Get to grips: Steering local actin dynamics with IQGAPs

EMBO Reports

Volumn 8, Issue 11, 2007, Pages 1019-1023

  Brandt, Dominique T ^a   Grosse, Robert ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN BINDING PROTEIN; ACTIN RELATED PROTEIN 2-3 COMPLEX; F ACTIN; IQ MOTIF CONTAINING GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; IQ MOTIF CONTAINING GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN 1; METHENAMINE; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ACTIN POLYMERIZATION; BINDING AFFINITY; CELL MOTILITY; CELL SHAPE; CELLULAR DISTRIBUTION; CYTOSKELETON; MICROTUBULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN FUNCTION; PROTEIN INTERACTION; REVIEW;

ACTIN-RELATED PROTEIN 2-3 COMPLEX; ACTINS; ANIMALS; GUANOSINE TRIPHOSPHATE; MICROFILAMENT PROTEINS; MICROTUBULES; MODELS, MOLECULAR; RAS GTPASE-ACTIVATING PROTEINS; WISKOTT-ALDRICH SYNDROME PROTEIN, NEURONAL;

EID: 35748946040     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/sj.embor.7401089     Document Type: Review

References (53)

1. Bashour AM, Fullerton AT, Hart MJ, Bloom GS (1997) IQGAP1, a Rac- and Cdc42-binding protein, directly binds and cross-links microfilaments. J Cell Bio 137: 1555-1566
2. Bensenor LB, Kan HM, Wang N, Wallrabe H, Davidson LA, Cai Y, Schafer DA, Bloom GS (2007) IQGAP1 regulates cell motility by linking growth factor signaling to actin assembly. J Cell Sci 120: 658-669
3. Brandt DT, Marion S, Griffiths G, Watanabe T, Kaibuchi K, Grosse R (2007) Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation. J Cell Biol 178: 193-200
4. Brill S, Li S, Lyman CW, Church DM, Wasmuth JJ, Weissbach L, Bernards A, Snijders AJ (1996) The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases. Mol Cell Biol 9: 4869-4878
5. Brown MD, Sacks DB (2006) IQGAP1 in cellular signaling: Bridging the GAP. Trends Cell Biol 16: 242-249
6. Colucci-Guyon E, Niedergang F, Wallar BJ, Peng J, Alberts AS, Chavrier P (2005) A role for mammalian diaphanous-related formins in complement receptor (CR3)-mediated phagocytosis in macrophages. Curr Biol 15: 2007-2012
7. Dong P, Nabeshima K, Nishimura N, Kawakami T, Hachisuga T, Kawarabayashi T, Iwasaki H (2006) Overexpression and diffuse expression pattern of IQGAP1 at invasion fronts are independent prognostic parameters in ovarian carcinomas. Cancer Lett 243: 120-127
8. Drees F, Pokutta S, Yamada S, Nelson WJ, Weis WI (2005) α-Catenin is a molecular switch that binds E-cadherin-β-catenin and regulates actin-filament assembly. Cell 123: 903-915
9. Eisenmann KM, West RA, Hildebrand D, Kitchen SM, Peng J, Sigler R, Zhang J, Siminovitch KA, Alberts AS (2007) T cell responses in mammalian diaphanous-related formin mDia1 knockout mice. J Biol Chem 282 25152-25158
10. Eng K, Naqvi NI, Wong KC, Balasubramanian MK (1998) Rng2p, a protein required for cytokinesis in fission yeast, is a component of the actomyosin ring and the spindle pole body. Curr Biol 8: 611-621
11. Faix J, Grosse R (2006) Staying in shape with formins. Dev Cell 10: 693-706
12. Faix J, Weber I, Mintert U, Kohler J, Lottspeich F, Marriott G (2001) Recruitment of cortexillin into the cleavage furrow is controlled by Rac1 and IQGAP-related proteins. EMBO J 20: 3705-3715
13. Fukata M, Kuroda S, Fujii K, Nakamura T, Shoji I, Matsuura Y, Okawa K, Iwamatsu A, Kikuchi A, Kaibuchi K (1997) Regulation of cross-linking of actin filament by IQGAP1, a target for Cdc42. J Biol Chem 272 29579-29583
14. Fukata M, Watanabe T, Noritake J, Nakagawa M, Yamaga M, Kuroda S, Matsuura Y, Iwamatsu A, Perez F, Kaibuchi K (2002) Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170. Cell 109: 873-885
15. Grohmanova K, Schlaepfer D, Hess Q, Gutierrez P, Beck M, Kroschewski R (2004) Phosphorylation of IQGAP1 modulates its binding to Cdc42, revealing a new type of rho-GTPase regulator. J Biol Chem 279 48495-48504
16. Hart MJ, Callow MG, Souza B, Polakis P (1996) IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs. EMBO J 15: 2997-3005
17. Izumi G, Sakisaka T, Baba T, Tanaka S, Morimoto K, Takai Y (2004) Endocytosis of E-cadherin regulated by Rac and Cdc42 small G proteins through IQGAP1 and actin filaments. J Cell Biol 166: 237-248
18. Jeong HW, Li Z, Brown MD, Sacks DB (2007) IQGAP1 binds Rap1 and modulates its activity. J Biol Chem 282: 20752-20762
19. Jia Z, Barbier L, Stuart H, Amrei M, Pelech S, Dennis JW, Metalnikov P, O'Donnel P, Nabi IR (2005) Tumor cell pseudopodial protrusions. J Biol Chem 280: 30564-30573
20. Kholmanskikh SS, Koeller HB, Wynshaw-Boris A, Gomez T, Letourneau PC, Ross ME (2006) Calcium-dependent interaction of Lis1 with IQGAP1 and Cdc42 promotes neuronal motility. Nat Neurosci 9: 50-57
21. Kuroda S, Fukata M, Kobayashi K, Nakafuku M, Nomura N, Iwamatsu A, Kaibuchi K (1996) Identification of IQGAP1 as a putative target for the small GTPases, Cdc42 and Rac1. J Biol Chem 271: 23363-23367
22. Kuroda S et al (1998) Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin-mediated cell-cell adhesion. Science 281: 832-835
23. Le Clainche C et al (2007) IQGAP1 stimulates actin assembly through the N-WASP-Arp2/3 pathway. J Biol Chem 282: 426-435
24. Li Z, Kim SH, Higgins JM, Brenner MB, Sacks DB (1999) IQGAP1 and calmodulin modulate E-cadherin function. J Biol Chem 274: 37885-37892
25. Li Z, McNulty DE, Marler KJ, Lim L, Hall C, Annan AS, Sacks DB (2005) IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner. J Biol Chem 280: 13871-13878
26. Lippincott J, Li R (1998) Sequential assembly of myosin II, an IQGAP-like protein, and filamentous actin to a ring structure involved in budding yeast cytokinesis. J Cell Biol 140: 355-366
27. Machesky LM (1998) Cytokinesis: IQGAPs find a function. Curr Biol 8: R202-R205
28. Mateer SC, McDaniel AE, Nicolas V, Habermacher GM, Lin MJ, Cromer DA, King ME, Bloom GS (2002) The mechanism for regulation of the F-actin binding activity of IQGAP1 by calcium/calmodulin. J Biol Chem 277: 12324-12333
29. Mateer SC, Morris LE, Cromer DA, Bensenor LB, Bloom GS (2004) Actin filament binding by a monomeric IQGAP1 fragment with a single calponin homology domain. Cell Motil Cytoskeleton 58: 231-241
30. May RC, Caron E, Hall A, Machesky LM (2000) Involvement of Arp2/3 complex in phagocytosis mediated by FcγR or CR3. Nat Cell Biol 2: 246-248
31. McDonald KL et al (2007) IQGAP1 and IGFBP2: Valuable biomarkers for determining prognosis in glioma patients. J Neuropathol Exp Neurol 66: 405-417
32. Nishimura Y, Mabuchi I (2003) An IQGAP-like protein is involved in actin assembly together with Cdc42 in the sea urchin egg. Cell Motil Cytoskeleton 56: 207-218
33. Noritake J, Fukata M, Sato K, Nakagawa M, Watanabe T, Izumi N, Wang S, Fukata Y, Kaibuchi K (2004) Positive role of IQGAP1, an effector of Rac1, in actin-meshwork formation at sites of cell-cell contact. Mol Biol Cell 15: 1065-1076
34. Noritake J, Watanabe T, Sato K, Wang S, Kaibuchi K (2005) IQGAP1: A key regulator of adhesion and migration. J Cell Sci 118: 2085-2092.
35. Osman MA, Cerione RA (1998) Iqg1p, a yeast homologue of the mammalian IQGAPs, mediates cdc42p effects on the actin cytoskeleton. J Cell Biol 142: 443-455
36. Pollard TD (2007) Regulation of actin filament assembly by Arp2/3 complex and formins. Annu Rev Biophys Biomol Struct 36: 451-477
37. Pruyne D, Evangelista M, Yang C, Bi E, Zigmond S, Bretscher A, Boone C (2002) Role of formins in actin assembly: Nucleation and barbed-end association. Science 297: 612-615
38. Ren JG, Li Z, Sacks DB (2007) IQGAP1 modulates activation of B-Raf. Proc Natl Acad Sci USA 104: 10465-10469
39. Roy M, Li Z, Sacks DB (2005) IQGAP1 is a scaffold for mitogen-activated protein kinase signaling. Mol Cell Biol 25: 7940-7952
40. Sahai E, Marshall CJ (2002) ROCK and Dia have opposing effects on adherens junctions downstream of Rho. Nat Cell Biol 4: 408-415
41. Sakata D, Taniguchi H, Yasuda S, Adachi-Morishima A, Hamazaki Y, Nakayama R, Miki T, Minato N, Narumiya S (2007) Impaired T lymphocyte trafficking in mice deficient in an actin-nucleating protein, mDia1. J Exp Med 204: 2031-2038
42. Schmidt VA, Scudder L, Devoe CE, Bernards A, Cupit LD, Bahou WF (2003) IQGAP2 functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganization. Blood 101: 3021-3028.
43. Shannon KB, Li R (1999) The multiple roles of Cyk1p in the assembly and function of the actomyosin ring in budding yeast. Mol Biol Cell 10: 283-296
44. Verma S, Shewan AM, Scott JA, Helwani FM, den Elzen NR, Miki H, Takenawa T, Yap AS (2004) Arp2/3 activity is necessary for efficient formation of E-cadherin adhesive contacts. J Biol Chem 279: 34062-34070
45. Wang S et al (2007) IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth. J Cell Sci 120: 567-577
46. Watanabe T, Wang S, Noritake J, Sato K, Fukata M, Takefuji M, Nakagawa M, Izumi N, Akiyama T, Kaibuchi K (2004) Interaction with IQGAP1 links APC to Rac1, Cdc42 and actin filaments during cell polarization and migration. Dev Cell 7: 871-883
47. Weissbach L, Settleman J, Kalady MF, Snijders AJ, Murthy AE, Yan YX, Bernards A (1994) Identification of a human rasGAP-related protein containing calmodulin-binding motifs. J Biol Chem 269: 20517-20521
48. Wen Y, Eng CH, Schmoranzer J, Cabrera-Poch N, Morris EJ, Chen M, Wallar BJ, Alberts AS, Gundersen GG (2004) EB1 and APC bind mDia to stabilize microtubules downstream of Rho and promote cell migration. Nat Cell Biol 9: 820-830
49. Wu J-Q, Pollard TD (2005) Counting cytokinesis proteins globally and locally in fission yeast. Science 310: 310-314
50. Wu J-Q, Sirotkin V, Kovar DR, Lord M, Beltzner CC, Kuhn JR, Pollard TD (2006) Assembly of the cytokinetic contractile ring from a broad band of nodes in fission yeast. J Cell Biol 174: 391-402
51. Yamashiro S, Noguchi T, Mabuchi I (2003) Localization of two IQGAPs in cultured cells and early embryos of Xenopus laevis. Cell Motil Cytoskeleton 55: 36-50
52. Yamashiro S, Abe H, Mabuchi I (2007) IQGAP2 is required for the cadherin-mediated cell-to-cell adhesion in Xenopus laevis embryos. Dev Biol 308: 485-493
53. Zhang J et al (1999) Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes. J Exp Med 190: 1329-1342