Endogenous enkephalin does not contribute to the cerebral anti-hyperalgesic action of gabapentin

Science China Life Sciences

Volumn 53, Issue 12, 2010, Pages 1428-1432

  Chen, Shao Hui ^a   Zhao, Jing ^a   Huang, Yu Guang ^a   Luo, Ai Lun ^a   Zuo, Ping Ping ^b   Yang, Nan ^b   Hao, Wen Yu ^b  

^a PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

^b INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

Author keywords

cerebral cortex; enkephalin; gabapentin; neuropathic pain

Indexed keywords

4 AMINOBUTYRIC ACID; AMINE; AMINO ACID RECEPTOR BLOCKING AGENT; CYCLOHEXANECARBOXYLIC ACID DERIVATIVE; ENKEPHALIN; GABAPENTIN;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BRAIN CORTEX; DRUG EFFECT; GENETICS; HYPERALGESIA; MALE; METABOLISM; MOUSE; PAIN ASSESSMENT; PATHOPHYSIOLOGY; PHYSIOLOGY;

AMINES; ANIMALS; CEREBRAL CORTEX; CYCLOHEXANECARBOXYLIC ACIDS; ENKEPHALINS; EXCITATORY AMINO ACID ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; HYPERALGESIA; MALE; MICE; MICE, INBRED BALB C; PAIN MEASUREMENT;

EID: 78650469404     PISSN: 16747305     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11427-010-4092-3     Document Type: Article

References (18)

1. Tsavaris N, Kopterides P, Kosmas C, et al. Gabapentin monotherapy for the treatment of chemotherapy-induced neuropathic pain: A pilot study. Pain Med, 2008, 9: 1209-1216.
2. Ross J R, Goller K, Hardy J, et al. Gabapentin is effective in the treatment of cancer-related neuropathic pain: A prospective, open-label study. J Palliat Med, 2005, 8: 1118-1126.
3. Gee N S, Brown J P, Dissanayake V U, et al. The novel anticonvulsant drug, gabapentin (Neurontin), binds to the alpha2delta subunit of a calcium channel. J Biol Chem, 1996, 271: 5768-5776.
4. 3H]gabapentin to a novel site in rat brain: Autoradiographic studies. Eur J Pharmacol, 1993, 244: 303-309.
5. Olson G A, Olson R D, Kastin A J. Endogenous opiates: 1996-A double blind ramdomized placebo-controlled trial. Peptides, 1997, 18: 1651-1688.
6. Noble F, Smadja C, Valverde O, et al. Pain-suppressive effects on various nociceptive stimuli (thermal, chemical, electrical and inflammatory) of the first orally active enkephlin-metabolizing enzyme inhibitor RB 120. Pain, 1997, 73: 383-391.
7. Spanos L J, Stafinsky J L, Crisp T. A comparative analysis of monoaminergic involvement in the spinal antinociceptive action of DAMPGO and DPDPE. Pain, 1989, 39: 329-335.
8. Meunier A, Latrémolière A, Mauborgne A, et al. Attenuation of pain-related behavior in a rat model of trigeminal neuropathic pain by viral-driven enkephalin overproduction in trigeminal ganglion neurons. Mol Ther, 2005, 11: 608-616.
9. Xu Y, Tian X B, An K, et al. Lumbar transplantation of immortalized enkephalin-expressing astrocytes attenuates chronic neuropathic pain. Eur J Pain, 2008, 12: 525-533.
10. Hao S, Hu J, Fink D J. Transgene-mediated enkephalin expression attenuates signs of naloxone-precipitated morphine withdrawal in rats with neuropathic pain. Behav Brain Res, 2009, 197: 84-89.
11. Thibault K, Elisabeth B, Sophie D, et al. Antinociceptive and anti-allodynic effects of oral PL37, a complete inhibitor of enkephalin-catabolizing enzymes, in a rat model of peripheral neuropathic pain induced by vincristine. Eur J Pharmacol, 2008, 600: 71-77.
12. Rocha L, Ondarza-Rovira R, Maidment N T. Gabapentin modifies extracellular opioid peptide content in amygdala: A microdialysis study. Epilepsy Res, 1999, 35: 13-20.
13. Mathiesen O, Møiniche S, Dahl J B. Gabapentin and postoperative pain: A qualitative and quantitative systematic review, with focus on procedure. BMC Anesthesiol, 2007, 7: 6.
14. Clivatti J, Sakata R K, Issy A M. Review of the use of gabapentin in the control of postoperative pain. Rev Bras Anestesiol, 2009, 59: 87-98.
15. Keskinbora K, Pekel A F, Aydinli I. Gabapentin and an opioid combination versus opioid alone for the management of neuropathic cancer pain: A randomized open trial. J Pain Symptom Manage, 2007, 34: 183-189.
16. Montazeri K, Kashefi P, Honarmand A. Pre-emptive gabapentin significantly reduces postoperative pain and morphine demand following lower extremity orthopaedic surgery. Singapore Med J, 2007, 48: 748-751.
17. Malmberg A B, Basbaum A I. Partial sciatic nerve injury in the mouse as a model of neuropathic pain: Behavioral and neuroanatomical correlates. Pain, 1998, 76: 215-222.
18. Chaplan S R, Bach F W, Pogrel J W, et al. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods, 1994, 53: 55-63.