Alpha-lipoic acid protects against potassium cyanide-induced seizures and mortality

Experimental and Toxicologic Pathology

Volumn 63, Issue 1-2, 2011, Pages 161-165

  Abdel Zaher, Ahmed O ^a   Abdel Hady, Randa H ^a   Abdel Moneim, Wafaa M ^a   Salim, Safa Y ^a  

^a Assiut University Faculty of Medicine   (Egypt)

Author keywords

Alpha lipoic acid; Malondialdehyde; Nitric oxide; Potassium cyanide

Indexed keywords

GLUTAMIC ACID; GLUTATHIONE; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; NITRIC OXIDE; NITRITE; POTASSIUM CYANIDE; THIOCTIC ACID;

ADULT ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLONIC SEIZURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; ENZYME ACTIVITY; LETHALITY; LIPID PEROXIDATION; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; TONIC SEIZURE;

ANIMALS; ANTIOXIDANTS; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTAMIC ACID; GLUTATHIONE; GLUTATHIONE PEROXIDASE; LETHAL DOSE 50; LIPID PEROXIDATION; MALE; MICE; NITRIC OXIDE; NITRITES; POTASSIUM CYANIDE; SEIZURES; THIOCTIC ACID;

ANIMALIA; MUS;

EID: 78650169342     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etp.2009.11.004     Document Type: Article

References (50)

1. Akpinar D., Yargicoglu P., Derin N., Aliciguzel Y., Agar A. The effect of lipoic acid on antioxidant status and lipid peroxidation in rats exposed to chronic restraint stress. Physiol Res 2008, 57:893-901.
2. Ardelt B.K., Borowitz J.L., Maduh E.U., Swain S.L., Isom G.E. Cyanide-induced lipid peroxidation in different organs: subcellular distribution and hydroperoxide generation in neuronal cells. Toxicology 1994, 89:127-137.
3. Ballantyne B. Comparative acute toxicity of hydrogen cyanide and its salts. Proceedings of fourth annual chemical defence bioscience review 1984, US Army Medical Research Institute of Chemical Defence, Maryland. R.E. Lindstorm (Ed.).
4. Beckman J.S., Beckman T.W., Chen J., Marshall P.A., Freeman B.A. Apparent hydroxyl radical production by peroxynitrite: implication for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 1990, 87:1620-1624.
5. Beckman J.S., Koppenol W.H. Nitric oxide, superoxide and peroxynitrite the good, the bad, and the ugly. Am Physiol Soc 1996, C1424-C1437.
6. Benveniste H.M., Dejer J., Schouboe A., Diemer N.H. Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J Neurochem 1984, 43:1369-1374.
7. Biewenga G.P., Haenen G.R., Bast A. The pharmacology of the antioxidant lipoic acid. Gen Pharmacol 1997, 29:315-331.
8. Bist R., Bhatt D.K. The evaluation of effect of alpha-lipoic acid and vitamin E on the lipid peroxidation, gamma-amino butyric acid and serotonin level in the brain of mice (Mus musculus) acutely intoxicated with lindane. J Neurol Sci 2009, 276:99-102.
9. Bliska A., Wlodek L. Lipoic acid-the drug of the future?. Pharmacol Res 2005, 57:570-577.
10. Borowitz J.L., Kanthasamy A.G., Isom G.E. Toxicodynamics of cyanide. Chemical warfare agents 1992, 209-236. Academic Press, San Diego. S.M. Somani (Ed.).
11. Bredt D.S., Snyder S.H. Nitric oxide, a novel neuronal messenger. Neuron 1992, 8:3-11.
12. Brown G.C., Borutaite V. Nitric oxide and mitochondrial respiration in the heart. Cardiovasc Res 2007, 75:283-290.
13. Cleeter M.W., Cooper J.M., Darley-Usmar V.M., Moncada S., Schapira A.H. Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases. FEBS Lett 1994, 345:50-54.
14. Demarco V.G., Scumpiac P.O., Bosanquet J.P., Skimming J.W. Alpha-lipoic acid inhibits endotoxin-stimulated expression of iNOS and nitric oxide independent of the heat shock response in RAW264.7 cells. Free Radic Res 2004, 38:675-682.
15. Goraca A., Ciesla W. Estimation of protective effect of lipoic acid in the brain of rats during lipopolsaccharide-induced oxidative stress. Pol Merkur Lekarski 2008, 24:419-421.
16. Green L.C., Wanger D.A., Glogowski J., Skipper PL Wishnok JS Tannenbaum SR. Analysis of nitrate, nitrite and (15N) nitrate in biological fluid. Anal Biochem 1982, 126:131-138.
17. Griffith O.W. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal Biochem 1980, 106:207-212.
18. Gunasekar P.G., Sun P.W., Kanthasamy A.G., Borowitz J.L., Isom G.E. Cyanide-induced neurotoxicity involves nitric oxide and reactive oxygen species generation after NMDA receptor activation. J Pharmacol Exp Ther 1996, 277:150-155.
19. Han D., Handelman G., Marcocci L., Sen C.K., Roy S., Kobuchi H., et al. Lipoic acid increases de novo synthesis of cellular glutathione by improving cysteine utilization. Biofactors 1997, 6:321-338.
20. Hatch R.C., Laflamme D.P., Jain A.V. Effects of various known and potential cyanide antagonists and a glutathione depletory on acute toxicity of cyanide in mice. Vet Hum toxicol 1990, 32:9-16.
21. Iravani M.M., Liu L., Rose S., Jenner P. Role of inducible nitric oxide synthase in N-methyl-d-aspartic acid-induced astroglial and micoglial degeneration. Brain Res 2004, 1029:103-113.
22. Jaeschke H. Reactive oxygen and mechanisms of inflammatory liver injury. J Gastroenterol Hepatol 2000, 15:718-724.
23. Jia Z., Zhu H., Vitto M.J., Misra B.R., Li Y., Misra H.P. Alpha-lipoic acid potently inhibits peroxynitrite-mediated DNA strasnd breakage and hydroxyl radical formation: implications for the neuroprotective effects of alpha-lipoic acid. Mol Cell Biochem 2009, 323:131-138.
24. Leavesley H.B., Li L., Prabhakaran K., Borowitz J.L., Isom G.E. Interaction of cyanide and nitric oxide with cytochrome c oxidase: implications for acute cyanide toxicity. Toxicol Sci 2008, 101:101-111.
25. Litchfield J.T., Wilcoxon F. A simplified method of evaluating dose-effect experiments. J Pharmacol Exp Ther 1949, 96:99-113.
26. Lund P. L-glutamine and L-glutamate: UV-method with glutaminase and glutamate dehydrogenase. Methods of enzymatic analysis 1986, 357-363. VCH verlagsgesellschaft, Weinheim. H.U. Bergmeyer (Ed.).
27. Maczurek A., Hager K., Kenklies M., Sharman M., Martins R., Engel J., et al. Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease. Adv Drug Deliv Rev 2008, 60:1463-1470.
28. Madrigal J.L.M., Moro M.A., Lizasoain I., Lorenzo P., Castrillo A., Bosca L., et al. Inducible nitric oxide synthase expression in brain cortex after acute restraint stress is regulated by nuclear factor k Β-mediated mechanisms. J Neurochem 2001, 76:532-541.
29. May G.R., Rowand W.S., McCormack J.G., Sheridan R.D. Neuroprotective profile of lifarizine (RS-87476) in rat cerebrocortical neurons in cultures. Br J Pharmacol 1995, 114:1365-1370.
30. Moini H., Packer L., Saris N.E. Antioxidant and prooxidant activities of α-lipoic acid and dihydrolipoic acid. Toxicol Appl Pharmacol 2002, 182:84-90.
31. Nakagawa H., Sumiki E., Takusagawa M., Ikote N., Matsushima Y., Ozawa T. Scavenegers for peroxynitrite; inhibition of tyrosine nitration and oxidation with tryptamine derivatives, alpha-lipoic acid synthetic compound. Chem Pharma Bull 2000, 48:261-265.
32. Nordberg J., Arner E.S. Reactive oxygen species, antioxidants and the mammalian thioredoxin system. Free Radic Biol 2001, 31:1287-1312.
33. Ogden J.E., Moor P. Inhibition of nitric oxide synthase-potential for a novel class of therapeutic agents. Trends Biotechnol 1995, 13:70-78.
34. Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979, 95:351-358.
35. Paglia D.E., Valentine W.N. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967, 70:158-170.
36. Patel M.N., Bk Ardelt, Yim G.K., Isom G.E. Cyanide induces ca++- dependent and independent release of glutamate from mouse brain slices. Neurosci Lett 1991, 131:42-44.
37. Perez-Asensio F.J., Hurtado O., Burguete M.C., Moro M.A., Salom J.B., Lizasoain I., et al. nhibition of iNOS activity by 1400W decreases glutamate release and ameliorates stroke outcome after experimental ischemia. Neurobiol Dis 2005, 18:375-384.
38. Prabhakaran K., Li L., Borwitz J.L., Isom G.E. Inducible nitric oxide synthase up-regulation and mitochondrial glutathione depletion mediate cyanide-induced necrosis in mesencephalic cells. Neurosci Res 2006, 84:1003-1011.
39. Radi R., Rodriguez M., Castro L., Telleri R. Inhibition of mitochondrial electron transport by peroxynitrite. Arch Biochem Biophys 1994, 308:89-95.
40. Shay P.K., Moreau R.F., Smith E.J., Hagen T.M. Is alpha-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity. IUBMB Life 2008, 60:362-367.
41. Shila S., Subathra M., Devi M.A., Panneerselvam C. Arsenic intoxication -induced reduction of glutathione level and the activity of related enzymes in rat brain regions: reversal by DL-alpha-lipoic acid. Arch Toxicol 2005, 79:140-146.
42. Shirpoor A., Minassian S., Salami S., Khadem-Ansari M.H., Yeghiazaryan M. Alpha-lipoic acid decreases DNA damage and oxidative stress induced by alcohol in the developing hippocampus and cerebellum of rat. Cell Physiol Biochem 2008, 22:769-776.
43. Shou Y., Gunasekar P.G., Borowitz J.L., Isom G.E. Cyanide-induced apoptosis involves oxidative stress-activated NF-kappa Β in cortical neurons. Toxicol Appl Pharmacol 2000, 164:196-205.
44. Sturm C.D., Frisella W.A., Yoom K.W. Attenuation of potassium cyanide-mediated neuronal cell death by adenosine. J Neurosurg 1993, 79:111-115.
45. Sun P., Rane S.G., Gunasekar P.G., Borowitz J.L., Isom G.E. Modulation of the NMDA receptor by cyanide: Enhancement of receptor-mediated responses. J Pharmacol Exp Ther 1997, 280:1341-1348.
46. Sun P., Rane S.G., Gunasekar P.G., Borowitz J.L., Isom G.E. Cyanide interaction with redox modulatory sites enhances NMDA receptor responses. J Biochem Mol Toxicol 1999, 13:253-259.
47. Trujillo M., Folkes L., Bartesaghi S., Kalyanaraman B., Wardman P., Radi R. Peroxynitrite-derived carbonate and nitrogen dioxide radicals readily react with lipoic and dihydrolipoic acid. Free Radic Biol Med 2005, 39:279-288.
48. Yamamoto H., Tang H. Preventive effect of melatonin against cyanide-induced seizures and lipid peroxidation in mice. Neurosci Lett 1996, 207:89-92.
49. Yamamoto H., Tang H. Effects of 2-amino-7-phosphonohepatanoic acid, melatonin or NG-nitro-L-arginine on cyanide or N-methyl-D-aspartate-induced neurotoxicity in rat cortical cells. Toxicol Lett 1998, 16:13-18.
50. Yamamoto H.A. A hypothesis for cyanide-induced tonic seizures with supporting evidence. Toxicology 1995, 95:19-26.