Antinociceptive and anti-allodynic effects of oral PL37, a complete inhibitor of enkephalin-catabolizing enzymes, in a rat model of peripheral neuropathic pain induced by vincristine

European Journal of Pharmacology

Volumn 600, Issue 1-3, 2008, Pages 71-77

  Thibault, Karine ^a   Elisabeth, Bonnard ^b   Sophie, Dubacq ^a   Claude, Fournié Zaluski Marie ^b   Bernard, Roques ^b,c   Bernard, Calvino ^a  

^a Brain Plasticity Unit   (France)

^b Pharmaleads SAS   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Antiallodynia; Antinociception; Inhibition of enkephalin metabolism; Neuropathic pain; Oral PL37; Vincristine

Indexed keywords

17 METHYLNALOXONE; 2 [(1 ETHOXYCARBONYLOXYETHOXYCARBONYLMETHYL)CARBAMOYL] 3 PHENYLPROPYLDISULFANYLMETHYL 3 METHYLSULFANYLPROPYLAMMONIUM; ANTINOCICEPTIVE AGENT; ENKEPHALIN DERIVATIVE; ENZYME INHIBITOR; UNCLASSIFIED DRUG; VINCRISTINE; VINCRISTINE SULFATE;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG DOSE COMPARISON; ENZYME INHIBITION; MALE; MECHANICAL STIMULATION; NEUROPATHIC PAIN; NEUROPHARMACOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORY NEUROPATHY;

ADMINISTRATION, ORAL; ANALGESICS; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; DISEASE MODELS, ANIMAL; DISULFIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENKEPHALINS; ENZYME INHIBITORS; INJECTIONS, INTRAPERITONEAL; MALE; NEURALGIA; PAIN MEASUREMENT; PROPYLAMINES; RATS; RATS, SPRAGUE-DAWLEY; TEMPERATURE; VINCRISTINE;

EID: 55949127639     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.10.004     Document Type: Article

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