Rosiglitazone reverses salbutamol-induced β 2-adrenoceptor tolerance in airway smooth muscle

British Journal of Pharmacology

Volumn 162, Issue 2, 2011, Pages 378-391

  Fogli, Stefano ^a   Pellegrini, Silvia ^a   Adinolfi, Barbara ^a   Mariotti, Veronica ^a   Melissari, Erika ^a   Betti, Laura ^a   Fabbrini, Laura ^a   Giannaccini, Gino ^a   Lucacchini, Antonio ^a   Bardelli, Claudio ^b   Stefanelli, Fabio ^a   Brunelleschi, Sandra ^b   Breschi, Maria Cristina ^a  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY OF EASTERN PIEDMONT   (Italy)

Author keywords

2 adrenoceptor desensitization; airway smooth muscle; chronic respiratory diseases; guinea pig; PPARI agonists; salbutamol

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; BETA ADRENERGIC RECEPTOR; CARBACHOL; CYCLIC AMP; FORSKOLIN; N (2 BENZOYLPHENYL) O [2 (METHYL 2 PYRIDINYLAMINO)ETHYL]TYROSINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; ROSIGLITAZONE; SALBUTAMOL;

AIRWAY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; BRONCHUS MUSCLE; CHOLINERGIC STIMULATION; CONTROLLED STUDY; DESENSITIZATION; DRUG MECHANISM; DRUG SENSITIVITY; DRUG TOLERANCE; GENE EXPRESSION REGULATION; GUINEA PIG; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR DOWN REGULATION; SMOOTH MUSCLE; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE FIBER; SMOOTH MUSCLE RELAXATION; TRACHEA MUSCLE;

ADRENERGIC BETA-2 RECEPTOR AGONISTS; ALBUTEROL; ANIMALS; ASTHMA; CARBACHOL; CELLS, CULTURED; DEXAMETHASONE; DRUG TOLERANCE; GUINEA PIGS; HUMANS; MALE; MUSCLE, SMOOTH; PPAR GAMMA; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RECEPTORS, ADRENERGIC, BETA-2; RESPIRATORY SYSTEM; RNA, MESSENGER; THIAZOLIDINEDIONES; TRACHEA;

EID: 78650399163     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.01021.x     Document Type: Article

References (42)

1. Adcock IM, Lane SJ, (2003). Corticosteroid-insensitive asthma: molecular mechanisms. J Endocrinol 178: 347-355.
2. Alexander SPH, Mathie A, Peters JA, (2009). Guide to receptors and channels (GRAC), 4th edn. Br J Pharmacol 158 (Suppl. 1): S1-S254.
3. Allen DB, (2002). Inhaled corticosteroid therapy for asthma in preschool children: growth issues. Pediatrics 109: 373-380.
4. Barnes PJ, (2002). Scientific rationale for inhaled combination therapy with long-acting beta2-agonists and corticosteroids. Eur Respir J 19: 182-191.
5. Barnes PJ, (2009). Corticosteroids. In:, Barnes PJ, Drazen JM, Rennard SI, Thompson NC, (eds). Asthma and COPD. Elsevier Science: San Diego, pp. 639-654.
6. Belvisi MG, Hele DJ, Birrell MA, (2006). Peroxisome proliferator- activated receptor gamma agonists as therapy for chronic airway inflammation. Eur J Pharmacol 533: 101-109.
7. Bogacka I, Gettys TW, de Jonge L, Nguyen T, Smith JM, Xie H, et al. (2007). The effect of beta-adrenergic and peroxisome proliferator-activated receptor-gamma stimulation on target genes related to lipid metabolism in human subcutaneous adipose tissue. Diabetes Care 30: 1179-1186.
8. Breschi MC, Blandizzi C, Fogli S, Martinelli C, Adinolfi B, Calderone V, et al. (2007). In vivo adenosine A(2B) receptor desensitization in guinea-pig airway smooth muscle: implications for asthma. Eur J Pharmacol 575: 149-157.
9. Broadley KJ, (2006). Beta-adrenoceptor responses of the airways: for better or worse? Eur J Pharmacol 533: 15-27.
10. Canning BJ, Chou Y, (2008). Using guinea pigs in studies relevant to asthma and COPD. Pulm Pharmacol Ther 21: 702-720.
11. Carswell H, Nahorski SR, (1983). Beta-adrenoceptor heterogeneity in guinea-pig airways: comparison of functional and receptor labelling studies. Br J Pharmacol 79: 965-971.
12. Cates CJ, Cates MJ, Lasserson TJ, (2008). Regular treatment with formoterol for chronic asthma: serious adverse events. Cochrane Database Syst Rev 4: CD006923.
13. Chitano P, Voynow JA, Pozzato V, Cantillana V, Burch LH, Wang L, et al. (2004). Ontogenesis of myosin light chain kinase mRNA and protein content in guinea pig tracheal smooth muscle. Pediatr Pulmonol 38: 456-464.
14. Combs TP, Wagner JA, Berger J, Doebber T, Wang WJ, Zhang BB, et al. (2002). Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: a potential mechanism of insulin sensitization. Endocrinology 143: 998-1007.
15. Cooper PR, Panettieri RA Jr, (2008). Steroids completely reverse albuterol-induced beta(2)-adrenergic receptor tolerance in human small airways. J Allergy Clin Immunol 122: 734-740.
16. Denning GM, Stoll LL, (2006). Peroxisome proliferator-activated receptors: potential therapeutic targets in lung disease? Pediatr Pulmonol 41: 23-34.
17. Deshpande DA, Penn RB, (2006). Targeting G protein-coupled receptor signaling in asthma. Cell Signal 18: 2105-2120.
18. Finney PA, Belvisi MG, Donnelly LE, Chuang TT, Mak JC, Scorer C, et al. (2000). Albuterol-induced downregulation of Gsalpha accounts for pulmonary beta(2)-adrenoceptor desensitization in vivo. J Clin Invest 106: 125-135.
19. Finney PA, Donnelly LE, Belvisi MG, Chuang TT, Birrell M, Harris A, et al. (2001). Chronic systemic administration of salmeterol to rats promotes pulmonary beta(2)-adrenoceptor desensitization and down-regulation of G(s alpha). Br J Pharmacol 132: 1261-1270.
20. Glass CK, Ogawa S, (2006). Combinatorial roles of nuclear receptors in inflammation and immunity. Nat Rev Immunol 6: 44-55.
21. Grootendorst DC, Sterk PJ, Heijerman HG, (2001). Effect of oral prednisolone on the bronchoprotective effect of formoterol in patients with persistent asthma. Eur Respir J 17: 374-379.
22. Hall IP, Daykin K, Widdop S, (1993). Beta 2-adrenoceptor desensitization in cultured human airway smooth muscle. Clin Sci (Lond) 84: 151-157. (Pubitemid 23053221)
23. Hu A, Nino G, Grunstein JS, Fatma S, Grunstein MM, (2008). Prolonged heterologous beta2-adrenoceptor desensitization promotes proasthmatic airway smooth muscle function via PKA/ERK1/2-mediated phosphodiesterase-4 induction. Am J Physiol Lung Cell Mol Physiol 294: L1055-L1067.
24. Huang TH, Razmovski-Naumovski V, Kota BP, Lin DS, Roufogalis BD, (2005). The pathophysiological function of peroxisome proliferator-activated receptor-gamma in lung-related diseases. Respir Res 6: 102.
25. Hughes TA, Stentz F, Gettys T, Smith SR, (2006). Combining beta-adrenergic and peroxisome proliferator-activated receptor gamma stimulation improves lipoprotein composition in healthy moderately obese subjects. Metabolism 55: 26-34.
26. Lee KS, Park SJ, Kim SR, Min KH, Jin SM, Lee HK, et al. (2006). Modulation of airway remodeling and airway inflammation by peroxisome proliferator-activated receptor gamma in a murine model of toluene diisocyanate-induced asthma. J Immunol 177: 5248-5257.
27. Loss JR 2nd, Hock RS, Farmer SG, Orzechowski RF, (2001). Racemic salbutamol administration to guinea-pigs selectively augments airway smooth muscle responsiveness to cholinoceptor agonists. J Auton Pharmacol 21: 211-217.
28. Mak JC, Nishikawa M, Shirasaki H, Miyayasu K, Barnes PJ, (1995). Protective effects of a glucocorticoid on downregulation of pulmonary beta 2-adrenergic receptors in vivo. J Clin Invest 96: 99-106.
29. Nie M, Corbett L, Knox AJ, Pang L, (2005). Differential regulation of chemokine expression by peroxisome proliferator-activated receptor gamma agonists: interactions with glucocorticoids and beta2-agonists. J Biol Chem 280: 2550-2561.
30. Nino G, Hu A, Grunstein JS, Grunstein MM, (2009). Mechanism regulating proasthmatic effects of prolonged homologous beta2-adrenergic receptor desensitization in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 297: L746-L757.
31. Nishikawa M, Mak JC, Shirasaki H, Barnes PJ, (1993). Differential down-regulation of pulmonary beta 1- and beta 2-adrenoceptor messenger RNA with prolonged in vivo infusion of isoprenaline. Eur J Pharmacol 247: 131-138.
32. Nishikawa M, Mak JC, Shirasaki H, Harding SE, Barnes PJ, (1994). Long-term exposure to norepinephrine results in down-regulation and reduced mRNA expression of pulmonary beta-adrenergic receptors in guinea pigs. Am J Respir Cell Mol Biol 10: 91-99.
33. Pang L, Nie M, Corbett L, Knox AJ, (2003). Cyclooxygenase-2 expression by nonsteroidal anti-inflammatory drugs in human airway smooth muscle cells: role of peroxisome proliferator-activated receptors. J Immunol 170: 1043-1051.
34. Pfaffl MW, (2001). A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29: e45.
35. R Development Core Team (2008). R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing: Vienna, ISBN 3-900051-07-0.
36. Roth M, Black JL, (2006). Transcription factors in asthma: are transcription factors a new target for asthma therapy? Curr Drug Targets 7: 589-595.
37. Roth M, Johnson PR, Rüdiger JJ, King GG, Ge Q, Burgess JK, et al. (2002). Interaction between glucocorticoids and beta2 agonists on bronchial airway smooth muscle cells through synchronised cellular signalling. Lancet 360: 1293-1299.
38. Sell H, Berger JP, Samson P, Castriota G, Lalonde J, Deshaies Y, et al. (2004). Peroxisome proliferator-activated receptor gamma agonism increases the capacity for sympathetically mediated thermogenesis in lean and ob/ob mice. Endocrinology 145: 3925-3934.
39. Shore SA, Moore PE, (2003). Regulation of beta-adrenergic responses in airway smooth muscle. Respir Physiol Neurobiol 137: 179-195.
40. Spears M, McSharry C, Thomson NC, (2006). Peroxisome proliferator- activated receptor-gamma agonists as potential anti-inflammatory agents in asthma and chronic obstructive pulmonary disease. Clin Exp Allergy 36: 1494-1504.
41. Spitzer WO, Suissa S, Ernst P, Horwitz RI, Habbick B, Cockcroft D, et al. (1992). The use of beta-agonists and the risk of death and near death from asthma. N Engl J Med 326: 501-506.
42. Vandesompele J, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F, (2002). Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 3: 2-12.