landi S. Mammalian class theta GST and differential susceptibility to carcinogens: a review. Mutat. Res. 2000, 463:247-283.
19. Marsch G.A., Botta S., Martin M.V., McCormick W.A., Guengerich F.P. Formation and mass spectrometric analysis of DNA and nucleoside adducts by S-(1-acetoxymethyl)glutathione and by glutathion S-transferase-mediated activation of dihalomethanes. Chem. Res. Toxicol. 2004, 17:45-54.
20. Morrow C.S., Chiu J., Cowan K.H. Posttranscriptional control of glutathione-s-transferase-pi gene-expression in human breast-cancer cells. J. Biol. Chem. 1992, 267:10544-10550.
21. Nelson H.H., Wiencke J.K., Christiani D.C., Cheng T.J., Zuo Z.F., Schwartz B.S., Lee B.K., Spitz M.R., Wang M., Xu X., et al. Ethnic differences in the prevalence of the homozygous deleted genotype of glutathione S-transferase theta. Carcinogenesis 1995, 16:1243-1245.
22. NIOSH National institute for occupational safety and health. Manual of analytical methods, methylene chloride. Method 1998, 1005(3):2-4.
23. NOM, Norma Oficial Mexicana, NOM-STPS-010-1999, 1999. Condiciones de seguridad e higiene en los centro de trabajo donde se manejen, transporten, procesen o almacenen sustancias químicas capaces de generar contaminación en el medio ambiente laboral.
24. Norppa H., Hirvonen A., Jarventaus H., Uuskula M., Tasa G., Ojajarvi A., Sorsa M. Role of GSTT1 and GSTM1 genotypes in determining individual sensitivity to sister chromatid exchange induction by diepoxybutane in cultured human lymphocytes. Carcinogenesis 1995, 16:1261-1264.
25. NTP, National Toxicology Program. Toxicology and carcinogenesis studies of dichloromethane (Methylene chloride) (CAS No. 75-09-2) in F344/N rats and B6C3F1 mice (Inhalation studies), 1985. National Toxicology Program Technical Report Services 306, pp. 1-208.
26. Olvera-Bello A.E., Vega L. Role of glutathione S-transferase enzymes in toxicology, pharmacology and human disease. Xenobitic Metabolizing Enzymes and Xenobiotic Receptors 2010, 45-66. Pharmacological and Toxicological Aspects, Research Signpost, India. G. Elizondo (Ed.).
27. OSHA, 1999. U.S. Department of Labor Occupational Safety and Health Administration. Code of Federal Regulations 29 CFR 1910.1052.
28. Ozturk S., Vatansever S., Cefle K., Palanduz S., Guler K., Erten N., Erk O., Karan M.A., Tascioglu C. Acute wood or coal exposure with carbon monoxide intoxication induces sister chromatid exchange. J. Toxicol. Clin. Toxicol. 2002, 40:115-120.
29. Pemble S., Schroeder K.R., Spencer S.R., Meyer D.J., Hallier E., Bolt H.M., Ketterer B., Taylor J.B. Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism. Biochem. J. 1994, 300(Pt 1):271-276.
30. Piantadosi C.A., Zhang J., Levin E.D., Folz R.J., Schmechel D.E. Apoptosis and delayed neuronal damage after carbon monoxide poisoning in the rat. Exp. Neurol. 1997, 147:103-114.
31. Preston R.J., Williams G.M. DNA-reactive carcinogens: mode of action and human cancer hazard. Crit. Rev. Toxicol. 2005, 35:673-683.
32. Reyes-Hernández O., Lares-Asseff I., Sosa-Macías M., Vega L., Albores A., Elizondo G. A comparative study of CYP3A4 polymorphisms in Mexican Amerindian and Mestizo populations. Pharmacology 2008, 81:97-103.
33. Schwer C.I., Mutschler M., Stoll P., Goebel U., Humar M., Hoetzel A., Schmidt R. Carbon monoxide releasing molecule-2 inhibits pancreatic stellate cell proliferation by activating p38 mitogen-activated protein kinase/heme oxygenase-1 signaling. Mol. Pharmacol. 2010, 77:660-669.
34. Starr T.B., Matanoski G., Anders M.W., Andersen M.E. Workshop overview: reassessment of the cancer risk of dichloromethane in humans. Toxicol. Sci. 2006, 91:20-28.
35. Thier R., Wiebel F.A., Hinkel A., Burger A., Bruning T., Morgenroth K., Senge T., Wilhelm M., Schulz T.G. Species differences in the glutathione transferase GSTT1-1 activity towards the model substrates methyl chloride and dichloromethane in liver and kidney. Arch. Toxicol. 1998, 72:622-629.
36. Watanabe K., Guengerich F.P. Limited reactivity of formyl chloride with glutathione and relevance to metabolism and toxicity of dichloromethane. Chem. Res. Toxicol. 2006, 19:1091-1096.
37. Watanabe K., Liberman R.G., Skipper P.L., Tannenbaum S.R., Guengerich F.P. Analysis of DNA adducts formed in vivo in rats and mice from 1,2-dibromoethane, 1,2-dichloroethane, dibromomethane, and dichloromethane using HPLC/accelerator mass spectrometry and relevance to risk estimates. Chem. Res. Toxicol. 2007, 20:1594-1600.
38. Wegiel B., Chin B.Y., Otterbein B.E. Inhale to survive, cycle or die? Carbon monoxide and cellular proliferation. Cell Cycle 2008, 7:1379-1384.
39. WHO, Word Health Organization Acta Toxicológica Argentina. Criterios de Salud Ambiental 1999, pp. 16-19.