IQGAP1 regulates cell proliferation through a novel CDC42-mTOR pathway

Journal of Cell Science

Volumn 122, Issue 12, 2009, Pages 2024-2033

  Wang, Jian Bin ^a   Sonn, Robert ^a   Tekietsadik, Yemmsrach K ^a   Samorodnitsky, Daniel ^a   Osman, Mahasin A ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

Cell growth; IQGAP1; Protein synthesis

Indexed keywords

IQ MOTIF CONTAINING GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN CDC42; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; PROTEIN KINASE;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DIVISION; CELL GROWTH; CELL MIGRATION; CELL PROLIFERATION; CELL SIZE; CELL TRANSFORMATION; CONTROLLED STUDY; CYTOKINESIS; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; ANIMAL; BIOLOGICAL MODEL; CELL CYCLE; CELL STRAIN 3T3; CHEMISTRY; GENETICS; METABOLISM; MOUSE; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION;

ANIMALS; CDC42 GTP-BINDING PROTEIN; CELL CYCLE; CELL PROLIFERATION; CYTOKINESIS; HELA CELLS; HUMANS; MICE; MODELS, BIOLOGICAL; NIH 3T3 CELLS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; RAS GTPASE-ACTIVATING PROTEINS; SIGNAL TRANSDUCTION;

EID: 68949186350     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.044644     Document Type: Article

References (45)

1. Balenci, L., Clarke, I. D., Dirks, P. B., Assard, N., Ducray, F., Jouvet, A., Belin, M. F. and Honnor, J. (2006). IQGAP1 protein specifies amplifying cancer cells in glioblastoma multiforme. Cancer Res. 66, 9074-9082.
2. Bean, J. M., Siggia, E. D. and Cross, F. R. (2006). Coherence and timing of cell cycle start examined at single cell resolution. Mol. Cell 21, 3-4.
3. Bensenor, L., Kan, H. M., Wang, N., Wallrabe, H., Davidson, L. A., Cai, Y., Schafer, D. A. and Bloom, S. G. (2007). IQGAP1 regulates cell motility by linking growth factor signaling to actin assembly. J. Cell Sci. 120, 658-669.
4. Brown, D. and Sacks, D. B. (2006). IQGAP1 in cellular signaling: bridging the GAP. Trends Cell Biol. 16, 242-249.
5. Brown, N. and Bicknell, S. R. (2001). Cell migration and the boyden chamber. In Metastasis Research Protocols, Vol. 2: Analysis of Cell Behavior In Vitro and In Vivo (ed. S. A. Brooks and U. Schumacher), pp. 47-54. Totowa, NJ: Humana Press.
6. Caldwell, C. M., Green, R. A. and Kaplan, K. B. (2007). APC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in Min mice. J. Cell Biol. 178, 1109-1120.
7. Cerione, R. A. (2004). Cdc42: new roads to travel. Trends Cell Biol. 14, 127-132.
8. Clark, E. A., Golub, T. R., Lander, E. S. and Hynes, R. O. (2000). Genomic analysis of metastasis reveals an essential role for RhoC. Nature 406, 532-535.
9. Cross, F. R. (1995). Starting the cell cycle: what's the point? Curr. Opin. Cell Biol. 7, 790-797.
10. Drenan, R. M., Liu, X., Bertram, P. G. and Zheng, X. F. S. (2004). FRAP/mTOR localization in the ER and the Golgi apparatus. J. Biol. Chem. 279, 772-778.
11. Ewen, M. E. and Lamb, J. (2004). The activities of cyclin D1 that drive tumorigenesis. Trends Mol. Med. 10, 158-162.
12. Fingar, D. C. and Blenis, J. (2004). Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 23, 3151-3171.
13. Fukata, M., Kuroda, S., Nakagawa, M., Kawajiri, A., Itoh, N., Shoji, I., Matsuura, Y., Yonehara, S., Kikuchi, A. and Kaibuchi, K. (1999). Cdc42 and Racl regulate the interaction of IQGAP1 with β-catenin. J. Biol. Chem. 274, 26044-26050.
14. Fukata, M., Nakagawa, M., Itoh, N., Kawajiri, A., Yamaga, I. M., Kuroda, S. and Kaibuchi, K. (2001). Involvement of IQGAP1, an effector of Rac1 and Cdc42 GTPase, in cell-cell dissociation during cell scattering. Mol. Cell. Biol. 21, 2165-2183.
15. Fukata, M., Watanabe, T., Noritake, J., Nakagawa, M., Yamaga, M., Kuroda, S., Matsuura, Y., Iwamatsu, A., Perez, F. and Kaibuchi, K. (2002). Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170. Cell 109, 873-885.
16. Grindstaff, K., Yeaman, K. C., Anandasabapathy, N., Hsu, S. C., Rodriguez-Boulan, E., Scheller, R. H. and Wilson, J. W. (1998). Sec6/ 8 complex is recruited to cell-cell contacts and specifies transport vesicle delivery to the basal-lateral membrane in epithelial cells. Cell 93, 731-740.
17. Grohmanova, K., Schlaepfer, D., Hess, D., Gutierrez, P., Beck, M. and Kroschewski, R. (2004). Phosphorylation of IQGAP1 modulates its binding to Cdc42, revealing a new type of Rho-GTPase regulator. J. Biol. Chem. 279, 48495-48504.
18. Harrington, L. S., Findlay, G. M. and Lamb, R. F. (2005). Restraining PI3K: mTOR signaling goes back to the membrane. Trends Biochem. Sci. 30, 35-42.
19. Jadeski, L., Mataraza, J. M., Jeong, H. W., Li, Z. and Sacks, D. B. (2007). IQGAP1 stimulates proliferation and enhances tumorigenesis of human breast epithelial Cells. J. Biol. Chem. 283, 1008-1017.
20. Kanda, M., Akira, N. and Uyeda, T. Q. P. (2005). Adhesion-dependent and contractile ring-independent equatorial furrowing during cytokinesis in mammalian cells. Mol. Biol. Cell 16, 3865-3872.
21. Kreitzer, G., Schmoranzer, J., Low, S. H., Li, X., Gan, Y., Weimbs, T., Simon, S. M. and Rodriguez-Boulan, E. (2003). Three-dimensional analysis of post-Golgi carrier exocytosis in epithelial cells. Nat. Cell Biol. 5, 126-136.
22. Le Clainche, C., Schlaepfer, D., Ferrari, A., Klingauf, M., Grohmanova, K., Veligodskiy, A., Dirdy, D., Le, D., Egile, C., Carlier, M. F. et al. (2007). IQGAP1 stimulates actin assembly through the N-Wasp-Arp2/3 pathway. J. Biol. Chem. 282, 426-435.
23. Li, S., Wang, Q., Chakladar, A., Bronson, R. T. and Bernards, A. (2000). Gastric hyperplasia in mice lacking the putative Cdc42 effector IQGAP1. Mol. Biol. Cell 20, 697-701.
24. Li, Z., McNulty, D. E., Marler, K. J., Lim, L., Hall, C., Annan, R. S. and Sacks, D. B. (2005). IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner. J. Biol. Chem. 280, 13871-13878.
25. Lin, R., Bagrodia, S., Cerione, R. A. and Manor, D. (1997). A novel Cdc42Hs mutant induces cellular transformation. Curr. Biol. 7, 794-797.
26. Mataraza, J. M., Li, Z. and Sacks, D. B. (2002). IQGAP1 is a component of Cdc42 signaling to the cytoskeleton. J. Biol. Chem. 277, 24753-24763.
27. Mateer, S. C., Wang, N. and Bloom, G. S. (2003). IQGAPs: integrators of the cytoskeleton, cell adhesion machinery, and signaling networks. Cell Motil. Cytoskeleton 55, 147-155.
28. Nabeshima, K., Shimao, Y., Inoue, T. and Koono, M. (2002). Immunohistochemical analysis of IQGAP1 expression in human colorectal carcinomas: its overexpression in carcinomas and association with invasion fronts. Cancer Lett. 176, 101-109.
29. Nelson, C. J., Rickheim, D. G., Tucker, M. M., Hansen, L. K. and Albrecht, J. H. (2003). Evidence that cyclin D1 mediates both growth and proliferation downstream of TOR in hepatocytes. J. Biol. Chem. 278, 3656-3663.
30. Niinaka, Y., Haga, A. and Raz, V. (2001). Quantification of cell motility. In Metastasis Research Protocols, Vol. 2: Analysis of Cell Behavior In Vitro and In Vivo (ed. S. A. Brooks and U. Schumacher), pp. 47-54. Totowa, NJ: Humana Press.
31. Nojima, H., Adachi, M., Matsui, T., Okawa, K., Shoichiro Tsukita, S. and Tsukita, S. (2008). IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade. Nat. Cell Biol. 10, 971-978.
32. Osman, M. A. and Cerione, R. A. (1998). Iqg1p, a yeast homologue of the mammalian IQGAPs, mediates Cdc42p effects on the actin cytoskeleton. J. Cell Biol. 142, 443-455.
33. Osman, M. A. and Cerione, R. A. (2005). Actin doesn't do the locomotion: secretion drives cell polarization. In Protein Trafficking: Mechanisms and Regulation (ed. N. Segev). Georgetown, TX: Landes Bioscience.
34. Osman, M. A., Konopka, J. B. and Cerione, R. A. (2002). Iqg1p links spatial and secretion landmarks to polarity and cytokinesis. J. Cell Biol. 159, 601-611.
35. Rittmeyer, E. N., Daniel, S., Hsu, S. C. and Osman, M. A. (2008). A dual role for IQGAP1 in regulating exocytosis. J. Cell Sci. 121, 391-408.
36. Roy, M., Li, Z. and Sacks, D. B. (2005). IQGAP1 is a scaffold for mitogen-activated protein kinase signaling. Mol. Cell. Biol. 25, 7940-7952.
37. Sabatini, D. (2006). mTOR and cancer: insights into a complex relationship. Nat. Rev. Cancer 6, 729-734.
38. Sakurai-Yageta, M., Recchi, C., Le Dez, G., Sibarita, J. B., Daviet, L., Camonis, C., D'Souza-Schorey, C. and Chavrier, P. (2008). The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA. J. Cell Biol. 181, 986-998.
39. Sarbassov, D. D., Guertin, D. A., Siraj, M. A. and Sabatini, D. M. (2005). Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307, 1098-1101.
40. Saurin, A. T., Durgan, J., Cameron, A. J., Faisal, A., Marber, M. S. and Parker, P. J. (2008). The regulated assembly of a PKC epsilon complex controls the completion of cytokinesis. Nat. Cell Biol. 10, 891-901.
41. Takemoto, H., Yuchiro, D., Shiozaki, H., Imamura, H., Utsunomya, T., Miyata, H., Yano, M., Inoue, M., Fujiwara, Y. and Monden, M. (2001). Localization of IQGAP1 is inversely correlated with intercellular adhesion mediated by E-cadherin in gastric cancers. Int. J. Cancer 91, 783-788.
42. Tapon, N., Moberg, K. H. and Hariharan, I. (2001). The coupling of cell growth to the cell cycle. Curr. Opin. Cell Biol. 13, 731-737.
43. Wullschleger, S., Loewith, R. and Hall, M. N. (2006). TOR signaling in growth and metabolism. Cell 124, 471-484.
44. Yang, J. Y., Zong, C. S., Xia, W., Yamaguchi, H., Ding, Q., Xie, X., Lang, J. Y., Lai, C. C., Chang, C. J., Huang, W. C. et al. (2008). ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation. Nat. Cell Biol. 10, 138-148.
45. Zhou, R., Guo, Z., Watson, C., Chen, E., Kong, R., Wang, W. and Yao, X. (2003). Polarized distribution of IQGAP proteins in gastric parietal cells and their roles in regulated epithelial cell secretion. Mol. Biol. Cell 14, 1097-1108.