메뉴 건너뛰기




Volumn 20, Issue 1, 2011, Pages 3-12

Morphologic analysis of focal and diffuse forms of congenital hyperinsulinism

Author keywords

Congenital hyperinsulinism; Histology; Hypoglycemia; Islets of Langerhans; Nesidioblastosis

Indexed keywords

DIAZOXIDE; GLUCOKINASE; GLUTAMATE DEHYDROGENASE; INSULIN; INSULIN ANTIBODY; PROINSULIN; SULFONYLUREA RECEPTOR;

EID: 78650497971     PISSN: 10558586     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.sempedsurg.2010.10.010     Document Type: Article
Times cited : (50)

References (40)
  • 1
    • 0024533359 scopus 로고
    • Hypoglycemia in infants and children
    • Haymond M.W. Hypoglycemia in infants and children. Endocrinol Metab Clin North Am 1989, 18:211-252.
    • (1989) Endocrinol Metab Clin North Am , vol.18 , pp. 211-252
    • Haymond, M.W.1
  • 2
    • 0001118413 scopus 로고
    • Idiopathic spontaneously occurring hypoglycemia in infants: clinical significance of problem and treatment
    • McQuarrie I. Idiopathic spontaneously occurring hypoglycemia in infants: clinical significance of problem and treatment. Am J Dis Child 1954, 87:399-428.
    • (1954) Am J Dis Child , vol.87 , pp. 399-428
    • McQuarrie, I.1
  • 3
    • 0019860996 scopus 로고
    • Nesidioblastosis of the pancreas in infancy
    • Aynsley-Green A. Nesidioblastosis of the pancreas in infancy. Dev Med Child Neurol 1981, 23:372-379.
    • (1981) Dev Med Child Neurol , vol.23 , pp. 372-379
    • Aynsley-Green, A.1
  • 4
    • 0019943490 scopus 로고
    • Persistent neonatal hypoglycemia due to hyperinsulinism: medical aspects
    • Landau H., Perlman M., Meyer S., et al. Persistent neonatal hypoglycemia due to hyperinsulinism: medical aspects. Pediatrics 1982, 70:440-446.
    • (1982) Pediatrics , vol.70 , pp. 440-446
    • Landau, H.1    Perlman, M.2    Meyer, S.3
  • 5
    • 0036135191 scopus 로고    scopus 로고
    • Heterogeneity of persistent hyperinsulinaemic hypoglycemia. A series of 175 cases
    • de Lonlay-Debeney P., Fournet J.-C., Touati G., et al. Heterogeneity of persistent hyperinsulinaemic hypoglycemia. A series of 175 cases. Eur J Pediatr 2002, 161:37-48.
    • (2002) Eur J Pediatr , vol.161 , pp. 37-48
    • de Lonlay-Debeney, P.1    Fournet, J.-C.2    Touati, G.3
  • 7
    • 0029024314 scopus 로고
    • Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion
    • Aguilar-Bryan L., Nichols C., Wechsler S., et al. Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion. Science 1995, 268:423-426.
    • (1995) Science , vol.268 , pp. 423-426
    • Aguilar-Bryan, L.1    Nichols, C.2    Wechsler, S.3
  • 8
    • 0028236583 scopus 로고
    • Familial hyperinsulinism maps to chromosome 11p14-15.1, 30 cM centromeric to the insulin gene
    • Glaser B., Chiu K.C., Anker R., et al. Familial hyperinsulinism maps to chromosome 11p14-15.1, 30 cM centromeric to the insulin gene. Nat Genet 1994, 7:185-188.
    • (1994) Nat Genet , vol.7 , pp. 185-188
    • Glaser, B.1    Chiu, K.C.2    Anker, R.3
  • 10
    • 0030764203 scopus 로고    scopus 로고
    • Persistent hyperinsulinemic hypoglycemia of infancy: therapy, clinical outcome and mutational analysis
    • Meissner T., Brune W., Mayatepek E. Persistent hyperinsulinemic hypoglycemia of infancy: therapy, clinical outcome and mutational analysis. Eur J Pediatr 1997, 156:754-757.
    • (1997) Eur J Pediatr , vol.156 , pp. 754-757
    • Meissner, T.1    Brune, W.2    Mayatepek, E.3
  • 11
    • 0344629350 scopus 로고    scopus 로고
    • A point mutation inactivating the sulfonylurea receptor causes the severe form of persistent hyperinsulinemic hypoglycemia of infancy in Finland
    • Otonkoski T., ämmälä C., Huopio H., et al. A point mutation inactivating the sulfonylurea receptor causes the severe form of persistent hyperinsulinemic hypoglycemia of infancy in Finland. Diabetes 1999, 48:408-415.
    • (1999) Diabetes , vol.48 , pp. 408-415
    • Otonkoski, T.1    ämmälä, C.2    Huopio, H.3
  • 12
    • 0029658241 scopus 로고    scopus 로고
    • Mutations in the sulfonylurea receptor gene are associated with familial hyperinsulinism in Ashkenazi Jews
    • Nestorowicz A., Wilson B.A., Schoor K.P., et al. Mutations in the sulfonylurea receptor gene are associated with familial hyperinsulinism in Ashkenazi Jews. Hum Mol Genet 1996, 5:1813-1822.
    • (1996) Hum Mol Genet , vol.5 , pp. 1813-1822
    • Nestorowicz, A.1    Wilson, B.A.2    Schoor, K.P.3
  • 13
    • 0032493123 scopus 로고    scopus 로고
    • Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene
    • Stanley C., Lieu Y., Hsu B., et al. Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene. N Engl J Med 1998, 338:1352-1357.
    • (1998) N Engl J Med , vol.338 , pp. 1352-1357
    • Stanley, C.1    Lieu, Y.2    Hsu, B.3
  • 14
    • 0032254148 scopus 로고    scopus 로고
    • Hypoglycémie hyperinsulinémique persistante du nouveau-né et du nourrisson
    • de Lonlay-Debeney P., Fournet J.C., Martin D., et al. Hypoglycémie hyperinsulinémique persistante du nouveau-né et du nourrisson. Arch Pediatr 1998, 5:1347-1352.
    • (1998) Arch Pediatr , vol.5 , pp. 1347-1352
    • de Lonlay-Debeney, P.1    Fournet, J.C.2    Martin, D.3
  • 15
    • 0019416744 scopus 로고
    • Nesidioblastosis of the pancreas: definition of the syndrome and the management of the severe neonatal hyperinsulinemic hypoglycemia
    • Aynsley-Green A., Polak J.M., Bloom S.R., et al. Nesidioblastosis of the pancreas: definition of the syndrome and the management of the severe neonatal hyperinsulinemic hypoglycemia. Arch Dis Child 1981, 56:496-508.
    • (1981) Arch Dis Child , vol.56 , pp. 496-508
    • Aynsley-Green, A.1    Polak, J.M.2    Bloom, S.R.3
  • 16
    • 0031045497 scopus 로고    scopus 로고
    • Is 95% pancreatectomy the procedure of choice for treatment of persistent hyperinsulinemic hypoglycaemia of the neonate?
    • Shilyansky J., Fisher S., Cutz E., et al. Is 95% pancreatectomy the procedure of choice for treatment of persistent hyperinsulinemic hypoglycaemia of the neonate?. J Pediatr Surg 1997, 32:342-346.
    • (1997) J Pediatr Surg , vol.32 , pp. 342-346
    • Shilyansky, J.1    Fisher, S.2    Cutz, E.3
  • 17
    • 0032937898 scopus 로고    scopus 로고
    • Congenital hyperinsulinism and the surgeon: lessons learned over 35 years
    • Lovvorn H.N., Nance M.L., Ferry R.J., et al. Congenital hyperinsulinism and the surgeon: lessons learned over 35 years. J Pediatr Surg 1999, 34:786-792.
    • (1999) J Pediatr Surg , vol.34 , pp. 786-792
    • Lovvorn, H.N.1    Nance, M.L.2    Ferry, R.J.3
  • 18
    • 0031732166 scopus 로고    scopus 로고
    • Pancreatic exocrine and endocrine function after pancreatectomy for persistent hyperinsulinaemic hypoglycaemia of infancy
    • Cade A., Walters M., Puntis J.W., et al. Pancreatic exocrine and endocrine function after pancreatectomy for persistent hyperinsulinaemic hypoglycaemia of infancy. Arch Dis Child 1998, 79:435-439.
    • (1998) Arch Dis Child , vol.79 , pp. 435-439
    • Cade, A.1    Walters, M.2    Puntis, J.W.3
  • 19
    • 0021320297 scopus 로고
    • The basic structural lesion of persistent neonatal hypoglycaemia with hyperinsulinism: deficiency of pancreatic D cells or hyperactivity of B-cells?
    • Rahier J., Fält K., Müntefering H., et al. The basic structural lesion of persistent neonatal hypoglycaemia with hyperinsulinism: deficiency of pancreatic D cells or hyperactivity of B-cells?. Diabetologia 1984, 26:282-289.
    • (1984) Diabetologia , vol.26 , pp. 282-289
    • Rahier, J.1    Fält, K.2    Müntefering, H.3
  • 20
    • 0001334566 scopus 로고
    • Nesidioblastoma, the islet tumor of the pancreas
    • Laidlaw G.F. Nesidioblastoma, the islet tumor of the pancreas. Am J Pathol 1938, 14:125-134.
    • (1938) Am J Pathol , vol.14 , pp. 125-134
    • Laidlaw, G.F.1
  • 21
    • 0031966603 scopus 로고    scopus 로고
    • Pancreatic B-cell proliferation in persistent hyperinsulinemic hypoglycemia of infancy: an immunohistochemical study of 18 cases
    • Sempoux C., Guiot Y., Dubois D., et al. Pancreatic B-cell proliferation in persistent hyperinsulinemic hypoglycemia of infancy: an immunohistochemical study of 18 cases. Mod Pathol 1998, 11:444-449.
    • (1998) Mod Pathol , vol.11 , pp. 444-449
    • Sempoux, C.1    Guiot, Y.2    Dubois, D.3
  • 22
    • 0024339361 scopus 로고
    • Diffuse and focal nesidioblastosis. A clinicopathological study of 24 patients with persistent neonatal hyperinsulinemic hypoglycemia
    • Goossens A., Gepts W., Saudubray J.M., et al. Diffuse and focal nesidioblastosis. A clinicopathological study of 24 patients with persistent neonatal hyperinsulinemic hypoglycemia. Am J Surg Pathol 1989, 13:766-775.
    • (1989) Am J Surg Pathol , vol.13 , pp. 766-775
    • Goossens, A.1    Gepts, W.2    Saudubray, J.M.3
  • 23
    • 0031782335 scopus 로고    scopus 로고
    • Neonatal hyperinsulinemic hypoglycemia: heterogeneity of the syndrome and keys for differential diagnosis
    • Sempoux C., Guiot Y., Lefebre A., et al. Neonatal hyperinsulinemic hypoglycemia: heterogeneity of the syndrome and keys for differential diagnosis. J Clin Endocrinol Metab 1998, 83:1455-1461.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 1455-1461
    • Sempoux, C.1    Guiot, Y.2    Lefebre, A.3
  • 24
    • 0035122262 scopus 로고    scopus 로고
    • The focal form of persistent hyperinsulinemic hypoglycemia of infancy
    • Sempoux C., Guiot Y., Rahier J. The focal form of persistent hyperinsulinemic hypoglycemia of infancy. Diabetes 2001, 50:S182-S183.
    • (2001) Diabetes , vol.50
    • Sempoux, C.1    Guiot, Y.2    Rahier, J.3
  • 25
    • 0030880778 scopus 로고    scopus 로고
    • Somatic deletion of the imprinted 11p15 region in sporadic persistent hyperinsulinemic hypoglycemia of infancy is specific of focal adenomatous hyperplasia and endorses partial pancreatectomy
    • de Lonlay P., Fournet J.C., Rahier J., et al. Somatic deletion of the imprinted 11p15 region in sporadic persistent hyperinsulinemic hypoglycemia of infancy is specific of focal adenomatous hyperplasia and endorses partial pancreatectomy. J Clin Invest 1997, 100:802-807.
    • (1997) J Clin Invest , vol.100 , pp. 802-807
    • de Lonlay, P.1    Fournet, J.C.2    Rahier, J.3
  • 26
    • 0032190017 scopus 로고    scopus 로고
    • Paternal mutation of the sulfonylurea receptor (SUR1) gene and maternal loss of 11p15 imprinted genes lead to persistent hyperinsulinism in focal adenomatous hyperplasia
    • Verkarre V., Fournet J.C., de Lonlay P., et al. Paternal mutation of the sulfonylurea receptor (SUR1) gene and maternal loss of 11p15 imprinted genes lead to persistent hyperinsulinism in focal adenomatous hyperplasia. J Clin Invest 1998, 102:1286-1291.
    • (1998) J Clin Invest , vol.102 , pp. 1286-1291
    • Verkarre, V.1    Fournet, J.C.2    de Lonlay, P.3
  • 27
    • 0031765251 scopus 로고    scopus 로고
    • Hyperinsulinism: molecular aetiology of focal disease
    • Ryan F., Devaney D., Joyce C., et al. Hyperinsulinism: molecular aetiology of focal disease. Arch Dis Child 1998, 79:445-447.
    • (1998) Arch Dis Child , vol.79 , pp. 445-447
    • Ryan, F.1    Devaney, D.2    Joyce, C.3
  • 28
    • 0034970925 scopus 로고    scopus 로고
    • Unbalanced expression of 11p15 imprinted genes in focal form of congenital hyperinsulinism: association with a reduction to homozygosity of a mutation in ABCC8 or KCNJ11
    • Fournet J.C., Mayaud C., de Lonlay P., et al. Unbalanced expression of 11p15 imprinted genes in focal form of congenital hyperinsulinism: association with a reduction to homozygosity of a mutation in ABCC8 or KCNJ11. Am J Pathol 2001, 158:2177-2184.
    • (2001) Am J Pathol , vol.158 , pp. 2177-2184
    • Fournet, J.C.1    Mayaud, C.2    de Lonlay, P.3
  • 29
    • 0035654182 scopus 로고    scopus 로고
    • P57KIP2 expression in normal islet cells and in hyperinsulinism of infancy
    • Kassem S.A., Ariel I., Thornton P.S., et al. p57KIP2 expression in normal islet cells and in hyperinsulinism of infancy. Diabetes 2001, 50:2763-2769.
    • (2001) Diabetes , vol.50 , pp. 2763-2769
    • Kassem, S.A.1    Ariel, I.2    Thornton, P.S.3
  • 30
    • 0037341243 scopus 로고    scopus 로고
    • The focal form of persistent hyperinsulinemic hypoglycemia of infancy: morphological and molecular studies show structural and functional differences with insulinoma
    • Sempoux C., Guiot Y., Dahan K., et al. The focal form of persistent hyperinsulinemic hypoglycemia of infancy: morphological and molecular studies show structural and functional differences with insulinoma. Diabetes 2003, 52:784-794.
    • (2003) Diabetes , vol.52 , pp. 784-794
    • Sempoux, C.1    Guiot, Y.2    Dahan, K.3
  • 31
    • 0029836983 scopus 로고    scopus 로고
    • Mutation of the pancreatic islet inward rectifier Kir 6.2 also leads to familial persistent hyperinsulinemic hypoglycemia of infancy
    • Thomas P., Ye Y., Lightner E. Mutation of the pancreatic islet inward rectifier Kir 6.2 also leads to familial persistent hyperinsulinemic hypoglycemia of infancy. Hum Mol Genet 1996, 5:1809-1812.
    • (1996) Hum Mol Genet , vol.5 , pp. 1809-1812
    • Thomas, P.1    Ye, Y.2    Lightner, E.3
  • 32
    • 0029021696 scopus 로고
    • Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy
    • Thomas P.M., Cote G.J., Wohllk N., et al. Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy. Science 1995, 268:426-429.
    • (1995) Science , vol.268 , pp. 426-429
    • Thomas, P.M.1    Cote, G.J.2    Wohllk, N.3
  • 33
    • 0034029974 scopus 로고    scopus 로고
    • Molecular basis and characterization of the hyperinsulinism/hyperammonemia syndrome. Predominance of mutations in exons 11 and 12 of the glutamate dehydrogenase Gene
    • Stanley C.A., Fang J., Kutyna K., et al. Molecular basis and characterization of the hyperinsulinism/hyperammonemia syndrome. Predominance of mutations in exons 11 and 12 of the glutamate dehydrogenase Gene. Diabetes 2000, 49:667-673.
    • (2000) Diabetes , vol.49 , pp. 667-673
    • Stanley, C.A.1    Fang, J.2    Kutyna, K.3
  • 34
    • 0032556969 scopus 로고    scopus 로고
    • Familial hyperinsulinism caused by an activating glucokinase mutation
    • Glaser B., Kesavan P., Heyman M., et al. Familial hyperinsulinism caused by an activating glucokinase mutation. N Engl J Med 1998, 338:226-230.
    • (1998) N Engl J Med , vol.338 , pp. 226-230
    • Glaser, B.1    Kesavan, P.2    Heyman, M.3
  • 35
    • 3242770556 scopus 로고    scopus 로고
    • Severe persistent hyperinsulinemic hypoglycemia due to a de novo glucokinase mutation
    • Cuesta-Muñoz A.L., Huopio H., Otonkoski T., et al. Severe persistent hyperinsulinemic hypoglycemia due to a de novo glucokinase mutation. Diabetes 2004, 53:2164-2168.
    • (2004) Diabetes , vol.53 , pp. 2164-2168
    • Cuesta-Muñoz, A.L.1    Huopio, H.2    Otonkoski, T.3
  • 36
    • 66649108506 scopus 로고    scopus 로고
    • Extremes of clinical and enzymatic phenotypes in children with hyperinsulinism caused by glucokinase activating mutations
    • Sayed S., Langdon D.R., Odili S., et al. Extremes of clinical and enzymatic phenotypes in children with hyperinsulinism caused by glucokinase activating mutations. Diabetes 2009, 58:1419-1427.
    • (2009) Diabetes , vol.58 , pp. 1419-1427
    • Sayed, S.1    Langdon, D.R.2    Odili, S.3
  • 37
    • 77950833891 scopus 로고    scopus 로고
    • Large islets, beta-cell proliferation, and a glucokinase mutation
    • Kassem S., Heyman M., Glaser B., et al. Large islets, beta-cell proliferation, and a glucokinase mutation. N Engl J Med 2010, 362:1348-1350.
    • (2010) N Engl J Med , vol.362 , pp. 1348-1350
    • Kassem, S.1    Heyman, M.2    Glaser, B.3
  • 38
    • 9144227075 scopus 로고    scopus 로고
    • A new morphological form of persistent hyperinsulinaemic hypoglycaemia of infancy: correlation with the clinical and phydiological data
    • Sempoux C., Guiot Y., Cosgrove K., et al. A new morphological form of persistent hyperinsulinaemic hypoglycaemia of infancy: correlation with the clinical and phydiological data. Horm Res 2002, 58:44.
    • (2002) Horm Res , vol.58 , pp. 44
    • Sempoux, C.1    Guiot, Y.2    Cosgrove, K.3
  • 39
    • 0031936418 scopus 로고    scopus 로고
    • Partial or near-total pancreatectomy for persistent neonatal hyperinsulinemic hypoglycemia: the pathologist's role
    • Rahier J., Sempoux C., Fournet J.C., et al. Partial or near-total pancreatectomy for persistent neonatal hyperinsulinemic hypoglycemia: the pathologist's role. Histopathology 1998, 32:15-19.
    • (1998) Histopathology , vol.32 , pp. 15-19
    • Rahier, J.1    Sempoux, C.2    Fournet, J.C.3
  • 40
    • 5044232961 scopus 로고    scopus 로고
    • Congenital hyperinsulinism: intraoperative biopsy interpretation can direct the extent of pancreatectomy
    • Suchi M., Thornton P.S., Adzick N.S., et al. Congenital hyperinsulinism: intraoperative biopsy interpretation can direct the extent of pancreatectomy. Am J Surg Pathol 2004, 28:1326-1335.
    • (2004) Am J Surg Pathol , vol.28 , pp. 1326-1335
    • Suchi, M.1    Thornton, P.S.2    Adzick, N.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.