Risk factors for serum alanine aminotransferase elevation: A cross-sectional study of healthy adult males in Tokyo, Japan

Digestive and Liver Disease

Volumn 42, Issue 12, 2010, Pages 882-887

  Gunji, Toshiaki ^a   Matsuhashi, Nobuyuki ^a   Sato, Hajime ^b   Iijima, Kimiko ^a   Fujibayashi, Kazutoshi ^a   Okumura, Mitsue ^a   Sasabe, Noriko ^a   Urabe, Akio ^a  

^a Kanto Teishin Hospital   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Alanine aminotransferase; Alcohol; Fatty liver; Insulin resistance; Steatosis

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GLUCOSE; GLYCOSYLATED HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ABNORMALLY HIGH SUBSTRATE CONCENTRATION IN BLOOD; ADULT; AGE DISTRIBUTION; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL CONSUMPTION; ARTICLE; BODY MASS; CIGARETTE SMOKING; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; ECHOGRAPHY; FATTY LIVER; GLUCOSE BLOOD LEVEL; HEALTH SURVEY; HUMAN; INTRAABDOMINAL FAT; JAPAN; MAJOR CLINICAL STUDY; MALE; PHYSICAL ACTIVITY; POPULATION RESEARCH; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR; SUBCUTANEOUS FAT; SYSTOLIC BLOOD PRESSURE;

ADULT; ALANINE TRANSAMINASE; ALCOHOL DRINKING; CROSS-SECTIONAL STUDIES; FATTY LIVER; HUMANS; INTRA-ABDOMINAL FAT; MALE; MIDDLE AGED; RISK FACTORS; TOKYO; TOMOGRAPHY, X-RAY COMPUTED;

EID: 78650286705     PISSN: 15908658     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dld.2010.04.001     Document Type: Article

References (51)

1. Daniel S., Ben-Menachem T., Vasudevan G., et al. Prospective evaluation of unexplained chronic liver transaminase abnormalities in asymptomatic and symptomatic patients. Am J Gastroenterol 1999, 94:3010-3014.
2. Mathiesen U.L., Franzen L.E., Fryden A., et al. The clinical significance of slightly to moderately increased liver transaminase values in asymptomatic patients. Scand J Gastroenterol 1999, 34:85-91.
3. Tanaka N., Tanaka E., Sheena Y., et al. Useful parameters for distinguishing nonalcoholic steatohepatitis with mild steatosis from cryptogenic chronic hepatitis in the Japanese population. Liver Int 2006, 26:956-963.
4. Bedogni G., Miglioli L., Masutti F., et al. Incidence and natural course of fatty liver in the general population: the Dionysos study. Hepatology 2007, 46:1387-1391.
5. Pendino G.M., Mariano A., Surace P., et al. Prevalence and etiology of altered liver tests: a population-based survey in a Mediterranean town. Hepatology 2005, 41:1151-1159.
6. Kondili L.A., Taliani G., Cerga G., et al. Correlation of alcohol consumption with liver histological features in non-cirrhotic patients. Eur J Gastroenterol Hepatol 2005, 17:155-159.
7. Becker U., Gronbeck M., Johansen D., et al. Lower risk for alcohol-induced cirrhosis in wine drinkers. Hepatology 2002, 35:868-875.
8. Baur J.A., Pearson K.J., Price N.L., et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006, 444:337-342.
9. Joosten M.M., Beulens J.W., Kersten S., et al. Moderate alcohol consumption increases insulin sensitivity and ADIPOQ expression in postmenopausal women: a randomized, crossover trial. Diabetologia 2008, 51:1375-1381.
10. Sierksma A., Patel H., Ouchi N., et al. Effect of moderate alcohol consumption on adiponectin, tumor necrosis factor-alpha, and insulin sensitivity. Diabetes Care 2004, 27:184-189.
11. Davies M.J., Baer D.J., Judd J.T., et al. Effects of moderate alcohol intake on fasting insulin and glucose concentrations and insulin sensitivity in postmenopausal women. JAMA 2002, 287:2559-2562.
12. Beulens J.W., Rimm E.B., Hu F.B., et al. Alcohol consumption, mediating biomarkers, and risk of type 2 diabetes among middle-aged women. Diabetes Care 2008, 31:2050-2055.
13. Shai I., Wainstein J., Harman-Boehm I., et al. Glycemic effects of moderate alcohol intake among patients with type 2 diabetes: a multicenter, randomized, clinical intervention trial. Diabetes Care 2007, 30:3011-3016.
14. Brand-Miller J.C., Fatema K., Middlemiss C., et al. Effect of alcoholic beverages on postprandial glycemia and insulinemia in lean, young, healthy adults. Am J Clin Nutr 2007, 85:1545-1551.
15. Athyros V.G., Liberopoulos E.N., Mikhailidis D.P., et al. Association of drinking pattern and alcohol beverage type with the prevalence of metabolic syndrome, diabetes, coronary heart disease, stroke, and peripheral arterial disease in a Mediterranean cohort. Angiology 2007, 58:689-697.
16. Gigleux I., Gagnon J., St-Pierre A., et al. Moderate alcohol consumption is more cardioprotective in men with the metabolic syndrome. J Nutr 2006, 136:3027-3032.
17. Femia R., Natali A., L'Abbate A., et al. Coronary atherosclerosis and alcohol consumption: angiographic and mortality data. Arterioscler Thromb Vasc Biol 2006, 26:1607-1612.
18. Suzuki A., Angulo P., Sauver J., et al. Light to moderate alcohol consumption is associated with lower frequency of hypertransaminasemia. Am J Gastroenterol 2007, 102:1912-1919.
19. Dunn W., Xu R., Schwimmer J.B. Modest wine drinking and decreased prevalence of suspected nonalcoholic fatty liver disease. Hepatology 2008, 47:1947-1954.
20. Dixon J.B., Bhathal P.S., O'Brien P.E. Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology 2001, 121:91-100.
21. Gunji T., Matsuhashi N., Sato H., et al. Light and moderate alcohol consumption significantly reduces the prevalence of fatty liver in the Japanese male population. Am J Gastroenterol 2009, 104:2189-2195.
22. Yamada T., Fukatsu M., Suzuki S., et al. Alcohol drinking may not be a major risk factor for fatty liver in Japanese undergoing a health checkup. Dig Dis Sci 2010, 55:176-182.
23. Hamaguchi M., Kojima T., Itoh Y., et al. The severity of ultrasonographic findings in nonalcoholic fatty liver disease reflects the metabolic syndrome and visceral fat accumulation. Am J Gastroenterol 2007, 102:2708-2715.
24. Palmentieri B., de Sio I., La Mura V., et al. The role of bright liver echo pattern on ultrasound B-mode examination in the diagnosis of liver steatosis. Dig Liver Dis 2006, 38:485-489.
25. Kim H.C., Chol S.H., Shin H.W., et al. Severity of ultrasonographic liver steatosis and metabolic syndrome in Korean men and women. World J Gastroenterol 2005, 11:5314-5321.
26. Anan F., Takahashi N., Shinohara T., et al. Smoking is associated with insulin resistance and cardiovascular autonomic dysfunction in type 2 diabetic patients. Eur J Clin Invest 2006, 36:459-465.
27. Zhou Y.J., Li Y.Y., Nie Y.Q., et al. Prevalence of fatty liver disease and its risk factors in the population of South China. World J Gastroenterol 2007, 13:6419-6424.
28. Bellentani S., Saccoccio G., Masutti F., et al. Prevalence of and risk factors for hepatic steatosis in Northern Italy. Ann Intern Med 2000, 132:112-117.
29. Angelico F., Del Ben M., Conti R., et al. Non-alcoholic fatty liver syndrome: a hepatic consequence of common metabolic diseases. J Gastroenterol Hepatol 2003, 18:588-594.
30. Lee S., Jin Kim Y., Yong Jeon T., et al. Obesity is the only independent factor associated with ultrasound-diagnosed non-alcoholic fatty liver disease: a cross-sectional case-control study. Scand J Gastroenterol 2006, 41:566-572.
31. Clark J.M., Brancati F.L., Diehl A.M. The prevalence and etiology of elevated aminotransferase levels in the United States. Am J Gastroenterol 2003, 98:960-967.
32. Ioannou G.N., Boyko E.J., Lee S.P. The prevalence and predictors of elevated serum aminotransferase activity in the United States in 1999-2002. Am J Gastroenterol 2006, 101:76-82.
33. Adams L.A., Knuiman M.W., Divitini M.L., et al. Body mass index is a stronger predictor of alanine aminotransferase levels than alcohol consumption. J Gastroenterol Hepatol 2008, 23:1089-1093.
34. Palmer M., Schaffner F. Effect of weight reduction on hepatic abnormalities in overweight patients. Gastroenterology 1990, 99:1408-1413.
35. Papatheodoridis G.V., Goulis J., Christodoulou D., et al. High prevalence of elevated liver enzymes in blood donors: associations with male gender and central adiposity. Eur J Gastroenterol Hepatol 2007, 19:281-287.
36. Chen C.H., Huang M.H., Yang J.C., et al. Prevalence and etiology of elevated serum alanine aminotransferase level in an adult population in Taiwan. J Gastroenterol Hepatol 2007, 22:1482-1489.
37. Di Bonito P., Sanguigno E., Di Fraia T., et al. Association of elevated serum alanine aminotransferase with metabolic factors in obese children: sex-related analysis. Metabolism 2009, 58:368-372.
38. Sanyal A.J., Campbell-Sargent C., Mirshahi F., et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 2001, 120:1183-1192.
39. Browning J.D., Szczepaniak L.S., Dobbins R., et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 2004, 40:1387-1395.
40. Park S.H., Jeon W.K., Kim S.H., et al. Prevalence and risk factors of non-alcoholic fatty liver disease among Korean adults. J Gastroenterol Hepatol 2006, 21:138-143.
41. Liangpunsakul S., Chalasani N. Unexplained elevations in alanine aminotransferase in individuals with the metabolic syndrome: results from the third National Health and Nutrition Survey (NHANES III). Am J Med Sci 2005, 329:111-116.
42. Hanley A.J., Wagenknecht L.E., Festa A., et al. Alanine aminotransferase and directly measured insulin sensitivity in a multiethnic cohort: the Insulin Resistance Atherosclerosis Study. Diabetes Care 2007, 30:1819-1827.
43. Kain K., Carter A.M., Grant P.J., et al. Alanine aminotransferase is associated with atherothrombotic risk factors in a British South Asian population. J Thromb Haemost 2008, 6:737-741.
44. Ruhl C.E., Everhart J.E. Joint effects of body weight and alcohol on elevated serum alanine aminotransferase in the United States population. Clin Gastroenterol Hepatol 2005, 3:1260-1268.
45. Alatalo P.I., Koivisto H.M., Hietala J.P., et al. Effect of moderate alcohol consumption on liver enzymes increases with increasing body mass index. Am J Clin Nutr 2008, 88:1097-1103.
46. Lalor P.F., Faint J., Aarbodem Y., et al. The role of cytokines and chemokines in the development of steatohepatitis. Semin Liver Dis 2007, 27:173-193.
47. Mantena S.K., King A.L., Andringa K.K., et al. Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases. Free Radic Biol Med 2008, 44:1259-1272.
48. de la Maza M.P., Hirsch S., Petermann M., et al. Changes in microsomal activity in alcoholism and obesity. Alcohol Clin Exp Res 2000, 24:605-610.
49. Song H.R., Yun K.E., Park H.S. Relation between alanine aminotransferase concentrations and visceral fat accumulation among nondiabetic overweight Korean women. Am L Clin Nutr 2008, 88:16-21.
50. Stranges S., Dorn J.M., Muti P., et al. Body fat distribution, relative weight, and liver enzyme levels: a population-based study. Hepatology 2004, 39:754-763.
51. Park B.J., Kim Y.J., Kim D.H., et al. Visceral adipose tissue area is an independent risk factor for hepatic steatosis. J Gastroenterol Hepatol 2008, 23:900-907.