Development and validation of a chemical hydrolysis method for dextromethorphan and dextrophan determination in urine samples: Application to the assessment of CYP2D6 activity in fibromyalgia patients

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 861, Issue 1, 2008, Pages 56-63

  Daali, Y ^a   Cherkaoui, S ^b   Doffey Lazeyras, F ^a   Dayer, P ^a   Desmeules, J A ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b Bracco Suisse SA   (Switzerland)

Author keywords

Chemical hydrolysis; CYP2D6; Dextromethorphan; Experimental design; Phenotype

Indexed keywords

BODY FLUIDS; CARBOXYLIC ACIDS; CONCENTRATION (PROCESS); HYDROLYSIS; METABOLITES; PATIENT TREATMENT;

CHEMICAL HYDROLYSIS; CYP2D6; DEXTROMETHORPHAN; EXPERIMENTAL DESIGN;

DRUG PRODUCTS;

ACETONITRILE; BETA GLUCURONIDASE; CYTOCHROME P450 2D6; DEXTROMETHORPHAN; DEXTRORPHAN; GLUCURONIC ACID; GLUCURONOSYLTRANSFERASE; HYDROCHLORIC ACID; LEVALLORPHAN; PHOSPHORIC ACID;

ACIDITY; ARTICLE; CATALYST; CHEMICAL HYDROLYSIS METHOD; CHEMOMETRICS; CONJUGATION; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; ENZYMATIC ASSAY; ENZYME ACTIVITY; FIBROMYALGIA; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROLYSIS; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; PERFORMANCE; PHENOTYPE; PRIORITY JOURNAL; PROCESS OPTIMIZATION; QUANTITATIVE ASSAY; TEMPERATURE SENSITIVITY; TIME; URINALYSIS; URINARY EXCRETION; VALIDATION PROCESS;

CYTOCHROME P-450 CYP2D6; DEXTROMETHORPHAN; DEXTRORPHAN; FIBROMYALGIA; HUMANS; HYDROLYSIS; REPRODUCIBILITY OF RESULTS;

EID: 37549051791     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2007.11.019     Document Type: Article

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