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Volumn 16, Issue 1, 1997, Pages 3-13

Methylene chloride induced mouse liver and lung tumours: An overview of the role of mechanistic studies in human safety assessment

Author keywords

Cancer; Human safety assessment; Methylene chloride

Indexed keywords

DICHLOROMETHANE; DNA; GLUTATHIONE TRANSFERASE;

EID: 0031015191     PISSN: 01445952     EISSN: None     Source Type: Journal    
DOI: 10.1177/0960327197016001021     Document Type: Article
Times cited : (56)

References (60)
  • 2
    • 77957186772 scopus 로고
    • Methylene chloride; a two year inhalation toxicity and oncogenicity study in rats and hamsters
    • Burek JD et al. Methylene chloride; A two year inhalation toxicity and oncogenicity study in rats and hamsters. Fundemental and Applied Toxicology 1984; 4: 30-47.
    • (1984) Fundemental and Applied Toxicology , vol.4 , pp. 30-47
    • Burek, J.D.1
  • 3
    • 0023026582 scopus 로고
    • A two year drinking-water study of dichloromethane in rodents, II. Mice
    • Serota DG et al. A two year drinking-water study of dichloromethane in rodents, II. Mice. Food and Chemical Toxicology 1986; 24: 959-63.
    • (1986) Food and Chemical Toxicology , vol.24 , pp. 959-963
    • Serota, D.G.1
  • 4
    • 0022966228 scopus 로고
    • A two year drinking-water study of dichloromethane in rodents, I. Rats
    • Serota DG et al. A two year drinking-water study of dichloromethane in rodents, I. Rats. Food and Chemical Toxicology 1986; 24: 951-8.
    • (1986) Food and Chemical Toxicology , vol.24 , pp. 951-958
    • Serota, D.G.1
  • 5
    • 77957182751 scopus 로고
    • A 2 year inhalation toxicity and oncogenicity study in rats
    • Nitschke KD et al. A 2 year inhalation toxicity and oncogenicity study in rats. Fundemental and Applied Toxicology 1988; 11: 48-59.
    • (1988) Fundemental and Applied Toxicology , vol.11 , pp. 48-59
    • Nitschke, K.D.1
  • 8
    • 0020510027 scopus 로고
    • The metabolic activation of dichloromethane and chlorofluoromethane in a bacterial mutation assay using Salmonella typhimurium
    • * - Industry sponsored studies Green T. The metabolic activation of dichloromethane and chlorofluoromethane in a bacterial mutation assay using Salmonella typhimurium. Mutation Research 1983; 118: 277-88.
    • (1983) Mutation Research , vol.118 , pp. 277-288
    • Green, T.1
  • 9
    • 0019350622 scopus 로고
    • Mutagenicity testing of dichloromethane in short-term mammalian tests
    • Jongen WMF et al. Mutagenicity testing of dichloromethane in short-term mammalian tests. Mutation Research 1981; 81: 203-13.
    • (1981) Mutation Research , vol.81 , pp. 203-213
    • Jongen, W.M.F.1
  • 10
    • 0020665015 scopus 로고
    • Induction of chromosome damage by methylene chloride in CHO cells
    • Thilager AK, Kumaroo V. Induction of chromosome damage by methylene chloride in CHO cells. Mutation Research 1983; 116: 361-7.
    • (1983) Mutation Research , vol.116 , pp. 361-367
    • Thilager, A.K.1    Kumaroo, V.2
  • 11
    • 8044227394 scopus 로고
    • Evaluation of dichloromethane in short-term in vitro genetic toxicity assays
    • Thilager AK et al. Evaluation of dichloromethane in short-term in vitro genetic toxicity assays. Environmental Mutagenesis 1984; 6: 418-9.
    • (1984) Environmental Mutagenesis , vol.6 , pp. 418-419
    • Thilager, A.K.1
  • 12
    • 0023143820 scopus 로고
    • Inactivity of methylene chloride in the mouse bone marrow micronucleus assay
    • * - Industry sponsored studies Sheldon T, Richardson CR, Elliott BM. Inactivity of methylene chloride in the mouse bone marrow micronucleus assay. Mutagenesis 1987; 2: 57-9.
    • (1987) Mutagenesis , vol.2 , pp. 57-59
    • Sheldon, T.1    Richardson, C.R.2    Elliott, B.M.3
  • 13
    • 0023554662 scopus 로고
    • Lack of UDS activity in the livers of mice exposed to dichloromethane
    • * - Industry sponsored studies Trueman RW, Ashby J. Lack of UDS activity in the livers of mice exposed to dichloromethane. Environmental and Molecular Mutagenesis 1987; 10: 189-95.
    • (1987) Environmental and Molecular Mutagenesis , vol.10 , pp. 189-195
    • Trueman, R.W.1    Ashby, J.2
  • 15
    • 0024398910 scopus 로고
    • Evaluation of dichloromethane as an inducer of DNA synthesis in the B6C3F1 mouse liver
    • * - Industry sponsored studies Lefevre PA, Ashby J. Evaluation of dichloromethane as an inducer of DNA synthesis in the B6C3F1 mouse liver. Carcinogenesis 1989; 10: 1067-72.
    • (1989) Carcinogenesis , vol.10 , pp. 1067-1072
    • Lefevre, P.A.1    Ashby, J.2
  • 18
    • 0025298312 scopus 로고
    • Cytogenetic analysis of mice exposed to dichloromethane
    • Allen et al. Cytogenetic analysis of mice exposed to dichloromethane. Environmental and Molecular Mutagenesis 1990; 15: 1-228.
    • (1990) Environmental and Molecular Mutagenesis , vol.15 , pp. 1-228
    • Allen1
  • 19
    • 0027298932 scopus 로고
    • Inhalation exposure to a hepatocarcinogenic concentration of methylene chloride does not induce sustained replicative DNA synthesis in hepatocytes of female B6C3F1 mice
    • Foley JF et al. Inhalation exposure to a hepatocarcinogenic concentration of methylene chloride does not induce sustained replicative DNA synthesis in hepatocytes of female B6C3F1 mice. Carcinogenesis 1993; 14: 811-7.
    • (1993) Carcinogenesis , vol.14 , pp. 811-817
    • Foley, J.F.1
  • 20
    • 8044257307 scopus 로고
    • The bronchiolar Clara cell: Selective cytotoxicity with methylene chloride
    • Proc. 11th. Int. Congr.
    • * - Industry sponsored studies Foster JR, Hext PM, Green T. The bronchiolar Clara cell: selective cytotoxicity with methylene chloride. Electron Microscopy Proc. 11th. Int. Congr., 1986; 2755-66.
    • (1986) Electron Microscopy , pp. 2755-2766
    • Foster, J.R.1    Hext, P.M.2    Green, T.3
  • 21
    • 77957177161 scopus 로고
    • Methylene chloride - An inhalation study to investigate pathological and biochemical events occurring in the lungs of mice over an exposure period of 90 days
    • * - Industry sponsored studies Foster JR et al. Methylene chloride - An inhalation study to investigate pathological and biochemical events occurring in the lungs of mice over an exposure period of 90 days. Fundemental and Applied Toxicology 1992; 18: 376-88.
    • (1992) Fundemental and Applied Toxicology , vol.18 , pp. 376-388
    • Foster, J.R.1
  • 22
    • 0028101990 scopus 로고
    • Methylene chloride: An inhalation study to investigate toxicity in the mouse lung using morphological, biochemical and Clara cell culture techniques
    • * - Industry sponsored studies Foster JR, Green T, Smith LL, Tittensor S, Wyatt I. Methylene chloride: an inhalation study to investigate toxicity in the mouse lung using morphological, biochemical and Clara cell culture techniques. Toxicology 1994; 91: 221-34.
    • (1994) Toxicology , vol.91 , pp. 221-234
    • Foster, J.R.1    Green, T.2    Smith, L.L.3    Tittensor, S.4    Wyatt, I.5
  • 23
    • 8044239860 scopus 로고    scopus 로고
    • DNA-protein crosslinks and cell proliferation in mice exposed to dichloromethane: Risk assessment with DPX as dosimeter
    • Heck Hd'A, Connolly R, Casanova M. DNA-protein crosslinks and cell proliferation in mice exposed to dichloromethane: Risk assessment with DPX as dosimeter. The Toxicologist 1996; 30: 473.
    • (1996) The Toxicologist , vol.30 , pp. 473
    • Heck, Hd'A.1    Connolly, R.2    Casanova, M.3
  • 24
    • 0027314749 scopus 로고
    • Ras proto-oncogene activation in liver and lung tumours from B6C3F1 mice exposed chronically to methylene chloride
    • Devereux TR, Foley JR, Maronpot RR, Kari F, Anderson M. Ras proto-oncogene activation in liver and lung tumours from B6C3F1 mice exposed chronically to methylene chloride. Carcinogenesis 1993; 14: 795-801.
    • (1993) Carcinogenesis , vol.14 , pp. 795-801
    • Devereux, T.R.1    Foley, J.R.2    Maronpot, R.R.3    Kari, F.4    Anderson, M.5
  • 25
    • 0016796470 scopus 로고
    • Metabolism of dihalomethanes to carbon monoxide. II. In vitro studies on the mechanism of the reaction
    • Kubic VL, Anders MW. Metabolism of dihalomethanes to carbon monoxide. II. In vitro studies on the mechanism of the reaction. Drug Metabolism and Disposition 1975; 3: 104-12.
    • (1975) Drug Metabolism and Disposition , vol.3 , pp. 104-112
    • Kubic, V.L.1    Anders, M.W.2
  • 26
    • 0018085060 scopus 로고
    • Metabolism of dihalomethanes to carbon monoxide. III. Studies on the mechanism of the reaction
    • Kubic VL, Anders MW. Metabolism of dihalomethanes to carbon monoxide. III. Studies on the mechanism of the reaction. Biochemical Pharmacology 1978; 27: 2349-55.
    • (1978) Biochemical Pharmacology , vol.27 , pp. 2349-2355
    • Kubic, V.L.1    Anders, M.W.2
  • 27
    • 0017186325 scopus 로고
    • Metabolism of dihalomethanes to formaldehyde and inorganic chloride
    • Ahmed AE, Anders MW. Metabolism of dihalomethanes to formaldehyde and inorganic chloride. Drug Metabolism and Disposition 1976; 4: 357-61.
    • (1976) Drug Metabolism and Disposition , vol.4 , pp. 357-361
    • Ahmed, A.E.1    Anders, M.W.2
  • 28
    • 0018176867 scopus 로고
    • Metabolism of dihalomethanes to formaldehyde and inorganic halide. II. Studies on the mechanism of the reaction
    • Ahmed AE, Anders MW. Metabolism of dihalomethanes to formaldehyde and inorganic halide. II. Studies on the mechanism of the reaction. Biochemical Pharmacology 1978; 27: 2021-25.
    • (1978) Biochemical Pharmacology , vol.27 , pp. 2021-2025
    • Ahmed, A.E.1    Anders, M.W.2
  • 29
    • 0022656857 scopus 로고
    • Metabolism of inhaled dihalomethanes in vivo: Differentiation of kinetic constants for two independent pathways
    • Gargas ML, Clewell HJ, Anderson ME. Metabolism of inhaled dihalomethanes in vivo: differentiation of kinetic constants for two independent pathways. Toxicology and Applied Pharmacology 1986; 82: 211-23.
    • (1986) Toxicology and Applied Pharmacology , vol.82 , pp. 211-223
    • Gargas, M.L.1    Clewell, H.J.2    Anderson, M.E.3
  • 30
    • 0026035519 scopus 로고
    • Role of human cytochrome P-450IIE1 in the oxidation of many low molecular weight cancer suspects
    • Guengerich FP, Kim DH, Iwasai M. Role of human cytochrome P-450IIE1 in the oxidation of many low molecular weight cancer suspects. Chemical Research in Toxicology 1991; 4: 168-79.
    • (1991) Chemical Research in Toxicology , vol.4 , pp. 168-179
    • Guengerich, F.P.1    Kim, D.H.2    Iwasai, M.3
  • 31
    • 0026033569 scopus 로고
    • Theta, a new class of glutathione transferases purified from rat and man
    • Meyer DJ et al. Theta, a new class of glutathione transferases purified from rat and man. Biochemical Journal 1991; 274: 409-14.
    • (1991) Biochemical Journal , vol.274 , pp. 409-414
    • Meyer, D.J.1
  • 32
    • 0029918491 scopus 로고    scopus 로고
    • The isolation of a theta class glutathione S-transferases active with methylene chloride
    • * - Industry sponsored studies Mainwaring GW, Davidson M, Green T. The isolation of a theta class glutathione S-transferases active with methylene chloride. Biochemical Journal 1996a; 314: 445-8.
    • (1996) Biochemical Journal , vol.314 , pp. 445-448
    • Mainwaring, G.W.1    Davidson, M.2    Green, T.3
  • 33
    • 0344673281 scopus 로고
    • A biological data base for methylene chloride risk assessment
    • Travis, C.C. (ed.). Plenum, New York
    • * - Industry sponsored studies Green T. A biological data base for methylene chloride risk assessment. In Travis, C.C. (ed.). Biologically-Based Methods for Cancer Risk Assessment. Plenum, New York, pp. 289-300, 1989.
    • (1989) Biologically-Based Methods for Cancer Risk Assessment , pp. 289-300
    • Green, T.1
  • 34
    • 0024515167 scopus 로고
    • In vitro metabolism of methylene chloride in human and animal tissues: Use in physiologically based pharmacokinetic models
    • Reitz RH, Mendrala AL, Guengerich FP. In vitro metabolism of methylene chloride in human and animal tissues: Use in physiologically based pharmacokinetic models. Toxicology and Applied Pharmacology 1989; 97: 230-46.
    • (1989) Toxicology and Applied Pharmacology , vol.97 , pp. 230-246
    • Reitz, R.H.1    Mendrala, A.L.2    Guengerich, F.P.3
  • 35
    • 0027161693 scopus 로고
    • Interindividual differences in the in vitro conjugation of methylene chloride with glutathione S-transferase in 22 human samples
    • Bogaards JPP, van Ommen B, van Bladeren PJ. Interindividual differences in the in vitro conjugation of methylene chloride with glutathione S-transferase in 22 human samples. Biochemical Pharmacology 1993; 45: 2166-69.
    • (1993) Biochemical Pharmacology , vol.45 , pp. 2166-2169
    • Bogaards, J.P.P.1    Van Ommen, B.2    Van Bladeren, P.J.3
  • 36
    • 0029160231 scopus 로고
    • Methylene chloride induced DNA damage: An interspecies comparison
    • * - Industry sponsored studies Graves RJ, Coutts C, Green T. Methylene chloride induced DNA damage: An interspecies comparison. Carcinogenesis 1995; 16: 1919-26.
    • (1995) Carcinogenesis , vol.16 , pp. 1919-1926
    • Graves, R.J.1    Coutts, C.2    Green, T.3
  • 37
    • 0027531684 scopus 로고
    • Polymorphism of glutathione conjugation of methyl bromide, ethylene oxide and dichloromethane in human blood: Influence on the induction of sister chromatid exchanges (SCE) in lymphocytes
    • Hallier E et al. Polymorphism of glutathione conjugation of methyl bromide, ethylene oxide and dichloromethane in human blood: influence on the induction of sister chromatid exchanges (SCE) in lymphocytes. Archives of Toxicology 1993; 67: 173-8.
    • (1993) Archives of Toxicology , vol.67 , pp. 173-178
    • Hallier, E.1
  • 38
    • 0028136267 scopus 로고
    • Metabolism of dichloromethane (methylene chloride) to formaldehyde in human erythrocytes: Influence of polymorphism of glutathione transferase Theta (GST T1-1)
    • Hallier E et al. Metabolism of dichloromethane (methylene chloride) to formaldehyde in human erythrocytes: influence of polymorphism of glutathione transferase Theta (GST T1-1). Archives of Toxicology 1994; 69: 423-7.
    • (1994) Archives of Toxicology , vol.69 , pp. 423-427
    • Hallier, E.1
  • 39
    • 0028231093 scopus 로고
    • Human glutathione S-transferase Theta (GSTT1): CDNA cloning and the characterization of a genetic polymorphism
    • Pemble et al. Human glutathione S-transferase Theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism. Biochemical Journal 1994; 300: 274-76.
    • (1994) Biochemical Journal , vol.300 , pp. 274-276
    • Pemble1
  • 40
    • 0029992218 scopus 로고    scopus 로고
    • Purification and characterisation of a new glutathione S-transferase, class theta, from human erythrocytes
    • Schroder KR et al. Purification and characterisation of a new glutathione S-transferase, class theta, from human erythrocytes. Archives of Toxicology 1996; 70: 559-66.
    • (1996) Archives of Toxicology , vol.70 , pp. 559-566
    • Schroder, K.R.1
  • 42
    • 0023158895 scopus 로고
    • Physiologically based pharmacokinetics and the risk assessment process for methylene chloride
    • Andersen ME et al. Physiologically based pharmacokinetics and the risk assessment process for methylene chloride. Toxicology and Applied Pharmacology 1987; 87: 185-205.
    • (1987) Toxicology and Applied Pharmacology , vol.87 , pp. 185-205
    • Andersen, M.E.1
  • 44
    • 0027298933 scopus 로고
    • Effect of varying exposure regimens on methylene chloride-induced lung and liver tumours in female B6C3F1 mice
    • Kari FW et al. Effect of varying exposure regimens on methylene chloride-induced lung and liver tumours in female B6C3F1 mice. Carcinogenesis 1993; 14: 819-26.
    • (1993) Carcinogenesis , vol.14 , pp. 819-826
    • Kari, F.W.1
  • 45
    • 0029163291 scopus 로고
    • Hepatic and pulmonary carcinogenicity of methylene chloride in mice: A search for mechanisms
    • Maronpot RR et al. Hepatic and pulmonary carcinogenicity of methylene chloride in mice: a search for mechanisms. Toxicologist 1995; 102: 73-81.
    • (1995) Toxicologist , vol.102 , pp. 73-81
    • Maronpot, R.R.1
  • 46
    • 0025057964 scopus 로고
    • Sequence analysis and expression of the bacterial dichloromethane dehalogenase structural gene, a member of the glutathione S-transferase supergene family
    • La Roche SD, Leisinger T. Sequence analysis and expression of the bacterial dichloromethane dehalogenase structural gene, a member of the glutathione S-transferase supergene family. Journal of Bacteriology 1990; 172: 164-71.
    • (1990) Journal of Bacteriology , vol.172 , pp. 164-171
    • La Roche, S.D.1    Leisinger, T.2
  • 47
    • 0027321555 scopus 로고
    • Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA1535 leads to base pair mutations upon exposure to dihalomethanes
    • Thier R et al. Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA1535 leads to base pair mutations upon exposure to dihalomethanes. Proceedings of the National Academy of Science 1993; 90: 8576-80.
    • (1993) Proceedings of the National Academy of Science , vol.90 , pp. 8576-8580
    • Thier, R.1
  • 48
    • 0028078458 scopus 로고
    • The role of formaldehyde and S-chloromethylglutathione in the bacterial mutagenicity of methylene chloride
    • * - Industry sponsored studies Graves RJ, Callander RD, Green T. The role of formaldehyde and S-chloromethylglutathione in the bacterial mutagenicity of methylene chloride. Mutation Research 1994; 320: 235-43.
    • (1994) Mutation Research , vol.320 , pp. 235-243
    • Graves, R.J.1    Callander, R.D.2    Green, T.3
  • 49
    • 74049108123 scopus 로고    scopus 로고
    • The possible role of S-chloromethylglutathione in the genotoxicity of dichloromethane
    • Dechert S, Dekant W. The possible role of S-chloromethylglutathione in the genotoxicity of dichloromethane. The Toxicologist 1996; 30: 479.
    • (1996) The Toxicologist , vol.30 , pp. 479
    • Dechert, S.1    Dekant, W.2
  • 50
    • 0028284646 scopus 로고
    • Relationship between hepatic DNA damage and methylene chloride-induced hepatocarcinogenicity in B6C3F1 mice
    • * - Industry sponsored studies Graves RJ, Coutts C, Eyton-Jones H, Green T. Relationship between hepatic DNA damage and methylene chloride-induced hepatocarcinogenicity in B6C3F1 mice. Carcinogenesis 1994; 15: 991-6.
    • (1994) Carcinogenesis , vol.15 , pp. 991-996
    • Graves, R.J.1    Coutts, C.2    Eyton-Jones, H.3    Green, T.4
  • 51
    • 0029964511 scopus 로고    scopus 로고
    • DNA sequence analysis of methylene chloride induced HPRT mutations in CHO cells: Comparison with the mutation spectrum obtained for 1,2-dibromoethane and formaldehyde
    • * - Industry sponsored studies Graves RJ, Trueman P, Jones S, Green T. DNA sequence analysis of methylene chloride induced HPRT mutations in CHO cells: Comparison with the mutation spectrum obtained for 1,2-dibromoethane and formaldehyde. Mutagenesis 1996; 11: 229-33.
    • (1996) Mutagenesis , vol.11 , pp. 229-233
    • Graves, R.J.1    Trueman, P.2    Jones, S.3    Green, T.4
  • 52
    • 0030010272 scopus 로고    scopus 로고
    • Mouse liver glutathione S-transferase mediated metabolism of methylene chloride to a mutagen in the CHO/HPRT assay
    • * - Industry sponsored studies Graves RJ, Green T. Mouse liver glutathione S-transferase mediated metabolism of methylene chloride to a mutagen in the CHO/HPRT assay. Mutation Research 1996; 367: 143-50.
    • (1996) Mutation Research , vol.367 , pp. 143-150
    • Graves, R.J.1    Green, T.2
  • 53
    • 0026667174 scopus 로고
    • Dichloromethane (methylene chloride): Metabolism to formaldehyde and formation of DNA-protein crosslinks in B6C3F1 mice and Syrian golden hamsters
    • Casanova M, Deyo DF, Heck H. Dichloromethane (methylene chloride): Metabolism to formaldehyde and formation of DNA-protein crosslinks in B6C3F1 mice and Syrian golden hamsters. Toxicology and Applied Pharmacology 1992; 114: 162-5.
    • (1992) Toxicology and Applied Pharmacology , vol.114 , pp. 162-165
    • Casanova, M.1    Deyo, D.F.2    Heck, H.3
  • 54
    • 0029790153 scopus 로고    scopus 로고
    • The distribution of theta class glutathione-S-transferases in mouse, rat and human liver and lung
    • * - Industry sponsored studies Mainwaring GW, Foster JR, Green T. The distribution of theta class glutathione-S-transferases in mouse, rat and human liver and lung. Biochemical Journal 1996b; 318: 297-303.
    • (1996) Biochemical Journal , vol.318 , pp. 297-303
    • Mainwaring, G.W.1    Foster, J.R.2    Green, T.3
  • 55
    • 0025215361 scopus 로고
    • Absence of adverse mortality effects in workers exposed to methylene chloride: An update
    • Hearne FT, Pifer JW, Grose F. Absence of adverse mortality effects in workers exposed to methylene chloride: an update. Journal of Occupational Medicine 1990; 32; 234-40.
    • (1990) Journal of Occupational Medicine , vol.32 , pp. 234-240
    • Hearne, F.T.1    Pifer, J.W.2    Grose, F.3
  • 57
    • 0006283760 scopus 로고    scopus 로고
    • Mortality of workers employed at a plant producing cellulose triacetate film base
    • Tommenson JA, Bonner SM, Heijne CG, Farrar DG. Mortality of workers employed at a plant producing cellulose triacetate film base. The Toxicologist 1996; 30: 481.
    • (1996) The Toxicologist , vol.30 , pp. 481
    • Tommenson, J.A.1    Bonner, S.M.2    Heijne, C.G.3    Farrar, D.G.4
  • 59
    • 0027978818 scopus 로고
    • Occupational exposure to chlorinated aliphatic hydrocarbons and risk of astrocytic brain cancer
    • Heineman EF et al. Occupational exposure to chlorinated aliphatic hydrocarbons and risk of astrocytic brain cancer. American Journal of Industrial Medicine 1994; 26: 155-69.
    • (1994) American Journal of Industrial Medicine , vol.26 , pp. 155-169
    • Heineman, E.F.1
  • 60
    • 0000060569 scopus 로고    scopus 로고
    • Proposed guidelines for carcinogen risk assessment
    • United States Environmental Protection Agency.
    • EPA. Proposed guidelines for carcinogen risk assessment. United States Environmental Protection Agency. Federal Register 1996; 61: 17960.
    • (1996) Federal Register , vol.61 , pp. 17960


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