Limited reactivity of formyl chloride with glutathione and relevance to metabolism and toxicity of dichloromethane

Chemical Research in Toxicology

Volumn 19, Issue 8, 2006, Pages 1091-1096

  Watanabe, Kengo ^a,b   Guengerich, F Peter ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON MONOXIDE; CHLORIDE; DICHLOROMETHANE; FORMYL CHLORIDE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOTRANSFORMATION; CHEMICAL REACTION; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIVER MICROSOME; MASS SPECTROMETRY; METABOLISM; NONHUMAN; OXIDATION; PH; PROTEIN BINDING; RAT; TOXICITY;

ANIMALS; CHROMATOGRAPHY, LIQUID; FORMIC ACIDS; GLUTATHIONE; HUMANS; MASS SPECTROMETRY; METHYLENE CHLORIDE; MICROSOMES, LIVER; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY;

EID: 33748672927     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx060087n     Document Type: Article

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