Cyanide-induced neurotoxicity involves nitric oxide and reactive oxygen species generation after N-methyl-D-aspartate receptor activation

Journal of Pharmacology and Experimental Therapeutics

Volumn 277, Issue 1, 1996, Pages 150-155

  Gunasekar, P G ^a   Sun, P W ^a   Kanthasamy, A G ^a,b   Borowitz, J L ^a   Isom, G E ^a  

^a PURDUE UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CATALASE; CYANIDE; DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N(G) NITRO DEXTRO ARGININE METHYL ESTER; NITRIC OXIDE; POTASSIUM CYANIDE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

AEROBIC METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; GRANULE CELL; LIPID PEROXIDATION; NEUROTOXICITY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION;

ANIMALS; ARGININE; CALCIUM; CEREBELLUM; DIZOCILPINE MALEATE; FREE RADICALS; LIPID PEROXIDATION; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; POTASSIUM CYANIDE; RATS; REACTIVE OXYGEN SPECIES; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0030430031     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. AKIRA, T., HENRY, D., BALDWIN, R. A. AND WASTERLAIN, C. G.: Nitric oxide participates in excitotoxic mechanisms induced by chemical hypoxia. Brain Res. 645: 285-290, 1994.
2. ARDELT, B. K., BOROWITZ, J. L. AND ISOM, G. E.: Brain lipid peroxidation and antioxidant protectant mechanisms following acute cyanide intoxication. Toxicology 56: 147-154, 1989.
3. ARDELT, B. K., BOROWITZ, J. L., MADUH, E. U., SWAIN, S. L. AND ISOM, G. E.: Cyanide-induced lipid peroxidation in different organs: Subcellular distribution and hydroperoxide generation in neuronal cells. Toxicology 89: 127-137, 1994.
4. BECKMAN, J. S., BECKMAN, T. W., CHEN, J. AND FREEMAN, B. A.: Apparent hydroxy radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci U.S A. 87: 1620-1624, 1990.
5. BREDT, D. S. AND SNYDER, S. H.: Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc. Natl. Acad. Sci. U.S.A. 87: 682-685, 1990.
6. BREDT, D. S. AND SNYDER, S. H.: Nitric oxide, a novel neuronal messenger. Neuron 8: 3-11, 1992.
7. CARELLA, F., GRASSI, M. P., SAVOIARDO, M., CONTRI, P., RAPUZZI, B. AND MANGONI, A.: Dystonic-Parkinsonian syndrome after cyanide poisoning: Clinical and MRI findings. J. Neurol. Neurosurg. Psychiatry 51: 1345-1348, 1988.
8. CERRUTI, C., SHENG, P., LADENHEIM, B., EPSTEIN, C. J. AND CADET, J. L.: Involvement of oxidative and L-arginine-NO pathways in the neurotoxicity of drugs of abuse in vitro. Clin. Exp. Pharmacol. Physiol. 22: 381-382, 1995.
9. CHEN, L. AND HUANG, L. Y. M.: Sustained potentiation of NMDA receptor-mediated glutamate responses through activation of protein kinase C by a μ opioid. Neuron 7: 319-326, 1991.
10. 2+ block of NMDA-receptor channels as a mechanism of modulation. Nature 356: 521-523, 1992.
11. CULCASI, M., LAFON-CAZAL, M., PIETRI, S. AND BOCKAERT, J.: Glutamate receptors induce a burst of superoxide via activation of nitric oxide synthase in arginine-depleted neurons. J. Biol. Chem. 269: 12589-12593, 1994.
12. DAWSON, V. L., DAWSON, T. M., LONDON, E. D., BREDT, D. S. AND SNYDER, S. H.: Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc. Natl. Acad. Sci. U.S.A. 88: 6368-6371, 1991.
13. DAWSON, V. L., DAWSON, T. M., BARTELEY, D. A., UHL, G. R. AND SNYDER, S. H.: Mechanism of nitric oxide-mediated neurotoxicity in primary brain cultures. J. Neurosci. 13: 2651-2661, 1993.
14. DAWSON, V. L.: Nitric oxide: Role in neurotoxicity. Clin. Exp. Pharmacol Physiol. 22: 305-308, 1995.
15. DUBINSKY, J. M. AND ROTHMAN, S. M.: Intracellular calcium concentrations during chemical hypoxia and excitotoxic neuronal injury. J. Neurosci. 11: 2545-2551, 1991.
16. GUNASEKAR, P. G., KANTHASAMY, A. G., BOROWITZ, J. L. AND ISOM, G. E.: Monitoring intracellular nitric oxide formation by dichlorofluorescin in neuronal cells. J. Neurosci. Meth. 61: 15-21, 1995a.
17. GUNASEKAR, P. G., KANTHASAMY, A. G., BOROWITZ, J. L. AND ISOM, G. E.: NMDA receptor activation produces concurrent generation of nitric oxide and reactive oxygen species: Implications for cell death. J. Neurochem. 65: 2016-2021, 1995b.
18. IGNARRO, L. J., BUGA, G. M., WOOD, K. S., BYRNS, R. E. AND CHAUDHURI, G.: Endothelium derived relaxing factor produced and released from artery and vein is nitric oxide. Proc. Natl. Acad. Sci. U.S.A. 84: 9265-9269, 1987.
19. JOHNSON, J. D., CONROY, W. G., BURRIS, K D. AND ISOM, G. E.: Peroxidation of brain lipids following cyanide intoxication in mice. Toxicology 46: 21-28, 1987.
20. KANTHASAMY, A. G., BOROWITZ, J. L., PAVLAKOVIC, G. AND ISOM, G. E.: Dopaminergic neurotoxicity of cyanide: Neurochemical, histological, and behavioral characterization. Toxicol. Appl. Pharmacol. 126: 156-163, 1994.
21. LAFON-CAZAL, M., PIETRI, S., CULCASI, M. AND BOCKAERT, J.: NMDA-dependent superoxide production and neurotoxicity. Nature 364: 535-537, 1993.
22. LEBEL, C. P. AND BONDY, S. C.: Oxygen radicals: Common mediators of neurotoxicity. Neurotoxicol. Teritol. 13: 341-346, 1991.
23. MONCADA, D., LEKIEFFRE, D., ARVIN, B. AND MELDRUM, B.: Effect of NO synthase inhibition on NMDA-and ischemia-induced hippocampal lesions. Neuroreport 3: 530-532, 1992.
24. MÜLLER, U. AND KRIEGLSTEIN, J.: Inhibitors of lipid peroxidation protect cultured neurons against cyanide-induced injury. Brain Res. 678: 265-268, 1995.
25. OHKAWA, H., OHISHI, N. AND YAGI, K.: Assay of lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95: 351-358, 1979.
26. 2+ dependent and independent release of glutamate from mouse brain slices. Neurosci. Lett. 131: 42-44, 1991.
27. PATEL, M. N., YIM, G. K. W. AND ISOM G. E.: Blockade of N-methyl-D-aspartate receptors prevents cyanide induced neuronal injury in primary hippocampal cultures. Toxicol. Appl. Pharmacol. 115: 124-129, 1992.
28. PATEL, M. N., YIM, G. K. W. AND ISOM, G. E.: N-methyl-D-aspartate receptors mediate cyanide-induced cytotoxicity in hippocampal cultures. Neurotoxicology 14: 35-40, 1993.
29. PATEL, M. N., PEOPLES, R. W., YIM, G. K. W. AND ISOM, G. E.: Enhancement of NMDA-mediated responses by cyanide. Neurochem. Res. 19: 1319-1323, 1994.
30. PAUWELS, P. J. AND LEYSEN, J. E.: Blockade of nitric oxide formation does not prevent glutamate-induced neurotoxicity in neuronal cultures from rat hippocampus. Neurosci. Lett. 143: 27-30, 1992.
31. PAVLAKOVIC, G., EYER, C. L. AND ISOM, G. E.: Neuroprotective effects of PKC inhibition against chemical hypoxia. Brain Res. 676: 205-211, 1995.
32. PELLEGRINI-GIAMPIETRO, D. E., CHERICI, G., ALESIANI, M., CARLÀ, V. AND MORONI, F.: Excitatory amino acid release from rat hippocampal slices as a consequence of free radical formation. J. Neurochem. 51: 1960-1963, 1988.
33. RAJDEV, S. AND REYNOLDS, I. J.: Glutamate-induced intracellular calcium changes and neurotoxicity in cortical neurons in vitro: Effects of chemical ischemia. Neuroscience 62: 667-679, 1994.
34. ROSENBERG, N. L., MYERS, J. A. AND MARTIN, W. R. W.: Cyanide-induced Parkinsonism: Clinical, MRI and 6-fluorodopa PET studies. Neurology 38: 142-144, 1989.
35. RUBBO, H., RADI, R., TRUJILLO, M., TELLERI, R., KALYANARAMAN, B., BARNES, S., KIRK, M. AND FREEMAN, B. A.: Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. J. Biol. Chem. 269: 26066-26075, 1994.
36. SUN, P , GUNASEKAR, P. G. AND ISOM, G. E.: Modulation of cyanide-induced enhancement of NMDA responses in rat cerebellar granule cells. Toxicologist 15: 144, 1995.
37. UITTI, R. J., RAJPUT, A. H., ASHENHURST, E. M. AND ROZDILSKY, B.: Cyanide-induced Parkinsonism: A clinicopathologic report. Neurology 35: 921-925, 1986.
38. VALENZUELA, R., COURT, J. AND GODOY, S.: Delayed cyanide induced dystonia. J. Neurol. Neurosurg. Psychiatry 55: 198-199, 1992.
39. 2+ in the oxidative stress-induced dissipation of the mitochondrial membrane potential. J. Biol. Chem. 269: 14546-14552, 1994.
40. VASSAULT, A.: Lactate dehydrogenase. In Methods of Enzymatic Analysis, ed. by H. U. Bergmeyer, vol. 3, pp. 118-126, Verlag Chemie, Weinheim, 1983.
41. WAY, J. L.: Cyanide intoxication and its mechanism of antagonism. Annu. Rev. Pharmacol. Toxicol. 24: 451-181, 1984.
42. 5-[imino(nitroamino)methyl]-L-ornithine) against cyanide-induced convulsions in mice. Toxicology 71: 277-283, 1992.
43. YAMAMOTO, H. A.: Protective effect of calmodulin inhibitors against acute cyanide-induced lethality and convulsions in mice. Toxicol. Lett. 66: 73-79, 1993.
44. 2 by cyanide in PC12 cells. Toxicol. Appl. Pharmacol. 124: 262-267, 1994.
45. YOUDIM, M. B. H., BEN-SHACHAR, D., ESHEL, G., FINBERG, J. P. M. AND RIEDERER, P.: The neurotoxicity of iron and nitric oxide: relevance to the etiology of Parkinson's disease. In Advances in Neurology, ed. by H. Narabayashi, T. Nagatsu, N. Yanagisawa and Y. Mizuno, vol.60, pp. 259-266, Raven Press, New York, 1993.
46. ZEEVALK, G. D. AND NICKLAS, W. J.: Chemically induced hypoglycemia and anoxia: relationship to glutamate receptor-mediated toxicity in retina. J. Pharmacol. Exp Ther. 253: 1285-1292, 1990.