Simultaneous quantification of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan in human plasma by ultra performance liquid chromatography/tandem triple-quadrupole mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis

Volumn 54, Issue 2, 2011, Pages 387-394

  Loos, Walter J ^a   de Graan, Anne Joy M ^a   de Bruijn, Peter ^a   van Schaik, Ron H N ^a   van Fessem, Marianne A C ^a   Lam, Mei Ho ^a   Mathijssen, Ron H J ^a   Wiemer, Erik A C ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

3 Hydroxymorphinan; 3 Methoxymorphinan; Dextromethorphan; Dextrorphan; Human plasma; UPLC MS MS

Indexed keywords

3 METHOXYMORPHINAN; ACETONITRILE; AMMONIUM HYDROXIDE; DEXTROMETHORPHAN; DEXTRORPHAN; DRUG METABOLITE; LITHIUM; NORLEVORPHANOL; UNCLASSIFIED DRUG;

ACCURACY; ANALYTIC METHOD; ARTICLE; CALIBRATION; DRUG BLOOD LEVEL; ELUTION; FLOW RATE; HUMAN; LIQUID LIQUID EXTRACTION; PHARMACOGENETICS; PLASMA; PRIORITY JOURNAL; STANDARD; TANDEM MASS SPECTROMETRY; TANDEM TRIPLE QUADRUPOLE MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

CHROMATOGRAPHY, LIQUID; DEXTROMETHORPHAN; DEXTRORPHAN; HUMANS; MASS SPECTROMETRY; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TIME FACTORS;

EID: 78650211571     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2010.08.033     Document Type: Article

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