Stimulation of toll-like receptor 2 with bleomycin results in cellular activation and secretion of pro-inflammatory cytokines and chemokines

Toxicology and Applied Pharmacology

Volumn 210, Issue 3, 2006, Pages 181-189

  Razonable, Raymund R ^a,b   Henault, Martin ^b   Paya, Carlos V ^a,b  

^a Mayo Clinic   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

Adverse drug reactions; Bleomycin; Cytokines; Inflammation; Toll like receptors

Indexed keywords

BLEOMYCIN; CHEMOKINE; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 8; MONOCLONAL ANTIBODY; TOLL LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL ACTIVATION; CELL LINE; CONTROLLED STUDY; CYTOKINE RELEASE; EMBRYO; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; KIDNEY CELL; MONOCYTE; PROTEIN EXPRESSION; TOXICITY;

ANTIMETABOLITES, ANTINEOPLASTIC; BLEOMYCIN; CELL LINE; CHEMOKINES; CYTOKINES; HUMANS; INTERLEUKINS; NF-KAPPA B; TOLL-LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR-ALPHA;

EID: 30844450369     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2005.05.002     Document Type: Article

References (42)

1. D. Arndt, R. Zeisig, D. Bechtel, and I. Fichtner Liposomal bleomycin: increased therapeutic activity and decreased pulmonary toxicity in mice Drug Delivery 8 2001 1 7
2. A. Azuma, T. Furuta, T. Enomoto, Y. Hashimoto, K. Uematsu, N. Nukariya, A. Murata, and S. Kudoh Preventive effect of erythromycin on experimental bleomycin-induced acute lung injury in rats Thorax 53 1998 186 189
3. J.K. Brieland, M.L. Jones, C.M. Flory, G.R. Miller, J.S. Warren, S.H. Phan, and J.C. Fantone Expression of monocyte chemoattractant protein-1 (MCP-1) by rat alveolar macrophages during chronic lung injury Am. J. Respir. Cell Mol. Biol. 9 1993 300 305
4. J.J. Carter, M.L. McLaughlin, and M.M. Bern Bleomycin-induced fatal hyperpyrexia Am. J. Med. 74 1983 523 525
5. B. Chen, L. Jiang, W. Zhao, R. Yu, and X.M. Hou Ameliorating effect of erythromycin on bleomycin-induced pulmonary fibrosis: role of alveolar macrophage activation and cytokine release Respirology 2 1997 151 155
6. R.M. Day, Y. Yang, Y.J. Suzuki, J. Stevens, R. Pathi, A. Perlmutter, B.L. Fanburg, and J.J. Lanzillo Bleomycin upregulates gene expression of angiotensin-converting enzyme via mitogen-activated protein kinase and early growth response 1 transcription factor Am. J. Respir. Cell Mol. Biol. 25 2001 613 619
7. R. de Wit, J.T. Roberts, P.M. Wilkinson, P.H. de Mulder, G.M. Mead, S.D. Fossa, P. Cook, L. de Prijck, S. Stenning, and L. Collette Equivalence of three or four cycles of bleomycin, etoposide, and cisplatin chemotherapy and of a 3- or 5-day schedule in good-prognosis germ cell cancer: a randomized study of the European Organization for Research and Treatment of Cancer Genitourinary Tract Cancer Cooperative Group and the Medical Research Council J. Clin. Oncol. 19 2001 1629 1640
8. W.E. Evans, G.C. Yee, W.R. Crom, C.B. Pratt, and A.A. Green Clinical pharmacology of bleomycin and cisplatin Head Neck Surg. 4 1981 98 110
9. J.L. Gonzalez-Vela, L. Panasci, M. Black, M. Pollak, and R. Margolese Combination chemotherapy with carboplatin and bleomycin for advanced and recurrent head and neck cancer: a phase II study J. Surg. Oncol. 39 1988 215 216
10. J. Hay, S. Shahzeidi, and G. Laurent Mechanisms of bleomycin-induced lung damage Arch. Toxicol. 65 1991 81 94
11. J. Herod, A. Burton, J. Buxton, J. Tobias, D. Luesley, S. Jordan, J. Dunn, and C.J. Poole A randomised, prospective, phase III clinical trial of primary bleomycin, ifosfamide and cisplatin (BIP) chemotherapy followed by radiotherapy versus radiotherapy alone in inoperable cancer of the cervix Ann. Oncol. 11 2000 1175 1181
12. W. Huang, G. Wang, D.S. Phelps, H. Al-Mondhiry, and J. Floros Combined SP-A-bleomycin effect on cytokines by THP-1 cells: impact of surfactant lipids on this effect Am. J. Physiol.: Lung. Cell Mol. Physiol. 283 2002 L94 L102
13. N. Kaminski, J.D. Allard, J.F. Pittet, F. Zuo, M.J. Griffiths, D. Morris, X. Huang, D. Sheppard, and R.A. Heller Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis Proc. Natl. Acad. Sci. U. S. A. 97 2000 1778 1783
14. S. Karmiol, D.G. Remick, S.L. Kunkel, and S.H. Phan Regulation of rat pulmonary endothelial cell interleukin-6 production by bleomycin: effects of cellular fatty acid composition Am. J. Respir. Cell Mol. Biol. 9 1993 628 636
15. N. Khalil, T.V. Parekh, R.N. O'Connor, and L.I. Gold Differential expression of transforming growth factor-beta type I and II receptors by pulmonary cells in bleomycin-induced lung injury: correlation with repair and fibrosis Exp. Lung Res. 28 2002 233 250
16. R.L. Levy, and S. Chiarillo Hyperpyrexia, allergic-type response and death occurring with low-dose bleomycin administration Oncology 37 1980 316 317
17. T. Maeyama, K. Kuwano, M. Kawasaki, R. Kunitake, N. Hagimoto, and N. Hara Attenuation of bleomycin-induced pneumopathy in mice by monoclonal antibody to interleukin-12 Am. J. Physiol.: Lung. Cell Mol. Physiol. 280 2001 L1128 L1137
18. G. Martinelli, E. Cocorocchio, P.C. Saletti, R. Orecchia, J. Bernier, N. Tradati, P. Santoro, C. Robertson, F.A. Peccatori, E. Zucca, and F. Cavalli Efficacy of vinblastine, bleomycin, methotrexate (VBM) combination chemotherapy with involved field radiotherapy in early stage (I-IIA) Hodgkin disease patients Leuk. Lymphoma 44 2003 1919 1923
19. E. Martinez-Moragon, J. Aparicio, M.C. Rogado, J. Sanchis, F. Sanchis, and V. Gil-Suay Pleurodesis in malignant pleural effusions: a randomized study of tetracycline versus bleomycin Eur. Respir. J. 10 1997 2380 2383
20. H. Matsuoka, T. Arai, M. Mori, S. Goya, H. Kida, H. Morishita, H. Fujiwara, I. Tachibana, T. Osaki, and S. Hayashi A p38 MAPK inhibitor, FR-167653, ameliorates murine bleomycin-induced pulmonary fibrosis Am. J. Physiol.: Lung. Cell Mol. Physiol. 283 2002 L103 L112
21. H. Miyamoto, I. Sugawara, A. Azuma, Y. Saito, N. Kohno, and S. Kudoh Differential secretion of cytokines and adhesion molecules by HUVEC stimulated with low concentrations of bleomycin Cell. Immunol. 219 2002 73 81
22. J.S. Munger, X. Huang, H. Kawakatsu, M.J. Griffiths, S.L. Dalton, J. Wu, J.F. Pittet, N. Kaminski, C. Garat, M.A. Matthay, D.B. Rifkin, and D. Sheppard The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis Cell 96 1999 319 328
23. K.C. Ong, V. Indumathi, J. Raghuram, and Y.Y. Ong A comparative study of pleurodesis using talc slurry and bleomycin in the management of malignant pleural effusions Respirology 5 2000 99 103
24. L.A. Ortiz, J. Lasky, R.F. Hamilton Jr., A. Holian, G.W. Hoyle, W. Banks, J.J. Peschon, A.R. Brody, G. Lungarella, and M. Friedman Expression of TNF and the necessity of TNF receptors in bleomycin-induced lung injury in mice Exp. Lung Res. 24 1998 721 743
25. S.H. Phan, M. Gharaee-Kermani, F. Wolber, and U.S. Ryan Stimulation of rat endothelial cell transforming growth factor-beta production by bleomycin J. Clin. Invest. 87 1991 148 154
26. R.R. Razonable, M. Henault, L.N. Lee, C. Laethem, P.A. Johnston, H.L. Watson, and C.V. Paya Secretion of proinflammatory cytokines and chemokines during amphotericin B exposure is mediated by coactivation of toll-like receptors 1 and 2 Antimicrob. Agents Chemother. 49 2005 1617 1621
27. E. Sato, S. Koyama, T. Masubuchi, A. Takamizawa, K. Kubo, S. Nagai, and T. Izumi Bleomycin stimulates lung epithelial cells to release neutrophil and monocyte chemotactic activities Am. J. Physiol. 276 1999 L941 L950
28. K. Sau, S.S. Mambula, E. Latz, P. Henneke, D.T. Golenbock, and S.M. Levitz The antifungal drug amphotericin B promotes inflammatory cytokine release by a Toll-like receptor- and CD14-dependent mechanism J. Biol. Chem. 278 2003 37561 37568
29. R.K. Scheule, R.C. Perkins, R. Hamilton, and A. Holian Bleomycin stimulation of cytokine secretion by the human alveolar macrophage Am. J. Physiol. 262 1992 L386 L391
30. A.S. Shen, C. Haslett, D.C. Feldsien, P.M. Henson, and R.M. Cherniack The intensity of chronic lung inflammation and fibrosis after bleomycin is directly related to the severity of acute injury Am. Rev. Respir. Dis. 137 1988 564 571
31. B. Shen, L. Du, C. Sanchez, D.J. Edwards, M. Chen, and J.M. Murrell Cloning and characterization of the bleomycin biosynthetic gene cluster from Streptomyces verticillus ATCC15003 J. Natl. Prod. 65 2002 422 431
32. S. Sleijfer Bleomycin-induced pneumonitis Chest 120 2001 617 624
33. S. Sleijfer, Z. Vujaskovic, P.C. Limburg, H. Schraffordt Koops, and N.H. Mulder Induction of tumor necrosis factor-alpha as a cause of bleomycin-related toxicity Cancer 82 1998 970 974
34. R.E. Smith Chemotactic cytokines mediate leukocyte recruitment in fibrotic lung disease Biol. Signals 5 1996 223 231
35. R.E. Smith, R.M. Strieter, S.H. Phan, N. Lukacs, and S.L. Kunkel TNF and IL-6 mediate MIP-1alpha expression in bleomycin-induced lung injury J. Leukocyte Biol. 64 1998 528 536
36. R.E. Smith, R.M. Strieter, S.H. Phan, N.W. Lukacs, G.B. Huffnagle, C.A. Wilke, M.D. Burdick, P. Lincoln, H. Evanoff, and S.L. Kunkel Production and function of murine macrophage inflammatory protein-1 alpha in bleomycin-induced lung injury J. Immunol. 153 1994 4704 4712
37. Y. Tokuhashi, F. Kikkawa, K. Tamakoshi, N. Suganuma, K. Kuzuya, Y. Arii, M. Kawai, S. Hattori, I. Kobayashi, Y. Furuhashi, N. Nakashima, and Y. Tomoda A randomized trial of cisplatin, vinblastine, and bleomycin versus cyclophosphamide, aclacinomycin, and cisplatin in epithelial ovarian cancer Oncology 54 1997 281 286
38. P.W. Van Barneveld, N.H. Mulder, T.W. Van der Mark, and D.T. Sleijfer Bleomycin and pulmonary toxicity Neth. J. Med. 28 1985 516 523
39. J. Vollmer, R. Weeratna, P. Payette, M. Jurk, C. Schetter, M. Laucht, T. Wader, S. Tluk, M. Liu, H.L. Davis, and A.M. Krieg Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities Eur. J. Immunol. 34 2004 251 262
40. K.A. Zarember, and P.J. Godowski Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines J. Immunol. 168 2002 554 561
41. K. Zhang, M. Gharaee-Kermani, M.L. Jones, J.S. Warren, and S.H. Phan Lung monocyte chemoattractant protein-1 gene expression in bleomycin-induced pulmonary fibrosis J. Immunol. 153 1994 4733 4741
42. X.Y. Zhang, S. Shimura, T. Masuda, H. Saitoh, and K. Shirato Antisense oligonucleotides to NF-kappaB improve survival in bleomycin-induced pneumopathy of the mouse Am. J. Respir. Crit. Care Med. 162 2000 1561 1568