Functional assessment of Toll-like receptor 2 and its relevance in patients with Staphylococcus aureus infection of joint prosthesis

Human Immunology

Volumn 72, Issue 1, 2011, Pages 47-53

  El Helou, Odette ^a   Berbari, Elie F ^a   Brown, Robert A ^a   Gralewski, Jonathon H ^a   Osmon, Douglas R ^a   Razonable, Raymund R ^a  

^a MAYO CLINIC   (United States)

Author keywords

Cytokines; Gene polymorphisms; Prosthetic joint infection; Staphylococcus aureus; Toll like receptors

Indexed keywords

BACTERIAL PROTEIN; PEPTIDOGLYCAN; TOLL LIKE RECEPTOR 2;

ADULT; ARTICLE; CELLULAR IMMUNITY; CLINICAL ASSESSMENT; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA SEQUENCE; FEMALE; GENE IDENTIFICATION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC RISK; HUMAN; HUMAN CELL; JOINT PROSTHESIS; MALE; PRIORITY JOURNAL; PROSTHESIS INFECTION; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION; SINGLE NUCLEOTIDE POLYMORPHISM; STAPHYLOCOCCUS INFECTION;

AGED; ARTHRITIS, INFECTIOUS; CASE-CONTROL STUDIES; COHORT STUDIES; FEMALE; GENETIC ASSOCIATION STUDIES; HEK293 CELLS; HUMANS; JOINT PROSTHESIS; MALE; MIDDLE AGED; PEPTIDOGLYCAN; POLYMORPHISM, SINGLE NUCLEOTIDE; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; SURVIVAL ANALYSIS; TOLL-LIKE RECEPTOR 2;

EID: 78650169149     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2010.10.001     Document Type: Article

References (42)

1. Medzhitov R., Preston-Hurlburt P., Janeway C.A. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997, 388:394-397.
2. Schwartz D.A., Cook D.N. Polymorphisms of the Toll-like receptors and human disease. Clin Infect Dis 2005, 41(Suppl 7):S403-S407.
3. Texereau J., Chiche J.D., Taylor W., Choukroun G., Comba B., Mira J.P. The importance of Toll-like receptor 2 polymorphisms in severe infections. Clin Infect Dis 2005, 41(Suppl 7):S408-S415.
4. Strunk T., Power Coombs M.R., Currie A.J., Richmond P., Golenbock D.T., Stoler-Barak L., et al. TLR2 mediates recognition of live Staphylococcus epidermidis and clearance of bacteremia. PLoS ONE 2010, 5. e10111.
5. Takeuchi O., Hoshino K., Akira S. Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J Immunol 2000, 165:5392-5396.
6. Akira S., Uematsu S., Takeuchi O. Pathogen recognition and innate immunity. Cell 2006, 124:783-801.
7. Eid A.J., Brown R.A., Paya C.V., Razonable R.R. Association between Toll-like receptor polymorphisms and the outcome of liver transplantation for chronic hepatitis C virus. Transplantation 2007, 84:511-516.
8. Hong J., Leung E., Fraser A.G., Merriman T.R., Vishnu P., Krissansen G.W. TLR2, TLR4 and TLR9 polymorphisms and Crohn's disease in a New Zealand Caucasian cohort. J Gastroenterol Hepatol 2007, 22:1760-1766.
9. Kijpittayarit S., Eid A.J., Brown R.A., Paya C.V., Razonable R.R. Relationship between Toll-like receptor 2 polymorphism and cytomegalovirus disease after liver transplantation. Clin Infect Dis 2007, 44:1315-1320.
10. Lorenz E., Mira J.P., Cornish K.L., Arbour N.C., Schwartz D.A. A novel polymorphism in the Toll-like receptor 2 gene and its potential association with staphylococcal infection. Infect Immun 2000, 68:6398-6401.
11. Moore C.E., Segal S., Berendt A.R., Hill A.V., Day N.P. Lack of association between toll-like receptor 2 polymorphisms and susceptibility to severe disease caused by Staphylococcus aureus. Clin Diagn Lab Immunol 2004, 11:1194-1197.
12. Sia I.G., Berbari E.F., Karchmer A.W. Prosthetic joint infections. Infect Dis Clin North Am 2005, 19:885-914.
13. Kurtz S., Lau E., Halpern M., Ong K. Trend shows growing orthopedic surgery case load. Will surgeons be able to keep up?. Mater Manag Health Care 2006, 15:61-62.
14. Razonable R.R., Henault M., Lee L.N., Laethem C., Johnston P.A., Watson H.L., Paya C.V. Secretion of proinflammatory cytokines and chemokines during amphotericin B exposure is mediated by coactivation of Toll-like receptors;1. And;2. Antimicrob Agents Chemother 2005, 49:1617-1621.
15. Razonable R.R., Henault M., Paya C.V. Stimulation of Toll-like receptor 2 with bleomycin results in cellular activation and secretion of pro-inflammatory cytokines and chemokines. Toxicol Appl Pharmacol 2006, 210:181-189.
16. Brown R.A., Gralewski J.H., Eid A.J., Knoll B.M., Finberg R.W., Razonable R.R. R753Q single-nucleotide polymorphism impairs Toll-like receptor 2 recognition of hepatitis C virus core and nonstructural 3 proteins. Transplantation 2010, 15(89):811-815.
17. Asong J., Wolfert M.A., Maiti K.K., Miller D., Boons G.J. Binding and cellular activation studies reveal that Toll-like receptor 2 Can differentially recognize peptidoglycan from Gram-positive and Gram-negative bacteria. J Biol Chem 2009, 284:8643-8653.
18. Saklad M. Grading of patients for surgical procedures. Anesthesiology 1941, 2:281-284.
19. Dziarski R., Gupta D. Peptidoglycan recognition in innate immunity. J Endotoxin Res 2005, 11:304-310.
20. Schwandner R., Dziarski R., Wesche H., Rothe M., Kirschning C.J. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by Toll-like receptor. 2. J Biol Chem 1999, 274:17406-17409.
21. Takeuchi O., Hoshino K., Kawai T., Sanjo H., Takada H., Ogawa T., et al. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 1999, 11:443-451.
22. Wang Q., Dziarski R., Kirschning C.J., Muzio M., Gupta D. Micrococci and peptidoglycan activate TLR2→MyD88→IRAK→TRAF→NIK→IKK→NF-kappaB signal transduction pathway that induces transcription of interleukin-8. Infect Immun 2001, 69:2270-2276.
23. Yoshimura A., Lien E., Ingalls R.R., Tuomanen E., Dziarski R., Golenbock D. Cutting edge: Recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J Immunol 1999, 163:1-5.
24. Iwaki D., Mitsuzawa H., Murakami S., Sano H., Konishi M., Akino T., Kuroki Y. The extracellular Toll-like receptor 2 domain directly binds peptidoglycan derived from Staphylococcus aureus. J Biol Chem 2002, 277:24315-24320.
25. Kurokawa K., Lee H., Roh K.B., Asanuma M., Kim Y.S., Nakayama H., et al. The triacylated ATP Binding cluster transporter substrate-binding lipoprotein of Staphylococcus aureus functions as a native ligand for Toll-like receptor. 2. J Biol Chem 2009, 284:8406-8411.
26. Stenzel W., Soltek S., Sanchez-Ruiz M., Akira S., Miletic H., Schluter D., Deckert M. Both TLR2 and TLR4 are required for the effective immune response in Staphylococcus aureus-induced experimental murine brain abscess. Am J Pathol 2008, 172:132-145.
27. Feng B.S., He S.H., Zheng P.Y., Wu L., Yang P.C. Mast cells play a crucial role in Staphylococcus aureus peptidoglycan-induced diarrhea. Am J Pathol 2007, 171:537-547.
28. Kumar A., Singh C.N., Glybina I.V., Mahmoud T.H., Yu F.S. Toll-like receptor 2 ligand-induced protection against bacterial endophthalmitis. J Infect Dis 2010, 15(201):255-263.
29. von Aulock S., Schroder N.W., Traub S., Gueinzius K., Lorenz E., Hartung T., et al. Heterozygous Toll-like receptor 2 polymorphism does not affect lipoteichoic acid-induced chemokine and inflammatory responses. Infect Immun 2004, 72:1828-1831.
30. Brown R.A., Gralewski J.H., Razonable R.R. The R753Q polymorphism abrogates Toll-like receptor 2 signaling in response to human cytomegalovirus. Clin Infect Dis 2009, 49:e96-e99.
31. Mullaly S.C., Kubes P. The role of TLR2 in vivo following challenge with Staphylococcus aureus and prototypic ligands. J Immunol 2006, 177:8154-8163.
32. Ogus A.C., Yoldas B., Ozdemir T., Uguz A., Olcen S., Keser I., et al. The Arg753GLn polymorphism of the human Toll-like receptor 2 gene in tuberculosis disease. Eur Respir J 2004, 23:219-223.
33. Schroder N.W., Diterich I., Zinke A., Eckert J., Draing C., von Baehr V., et al. Heterozygous Arg753Gln polymorphism of human TLR-2 impairs immune activation by Borrelia burgdorferi and protects from late stage Lyme disease. J Immunol 2005, 175:2534-2540.
34. Berbari E.F., Osmon D.R., Duffy M.C., Harmssen R.N., Mandrekar J.N., Hanssen A.D., Steckelberg J.M. Outcome of prosthetic joint infection in patients with rheumatoid arthritis: The impact of medical and surgical therapy in 200 episodes. Clin Infect Dis 2006, 42:216-223.
35. Sachse F., Becker K., Rudack C. Incidence of staphylococcal colonization and of the 753Q toll-like receptor 2 variant in nasal polyposis. Am J Rhinol Allergy 2004, 24:e10-e13.
36. Ozinsky A., Underhill D.M., Fontenot J.D., Hajjar A.M., Smith K.D., Wilson C.B., et al. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors. Proc Natl Acad Sci U S A 2000, 97:13766-13771.
37. Takeuchi O., Sato S., Horiuchi T., Hoshino K., Takeda K., Dong Z., et al. Cutting edge: Role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol 2002, 169:10-14.
38. Hruz P., Zinkernagel A.S., Jenikova G., Botwin G.J., Hugot J.P., Karin M., et al. NOD2 contributes to cutaneous defense against Staphylococcus aureus through alpha-toxin-dependent innate immune activation. Proc Natl Acad Sci U S A 2009, 106:12873-12878.
39. Kielian T., Esen N., Bearden E.D. Toll-like receptor 2 (TLR2) is pivotal for recognition of S. aureus peptidoglycan but not intact bacteria by microglia. Glia 2005, 49:567-576.
40. Knapp S., Wieland C.W., van 't Veer C., Takeuchi O., Akira S., Florquin S., van der Poll T. Toll-like receptor 2 plays a role in the early inflammatory response to murine pneumococcal pneumonia but does not contribute to antibacterial defense. J Immunol 2004, 172:3132-3138.
41. Ryu Y.H., Baik J.E., Yang J.S., Kang S.S., Im J., Yun C.H., et al. Differential immunostimulatory effects of Gram-positive bacteria due to their lipoteichoic acids. Int Immunopharmacol 2009, 9:127-133.
42. Azuma M., Sawahata R., Akao Y., Ebihara T., Yamazaki S., Matsumoto M., et al. The peptide sequence of diacyl lipopeptides determines dendritic cell TLR2-mediated NK activation. PLoS ONE 2010, 5:e12550.