Prevalence and etiology of altered liver tests: A population-based survey in a Mediterranean town

Hepatology

Volumn 41, Issue 5, 2005, Pages 1151-1159

  Pendino, Gaspare Maria ^a   Mariano, Andrea ^b   Surace, Pasquale ^c   Caserta, Carmelo Antonio ^a   Fiorillo, Maria Teresa ^c   Amante, Angela ^a   Bruno, Stefania ^a   Mangano, Carmelo ^d   Polito, Irene ^e   Amato, Fulvia ^a   Cotichini, Rodolfo ^b   Stroffolini, Tommaso ^a,b   Mele, Alfonso ^b   Gutamo, Giovanni ^f   Marra, Marisa ^f   Giovinazzo, Girolamo ^f   Pelle, Antonino ^f   Falletti, Antonio ^f   Martino, Franco ^f   Pisano, Francesco ^f   Iamundo, Caterina ^f   Giovinazzo, Antonino ^f   Licordari, Amalia ^f   Maugeri, Gino ^f   Luccisano, Giuseppe ^f   Caligiuri, Marcella ^f   Surace, Monica ^f   Carpentieri, Maria Stella ^f   Messineo, Federica ^f   Alicante, Saverio ^f   more..

^a Divisione di Medicina 1   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c Laboratorio   (Italy)

^d BIANCHI MELACRINO MORELLI HOSPITAL   (Italy)

^e UNIVERSITY OF MESSINA   (Italy)

^f Istituto Superiore di Sanita ^*

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; AGED; ALCOHOL CONSUMPTION; BODY WEIGHT; CONFIDENCE INTERVAL; CONTROLLED STUDY; DIET; ECHOGRAPHY; FEMALE; HEALTH SURVEY; HEPATITIS B; HEPATITIS B VIRUS; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HYPERCHOLESTEROLEMIA; HYPERGLYCEMIA; ITALY; LIVER DYSFUNCTION; LIVER FUNCTION TEST; LIVER INJURY; MALE; METABOLISM; NONALCOHOLIC FATTY LIVER; POPULATION; PREVALENCE; PRIORITY JOURNAL; REVIEW; SCHOOL CHILD; SCREENING; SOUTHERN EUROPE; TIME SERIES ANALYSIS;

ADULT; AGED; ALCOHOL DRINKING; DIET, MEDITERRANEAN; FEMALE; HEPATITIS B; HEPATITIS C; HUMANS; ITALY; LIVER DISEASES; LIVER FUNCTION TESTS; MALE; MIDDLE AGED; PREVALENCE;

EID: 20944449901     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.20689     Document Type: Review

References (50)

1. Marchesini G, Brizi M, Bianchi G, Tomassetti S, Bugianesi E, Lenzi M, et al. Non-alcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes 2001;50:1844-1850.
2. Marchesini G, Bugianesi E, Forlani G, Cerrelli F, Lenzi M, Manini R, et al. Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. HEPATOLOGY 2003;37:917-923.
3. Bugianesi E, Zannoni C, Vanni E, Marzocchi R, Marchesini G. Non-alcoholic fatty liver and insulin resistance: a cause-effect relationship? Dig Liver Dis 2004;36:165-173.
4. Brunt EM. Nonalcoholic steatohepatitis. Semin Liver Dis 2004;24:3-20.
5. World Health Organization. Obesity: Preventing and Managing the Global Epidemic. Geneva, Switzerland: World Health Organization, 1998.
6. Flegal KM, Carroll MD, Ogden CL, Johnson CL. Prevalence and trends in obesity among US adults, 1999-2000. JAMA 2002;288:1723-1727.
7. The Italian Cardiovascular Epidemiological Observatory - Research Group/The Italian Atlas of Cardiovascular Diseases. Ital Heart J 2004; 5(Suppl 3):49S-92S.
8. Friedman LS, Dienstag JL, Watkins E, Hinkle CA, Spiers JA, Rieder SV, et al. Evaluation of blood donors with elevated serum alanine aminotransferase levels. Ann Intern Med 1987;107:137-144.
9. Katkov WN, Friedman LS, Cody H, Evans A, Kuo G, Choo QL, et al. Elevated serum alanine aminotransferase levels in blood donors: the contribution of hepatitis C virus. Ann Intern Med 1991;115:882-884.
10. Kundrotas LW, Clement DJ. Serum alanine aminotransferase (ALT) elevation in asympromatic US Air Force basic trainee blood donors. Dig Dis Sci 1993;38:2145-2150.
11. Strauss RS, Barlow SE, Dietz WH. Prevalence of abnormal serum amino-transferase values in overweight and obese adolescents. J Pediatr 2000;136:727-733.
12. Daniel S, Ben-Menachem T, Vasudevan G, Ma CK, Blumenkehl M. Prospective evaluation of unexplained chronic liver transaminase abnormalities in asymptomatic and symptomatic patients. Am J Gastroenterol 1999;94:3010-3014.
13. Skelly MM, James PD, Ryder SD. Findings on liver biopsy to investigate abnormal liver function tests in the absence of diagnostic serology. J Hepatol 2001;35:195-199.
14. Stroffolini T, Sagnelli E, Mele A, Craxì A, Almasio P. The aetiology of chronic hepatitis in Italy: results from a multicentre national study. Digest Liver Dis 2004;36:829-833.
15. Sagnelli E, Stroffolini T, Mele A, Almasio P. The importance of HCV on the burden of chronic liver disease in Italy: a multicentre study. J Med Virol 2005;75:522-527.
16. Clark JM, Brancati FL, Diehl AM. The prevalence and etiology of elevated aminotransferase levels in the United States. Am J Gastroenterol 2003;98:960-967.
17. Bellentani S, Tiribelli C, Saccoccio G, Sodde M, Frattin N, De Martin C, et al. Prevalence of chronic liver disease in the general population of Northern Italy: the Dionysos Study. HEPATOLOGY 1994;20:1442-1449.
18. Bellentani S, Tiribeili C. The spectrum of liver disease in the general population: lesson from the Dionysos Study. J Hepatol 2001;35:531-537.
19. Guadagnino V, Stroffolini T, Rapicetta M, Costantino A, Kondili LA, Menniti-Ippolito F, et al. Prevalence, risk factors and genotype distribution of hepatitis C virus infection in the general population: a community-based survey in Southern Italy. HEPATOLOGY 1997;26:1006-1011.
20. Maio G, D'Argenio P, Stroffolini T, Bozza A, Sacco L, Tosti ME, et al. Hepatitis C virus infection and alanine transaminase levels in the general population: a survey in a Southern Italian town. J Hepatol 2000;33:116-120.
21. Di Stefano R, Stroffolini T, Ferraro D, Usticano A, Valenza LM, Montalbano L, et al. Endemic hepatitis C virus infection in a Sicilian town: further evidence for iatrogenic trasmission. J Med Virol 2002;67:339-344.
22. Bellentani S, Pozzato G, Saccoccio G, Crovatto M, Crocè LS, Mazzoran L, et al. Clinical course and risk factors of hepatitis C virus related liver disease in the general population: report from the Dionysos Study. Gut 1999;44:874-880.
23. Tiribelli C, Bellentani S, Campello C. The North-to-South gradient of hepatitis C virus infection. Scand J Gastroenterol 2003;8:805-806.
24. Ferenci P, Caca K, Loudianos G, Mieli-Vergani G, Tanner S, Sternlieb I, et al. Diagnosis and phenotypic classification of Wilson disease. Liver Int 2003;23:139-142.
25. Alvarez F, Berg PA, Bianchi FB, Burroughs AK, Cancado EL, Chapman RW, et al. International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis. J Hepatol 1999;31:929-938.
26. Taal BG, Schalm SW, ten Kate FW, Hermans J, Geertzen RG, Feltkamp BE. Clinical diagnosis of primary biliary cirrhosis: a classification based on major and minor criteria. Hepatogastroenterology 1983;30:178-182.
27. Adams PC, Chakrabarti S. Genotypic/phenotypic correlations in genetic hemochromatosis: evolution of diagnostic criteria. Gastroenterology 1998; 114:319-323.
28. Saverymuttu S, Joseph A, Maxwell J. Ultrasound scanning in the detection of hepatic fibrosis and steatosis. Brit Med J 1986;292:13-15.
29. Saadeh S, Younossi ZM, Remer EM, Gramlich T, Ong JP, Hurley M, et al. The utility of radiological imaging in nonalcoholic fatty liver disease. Gastroenterology 2002;123:745-750.
30. Bellentani S, Saccoccio G, Costa G, Tiribelli C, Manenti F, Sodde M, et al. Drinking habits as cofactors of risk for alcohol induced liver damage. The Dionysos Study Group. Gut 1997;41:845-850.
31. Becker U, Deis A, Sorensen TI, Gronbaek M, Borch-Johnsen K, Muller CF, et al. Prediction of risk of liver disease by alcohol intake, sex, and age: a prospective population study. HEPATOLOGY 1996;23:1025-1029.
32. McCullough AJ, O'Connor JF. Alcoholic liver disease: proposed recommendations for the American College of Gastroenterology. Am J Gastroenterol 1998;93:2002-2036.
33. Stroffolini T, Sagnelli E, Almasio P, Ferrigno L, Craxì A, Mele A. Characteristics of liver cirrhosis in Italy: results from a multicentre national study. Dig Liver Dis 2004;36:56-60.
34. Prati D, Taioli E, Zanella A, Della Torre E, Butelli S, Del Vecchio E, et al. Updated definitions of healthy ranger for serum alanine aminoctansferase levels. Ann Intern Med 2002;137:1-9.
35. Kaplan MM. Alanine aminotransferase levels: what's normal? Ann Intern Med 2002;137:49-51.
36. Alter MJ, Kruszon-Moran D, Nainan OV, McQuillan GM, Gao F, Moyer LA, et al. The prevalence of hepatitis C virus infection in the United States, 1988 through 1994. N Engl J Med 1999;341:556-562.
37. Stroffolini T, Chiaramonte M, Craxì A, Franco E, Rapicetta M, Trivello R, et al. Baseline sero-epidemiology of hepatitis B virus infection in children and teenagers in Italy. A survey before mass hepatitis B vaccination. J Infect 1991;22:191-199.
38. Stroffolini T, Guadagnino V, Chionne P, Procopio B, Mazzuca EG, Quintieri F, et al. A population based survey of hepatitis B virus infection in a Southern Italian town. Ital J Gastroenterol Hepatol 1997;29:415-419.
39. Stroffolini T, Bianco E, Szklo A, Bernacchia R, Bove C, Colucci M, et al. Factors affecting the compliance of the antenatal hepatitis B screening programme in Italy. Vaccine 2003;21:1246-1249.
40. Yu As, Keeffe EB. Elevated AST or ALT to nonalcoholic fatty liver disease: accurate predictor of disease prevalence? Am J Gastroenterol 2003;98:955-956.
41. Expert Panel on Detection Evaluation and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA 2001;285:2486-2497.
42. Stranges S, Dorn JM, Muti P, Freudenheim JL, Farinaro E, Russell M, et al. Body fat distribution, relative weight, and liver enzyme levels: a population-based study. HEPATOLOGY 2004;39:754-763.
43. Poonawala A, Nair SP, Thuluvath PJ. Prevalence of obesity and diabetes in patients with cryptogenic cirrhosis: a case-control study. HEPATOLOGY 2000;32:689-692.
44. Ratziu V, Giral P, Charlotte F, Bruckert E, Thibault V, Theodorou I, et al. Liver fibrosis in overweight patients. Gastroenterology 2000;118:1117-1123.
45. Falck-Ytter Y, Younossi ZM, Marchesini G, McCullough AJ. Clinical features and natural history of nonalcoholic steatosis syndromes. Semin Liver Dis 2001;21:17-26.
46. Bugianesi E, Leone N, Vanni E, Marchesini G, Brunello F, Carucci P, et al. Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellularcarcinoma. Gastroenterology 2002;123: 134-140.
47. Marrero JA, Fontana RJ, Su GL, Conjeevaram HS, Emick DM, Lok AS. NAFLD may be a common underlying disease in patients with hepatocellular carcinoma in the United States. HEPATOLOGY 2002;36:1349-1354.
48. Bellentani S, Saccoccio G, Masutti F, Crocè LS, Brandi G, Sasso F, et al. Prevalence and risk factors for hepatic steatosis in Northern Italy. Ann Intern Med 2000;132:112-117.
49. Nomura H, Kashiwagi S, Hayashi J, Kajiiyama W, Tani S, Goto M. Prevalence of fatty liver in a general population of Okinawa, Japan. Jpn J Med 1988;27:142-149.
50. Wanless IR, Lentz JS. Party liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors. HEPATOLOGY 1990;12:1106-1110.