Pancreatic B-cell proliferation in persistent hyperinsulinemic hypoglycemia of infancy: An immunohistochemical study of 18 cases

Modern Pathology

Volumn 11, Issue 5, 1998, Pages 444-449

  Sempoux, C ^a,c   Guiot, Y ^a   Dubois, D ^a   Nollevaux, M C ^a   Saudubray, J M ^b   Nihoul Fekete, C ^b   Rahier, J ^a  

^a CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

^c UNIVERSITY OF LOUVAIN MEDICAL SCHOOL   (Belgium)

Author keywords

B cell proliferation; Hyperinsulinism; Ki 67 detection; Nesidioblastosis

Indexed keywords

GLUCOSE; INSULIN; KI 67 ANTIGEN;

ARTICLE; CELL PROLIFERATION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; HYPERINSULINEMIA; HYPOGLYCEMIA; INSULIN RELEASE; INSULINOMA; PANCREAS ADENOMA; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL HYPERPLASIA; PRIORITY JOURNAL;

ADENOMA; ADOLESCENT; CELL DIVISION; CHILD; CHILD, PRESCHOOL; HUMANS; HYPERINSULINISM; HYPERPLASIA; HYPOGLYCEMIA; IMMUNOHISTOCHEMISTRY; INFANT; INSULIN; ISLETS OF LANGERHANS; KI-67 ANTIGEN; PANCREATECTOMY; SYNDROME;

EID: 0031966603     PISSN: 08933952     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. McQuarrie I. Idiopathic spontaneously occurring hypoglycemia in infants: clinical significance of problem and treatment. Am J Dis Child 1954;87:399-428.
2. Glaser B, Chiu KC, Anker R, Nestorowicz A, Landau H, Ben-Bassat H, et al. Familial hyperinsulinism maps to chromosome 11p14-15.1, 30 cM centromeric to the insulin gene. Nat Genet 1994;7:185-8.
3. Thomas PM, Cote GJ, Wohlik N, Haddad B, Mathew PM, Rabl W, et al. Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy. Science 1995;268:426-9.
4. +-ATP channels in pancreatic B cells causes persistent hyperinsulinemic hypoglycemia of infancy. Nat Med 1996;2:1344-7.
5. Daneman D, Ehrlich RM. The enigma of persistent hyperinsulinemic hypoglycemia of infancy. J Pediatr 1993;123:573-5.
6. Goossens A, Gepts W, Saudubray JM, Bonnefont JP, Nihoul-Fekete C, Heitz PU, et al. Diffuse and focal nesidioblastosis: a clinicopathological study of 24 patients with persistent neonatal hyperinsulinemic hypoglycemia. Am J Surg Pathol 1989;13:766-75.
7. Sempoux C, Poggi F, Brunelle F, Saudubray JM, Fekete C, Rahier J. Nesidioblastosis and persistent neonatal hyperinsulinism. Diabete Metab 1995;21:402-7.
8. Rahier J, Fält K, Müntefering H, Becker K, Gepts W, Falkmer S. The basic structural lesion of persistent neonatal hypoglycaemia with hyperinsulinism: deficiency of pancreatic D cells or hyperactivity of B cells? Diabetologia 1984;26:282-9.
9. Rahier J, Sempoux C, Fournet JC, Poggi F, Brunelle F, Nihoul-Fekete C, et al. Partial or near-total pancreatectomy for persistent neonatal hyperinsulinemic hypoglycemia: a pathologist's role. Histopathology 1998;32:15-9.
10. Poggi-Travert F, Rahier J, Brunelle F, Fekete C, Saudubray JM. Hyperinsulinismes de l'enfant: à propos d'une série de 56 cas (1984-1994). In: Flammarion, editor. Journées parisiennes de pédiatrie. Paris: Médecine-Sciences Flammarion; 1994.
11. Laidlaw GF. Nesidioblastoma, the islet tumor of the pancreas. Am J Pathol 1938;14:125-34.
12. Yakovac WC, Baker L, Hummeler K. β-cell nesidioblastosis in idiopathic hypoglycemia of infancy. J Pediatr 1971;79:226-31.
13. Heitz PU, Klöppel G, Häcki WH, Polak JM, Pearse AGE. Nesidioblastosis: the pathologic basis of persistent hyperinsulinemic hypoglycemia in infants. Morphologic and quantitative analysis of seven cases based on specific immunostaining and electron microscopy. Diabetes 1977;26:632-42.
14. Dahms BB, Landing BH, Blaskovics M, Roe TF. Nesidioblastosis and other islet cell abnormalities in hyperinsulinemic hypoglycemia of childhood. Hum Pathol 1980;11:641-9.
15. Gerdes J, Lemke H, Baisch H, Wacker H, Schwab V, Stein H. Cell-cycle analysis of a cell proliferation associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 1984;133:1710-5.
16. Brown DC, Gatter KC. Monoclonal antibody Ki-67: its use in histopathology. Histopathology 1990;17:489-503.
17. Cattoretti G, Becker MHG, Key G, Duchrow M, Schüler C, Galle J, et al. Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB-1 and MIB-3) detect proliferating cells in microwave-processed, formalin-fixed, paraffin sections. J Pathol 1992;168:357-63.
18. Shi SR, Key MC, Kalra KL. Antigen retrieval in formalin-fixed, paraffin-embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections. J Histochem Cytochem 1991;39: 741-8.
19. Hendricks IB, Wilkinson EJ. Quality control considerations for Ki-67 detection and quantitation in paraffin-embedded tissue. J Cell Biochem 1994;Suppl 19:105-10.
20. Weidner N, Moore DH, Vartanian R. Correlation of Ki-67 antigen expression with mitotic figure index and tumor grade in breast carcinomas using the novel paraffin reaction MIB-1 antibody. Hum Pathol 1994;25:337-42.
21. Jaffe R, Hashida Y, Yunis EJ. Pancreatic pathology in hyperinsulinemic hypoglycemia of infancy. Lab Invest 1980;42: 356-65.
22. Goudswaard WB, Houthoff H, Koudstaal J, Zwierstra RP. Nesidioblastosis and endocrine hyperplasia of the pancreas: a secondary phenomenon. Hum Pathol 1986;17:46-54.
23. Rahier J. Relevance of endocrine pancreas nesidioblastosis to hyperinsulinemic hypoglycemia. Diabetes Care 1989;12: 164-6.
24. de Lonlay P, Fournet JC, Rahier J, Gross-Morand MS, Poggi-Travert F, Foussier V, et al. A somatic deletion of the imprinted 11p15 region in sporadic persistent hyperinsulinemic hypoglycemia of infancy is specific of focal adenomatous hyperplasia and endorses partial pancreatectomy. J Clin Invest 1997;4:802-7.