Levo is in the air: Take a deep breath!

Critical Care Medicine

Volumn 36, Issue 6, 2008, Pages 1979-1981

  Ertmer, Christian ^a   Westphal, Martin ^a   Morelli, Andrea ^b  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Acute lung injury; Hemodynamics; Levosimendan; Sepsis; Septic shock; Ventilator induced lung injury

Indexed keywords

ADRENERGIC RECEPTOR; ANTIBIOTIC AGENT; CATECHOLAMINE; DOBUTAMINE; HEMOGLOBIN; LEVOSIMENDAN; NORADRENALIN; CARDIOTONIC AGENT; HYDRAZONE DERIVATIVE; PYRIDAZINE DERIVATIVE; SIMENDAN;

ADULT; CASE REPORT; CHOLECYSTECTOMY; CONTINUOUS INFUSION; DISEASE SEVERITY; DRUG MEGADOSE; EDITORIAL; END TO END ANASTOMOSIS; FEMALE; HEART FAILURE; HEMOGLOBIN BLOOD LEVEL; HUMAN; HYPOTENSION; INTENSIVE CARE; INTESTINE PERFORATION; INTESTINE RESECTION; METAMORPHOSIS; MULTIPLE ORGAN FAILURE; OXYGEN SATURATION; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; SEPTIC SHOCK; TREATMENT RESPONSE; ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL; DISEASE MODEL; DRUG EFFECT; HEMODYNAMICS; INHALATIONAL DRUG ADMINISTRATION; NOTE; POSTOPERATIVE COMPLICATION; RAT; RISK FACTOR;

ADMINISTRATION, INHALATION; ADULT; ANIMALS; CARDIOTONIC AGENTS; DISEASE MODELS, ANIMAL; FEMALE; HEMODYNAMICS; HUMANS; HYDRAZONES; MULTIPLE ORGAN FAILURE; POSTOPERATIVE COMPLICATIONS; PYRIDAZINES; RATS; RESPIRATORY DISTRESS SYNDROME, ADULT; RISK FACTORS; SHOCK, SEPTIC;

EID: 45149111309     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e318176aae9     Document Type: Editorial

References (13)

1. Morelli A, Teboul JL, Maggiore SM, et al: Effects of levosimendan on right ventricular afterload in patients with acute respiratory distress syndrome: A pilot study. Crit Care Med 2006; 34:2287-2293
2. Boost KA, Hoegl S, Hofstetter C, et al: Inhaled levosimendan reduces mortality and release of proinflammatory mediators in a rat model of experimental ventilator-induced lung injury. Crit Care Med 2008; 36: 1873-1879
3. Parker JC, Hernandez LA, Peevy KJ: Mechanisms of ventilator-induced lung injury. Crit Care Med 1993; 21:131-143
4. Li LF, Yu L, Quinn DA: Ventilation-induced neutrophil infiltration depends on c-Jun N-terminal kinase. Am J Respir Crit Care Med 2004; 169:518-524
5. Schmeck J, Janzen R, Munter K, et al: Endo-thelin-1 and thromboxane A2 increase pulmonary vascular resistance in granulocyte-mediated lung injury. Crit Care Med 1998; 26:1868-1874
6. Mendez MP, Morris SB, Wilcoxen S, et al: Shedding of soluble ICAM-1 into the alveolar space in murine models of acute lung injury. Am J Physiol Lung Cell Mol Physiol 2006; 290:L962-L970
7. Parissis JT, Karavidas A, Bistola V, et al: Effects of levosimendan on flow-mediated va-sodilation and soluble adhesion molecules in patients with advanced chronic heart failure. Atherosclerosis 2008;197:278-282
8. Gruhn N, Nielsen-Kudsk JE, Theilgaard S, et al: Coronary vasorelaxant effect of levosi-mendan, a new inodilator with calcium-sensitizing properties. J Cardiovasc Pharmacol 1998; 31:741-749
9. Zager RA, Johnson AC, Lund S, et al: Levo-simendan protects against experimental en-dotoxemic acute renal failure. Am J Physiol Renal Physiol 2006; 290:F1453-F1462 10. Lepran I, Pollesello P, Vajda S, et al: Preconditioning effects of levosimendan in a rabbit cardiac ischemia-reperfusion model. J Cardiovasc Pharmacol 2006; 48:148-152
10. Adamopoulos S, Parissis JT, Iliodromitis EK, et al: Effects of levosimendan versus dobutamine on inflammatory and apopto-tic pathways in acutely decompensated chronic heart failure. Am J Cardiol 2006; 98:102-106
11. Rivers E, Nguyen B, Havstad S, et al: Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Medt 2001; 345:1368-1377
12. Morelli A, Ertmer C, Lange M, et al: Continuous terlipressin infusion in patients with septic shock: Less may be best, and the earlier the better? Intensive Care Med 2007; 33:1669-1670
13. Kumar A, Roberts D, Wood KE, et al: Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006; 34:1589-1596