Engineering peptide inhibitors to overcome PDZ binding promiscuity

Angewandte Chemie - International Edition

Volumn 49, Issue 51, 2010, Pages 9912-9916

  Vouilleme, Lars ^a   Cushing, Patrick R ^b   Volkmer, Rudolf ^a   Madden, Dean R ^b   Boisguerin, Prisca ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

CAL; cystic fibrosis; PDZ domain; peptide engineering; SPOT synthesis

Indexed keywords

CAL; CYSTIC FIBROSIS; FLUORESCENCE POLARIZATION; INTEGRATED APPROACH; PDZ DOMAINS; PEPTIDE INHIBITORS; SCREENING TECHNOLOGY; SPECIFIC INHIBITORS; SPOT SYNTHESIS;

PEPTIDES;

CARRIER PROTEIN; CFTR PROTEIN, HUMAN; GOPC PROTEIN, HUMAN; MEMBRANE PROTEIN; PEPTIDE; PEPTIDE LIBRARY; TRANSMEMBRANE CONDUCTANCE REGULATOR;

AMINO ACID SEQUENCE; ARTICLE; CYSTIC FIBROSIS; DRUG DESIGN; DRUG EFFECT; GENETICS; HUMAN; METABOLISM; PDZ DOMAIN; PROTEIN BINDING; PROTEIN ENGINEERING; SYNTHESIS;

AMINO ACID SEQUENCE; CARRIER PROTEINS; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DRUG DESIGN; HUMANS; MEMBRANE PROTEINS; PDZ DOMAINS; PEPTIDE LIBRARY; PEPTIDES; PROTEIN BINDING; PROTEIN ENGINEERING;

EID: 78650271909     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201005575     Document Type: Article

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