Gabapentin is effective in the treatment of cancer-related neuropathic pain: A prospective, open-label study

Journal of Palliative Medicine

Volumn 8, Issue 6, 2005, Pages 1118-1126

  Ross, J R ^a   Goller, K ^a   Hardy, J ^a,b   Riley, J ^a   Broadley, K ^a   A'Hern, R ^a   Williams, J ^a  

^a ROYAL MARSDEN HOSPITAL   (United Kingdom)

^b MATER ADULT HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; ANTIDEPRESSANT AGENT; ANTINEOPLASTIC AGENT; GABAPENTIN; HORMONE; OPIATE; STEROID;

ADULT; AGED; ANALYSIS OF VARIANCE; ARTICLE; BLURRED VISION; BRIEF PAIN INVENTORY; CANCER CHEMOTHERAPY; CANCER PAIN; CANCER RADIOTHERAPY; CANCER SURGERY; CLINICAL TRIAL; CONFIDENCE INTERVAL; DAILY LIFE ACTIVITY; DEMOGRAPHY; DISEASE SEVERITY; DIZZINESS; DROWSINESS; DRUG EFFICACY; DRUG RESPONSE; EVALUATION; FEMALE; GENDER; HALLUCINATION; HEADACHE; HEARTBURN; HUMAN; MAJOR CLINICAL STUDY; MALE; NAUSEA; NEUROPATHIC PAIN; OPEN STUDY; OUTCOMES RESEARCH; PAIN ASSESSMENT; PREDICTION; PROSPECTIVE STUDY; SCORING SYSTEM; SEX DIFFERENCE; TREMOR; UNSTEADINESS;

AGED; AMINES; ANALGESICS; ANALYSIS OF VARIANCE; CYCLOHEXANECARBOXYLIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GAMMA-AMINOBUTYRIC ACID; GREAT BRITAIN; HUMANS; MALE; MIDDLE AGED; NEOPLASMS; PAIN; PERIPHERAL NERVOUS SYSTEM DISEASES; PROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 29444449131     PISSN: 10966218     EISSN: None     Source Type: Journal    
DOI: 10.1089/jpm.2005.8.1118     Document Type: Article

References (31)

1. Pullar S, Palmer AM: Pharmacotherapy for neuropathic pain: Progress and prospects. Drug News Perspect 2003;16:622-630.
2. Dickenson AH, Suzuki R: Opioids in neuropathic pain: Clues from animal studies. Eur J Pain 2005;9: 113-116.
3. Wiffen P, Collins S, McQuay H, Carroll D, Jadad A, Moore A: Anticonvulsant drugs for acute and chronic pain. Cochrane Database Syst Rev 2000;CD001133.
4. McQuay HJ, Tramer M, Nye BA, Carroll D, Wiffen PJ, Moore RA: A systematic review of antidepressants in neuropathic pain. Pain 1996;68:217-227.
5. Harding LM, Kristensen JD, Baranowski AP: Differential effects of neuropathic analgesics on wind-uplike pain and somatosensory function in healthy volunteers. Clin J Pain 2005 Mar;21(2):127-132.
6. Kocsis JD, Honmou O: Gabapentin increases GABA-induced depolarization in rat neonatal optic nerve. Neurosci Lett 1994;169:181-184.
7. Taylor CP: Mechanisms of action of gabapentin. Rev Neurol (Paris) 1997;153(Suppl 1):S39-S45.
8. Backonja M, Beydoun A, Edwards KR, Schwartz SL, Fonseca V, Hes M, La Moreaux L, Gavofalo E: Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: A randomized controlled trial. JAMA 1998;280:1831-1836.
9. Pandey CK, Bose N, Garg G, Singh N, Baronia A, Agarwal A, Singh PK, Singh U: Gabapentin for the treatment of pain in guillain-barre syndrome: A double-blinded, placebo-controlled, crossover study. Anesth Analg 2002;95:1719-1723.
10. Rice AS, Maton S: Gabapentin in postherpetic neuralgia: A randomised, double blind, placebo controlled study. Pain 2001;94:215-224.
11. Rowbotham M, Harden N, Stacey B, Bernstein P, Magnus-Miller L: Gabapentin for the treatment of postherpetic neuralgia: A randomized controlled trial. JAMA 1998;280:1837-1842.
12. Spira PJ, Beran RG: Gabapentin in the prophylaxis of chronic daily headache: A randomized, placebo-controlled study. Neurology 2003;61:1753-1759.
13. Hahn K, Arendt G, Braun JS, von Giesen HJ, Husstedt IW, Maschke M, Straube ME, Schielke E; German Neuro:AIDS Working Group: A placebo-controlled trial of gabapentin for painful HIV-associated sensory neuropathies. J Neurol 2004;251:1260-1266.
14. Caraceni A, Zecca E, Martini C, De Conno F: Gabapentin as an adjuvant to opioid analgesia for neuropathic cancer pain. J Pain Symptom Manage 1999;17:441-445.
15. Chandler A, Williams JE: Gabapentin, an adjuvant treatment for neuropathic pain in a cancer hospital. J Pain Symptom Manage 2000;20:82-86.
16. Daut RL, Cleeland CS, Flanery RC: Development of the Wisconsin Brief Pain Questionnaire to assess pain in cancer and other diseases. Pain 1983;17:197-210.
17. Caraceni A, Zecca E, Bonezzi C, Arcuri E, Tur RY, Maltoni M, Visentin M, Gorni G, Martini C, Tirell W, Barbieri M, DeConno F: Gabapentin for neuropathic cancer pain: A randomized controlled trial from the Gabapentin Cancer Pain Study Group. J Clin Oncol 2004;22:2909-2917.
18. Cepeda MS, Africano JM, Polo R, Alcala R, Carr DB: What decline in pain intensity is meaningful to patients with acute pain? Pain 2003;105:151-157.
19. Craft RM: Sex differences in drug- and non-drug-induced analgesia. Life Sci 2003;72:2675-2688.
20. Sarton E, Olofsen E, Romberg R, den Hartigh J, Kest B, Nieuwenhuijs D, Burm A, Teppuma L, Dohan A: Sex differences in morphine analgesia: An experimental study in healthy volunteers. Anesthesiology 2000;93:1245-1254.
21. Boyd RA, Turck D, Abel RB, Sedman AJ, Bockbrader HN: Effects of age and gender on single-dose pharmacokinetics of gabapentin. Epilepsia 1999;40:474-479.
22. Dirks J, Fredensborg BB, Christensen D, Fomsgaard JS, Flyger H, Dahl JB: A randomized study of the effects of single-dose gabapentin versus placebo on postoperative pain and morphine consumption after mastectomy. Anesthesiology 2002;97:560-564.
23. Fassoulaki A, Patris K, Sarantopoulos C, Hogan Q: The analgesic effect of gabapentin and mexiletine after breast surgery for cancer. Anesth Analg 2002; 95:985-991.
24. Sist TC, Filadora VA, Miner M, Lema M: Experience with gabapentin for neuropathic pain in the head and neck: Report of ten cases. Reg Anesth 1997;22:473-478.
25. Elwes RD, Binnie CD: Clinical pharmacokinetics of newer antiepileptic drugs. Lamotrigine, vigabatrin, gabapentin and oxcarbazepine. Clin Pharmacokinet 1996;30:403-415.
26. Oneschuk D, al Shahri MZ: The pattern of gabapentin use in a tertiary palliative care unit. J Palliat Care 2003;19:185-187.
27. Shimoyama M, Shimoyama N, Inturrisi CE, Elliott KJ: Gabapentin enhances the antinociceptive effects of spinal morphine in the rat tail-flick test. Pain 1997;72: 375-382.
28. Gilron I, Bailey JM, Tu D, Holden R, Weaver D, Houlden RL: Morphine, gabapentin, or their combination for neuropathic pain. N Engl J Med 2005;352: 1324-1334.
29. Berger A, Dukes E, McCarberg B, Liss M, Oster G: Change in opioid use after the initiation of gabapentin therapy in patients with postherpetic neuralgia. Clin Ther 2003;25:2809-2821.
30. Ross JR, Waight C, Riley J, Broadley K: Gabapentin: resistant neuropathic pain and malignancy. Palliat Med 2001;15:348-349.
31. Bennett MI, Smith BH, Torrance N, Potter J: The S-LANSS score for identifying pain of predominantly neuropathic origin: Validation for use in clinical and postal research. J Pain 2005;6:149-158.