Enhanced anorexigenic signaling in lean obesity resistant syndecan-3 null mice

Neuroscience

Volumn 171, Issue 4, 2010, Pages 1032-1040

  Zheng, Q ^a   Zhu, J ^a   Shanabrough, M ^b   Borok, E ^b   Benoit, S C ^b   Horvath, T L ^c   Clegg, D J ^b   Reizes, O ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

melanocyte stimulating hormone; Agouti related protein; MTII; Obesity; Syndecan 3

Indexed keywords

AGOUTI RELATED PROTEIN; ALPHA INTERMEDIN; MELANOTAN II; MESSENGER RNA; NEUROPEPTIDE Y; PROTEIN C FOS; SYNDECAN 3;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; FEEDING BEHAVIOR; FOOD INTAKE; HYPOTHALAMUS; HYPOTHALAMUS PERIVENTRICULAR NUCLEUS; IMMUNOFLUORESCENCE; IMMUNOREACTIVITY; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

AGOUTI-RELATED PROTEIN; ALPHA-MSH; ANALYSIS OF VARIANCE; ANIMALS; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; FEEDING BEHAVIOR; FOOD DEPRIVATION; GENE EXPRESSION REGULATION; MALE; MICE; MICE, KNOCKOUT; NEURONS; NEUROPEPTIDE Y; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PROTO-ONCOGENE PROTEINS C-FOS; SIGNAL TRANSDUCTION; SYNDECAN-3; TIME FACTORS;

EID: 78650170672     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2010.09.060     Document Type: Article

References (30)

1. Abizaid A., Gao Q., Horvath T.L. Thoughts for food: brain mechanisms and peripheral energy balance. Neuron 2006, 51:691-702.
2. Bagnol D., Lu X.Y., Kaelin C.B., Day H.E., Ollmann M., Gantz I., Akil H., Barsh G.S., Watson S.J. Anatomy of an endogenous antagonist: relationship between Agouti-related protein and proopiomelanocortin in brain. J Neurosci 1999, 19:RC26.
3. Baskin M.L., Ard J., Franklin F., Allison D.B. Prevalence of obesity in the United States. Obes Rev 2005, 6:5-7.
4. Bernfield M., Gotte M., Park P.W., Reizes O., Fitzgerald M.L., Lincecum J., Zako M. Functions of cell surface heparan sulfate proteoglycans. Annu Rev Biochem 1999, 68:729-777.
5. Bowen H., Mitchell T.D., Harris R.B. Method of leptin dosing, strain, and group housing influence leptin sensitivity in high-fat-fed weanling mice. Am J Physiol Regul Integr Comp Physiol 2003, 284:R87-R100.
6. Cepoi D., Phillips T., Cismowski M., Goodfellow V.S., Ling N., Cone R.D., Fan W. Assessment of a small molecule melanocortin-4 receptor-specific agonist on energy homeostasis. Brain Res 2004, 1000:64-71.
7. Cohen H.Y., Miller C., Bitterman K.J., Wall N.R., Hekking B., Kessler B., Howitz K.T., Gorospe M., de Cabo R., Sinclair D.A. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 2004, 305:390-392.
8. Couzin J. Research on aging. Gene links calorie deprivation and long life in rodents. Science 2004, 304:1731.
9. Elmquist J.K., Elias C.F., Saper C.B. From lesions to leptin: hypothalamic control of food intake and body weight. Neuron 1999, 22:221-232.
10. Finkel T. Ageing: a toast to long life. Nature 2003, 425:132-133.
11. Friedman J.M. Leptin and the regulation of body weight. Harvey Lect 1999, 95:107-136.
12. Fung S., Hruby V.J. Design of cyclic and other templates for potent and selective peptide alpha-MSH analogues. Curr Opin Chem Biol 2005, 9:352-358.
13. Haslam D.W., James W.P. Obesity. Lancet 2005, 366:1197-1209.
14. Hienola A., Tumova S., Kulesskiy E., Rauvala H. N-syndecan deficiency impairs neural migration in brain. J Cell Biol 2006, 174:569-580.
15. Hsueh Y.P., Sheng M. Regulated expression and subcellular localization of syndecan heparan sulfate proteoglycans and the syndecan-binding protein CASK/LIN-2 during rat brain development. J Neurosci 1999, 19:7415-7425.
16. Johnson K.G., Tenney A.P., Ghose A., Duckworth A.M., Higashi M.E., Parfitt K., Marcu O., Heslip T.R., Marsh J.L., Schwarz T.L., et al. The HSPGs Syndecan and Dallylike bind the receptor phosphatase LAR and exert distinct effects on synaptic development. Neuron 2006, 49:517-531.
17. Kaksonen M., Pavlov I., Voikar V., Lauri S.E., Hienola A., Riekki R., Lakso M., Taira T., Rauvala H. Syndecan-3-deficient mice exhibit enhanced LTP and impaired hippocampus-dependent memory. Mol Cell Neurosci 2002, 21:158-172.
18. Kantor D.B., Chivatakarn O., Peer K.L., Oster S.F., Inatani M., Hansen M.J., Flanagan J.G., Yamaguchi Y., Sretavan D.W., Giger R.J., et al. Semaphorin 5A is a bifunctional axon guidance cue regulated by heparan and chondroitin sulfate proteoglycans. Neuron 2004, 44:961-975.
19. Myers M.G., Patti M.E., Leshan R.L. Hitting the target: leptin and perinatal nutrition in the predisposition to obesity. Endocrinology 2005, 146:4209-4210.
20. Ogden C.L., Carroll M.D., Curtin L.R., McDowell M.A., Tabak C.J., Flegal K.M. Prevalence of overweight and obesity in the United States, 19992004. JAMA 2006, 295:1549-1555.
21. Park P.W., Reizes O., Bernfield M. Cell surface heparan sulfate proteoglycans: selective regulators of ligand-receptor encounters. J Biol Chem 2000, 275:29923-29926.
22. Peirson S.N., Butler J.N., Foster R.G. Experimental validation of novel and conventional approaches to quantitative real-time PCR data analysis. Nucleic Acids Res 2003, 31:e73.
23. Pfaffl M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001, 29:e45.
24. Reizes O., Benoit S.C., Clegg D.J. The role of syndecans in the regulation of body weight and synaptic plasticity. Int J Biochem Cell Biol 2007, 40:28-45.
25. Reizes O., Benoit S.C., Strader A.D., Clegg D.J., Akunuru S., Seeley R.J. Syndecan-3 modulates food intake by interacting with the melanocortin/AgRP pathway. Ann N Y Acad Sci 2003, 994:66-73.
26. Reizes O., Lincecum J., Wang Z., Goldberger O., Huang L., Kaksonen M., Ahima R., Hinkes M.T., Barsh G.S., Rauvala H., et al. Transgenic expression of syndecan-1 uncovers a physiological control of feeding behavior by syndecan-3. Cell 2001, 106:105-116.
27. Spiegelman B.M., Flier J.S. Obesity and the regulation of energy balance. Cell 2001, 104:531-543.
28. Steigemann P., Molitor A., Fellert S., Jackle H., Vorbruggen G. Heparan sulfate proteoglycan syndecan promotes axonal and myotube guidance by slit/robo signaling. Curr Biol 2004, 14:225-230.
29. Strader A.D., Reizes O., Woods S.C., Benoit S.C., Seeley R.J. Mice lacking the syndecan-3 gene are resistant to diet-induced obesity. J Clin Invest 2004, 114:1354-1360.
30. Thiele T.E., van Dijk G., Yagaloff K.A., Fisher S.L., Schwartz M., Burn P., Seeley R.J. Central infusion of melanocortin agonist MTII in rats: assessment of c-Fos expression and taste aversion. Am J Physiol 1998, 274:R248-R254.