Assessing variability and comparing short-term biomarkers of styrene exposure using a repeated measurements approach

Toxicology Letters

Volumn 192, Issue 1, 2010, Pages 40-44

  Fustinoni, S ^a   Manini, P ^b   Campo, L ^a   De Palma, G ^c   Andreoli, R ^b   Mutti, A ^b   Bertazzi, P A ^a   Rappaport, S M ^d  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF PARMA   (Italy)

^c Department of Experimental and Applied Medicine   (Italy)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Biomarkers; Styrene; Variability

Indexed keywords

4 VINYLPHENOL; ACETYLCYSTEINE; BIOLOGICAL MARKER; CREATININE; MANDELIC ACID; PHENYLGLYCINE; PHENYLGLYOXYLIC ACID; STYRENE; STYRENE OXIDE; UNCLASSIFIED DRUG;

ADULT; AIR ANALYSIS; ARTICLE; BIOLOGICAL MONITORING; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CREATININE URINE LEVEL; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; GENETIC POLYMORPHISM; HUMAN; MALE; OCCUPATIONAL EXPOSURE; OCCUPATIONAL TOXICOLOGY; PRIORITY JOURNAL; SMOKING HABIT; URINALYSIS;

ACETYLCYSTEINE; ADULT; BIOLOGICAL MARKERS; CHROMATOGRAPHY, LIQUID; ENVIRONMENTAL EXPOSURE; GLYCINE; GLYOXYLATES; HUMANS; LEAST-SQUARES ANALYSIS; MALE; MANDELIC ACIDS; PHENOLS; STYRENE; TANDEM MASS SPECTROMETRY;

EID: 72949100380     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2009.02.004     Document Type: Article

References (20)

1. American Conference of Governmental Industrial Hygienists (ACGIH); TLVs and BEIs based on the documentation of the threshold limit values for chemical substances and physical agents & biological indices. Cincinnati, USA: ACGIH, 2007.
2. De Palma G., Manini P., Mozzoni P., Andreoli R., Bergamaschi E., Cavazzini S., Franchini I., and Mutti A. Polymorphism of xenobiotic-metabolizing enzymes and excretion of styrene-specific mercapturic acids. Chem. Res. Toxicol. 14 (2001) 1393-1400
3. Deutsche Forschungsgemeinschaft (DFG): List of MAK and BAT values 2007. Report No 43, Weinheim: DFG, WILEY-VCH, 2007.
4. Fustinoni S., Campo L., Manini P., Buratti M., Waidyanatha S., De Palma G., 323 Mutti A., Foa V., Colombi A., and Rappaport S.M. An integrated approach to biomonitoring exposure to styrene and styrene-(7,8)-oxide using a repeated measurements sampling design. Biomarkers 13 (2008) 560-578
5. Ghittori S., Imbriani M., Pezzagno G., and Capodoglio E. The urinary concentration of solvents as a biological indicator of exposure: proposal for the biological equivalent exposure limit for nine solvents. Am. Ind. Hyg. Assoc. J. 48 (1987) 786-790
6. Haufroid V., Buchet J.P., Gardinal S., Ghittori S., Imbriani M., Hirvonen A., and Lison D. Importance of genetic polymorphisms of drug-metabolizing enzymes for the interpretation of biomarkers of exposure to styrene. Biomarkers 6 (2001) 236-249
7. Kromhout H., Symanski E., and Rappaport S.M. A comprehensive evaluation of within- and between-worker components of occupational exposure to chemical agents. Ann. Occup. Hyg. 37 (1993) 253-280
8. International Agency for Research on Cancer (IARC). IARC monographs on the evaluation of carcinogenic risk to humans. Some Industrial Chemicals vol.60 (1994), IARC, Lyon pp. 233-320
9. Liljelind I., Rappaport S., Eriksson K., Andersson J., Bergdahl I.A., Sunesson A.-L., and Jarvholm B. Exposure assessment of monoterpernes and styrene: a comparison of air sampling and biomonitoring. Occ. Environ. Med. 60 (2003) 599-603
10. Lin Y.S., Kupper L.L., and Rappaport S.M. Air samples versus biomarkers for epidemiology. Occup. Environ. Med. 62 (2005) 750-760
11. Manini P., Andreoli R., Poli D., De Palma G., Mutti A., and Niessen W.M.A. Liquid chromatography/electrospray tandem mass spectrometry characterization of styrene metabolism in man and rat. Rapid Commun. Mass Spectrom. 16 (2002) 2239-2248
12. Manini P., Buzio L., Andreoli R., Goldoni M., Bergamaschi E., Jakubowski M., Vodicka P., Hirvonen P., and Mutti A. Assessment of biotransformation of the arene moiety of styrene in volunteers and occupationally exposed workers. Toxicol. Appl. Pharmacol. 189 (2003) 160-169
13. Miller R.R., Newhook R., and Poole A. Styrene production, use, and human exposure. Crit. Rev. Toxicol. 24 S1 (1994) S1-S10
14. Rappaport S.M. Assessment of long-term exposures to toxic substances in air. Ann. Occup. Hyg. 35 (1991) 61-121
15. Rappaport S.M., and Kupper L.L. Quantitative Exposure Assessment (2008), Rappaport S.M. Publisher, El Cerrito, CA, USA
16. Rappaport S.M., and Kupper L.L. Variability of environmental exposures to volatile organic compounds. J. Expo. Anal. Environ. Epidemiol. 14 (2004) 92-107
17. Symanski E., Bergamaschi E., and Mutti A. Inter- and intra-individual sources of validation in levels of urinary styrene metabolites. Int. Arch. Occup. Environ. Health 74 (2001) 336-344
18. Symanski E., Greeson N.M.H., and Chan W. Evaluating measurement error in estimates of worker exposure assessed in parallel by personal and biological monitoring. Am. J. Ind. Med. 50 (2007) 112-121
19. Tornero-Velez R., Waidyanatha S., Echeverria D., and Rappaport S.M. Measurements of styrene-7,8-oxide and other oxidation products of styrene in air. J. Environ. Monit. 2 (2000) 111-117
20. WHO. Biological Monitoring of Chemical Exposure in the Workplace Guidelines vol. 1 (1996), World Health Organization, Geneva