Mammea E/BB, an isoprenylated dihydroxycoumarin protonophore that potently uncouples mitochondrial electron transport, disrupts hypoxic signaling in tumor cells

Journal of Natural Products

Volumn 73, Issue 11, 2010, Pages 1868-1872

  Du, Lin ^a   Mahdi, Fakhri ^a   Jekabsons, Mika B ^b   Nagle, Dale G ^a   Zhou, Yu Dong ^a  

^a UNIVERSITY OF MISSISSIPPI   (United States)

^b UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANION; DAPHNETIN; HYPOXIA INDUCIBLE FACTOR 1; MAMMEA AMERICANA EXTRACT; MAMMEA E BB; PLANT EXTRACT; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANTIMICROBIAL ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CANCER INHIBITION; CELL HYPOXIA; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG INHIBITION; DRUG ISOLATION; ELECTRON TRANSPORT; HUMAN; HUMAN CELL; IC 50; MAMMEA; MITOCHONDRIAL ENERGY TRANSFER; NONHUMAN; PROTEIN SECRETION; PROTON TRANSPORT;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; COUMARINS; DISEASE MODELS, ANIMAL; DOMINICA; ELECTRON TRANSPORT; FEMALE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; MAMMEA; MITOCHONDRIA; MOLECULAR STRUCTURE; PLANT BARK; PRENYLATION; VASCULAR ENDOTHELIAL GROWTH FACTORS;

ANIMALIA; MAMMEA;

EID: 78650204359     PISSN: 01633864     EISSN: 15206025     Source Type: Journal    
DOI: 10.1021/np100501n     Document Type: Article

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