Induction of cytochrome P450 1A1 in multiple organs of minipigs after oral exposure to soils contaminated with polycyclic aromatic hydrocarbons (PAH)

Archives of Toxicology

Volumn 76, Issue 5-6, 2002, Pages 326-334

  Roos, Peter H ^a,c   Tschirbs, Sebastian ^a   Welge, Peter ^a   Hack, Alfons ^a   Theegarten, Dirk ^b   Mogilevski, Grigori ^b   Wilhelm, Michael ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b INSTITUT FÜR PATHOLOGIE   (Germany)

^c LEIBNIZ RESEARCH CENTRE FOR WORKING ENVIRONMENT AND HUMAN FACTORS   (Germany)

Author keywords

Biomarker of effect; Contaminated soil; CYP1A1; Cytochrome P450; Duodenum; Induction; Kidney; Liver; Minipig; Oral exposure; Polycyclic aromatic hydrocarbons (PAH)

Indexed keywords

CYTOCHROME P450 1A1; ETHOXYRESORUFIN DEETHYLASE; POLYCYCLIC AROMATIC HYDROCARBON; RESORUFIN; BIOLOGICAL MARKER;

ABSORPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DUODENUM; ENZYME ACTIVITY; ENZYME INDUCTION; FEMALE; KIDNEY; LIVER; LUNG; MALE; NONHUMAN; ORGAN DISTRIBUTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RISK ASSESSMENT; SOIL; SPLEEN; SWINE; ANIMAL; BIOSYNTHESIS; DRUG EFFECT; ENZYMOLOGY; IMMUNOBLOTTING; LIVER MICROSOME; MINIPIG; ORAL DRUG ADMINISTRATION; PATHOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; SOIL POLLUTANT;

ANIMALIA; SUS SCROFA;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL MARKERS; CYTOCHROME P-450 CYP1A1; DUODENUM; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME INDUCTION; FEMALE; IMMUNOBLOTTING; KIDNEY; LUNG; MALE; MICROSOMES, LIVER; POLYCYCLIC HYDROCARBONS, AROMATIC; SOIL POLLUTANTS; SPLEEN; SWINE; SWINE, MINIATURE;

EID: 0036016868     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-002-0334-x     Document Type: Article

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