Prevalence and etiology of elevated serum alanine aminotransferase level in an adult population in Taiwan

Journal of Gastroenterology and Hepatology (Australia)

Volumn 22, Issue 9, 2007, Pages 1482-1489

  Chen, Chien Hua ^a   Huang, Min Ho ^a   Yang, Jee Chun ^a   Nien, Chiu Kue ^a   Yang, Chi Chieh ^a   Yeh, Yung Hsiang ^a   Yueh, Sen Kou ^a  

^a SHOW CHWAN MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Alanine aminotransferase; Hepatitis B; Hepatitis C; Non alcoholic fatty liver disease; Ultrasonography

Indexed keywords

ALANINE AMINOTRANSFERASE; HEPATITIS B SURFACE ANTIGEN; HEPATITIS C ANTIBODY;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL CONSUMPTION; ARTICLE; BLOOD ANALYSIS; BODY MASS; CONFIDENCE INTERVAL; DISEASE PREDISPOSITION; ECHOGRAPHY; FATTY LIVER; FEMALE; GLUCOSE BLOOD LEVEL; HEPATITIS B; HEPATITIS C; HUMAN; HYPERTRIGLYCERIDEMIA; HYPERURICEMIA; LIVER DISEASE; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; NONALCOHOLIC FATTY LIVER; POPULATION RESEARCH; PREDICTOR VARIABLE; PREVALENCE; PRIORITY JOURNAL; RURAL AREA; STRUCTURED INTERVIEW; STRUCTURED QUESTIONNAIRE; TAIWAN; UNITED STATES; UNIVARIATE ANALYSIS;

EID: 34547964678     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2006.04615.x     Document Type: Article

References (30)

1. Pendino GM, Mariano A, Surace P et al. Prevalence and etiology of altered liver tests: a population-based survey in a Mediterranean town. Hepatology 2005 41 : 1151 9.
2. Marchesini G, Bugianesi E, Forlani G et al. Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology 2003 37 : 917 23.
3. Flegal KM, Carroll MD, Ogden CL, Johnson CL. Prevalence and trends in obesity among US adults, 1999-2000. JAMA 2002 288 : 1723 7.
4. Chen DS, Sung JL. Hepatitis B virus infection and chronic liver diseases in Taiwan. Acta Hepatogastroenterol. 1978 25 : 423 30.
5. Lee SD, Chan CY, Wang YJ et al. Seroepidemiology of hepatitis C virus infection in Taiwan. Hepatology 1991 13 : 830 3.
6. Katkov WN, Friedman LS, Cody H et al. Elevated serum alanine aminotransferase levels in blood donors: the contribution of hepatitis C. Ann. Intern. Med. 1991 115 : 882 4.
7. Chang CJ, Ko YC, Liu HW. Serum alanine aminotransferase levels in relation to hepatitis B and C virus infections among drug abusers in an area hyperendemic for hepatitis B. Dig. Dis. Sci. 2000 45 : 1949 52.
8. Hultcrantz R, Gabrielsson N. Patients with persistent elevation of aminotransferases: investigation with ultrasonography, radionuclide imaging and liver biopsy. J. Intern. Med. 1993 233 : 7 12.
9. Mendler MH, Bouillet P, LeSidaner A et al. Dual-energy CT in the diagnosis and quantification of fatty liver: limited clinical value in comparison to ultrasound scan and single-energy CT, with special reference to iron overload. J. Hepatol. 1998 28 : 785 94.
10. Saverymuttu SH, Joseph AE, Maxwell JD. Ultrasound scanning in the detection of hepatic fibrosis and steatosis. BMJ 1986 292 : 13 15.
11. Mulhall BP, Ong JP, Younossi ZM. Non-alcoholic fatty liver disease: an overview. J. Gastroenterol. Hepatol. 2002 17 : 1136 43.
12. Saadeh S, Younossi ZM, Remer EM et al. The utility of radiological imaging in nonalcoholic fatty liver disease. Gastroenterology 2002 123 : 745 50.
13. Scatarige JC, Scott WW, Donovan PJ, Siegelmann SS, Sanders RC. Fatty infiltration of the liver: ultrasonographic and computed tomographic correlation. J. Ultrasound Med. 1984 3 : 9 14.
14. Choudhury J, Sanyal AJ. Clinical aspects of fatty liver disease. Semin. Liver Dis. 2004 24 : 349 62.
15. Sanyal AJ, Contos MJ, Sterling RK et al. Nonalcoholic fatty liver disease in patients with hepatitis C is associated with features of the metabolic syndrome. Am. J. Gastroenterol. 2003 98 : 2064 71.
16. Marchesini G, Brizi M, Morselli-Labate AM et al. Association of nonalcoholic fatty liver disease with insulin resistance. Am. J. Med. 1999 107 : 450 5.
17. Chitturi S, Abeygunasekera S, Farrell GC et al. NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome. Hepatology 2002 35 : 373 9.
18. Bugianesi E, Manzini P, D'Antico S et al. Relative contribution of iron burden, HFE mutations, and insulin resistance to fibrosis in nonalcoholic fatty liver. Hepatology 2004 39 : 179 87.
19. Chen DS. Natural history of chronic hepatitis B virus infection: new light on an old story. J. Gastroenterol. Hepatol. 1993 8 : 470 5.
20. Wang CS, Chang TT, Chou P. Differences in risk factors for either a hepatitis B carrier or anti-hepatitis C+ in a hepatoma-hyperendemic area in rural Taiwan. J. Clin. Epidemiol. 1998 51 : 733 8.
21. Maio G, D'Argenio P, Stroffolini T et al. Hepatitis C virus infection and alanine transaminase levels in the general population: a survey in a southern Italian town. J. Hepatol. 2000 33 : 116 20.
22. Hayashi N, Kanto T, Takehara T. Immunopathogenesis of type C hepatitis: dendritic cell in HCV infection. J. Gastroenterol. Hepatol. 2004 19 : S84 S87.
23. Soguero C, Joo M, Chianese-Bullock KA, Nguyen DT, Tung K, Hahn YS. Hepatitis C virus core protein leads to immune suppression and liver damage in a transgenic murine model. J. Virol. 2002 76 : 9345 54.
24. Monto A, Alonzo J, Watson JJ, Grunfeld C, Wright TL. Steatosis in chronic hepatitis C: relative contributions of obesity, diabetes mellitus, and alcohol. Hepatology 2002 36 : 729 36.
25. Fiore G, Fera G, Napoli N, Vella F, Schiraldi O. Liver steatosis and chronic hepatitis C: a spurious association? Eur. J. Gastroenterol. Hepatol. 1996 8 : 125 9.
26. Liu CJ, Jeng YM, Chen PJ et al. Influence of metabolic syndrome, viral genotype and antiviral therapy on superimposed fatty liver disease in chronic hepatitis C. Antiviral Ther. 2005 10 : 405 15.
27. Perlemuter G, Sabile A, Letteron P et al. Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: a model of viral-related steatosis. FASEB J. 2002 16 : 185 94.
28. Yamaguchi A, Tazuma S, Nishioka T et al. Hepatitis C virus core protein modulates fatty acid metabolism and thereby causes lipid accumulation in the liver. Dig. Dis. Sci. 2005 50 : 1361 71.
29. Kao JH, Chen PJ, Lai MY et al. Genotypes of hepatitis C virus in Taiwan and the progression of liver disease. J. Clin. Gastroenterol. 1995 21 : 233 7.
30. Liu CJ, Chen PJ, Shau WY, Kao JH, Lai MY, Chen DS. Clinical aspects and outcomes of volunteer blood donors testing positive for hepatitis-C virus infection in Taiwan: a prospective study. Liver Int. 2003 23 : 148 55.