Role of exogenous melatonin in reducing the nephrotoxic effect of daunorubicin and doxorubicin in the rat

Journal of Pineal Research

Volumn 33, Issue 2, 2002, Pages 95-100

  Dziȩgiel, Piotr ^a   Suder, Elzbieta ^a   Surowiak, Paweł ^a   Jethon, Zbigniew ^a   Rabczyński, Jerzy ^a   Januszewska, Lidia ^a   Sopel, Mirosław ^a   Zabel, Maciej ^a,b  

^a WROCLAW MEDICAL UNIVERSITY   (Poland)

^b POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

Daunorubicin; Doxorubicin; Melatonin; Nephrotoxicity; Oxidative stress

Indexed keywords

ALKENE DERIVATIVE; DAUNORUBICIN; DOXORUBICIN; MALONALDEHYDE; MELATONIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSAY; CARDIOTOXICITY; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DRUG MECHANISM; HISTOPATHOLOGY; HORMONE ACTION; KIDNEY INJURY; LIPID PEROXIDATION; NEPHROTOXICITY; NONHUMAN; PROTECTION; RAT; RAT STRAIN;

EID: 0036720348     PISSN: 07423098     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-079X.2002.02902.x     Document Type: Article

References (54)

1. The melatonin rhythm both a clock and a calendar
2. Cellular mechanisms of melatonin action
3. Melatonin and human puberty: Current perspectives
4. The pineal gland and prolactin
5. Oxidative damage in the central nervous system: Protection by melatonin
6. Interactions of the pineal hormone melatonin with oxygen-centered free radicals: A brief review
7. Melatonin in relation to cellular antioxidative defence mechanisms
8. Melatonin: A potent, endogenous hydroxyl radical scavenger
9. Melatonin protects against stress-induced gastric lesions by scavenging the hydroxyl radical
10. Scavenging effect of melatonin on hydroxyl radicals generated by alloxan
11. Hydroxyl radical reaction with melatonin molecule: A computation study
12. The pineal hormone melatonin inhibits DNA adduct formation induced by chemical carcinogen safrole in vivo
13. Melatonin: A peroxyl radical scavenger more effective than vitamin E
14. Neurohormone melatonin prevents cell damage: Effect on gene expression for antioxidant enzymes
15. Melatonin stimulates brain glutathione peroxidase activity
16. Antioxidative role of melatonin in lead-induced intoxication
17. Melatonin increases gene expression for antioxidant enzymes in rat brain cortex
18. Melatonin stimulates the activity of the detoxifying enzyme glutathione peroxidase in several tissues of chickens
19. The significance of the metabolism of the neurohormone melatonin: Antioxidative protection and formation of bioactive substances
20. Melatonin - A highly potent endogenous radical scavenger and electron donor: New aspects of the oxidation chemistry of this indole assessed in vitro
21. Cyclic 3-hydroxymelatonin: A melatonin metabolite generated as a result of hydroxyl radical scavenging
22. A novel melatonin metabolite, cyclic 3-hydroxymelatonin: A biomarker of in vivo hydroxyl radical generation
23. Melatonin protects hipocampal neurons in vivo against kainic acid-induced damage in mice
24. Inhibitory effect of melatonin on cataract formation in newborn rats: Evidence for an antioxidative role for melatonin
25. Oxidative damage in the liver induced by ischemia-reperfusion: Protection by melatonin
26. Marked reduction of radiation-induced micronuclei in human blood lymphocytes pretreated with melatonin
27. Clinical pharmacology of cancer chemotherapy
28. Anticancer agents
29. Analyses of the molecular mechanism of adriamycin-induced cardiotoxicity
30. Lipid peroxidation of rat myocardial tissue following daunomycin administration
31. Dexrazoxane in the prevention of doxorubicin-induced cardiotoxicity
32. Anthracycline antibiotics in cancer therapy
33. Epidemiology of anthracycline cardiotoxicity in children and adults
34. Anthracyclines in the treatment of cancer
35. Anthracyclines: A review of general and special toxicity studies
36. Roles of reactive oxygen species and antioxidant enzymes in murine daunomycin-induced nephropathy
37. Effects of ICRF-186 [(L)1,2-bis(3,5-dioxopiperazinyl-1-yl) propane] on the toxicity of doxorubicin in spontaneously hypertensive rats
38. The influence of cyclosporin on lipid peroxidation and superoxide dismutase in adriamycin nephropathy in rats
39. ICRF-187 (dexrazoxan) protects from adriamycin-induced nephrotic syndrome in rats
40. Protective effect of ICRF-187 on doxorubicin-induced cardiac and renal toxicity in spontaneously hypertensive (SHR) and normotensive (WKY) rats
41. Comparison of the severity of the chronic cardiotoxicity produced by doxorubicin in normotensive and hypertensive rats
42. The cardiotoxicity of chemotherapeutic drugs
43. Anthracycline-induced cardiotoxicity
44. Vitamin A inhibits doxorubicin-induced membrane lipid peroxidation in rat tissues in vivo
45. The influence of doxorubicin and 4′-epi-doxorubicin on lipid peroxidation in mouse heart, lungs and liver
46. Melatonin protects against cardiac toxicity of doxorubicin in rat
47. Protective effect of melatonin against adriamycin toxicity in the rat
48. Antioxidative effect of melatonin in rat brain oxidative stress induced by adriamycin
49. Melatonin, a pineal hormone with antioxidant property, protects against adriamycin cardiomyopathy in rats
50. Melatonin and oxidative damage in mice liver induced by the prooxidant antitumor drug, adriamycin
51. Melatonin decrease bone marrow and lymphatic toxicity of adriamycin in mice bearing TLX5 lymphoma
52. Role of exogenous melatonin in reducing the cardiotoxic effect of daunorubicin and doxorubicin in the rat
53. Hyperlipidemic nephropathy induced by adriamycin: Effect of melatonin administration
54. Ultrastructural alterations of the myocardium induced by doxorubicin. A scanning electron microscopic study