Effects of levosimendan in normodynamic endotoxaemia: a controlled experimental study

Resuscitation

Volumn 69, Issue 2, 2006, Pages 277-286

  Dubin, Arnaldo ^a   Maskin, Bernardo ^a   Murias, Gastón ^a   Pozo, Mario Omar ^a   Sottile, Juan Pablo ^a   Barán, Marcelo ^a   Edul, Vanina Siham Kanoore ^a   Canales, Héctor Saúl ^a   Estenssoro, Elisa ^a  

^a FACULTAD DE CIENCIAS MÉDICAS   (Argentina)

Author keywords

Intramucosal carbon dioxide; Lactic acidosis; Levosimendan; Septic shock

Indexed keywords

ENDOTOXIN; LEVOSIMENDAN;

ACIDOSIS; ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOGENIC SHOCK; CONTROLLED STUDY; DRUG EFFECT; ENDOTOXEMIA; HEART OUTPUT; HEART STROKE VOLUME; INTESTINE BLOOD FLOW; MEAN ARTERIAL PRESSURE; NONHUMAN; OXYGEN CONSUMPTION; OXYGEN TRANSPORT; PRIORITY JOURNAL; SHEEP; STUDENT T TEST;

ACIDOSIS; ANIMALS; DISEASE MODELS, ANIMAL; ENDOTOXEMIA; ESCHERICHIA COLI INFECTIONS; HEMODYNAMIC PROCESSES; HYDRAZONES; INTESTINAL MUCOSA; LACTIC ACID; OXYGEN; PYRIDAZINES; SHEEP; VASODILATOR AGENTS;

EID: 33748043321     PISSN: 03009572     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resuscitation.2005.08.002     Document Type: Article

References (38)

1. Angus D.C., Linde-Zwirble W.T., Lidicker J., Clermont G., Carcillo J., and Pinsky M.R. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 29 (2001) 1303-1310
2. Parrillo J.E. Pathogenetic mechanisms of septic shock. N Engl J Med 328 (1993) 1471-1477
3. Task Force of the American College of Critical Care Medicine, Society of Critical Care. Practice parameters for hemodynamic support of sepsis in adult patients in sepsis. Crit Care Med 27 (1999) 639-660
4. Fiddian-Green R.G., Haglund U., Gutierrez G., and Shoemaker W.C. Goals for the resuscitation of shock. Crit Care Med 21 (1993) S25-S31
5. Mark P., and Mohedin M. The contrasting effects of dopamine and norepinephrine on systemic and splanchnic oxygen utilization in hyperdynamic sepsis. JAMA 272 (1994) 1354-1357
6. Sautner T., Wessely C., Riegler M., Sedivy R., Gotzinger P., Losert U., et al. Early effects of catecholamine therapy on mucosal integrity, intestinal blood flow, and oxygen metabolism in porcine endotoxin shock. Ann Surg 228 (1998) 239-248
7. Neviere R., Mathieu D., Chagnon J.L., Lebleu N., and Wattel F. The contrasting effects of dobutamine and dopamine on gastric mucosal perfusion in septic patients. Am J Respir Crit Care Med 154 (1996) 1684-1688
8. Buwalda M., and Ince C. Opening the microcirculation: can vasodilators be useful in sepsis?. Intensive Care Med 28 (2002) 1208-1217
9. Follath F., Cleland J.G., Just H., Papp J.G., Scholz H., Peuhkurinen K., et al. Efficacy and safety of intravenous levosimendan compared with dobutamine in severe low-output heart failure (the LIDO study): a randomised double-blind trial. Lancet 360 (2002) 196-202
10. + channel in rat ventricular cells. J Pharmacol Exp Ther 283 (1997) 375-383
11. Oldner A., Konrad D., Weitzberg E., Rudehill A., Rossi P., and Wanecek M. Effects of levosimendan, a novel inotropic calcium-sensitizing drug, in experimental septic shock. Crit Care Med 29 (2001) 2185-2193
12. 2 concentration difference. J Appl Physiol 74 (1993) 959-964
13. Fink M.P., and Heard S.O. Laboratory models of sepsis and septic shock. J Surg Res 49 (1990) 186-196
14. Traber D.L., Flynn J.T., Herndon D.N., Redl H., Schlag G., and Traber L.D. Comparison of cardiopulmonary responses to single bolus and continuous infusion of endotoxin in an ovine model. Circ Shock 27 (1989) 123-138
15. Antonsson J.B., Engstrom L., Rasmussen I., Wollert S., and Haglund U.H. Changes in gut intramucosal pH and gut oxygen extraction ratio in a porcine model of peritonitis and hemorrhage. Crit Care Med 23 (1995) 1872-1881
16. O2 in endotoxemic dogs during shock and resuscitation. J Appl Physiol 76 (1994) 793-800
17. Revelly J.P., Ayuse T., Brienza N., Fessler H.E., and Robotham J.L. Endotoxic shock alters distribution of blood flow within the intestinal wall. Crit Care Med 24 (1996) 1345-1351
18. VanderMeer T.J., Wang H., and Fink M.P. Endotoxemia causes ileal mucosal acidosis in the absence of mucosal hypoxia in a normodynamic porcine model of septic shock. Crit Care Med 23 (1995) 1217-1226
19. Fink M. Cytopathic hypoxia. Mitochondrial dysfunction as mechanism contributing to organ dysfunction in sepsis. Crit Care Clin 17 (2001) 219-237
20. 2 difference during regional ischemic or hypoxic hypoxia. J Appl Physiol 89 (2000) 1317-1321
21. C O2) fails to increase during hypoxic hypoxia. Crit Care 6 (2002) 514-520
22. C O2 gradient does not reflect intestinal dysoxia in anemic hypoxia. J Trauma 57 (2004) 1211-1217
23. C O2 gap is associated with impaired villus microcirculation in endotoxic pigs. Intensive Care Med 27 (2001) 757-766
24. Dubin A., Murias G., Maskin B., Pozo M., Sottile J.P., Barán M., et al. Increased blood flow prevents intramucosal acidosis in sheep endotoxemia: a controlled study. Crit Care 9 (2004-2005) R66-R73
25. Brighman K.L., Bowers R.E., and Haynes J. Increased sheep lung vascular permeability caused by Escherichia coli endotoxin. Circ Res 45 (1979) 292-297
26. Behrends M., and Peters J. The calcium sensitizer levosimendan attenuates endotoxin-evoked myocardial dysfunction in isolated guinea pig hearts. Intensive Care Med 29 (2003) 1802-1807
27. 2+ transients under acidotic condition in aequorin-loaded canine ventricular myocardium. Naunyn-Schmiedeberg's Arch Pharmacol 366 (2002) 440-448
28. Fink M.P., Antonsson J.B., Wang H.L., and Rothschild H.R. Etiology of increased intestinal permeability in endotoxic pigs: limited role for mesenteric hypoperfusion. Arch Surg 126 (1991) 211-219
29. Landow L., and Andersen L.W. Splanchnic ischaemia and its role in multiple organ failure. Acta Anaesthesiol Scand 38 (1994) 626-639
30. De Backer D., Creteur J., Preiser J.C., Dubois M.C., and Vincent J.L. Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med 166 (2002) 98-104
31. Spronk P.E., Ince C., Gardien M.J., Mathura K.R., Oudemans-van Straaten H.M., and Zandstra D.F. Nitroglicerin in septic shock after intravascular volume resuscitation. Lancet 360 (2002) 1395-1396
32. O2. J Appl Physiol 68 (1990) 833-842
33. Chasiotis D., Sahlin K., and Hultman E. Regulation of glycogenolysis in human muscle in response to epinephrine infusion. J Appl Physiol 54 (1983) 45-50
34. James J.H., Wagner K.R., King J.K., Leffler R.E., Upputuri R.K., Balasubramaniam A., et al. Stimulation of both aerobic glycolysis and Na(+)-K(+)-ATPase activity in skeletal muscle by epinephrine or amylin. Am J Physiol 277 (1999) 176-186
35. Levy B., Mansart A., Bollaert P.E., Franck P., and Mallie J.P. Effects of epinephrine and norepinephrine on hemodynamics, oxidative metabolism, and organ energetics in endotoxemic rats. Intensive Care Med 29 (2003) 292-300
36. Lynch J.P., Mhyre J.G., and Dantzker D.R. Influence of cardiac output on intrapulmonary shunt. J Appl Physiol 46 (1979) 315-321
37. Lumb A. Nunn's applied respiratory physiology. 5th ed. (2000), Butterworth-Heineman, Oxford
38. D'Orio V., Halleux J., Rodriguez L.M., Wahlen C., and Marcelle R. Effects of Escherichia coli endotoxin on pulmonary vascular resistance in intact dogs. Crit Care Med 14 (1986) 802-806