Effects of levosimendan and dobutamine in experimental acute endotoxemia: A preliminary controlled study

Intensive Care Medicine

Volumn 33, Issue 3, 2007, Pages 485-494

  Dubin, Arnaldo ^a   Murias, Gastón ^a   Sottile, Juan Pablo ^a   Pozo, Mario Omar ^a   Barán, Marcelo ^a   Edul, Vanina Siham Kanoore ^a   Canales, Héctor Saúl ^a   Etcheverry, Graciela ^a   Maskin, Bernardo ^a   Estenssoro, Elisa ^a  

^a FACULTAD DE CIENCIAS MÉDICAS   (Argentina)

Author keywords

Dobutamine; Gastrointestinal tonometry; Lactate; Levosimendan; Oxygen transport; Septic shock

Indexed keywords

DOBUTAMINE; ENDOTOXIN; LACTIC ACID; LEVOSIMENDAN; OXYGEN;

ACIDOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBON DIOXIDE TENSION; CONTROLLED STUDY; ENDOTOXEMIA; INTESTINE BLOOD FLOW; LABORATORY TEST; LOADING DRUG DOSE; NONHUMAN; SEPTIC SHOCK; SYSTEMIC CIRCULATION;

ACIDOSIS; ANALYSIS OF VARIANCE; ANIMALS; CARDIOTONIC AGENTS; DOBUTAMINE; ENDOTOXEMIA; HYDRAZONES; LACTIC ACID; OXYGEN; PROSPECTIVE STUDIES; PYRIDAZINES; RANDOM ALLOCATION; SHEEP; SHOCK, SEPTIC; SPLANCHNIC CIRCULATION;

EID: 33847354282     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00134-006-0519-5     Document Type: Article

References (46)

1. Parrillo JE (1993) Pathogenetic mechanisms of septic shock. N Engl J Med 328:1471-1477
2. Fiddian-Green RG, Haglund U, Gutierrez G, Shoemaker WC (1993) Goals for the resuscitation of shock. Crit Care Med 21:S25-S31
3. Mark P, Mohedin M (1994) The contrasting effects of dopamine and norepinephrine on systemic and splanchnic oxygen utilization in hyperdynamic sepsis. JAMA 272:1354-1357
4. Neviere R, Mathieu D, Chagnon JL, Lebleu N,Wattel F (1996) The contrasting effects of dobutamine and dopamine on gastric mucosal perfusion in septic patients. Am J Respir Crit Care Med 154:1684-1688
5. Buwalda M, Ince C (2002) Opening the microcirculation: Can vasodilators be useful in sepsis? Intensive Care Med 28:1208-1217
6. Follath F, Cleland JG, Just H, Papp JG, Scholz H, Peuhkurinen K, Harjola VP, Mitrovic V, Abdalla M, Sandell EP, Lehtonen L, Steering Committee and Investigators of the Levosimendan Infusion versus Dobutamine (LIDO) Study (2002) Efficacy and safety of intravenous levosimendan compared with dobutamine in severe low-output heart failure (the LIDO study): a randomised double-blind trial. Lancet 360:196-202
7. + channel in rat arterial myocytes. Eur J Pharmacol 333:249-259
8. Oldner A, Konrad D, Weitzberg E, Rudehill A, Rossi P, Wanecek M (2001) Effects of levosimendan, a novel inotropic calcium-sensitizing drug, in experimental septic shock. Crit Care Med 29:2185-2193
9. Morelli A, De Castro S, Teboul JL, Singer M, Rocco M, Conti G, De Luca L, Di Angelantonio E, Orecchioni A, Pandian NG, Pietropaoli P (2005) Effects of levosimendan on systemic and regional hemodynamics in septic myocardial depression. Intensive Care Med 31:638-644
10. Dubin A, Maskin B, Murias G, Pozo MO, Sottile JP, Baran M, Edul VS, Canales HS, Estenssoro E (2006) Effects of levosimendan in normodynamic endotoxemia: a controlled experimental study. Resuscitation 69:277-286
11. Dubin A, Murias G, Silva C, Maskin B, Sottile JP, Barán M, Pozo M, Kanoore Edul VS, Canales HS, Etcheverry G, Estenssoro E (2004) Effects of levosimendan in endotoxemic sheep: a controlled study. Intensive Care Medicine 30:S103
12. Constable PD (2001) Total weak acid concentration and effective dissociation constant of nonvolatile buffers in human plasma. J Appl Physiol 91:1364-1371
13. Traber DL, Flynn JT, Herndon DN, Redl H, Schlag G, Traber LD (1989) Comparison of cardiopulmonary responses to single bolus and continuous infusion of endotoxin in an ovine model. Circ Shock 27:123-138
14. Behrends M, Peters J (2003) The calcium sensitizer levosimendan attenuates endotoxin-evoked myocardial dysfunction in isolated guinea pig hearts. Intensive Care Med 29:1802-1807
15. + transients under acidotic condition in aequorin-loaded canine ventricular myocardium. Naunyn Schmiedebergs Arch Pharmacol 366:440-448
16. Schwarte LA, Picker O, Bornstein SR, Fournell A, Scheeren TWL (2005) Levosimendan is superior to milrinone and dobutamine in selectively increasing microvascular gastric mucosal oxygenation in dogs. Crit Care Med 33:135-142
17. Dellinger RP, Carlet JM, Masur H, Gerlach H, Calandra T, Cohen J, Gea-Banacloche J, Keh D, Marshall JC, Parker MM, Ramsay G, Zimmerman JL, Vincent JL, Levy MM (2004) Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Intensive Care Med 30:536-555
18. Ruffolo RR Jr (1987) Review: The pharmacology of dobutamine. Am J Med Sci 294:244-248
19. Hayes MA, Timmins AC, Yau E, Palazzo M, Hinds CJ, Watson D (1994) Elevation of systemic oxygen delivery in the treatment of critically ill patients. N Engl J Med 330:1717-1722
20. Pagnamenta A, Fesler P, Vandinivit A, Brimioulle S, Naeije R (2003) Pulmonary vascular effects of dobutamine in experimental pulmonary hypertension. Crit Care Med 31:1140-1146
21. Kellum JA (2002) Fluid resuscitation and hyperchloremic acidosis in experimental sepsis: improved short-term survival and acid-base balance with Hextend compared with saline. Crit Care Med 30:300-305
22. Durward A, Skellett S, Mayer A, Taylor D, Tibby SM, Murdoch IA (2001) The value of the chloride:sodium ratio in differentiating the aetiology of metabolic acidosis. Intensive Care Med 27:828-835
23. + ATPase activity and raised lactate concentrations in septic shock: a prospective study. Lancet 365:871-875
24. Brown SD, Clark C, Gutierrez G (1996) Pulmonary lactate release in patients with sepsis and the adult respiratory distress syndrome. J Crit Care 11:2-8
25. Rackow EC, Mecher C, Astiz ME, Goldstein C, McKee D, Weil MH (1990) Unmeasured anion during severe sepsis with metabolic acidosis. Circ Shock 30:107-115
26. Fink M (2001) Cytopathic hypoxia. Mitochondrial dysfunction as mechanism contributing to organ dysfunction in sepsis. Crit Care Clin 17:219-237
27. Antonsson JB, Engstrom L, Rasmussen I, Wollert S, Haglund UH (1995) Changes in gut intramucosal pH and gut oxygen extraction ratio in a porcine model of peritonitis and hemorrhage. Crit Care Med 23:1872-1881
28. 2 in endotoxemic dogs during shock and resuscitation. J Appl Physiol 76:793-800
29. VanderMeer TJ, Wang H, Fink MP (1995) Endotoxemia causes ileal mucosal acidosis in the absence of mucosal hypoxia in a normodynamic porcine model of septic shock. Crit Care Med 23:1217-1226
30. 2 difference during regional ischemic or hypoxic hypoxia. J Appl Physiol 89:1317-1321
31. 2 gap fails to increase during hypoxic hypoxia. Critical Care 6:514-520
32. 2 gradient does not reflect intestinal dysoxia in anemic hypoxia. J Trauma 57:1211-1217
33. Dubin A, Murias G, Maskin B, Pozo MO, Sottile JP, Baran M, Edul VS, Canales HS, Badie JC, Etcheverry G, Estenssoro E (2005) Increased blood flow prevents intramucosal acidosis in sheep endotoxemia: A controlled study. Critical Care 9:R66-R73
34. 2 gap is associated with impaired villus microcirculation in endotoxic pigs. Intensive Care Med 27:757-766
35. Silva E, DeBacker D, Créteur J, Vincent JL (1998) Effects of vasoactive drugs on gastric intramucosal pH. Crit Care Med 26:1749-1758
36. Lisbon A (2003) Dopexamine, dobutamina, and dopamine increase splanchnic blood flow. What is the evidence? Chest 123:430S-463S
37. Heino A, Hartikainen J, Merasto ME, Koski EM, Tenhunen J, Alhava E, Takala J (2000) Effects of dobutamina on splanchnic tissue perfusion during partial superior mesenteric artery occlusion. Crit Care Med 28:3484-3490
38. Hiltebrand LB, Krejci V, Sigurdsson GH (2004) Effects of dopamine, dobutamina, and dopexamine on microcirculatory blood flow in the gastrointestinal tract during sepsis and anesthesia. Anesthesiology 100:1188-1197
39. Lebuffe G, Levy B, Neviere R, Chagnon JL, Perrigault PF, Duranteau J, Edouard A, Teboul JL, Vallet B (2002) Dobutamine and gastric-to-arterial carbon dioxide gap in severe sepsis without shock. Intensive Care Med 28:265-271
40. Neviere R, Chagnon JL, Vallet B, Lebleu N, Marechal X, Mathieu D, Wattel F, Dupuis B (1997) Dobutamine improves gastrointestinal mucosal blood flow in a porcine model of endotoxic shock. Crit Care Med 25:1371-1377
41. De Backer D, Zhang H, Manikis P, Vincent JL (1996) Regional effects of dobutamine in endotoxic shock. J Surg Res 65:93-100
42. Demling RH, Smith M, Gunther R, Flynn JT, Gee MH (1981) Pulmonary injury and prostaglandin production during endotoxemia in conscious sheep. Am J Physiol 240:H348-H353
43. Lynch JP, Mhyre JG, Dantzker DR (1979) Influence of cardiac output on intrapulmonary shunt. J Appl Physiol 46:315-321
44. Tibayan FA, Chesnutt AN, Folkesson HG, Eandi J, Matthay MA (1997) Dobutamine increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation. Am J Respir Crit Care Med 156:438-444
45. Nuckton TJ, Alonso JA, Kallet RH, Daniel BM, Pittet JF, Eisner MD, Matthay MA (2002) Pulmonary dead-space fraction as a risk factor for death in the acute respiratory distress syndrome. N Engl J Med 25;346:1281-1286
46. Malbrain ML, Chiumello D, Pelosi P, Wilmer A, Brienza N, Malcangi V, Bihari D, Innes R, Cohen J, Singer P, Japiassu A, Kurtop E, De Keulenaer BL, Daelemans R, Del Turco M, Cosimini P, Ranieri M, Jacquet L, Laterre PF, Gattinoni L (2004) Prevalence of intra-abdominal hypertension in critically ill patients: a multicentre epidemiological study. Intensive Care Med 30:822-829