Effects of melatonin on lipid peroxidation and antioxidative enzyme activities in the liver, kidneys and brain of rats administered with benzo(a)pyrene

Experimental and Toxicologic Pathology

Volumn 63, Issue 1-2, 2011, Pages 97-103

  Murawska Ciałowicz, Eugenia ^a,b   Jethon, Zbigniew ^b   Magdalan, Jan ^a   Januszewska, Lidia ^a   Podhorska Okołów, Marzena ^a   Zawadzki, Marcin ^a   Sozański, Tomasz ^a   Dziegiel, Piotr ^a  

^a WROCLAW MEDICAL UNIVERSITY   (Poland)

^b UNIVERSITY SCHOOL OF PHYSICAL EDUCATION   (Poland)

Author keywords

Antioxidative enzymes; Benzo(a)pyrene; Catalase; Glutathione reductase; Lipid peroxidation; Melatonin; Superoxide dismutase

Indexed keywords

ALKENE; BENZO[A]PYRENE; CATALASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; MELATONIN; SODIUM CHLORIDE; SUPEROXIDE DISMUTASE;

ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN HOMOGENATE; CELL PROTECTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; KIDNEY HOMOGENATE; LIPID PEROXIDATION; LIVER HOMOGENATE; MALE; NONHUMAN; OXIDATIVE STRESS; RAT;

ANIMALS; ANTIOXIDANTS; BENZO(A)PYRENE; BRAIN; CATALASE; ENVIRONMENTAL POLLUTANTS; GLUTATHIONE; GLUTATHIONE PEROXIDASE; KIDNEY; LIPID PEROXIDATION; LIVER; MALE; MALONDIALDEHYDE; MELATONIN; RATS; RATS, INBRED STRAINS; SUPEROXIDE DISMUTASE;

ANIMALIA; RATTUS;

EID: 78650171042     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etp.2009.10.002     Document Type: Article

References (63)

1. Acuna-Castroviejo D., Escames G., Macias M., Munoz Hoyos A., Molina Carballo A., Arauzo M., Montes R. Cell protective role of melatonin in the brain. J Pineal Res 1995, 19:57-63.
2. Aebi H. Catalase in vitro. Meth Enzymol 1984, 105:121-126.
3. Anisimov V.N., Popovich I.G., Zabezhinski M.A., Anisimov S.V., Vesnushkin G.M., Vinogradova I.A. Melatonin as antioxidant, geroprotector and anticarcinogen. Biochim Biophys Acta 2006, 1757:573-589.
4. Becher G., Bjorseth A. Determination of exposure to polycyclic aromatic hydrocarbons by analysis of human urine. Cancer Lett 1983, 17:301-311.
5. Bharti V.K., Srivastava R.S. Fluoride-induced oxidative stress in rat's brain and its amelioration by buffalo (Bubalus bubalis) pineal proteins and melatonin. Biol Trace Elem Res 2009, 130:131-140.
6. Bongiovanni B., De Lorenzi P., Ferri A., Konjuh C., Rassetto M., Evangelista de Duffard A.M., Cardinali D.P., Duffard R. Melatonin decreases the oxidative stress produced by 2,4-dichlorophenoxyacetic acid in rat cerebellar granule cells. Neurotox Res 2007, 11:93-99.
7. Buyukokuroglu M.E., Cemek M., Yurumez Y., Yavuz Y., Aslan A. Antioxidative role of melatonin in organophosphate toxicity in rats. Cell Biol Toxicol 2008, 24:151-158.
8. Carampin P., Rosan S., Dalzoppo D., Zagotto G., Zatta P. Some biochemical properties of melatonin and the characterization of a relevant metabolite arising from its interaction with H2O2. J Pineal Res 2003, 34:134-142.
9. Chuang J.I., Chen T.H. Effect of melatonin on temporal changes of reactive oxygen species and glutathione after MPP(+) treatment in human astrocytoma U373MG cells. J Pineal Res 2004, 36:117-125.
10. Collins J.F., Brown J.P., Dawson S.V., Marty M.A. Risk assessment for benzo(a)pyrene. Regul Toxicol Pharmacol 1991, 13:170-184.
11. De Almeida E.A., Martinez G.R., Klitzke C.F., de Medeiros M.H., Di Mascio P. Oxidation of melatonin by singlet molecular oxygen (O2 (1deltag)) produces N1-acetyl-N2-formyl-5-methoxykynurenine. J Pineal Res 2003, 35:131-137.
12. Dziegiel P., Jethon Z., Suder E., Sopel M., Rabczynski J., Surowiak P., Zabel M. Role of exogenous melatonin in reducing the cardiotoxic effect of daunorubicin and doxorubicin in the rat. Exp Toxicol Pathol 2002, 53:433-439.
13. Dziegiel P., Murawska - Ciałowicz E., Jethon Z., Januszewska L., Podhorska - Okolow M., Surowiak P., Zawadzki M., Rabczynski J., Zabel M. Melatonin stimulates the activity of protective antioxidaive enzymes in myocardial cells of rats in the course of doxorubicin intoxication. J Pineal Res 2003, 35:183-187.
14. Dziegiel P., Suder E., Surowiak P., Jethon Z., Rabczynski J., Januszewska L., Sopel M., Zabel M. Role of exogenous melatonin in reducing the nephrotoxic effect of daunorubicin and doxorubicin in the rat. J Pineal Res 2002, 33:95-100.
15. Escames G., Guerrero J.M., Reiter R.J., Garcia J.J., Munoz-Hoyos A., Ortiz G.G., Oh C.S. Melatonin and vitamin E limit nitric oxide-induced lipid peroxidation in rat brain homogenates. Neurosci Lett 1997, 230:147-150.
16. Esparza J.L., Gomez M., Nogue's M.R., Paternain J.L., Mallol J., Domingo J.L. Melatonin reduces oxidative stress and increases gene expression in the cerebral cortex and cerebellum of aluminum exposed rats. J Pineal Res 2005, 39:129-136.
17. Evans P.H. Free radicals in brain metabolism and pathology. Br Med Bull 1995, 49:577-587.
18. Fischer T.W., Scholz G., Knoll B., Hipler U.C., Elsner P. Melatonin suppresses reactive oxygen species induced by UV irradiation in leucocytes. J Pineal Res 2004, 37:107-112.
19. Gilad E., Cuzzocrea S., Zingarelli B., Salzman A.L., Szabo C. Melatonin is a scavenger of peroxynitrite. Life Sci 1997, 60:169-174.
20. Hung M.W., Tipoe G.L., Poon A.M., Reiter R.J., Fung M.L. Protective effect of melatonin against hippocampal injury of rats with intermittent hypoxia. J Pineal Res 2008, 44:214-221.
21. Jongeneelen, F.J., 1990. Biological monitoring of occupational exposure to polycyclic aromatic hydrocarbons. Doctoral Thesis. Catholic University in Nijmegen, Holland. Scientific Publisher, Nijmegen, Repro KUN.
22. Kim K.B., Lee B.M. Oxidative stress to DNA, protein, and antioxidant enzymes (superoxide dismutase and catalase) in rats treated with benzo(a)pyrene. Cancer Lett 1997, 113:205-212.
23. Konstandi M., Lang M.A., Kostakis D., Johnson E.O., Marselos M. Predominant role of peripheral catecholamines in the stress-induced modulation of CYP1A2 inducibility by benzo(a)pyrene. Basic Clin Pharmacol Toxicol 2008, 102:35-44.
24. Korkmaz A., Reiter R.J., Topal T., Manchester L.C., Oter S., Tan D.X. Melatonin: an established antioxidant worthy of use in clinical trials. Mol Med 2009, 15:43-50.
25. Kumar C.A., Das U.N. Effect of melatonin on two stage skin carcinogenesis in Swiss mice. Med Sci Monit 2000, 6:471-475.
26. Leaden P., Barrionuevo J., Catala A. The protection of long chain polyunsaturated fatty acids by melatonin during nonenzymatic lipid peroxidation of rat liver microsomes. J Pineal Res 2002, 32:129-134.
27. Lee B.M., Jang J.J., Kim H.S. Benzo[a]pyrene diol-epoxide-I-DNA and oxidative DNA adducts associated with gastric adenocarcinoma. Cancer Lett 1998, 125:61-68.
28. Lee S.K., Lee B.M. Oxidation of erythrocyte protein and lipid, and hemolysis in rabbit red blood cells treated with benzo[a]pyrene or adriamycin. J Toxicol Environ Health 1997, 51:557-569.
29. Longoni B., Salgo G., Pryor W.A., Marchiafava P.L. Effects of melatonin on lipid peroxidation induced by oxygen radicals. Life Sci 1998, 62:853-859.
30. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J Biol Chem 1951, 193:265-275.
31. Manda K., Ueno M., Anzai K. AFMK, a melatonin metabolite, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice. J Pineal Res 2007, 42:386-393.
32. Mauriz J.L., Molpeceres V., García-Mediavilla M.V., González P., Barrio J.P., González-Gallego J. Melatonin prevents oxidative stress and changes in antioxidant enzyme expression and activity in the liver of aging rats. J Pineal Res 2007, 42:222-230.
33. Menendez-Pelaez A., Poeggeler B., Reiter R.J., Barlow-Walden L., Pablos M.I., Tan D.X. Nuclear localization of melatonin in different mammalian tissues: immunocytochemical and radioimmunoassay evidence. J Cell Biochem 1993, 53:373-382.
34. Moir D., Viau A., Chu I., Withey J., McMullen E. Pharmacokinetics of benzo[a]pyrene in the rat. J Toxicol Environ Health A 1998, 53:507-530.
35. Ohta Y., Kongo M., Kishikawa T. Effect of melatonin on changes in hepatic antioxidant enzyme activities in rats treated with alpha-naphthylisothiocyanate. J Pineal Res 2001, 31:370-377.
36. Ohta Y., Kongo M., Kishikawa T. Preventive effect of melatonin on the progression of alpha-naphthylisothiocyanate-induced acute liver injury in rats. J Pineal Res 2003, 34:185-193.
37. Ohta Y., Kongo M., Sasaki E., Nishida K., Ishiguro I. Therapeutic effect of melatonin on carbon tetrachloride-induced acute liver injury in rats. J Pineal Res 2000, 28:119-126.
38. Persson E., Larsson P., Tjälve H. Cellular activation and neuronal transport of intranasally instilled benzo(a)pyrene in the olfactory system of rats. Toxicol Lett 2002, 133:211-219.
39. Reiter R.J. Oxidative processes and antioxidative defense mechanisms in the aging brain. FASEB J 1995, 9:526-533.
40. Reiter R.J. Functional aspects of the pineal hormone melatonin in combating cell and tissue damage induced by free radicals. Eur J Endocrinol 1996, 134:412-420.
41. Reiter R.J., Korkmaz A., Paredes S.D., Manchester L.C., Tan D.X. Melatonin reduces oxidative/nitrosative stress due to drugs, toxins, metals, and herbicides. Neuro Endocrinol Lett 2008, 29:609-613.
42. Reiter R.J., Maestroni G.J. Melatonin in relation to the antioxidative defense and immune systems: possible implications for cell and organ transplantation. J Mol Med 1999, 77:36-39.
43. Reiter R.J., Tan D.X., Maldonado M.D. Melatonin as an antioxidant: physiology versus pharmacology. J Pineal Res 2005, 39:215-216.
44. Reiter R.J., Tan D.X., Manchester L.C., Qi W. Biochemical reactivity of melatonin with reactive oxygen and nitrogen species: a review of the evidence. Cell Biochem Biophys 2001, 34:237-256.
45. Rodriguez C., Mayo J.C., Sainz R.M., Antolin I., Herrera F., Martin V., Reiter R.J. Regulation of antioxidant enzymes: a significant role for melatonin. J Pineal Res 2004, 36:1-9.
46. Roos P.H., Tschirbs S., Welge P., Hack A., Theegarten D., Mogilevski G., Wilhelm M. Induction of cytochrome P 450 1A1 in multiple organs of minipigs after oral exposure to soils contaminated with polycyclic aromatic hydrocarbons (PAH). Arch Toxicol 2002, 76:326-334.
47. Saunders C.R., Das S.K., Ramesh A., Shockley D.C., Mukherjee S. Benzo(a)pyrene-induced acute neurotoxicity in the F-344 rat: role of oxidative stress. J Appl Toxicol 2006, 26:427-438.
48. Sewerynek E., Poeggeler B., Melchiorri D., Reiter R.J. H2O2-induced lipid peroxidation in rat brain homogenates is greatly reduced by melatonin. Neurosci Lett 1995, 195:203-205.
49. Sharma R., Haque A.K., Awasthi S., Singh S.V., Piper J.T., Awasthi Y.C. Differential carcinogenicity of benzo[a]pyrene in male and female CD-1 mouse lung. J Toxicol Environ Health 1997, 52:45-62.
50. Srivastava S.K., Hu X., Xia H., Zaren H.A., Chatterjee M.L., Agarwal R., Singh S.V. Mechanism of differential efficacy of garlic organosulfides in preventing benzo(a)pyrene-induced cancer in mice. Cancer Lett 1997, 118:61-67.
51. Sullivan P.D. Free radicals of benzo(a)pyrene and derivatives. Environ Health Perspect 1985, 64:283-295.
52. Tan D.X., Chen L.D., Poeggeler B., Manchester L.C. Melatonin: a potent, endogenous hydroxyl radical scavenger. Endocrine J 1993, 1:57-60.
53. Tan D.X., Manchester L.C., Reiter R.J., Plummer B.F., Limson J., Weintraub S.T., Qi W. Melatonin directly scavenges hydrogen peroxide: a potentially new metabolic pathway of melatonin biotransformation. Free Radic Biol Med 2000, 29:1177-1185.
54. Tan D.X., Manchester L.C., Terron M.P., Flores L.J., Reiter R.J. One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species?. J Pineal Res 2007, 42:28-42.
55. Taysi S., Koc M., Buyukokuroglu M.E., Altinkaynak K., Sahin Y.N. Melatonin reduces lipid peroxidation and nitric oxide during irradiation-induced oxidative injury in the rat liver. J Pineal Res 2003, 34:173-177.
56. Túnez I., del Carmen Munoz, Feijoo M., Valdelvira M.E., Rafael Munoz - Castaneda J., Montilla P. Melatonin effect on renal oxidative stress under constant light exposure. Cell Biochem Funct 2003, 21:35-40.
57. Urata Y., Honma S., Goto S., Todoroki S., Iida T., Cho S., Honma K., Kondo T. Melatonin induces gamma-glutamylcysteine synthetase mediated by activation protein-1 in human vascular endothelial cells. Free Radic Biol Med 1999, 27:838-847.
58. Uz T., Arslan A.D., Kurtuncu M., Imbesi M., Akhisaroglu M., Dwivedi Y., Pandey G.N., Manev H. The regional and cellular expression profile of the melatonin receptor MT1 in the central dopaminergic system. Brain Res Mol Brain Res 2005, 136:45-53.
59. Vesnushkin G.M., Plotnikova N.A., Semenchenko A.I., Anisimov V.N. Dose-dependent inhibitory effect of melatonin on carcinogenesis induced by benzo[a]pyrene in mice. J Exp Clin Cancer Res 2006, 25:507-513.
60. Vesnushkin G.M., Plotnikova N.A., Anisimov V.N. Melatonin suppresses benz(a)pyrene-induced carcinogenesis in mice. Vopr Onkol 2007, 53:60-65.
61. Yang Y., Sjovall J., Rafter J., Gustafsson J.A. Characterization of neutral metabolites of benzo[a]pyrene in urine from germfree rats. Carcinogenesis 1994, 15:681-687.
62. Zang L.Y., Cosma G., Gardner H., Vallyathan V. Scavenging of reactive oxygen species by melatonin. Biochim Biophys Acta 1998, 1425:469-477.
63. Zhang H.M., Nie J.S., Wang F., Shi Y.T., Zhang L., Antonucci A., Liu H.J., Wang J., Zhao J., Zhang Q.L., Wang L.P., Song J., Xue C.E., Di Gioacchino M., Niu Q. Effects of benzo[a]pyrene on autonomic nervous system of coke oven workers. J Occup Health 2008, 50:308-316.