In vitro metabolism, glutathione conjugation, and CYP isoform specificity of epoxidation of 4-vinylphenol

Xenobiotica

Volumn 41, Issue 1, 2011, Pages 6-23

  Zhang, Fagen ^a   Lowe, Ezra R ^a   Rick, David L ^a   Qiu, Xiaohua ^a   Leibold, E ^b   Cruzan, George ^c   Bartels, Michael J ^a  

^a DOW CHEMICAL COMPANY   (United States)

^b BASF SE   (Germany)

^c ToxWorks   (United States)

Author keywords

4 vinylphenol; CYP inhibition; Glutathione conjugation; Microsomal incubation

Indexed keywords

4 (2 OXIRANYL)PHENOL; 4 ETHENYL 1,2 BENZENEDIOL; 4 VINYLPHENOL; CYTOCHROME P450; DIETHYLDITHIOCARBAMIC ACID; DRUG METABOLITE; GLUTATHIONE; STYRENE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; EPOXIDATION; GLUTATHIONE METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; LUNG PARENCHYMA; LUNG TOXICITY; MALE; MASS FRAGMENTOGRAPHY; MASS SPECTROMETRY; METABOLITE; MICROSOME; MOUSE; NONHUMAN; OXIDATION; RADIOACTIVITY; RAT; SPECIES DIFFERENCE;

ANIMALS; CARBON RADIOISOTOPES; CATECHOLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DITIOCARB; GLUTATHIONE; HUMANS; ISOENZYMES; LUNG; MALE; METABOLIC NETWORKS AND PATHWAYS; MICE; MICROSOMES, LIVER; NADP; OXIDATION-REDUCTION; PHENOLS; RADIOACTIVITY; RATS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SUBSTRATE SPECIFICITY;

MUS; RATTUS;

EID: 78650227960     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2010.523735     Document Type: Article

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