Synthesis and pharmacological evaluation of newer thiazolo [3,2-a] pyrimidines for anti-inflammatory and antinociceptive activity

Medicinal Chemistry Research

Volumn 19, Issue 9, 2010, Pages 1245-1258

  Alam, Ozair ^a   Khan, Suroor A ^a   Siddiqui, Nadeem ^a   Ahsan, Waquar ^a  

^a HAMDARD UNIVERSITY   (India)

Author keywords

Acute toxicity; Anti inflammatory; Antinociceptive; Thiazolopyrimidine

Indexed keywords

2 (2 CHLOROBENZYLIDENE) 5 (4 CHLOROPHENYL) 7 METHYL 3 OXO 2,3 DIHYDRO 5H THIAZOLO[3,2 A]PYRIMIDINE 6 CARBOXYLIC ACID (4 FLUOROPHENYL)AMIDE; 2 (2 CHLOROBENZYLIDENE) 5 (4 FLUOROPHENYL) 7 METHYL 3 OXO 2,3 DIHYDRO 5H THIAZOLO[3,2 A]PYRIMIDINE 6 CARBOXYLIC ACID (4 FLUOROPHENYL)AMIDE; 2 (2 CHLOROBENZYLIDENE) 7 METHYL 5 (2 NITROPHENYL) 3 OXO 2,3 DIHYDRO 5H THIAZOLO[3,2 A]PYRIMIDINE 6 CARBOXYLIC ACID (4 FLUOROPHENYL)AMIDE; 2 (2 CHLOROBENZYLIDENE) 7 METHYL 5 (4 NITROPHENYL) 3 OXO 2,3 DIHYDRO 5H THIAZOLO[3,2 A]PYRIMIDINE 6 CARBOXYLIC ACID (4 FLUOROPHENYL)AMIDE; 2 (2,4 DICHLOROBENZYLIDENE) 7 METHYL 5 (4 NITROPHENYL) 3 OXO 2,3 DIHYDRO 5H THIAZOLO[3,2 A]PYRIMIDINE 6 CARBOXYLIC ACID (4 FLUOROPHENYL)AMIDE; 2 (4 BROMOBENZYLIDENE) 5 (4 CHLOROPHENYL) 7 METHYL 3 OXO 2,3 DIHYDRO 5H THIAZOLO[3,2 A]PYRIMIDINE 6 CARBOXYLIC ACID (4 FLUOROPHENYL)AMIDE; 2 (4 BROMOBENZYLIDENE) 7 METHYL 5 (2 NITROPHENYL) 3 OXO 2,3 DIHYDRO 5H THIAZOLO[3,2 A]PYRIMIDINE 6 CARBOXYLIC ACID (4 FLUOROPHENYL)AMIDE; 2 (4 CHLOROBENZYLIDENE) 5 (4 FLUOROPHENYL) 7 METHYL 3 OXO 2,3 DIHYDRO 5H THIAZOLO[3,2 A]PYRIMIDINE 6 CARBOXYLIC ACID (4 FLUOROPHENYL)AMIDE; 2 (4 CHLOROBENZYLIDENE) 7 METHYL 5 (4 NITROPHENYL) 3 OXO 2,3 DIHYDRO 5H THIAZOLO[3,2 A]PYRIMIDINE 6 CARBOXYLIC ACID (4 FLUOROPHENYL)AMIDE; 2 (4 METHOXYBENZYLIDENE) 7 METHYL 5 (4 NITROPHENYL) 3 OXO 2,3 DIHYDRO 5H THIAZOLO[3,2 A]PYRIMIDINE 6 CARBOXYLIC ACID (4 FLUOROPHENYL)AMIDE; 2 BENZYLIDENE 5 (4 BROMOPHENYL) 7 METHYL 3 OXO 2,3 DIHYDRO 5H THIAZOLO[3,2 A]PYRIMIDINE 6 CARBOXYLIC ACID (4 FLUOROPHENYL)AMIDE; 2 BENZYLIDENE 7 METHYL 5 (4 NITROPHENYL) 3 OXO 2,3 DIHYDRO 5H THIAZOLO[3,2 A]PYRIMIDINE 6 CARBOXYLIC ACID (4 FLUOROPHENYL)AMIDE; 5 (4 BROMOPHENYL) 2 (3,4 DICHLOROBENZYLIDENE) 7 METHYL 3 OXO 2,3 DIHYDRO 5H THIAZOLO[3,2 A]PYRIMIDINE 6 CARBOXYLIC ACID (4 FLUOROPHENYL)AMIDE; 5 (4 BROMOPHENYL) 2 (3,4 DIMETHOXYBENZYLIDENE) 7 METHYL 3 OXO 2,3 DIHYDRO 5H THIAZOLO[3,2 A]PYRIMIDINE 6 CARBOXYLIC ACID (4 FLUOROPHENYL)AMIDE; 5 (4 BROMOPHENYL) 2 (4 CHLOROBENZYLIDENE) 7 METHYL 3 OXO 2,3 DIHYDRO 5H THIAZOLO[3,2 A]PYRIMIDINE 6 CARBOXYLIC ACID (4 FLUOROPHENYL)AMIDE; 5 (4 BROMOPHENYL) 7 METHYL 2 (4 METHYLBENZYLIDENE) 3 OXO 2,3 DIHYDRO 5H THIAZOLO[3,2 A]PYRIMIDINE 6 CARBOXYLIC ACID (4 FLUOROPHENYL)AMIDE; 5 (4 CHLOROPHENYL) 2 (2,4 DICHLOROBENZYLIDENE) 7 METHYL 3 OXO 2,3 DIHYDRO 5H THIAZOLO[3,2 A]PYRIMIDINE 6 CARBOXYLIC ACID (4 FLUOROPHENYL)AMIDE; 5 (4 CHLOROPHENYL) 2 (4 FLUOROBENZYLIDENE) 7 METHYL 3 OXO 2,3 DIHYDRO 5H THIAZOLO[3,2 A]PYRIMIDINE 6 CARBOXYLIC ACID (4 FLUOROPHENYL)AMIDE; 5 (4 CHLOROPHENYL) 7 METHYL 2 (2 NITROBENZYLIDENE) 3 OXO 2,3 DIHYDRO 5H THIAZOLO[ 3,2 A]PYRIMIDINE 6 CARBOXYLIC ACID (4 FLUORO-PHENYL) AMIDE; 5 (4 FLUOROPHENYL) 7 METHYL 2 (4 NITROBENZYLIDENE) 3 OXO 2,3 DIHYDRO 5H THIAZOLO[3,2 A]PYRIMIDINE 6 CARBOXYLIC ACID (4 FLUOROPHENYL)AMIDE; ANTIINFLAMMATORY AGENT; ANTINOCICEPTIVE AGENT; DICLOFENAC; PHENYLBUTAZONE; PYRIMIDINE DERIVATIVE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; LETHAL DOSE; NONHUMAN; PAW EDEMA; RAT; STRUCTURE ACTIVITY RELATION; THERMAL STIMULATION; ULCEROGENESIS;

EID: 78650176048     PISSN: 10542523     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00044-009-9267-8     Document Type: Article

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