Neoadjuvant therapy induces loss of MSH6 expression in colorectal carcinoma

American Journal of Surgical Pathology

Volumn 34, Issue 12, 2010, Pages 1798-1804

  Bao, Fei ^a   Panarelli, Nicole C ^b   Rennert, Hanna ^b   Sherr, David L ^b   Yantiss, Rhonda K ^b  

^a NewYork Presbyterian Hospital   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

hereditary nonpolyposis colorectal cancer; immunohistochemistry; Lynch syndrome; microsatellite instability; mismatch repair

Indexed keywords

DNA BINDING PROTEIN; G T MISMATCH BINDING PROTEIN; G-T MISMATCH-BINDING PROTEIN; TUMOR MARKER;

ADENOCARCINOMA; ADJUVANT THERAPY; AGED; ARTICLE; CANCER STAGING; COLON RESECTION; COLORECTAL TUMOR; FEMALE; GENETICS; HUMAN; MALE; METABOLISM; MICROSATELLITE INSTABILITY; MIDDLE AGED; MISMATCH REPAIR; PATHOLOGY; RETROSPECTIVE STUDY;

ADENOCARCINOMA; AGED; COLECTOMY; COLORECTAL NEOPLASMS; DNA MISMATCH REPAIR; DNA-BINDING PROTEINS; FEMALE; HUMANS; MALE; MICROSATELLITE INSTABILITY; MIDDLE AGED; NEOADJUVANT THERAPY; NEOPLASM STAGING; RETROSPECTIVE STUDIES; TUMOR MARKERS, BIOLOGICAL;

EID: 78650411142     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e3181f906cc     Document Type: Article

References (32)

1. Adjuvant Radiotherapy for Rectal Cancer. A systematic overview of 8,507 patients from 22 randomised trials. Lancet. 2001;358: 1291-1304.
2. Colon and rectum Edge SB, Byrd DR, Compton, CC, et al. ed. AJCC Cancer Staging Manual. Philadelphia: Springer 2010, 143-164.
3. D'Onofrio GM, Tan EG. Is colorectal carcinoma in the young a more deadly disease? Aust N Z J Surg. 1985;55:537-540.
4. Jarvinen HJ, Renkonen-Sinisalo L, Aktan-Collan K, et al. Ten years after mutation testing for lynch syndrome: cancer incidence and outcome in mutation-positive and mutation-negative family members. J Clin Oncol. 2009;27:4793-4797.
5. Jenkins MA, Hayashi S, O'Shea AM, et al. pathology features in Bethesda guidelines predict colorectal cancer microsatellite instability: a Population-based Study. Gastroenterology. 2007;133:48-56.
6. Kakar S, Aksoy S, Burgart LJ, et al. Mucinous carcinoma of the colon: correlation of loss of mismatch repair enzymes with clinicopathologic features and survival. Mod Pathol. 2004;17:696-700.
7. Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell. 1996;87:159-170.
8. Lindor NM, Burgart LJ, Leontovich O, et al. Immunohistochem-istry versus microsatellite instability testing in phenotyping color-ectal tumors. J Clin Oncol. 2002;20:1043-1048.
9. Mahdavinia M, Bishehsari F, Ansari R, et al. Family history of colorectal cancer in Iran. BMC Cancer. 2005;5:112.
10. Mangold E, Pagenstecher C, Friedl W, et al. Tumours from Msh2 mutation carriers show loss of Msh2 expression but many tumours from mlh1 mutation carriers exhibit weak positive MLH1 staining. J Pathol. 2005;207:385-395.
11. Minardi AJ Jr, Sittig KM, Zibari GB, et al. Colorectal cancer in the young patient. Am Surg. 1998;64:849-853.
12. O'Connell JB, Maggard MA, Liu JH, et al. Rates of colon and rectal cancers are increasing in young adults. Am Surg. 2003;69:866-872.
13. Oberschmid BI, Dietmaier W, Hartmann A, et al. Distinct secreted frizzled receptor protein 1 staining pattern in patients with hyperplastic polyposis coli syndrome. Arch Pathol Lab Med. 2004; 128:967-973.
14. Ota DM. Preoperative radiotherapy for rectal cancer: benefits and controversies. Ann Surg Oncol. 1996;3:419-420.
15. Overbeek LI, Ligtenberg MJ, Willems RW, et al. Interpretation of immunohistochemistry for mismatch repair proteins is only reliable in a specialized setting. Am J Surg Pathol. 2008;32:1246-1251.
16. Parramore JB, Wei JP, Yeh KA. Colorectal cancer in patients under forty: presentation and outcome. Am Surg. 1998;64:563-567 [discussion 567-568].
17. Ryan R, Gibbons D, Hyland JM, et al. Pathological response following long-course neoadjuvant chemoradiotherapy for locally advanced rectal cancer. Histopathology. 2005;47:141-146.
18. Saltz LB, Minsky B. Adjuvant therapy of cancers of the colon and rectum. Surg Clin North Am. 2002;82:1035-1058.
19. Samowitz WS, Albertsen H, Herrick J, et al. Evaluation of a large, population-based sample supports a cpg island methylator pheno-type in colon cancer. Gastroenterology. 2005;129:837-845.
20. Savas N, Dagli U, Akbulut S, et al. Colorectal cancer localization in young patients: should we expand the screening program? Dig Dis Sci. 2007;52:798-802.
21. Shia J. Immunohistochemistry versus microsatellite instability testing for screening colorectal cancer patients at risk for hereditary nonpolyposis colorectal cancer syndrome. Part I. the utility of immunohistochemistry. J Mol Diagn. 2008;10:293-300.
22. Shia J, Ellis NA, Paty PB, et al. Value of Histopathology in predicting microsatellite instability in hereditary nonpolyposis colorectal cancer and sporadic colorectal cancer. Am J Surg Pathol. 2003;27:1407-1417.
23. Shia J, Guillem JG, Moore HG, et al. Patterns of morphologic alteration in residual rectal carcinoma following preoperative chemoradiation and their association with long-term outcome. Am J Surg Pathol. 2004;28:215-223.
24. Shia J, Klimstra DS, Nafa K, et al. Value of immunohistochemical detection of DNA mismatch repair proteins in predicting germline mutation in hereditary colorectal neoplasms. Am J Surg Pathol. 2005;29:96-104.
25. Smyrk TC, Watson P, Kaul K, et al. Tumor-infiltrating lymphocytes are a marker for microsatellite instability in colorectal carcinoma. Cancer. 2001;91:2417-2422.
26. Stoffel E, Mukherjee B, Raymond VM, et al. Calculation of risk of colorectal and endometrial cancer among patients with lynch syndrome. Gastroenterology. 2009;137:1621-1627.
27. Torlakovic E, Skovlund E, Snover DC, et al. Morphologic reappraisal of serrated colorectal polyps. Am J Surg Pathol. 2003; 27:65-81.
28. Toyota M, Ahuja N, Ohe-Toyota M, et al. Cpg island methylator phenotype in colorectal cancer. Proc Natl Acad Sci USA. 1999; 96:8681-8686. (Pubitemid 29354851)
29. Umar A, Boland CR, Terdiman JP, et al. Revised Bethesda guidelines for hereditary nonpolyposis colorectal cancer (lynch syndrome) and microsatellite instability. J Natl Cancer Inst. 2004;96: 261-268. (Pubitemid 38256271)
30. Watson P, Vasen HF, Mecklin JP, et al. The risk of extra-colonic, extra-endometrial cancer in the lynch syndrome. Int J Cancer. 2008; 123:444-449.
31. Yantiss RK, Goodarzi M, Zhou XK, et al. Clinical, pathologic, and molecular features of early-onset colorectal carcinoma. Am J Surg Pathol. 2009;33:572-582.
32. Yantiss RK, Panczykowski A, Misdraji J, et al. A comprehensive study of nondysplastic and dysplastic serrated polyps of the vermiform appendix. Am J Surg Pathol. 2007;31:1742-1753.