Anti-arthritic effects of an ethanolic extract of capparis erythrocarpos isert roots in freund's adjuvant-induced arthritis in rats

Journal of Pharmacology and Toxicology

Volumn 6, Issue 3, 2011, Pages 201-217

  Danquah, Cynthia Amaning ^a   Woode, Eric ^a   Boakye Gyasi, Eric ^a  

^a KWAME NKRUMAH UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Ghana)

Author keywords

Complete freund's adjuvant; Inflammation; Plethysmograph; Synovitis

Indexed keywords

ALCOHOL; ANTIRHEUMATIC AGENT; CAPPARIS ERYTHROCARPOS EXTRACT; DEXAMETHASONE; FREUND ADJUVANT; METHOTREXATE; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CAPPARIS; CAPPARIS ERYTHROCARPOS; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FEMALE; MALE; NONHUMAN; PLANT ROOT; RAT; RHEUMATOID ARTHRITIS; SOLVENT EXTRACTION;

EID: 78650112043     PISSN: 1816496X     EISSN: 2152100X     Source Type: Journal    
DOI: 10.3923/jpt.2011.201.217     Document Type: Article

References (60)

1. Abbiw, D.K., 1990. Useful Plants of Ghana. 1st Edn., Intermediate Technology Publications and Royal Botanic Gardens Kew, London, ISBN: 1-85339-043-7, pp: 337.
2. Abotsi, W.M.K., E. Woode, G.K. Amooson, A. Amo-Banmah and E. Boakye-Gyasi, 2010. Antiarthritic and antioxidant effects of the leaf extract of Ficus exasperata P. Beauv. (Moraceae). Pharmacogn. Res., 2: 89-97.
3. Agarwal, R.B. and V.D. Rangari, 2003. Phytochemical investigation and evaluation of anti-inflammatory and a nti-arthritic activities of essential oil of Strobilanthus ixiocephala Benth. Indian J. Exp. Biol., 41: 890-894.
4. Agarwal, S.K. and M.B. Brenner, 2006. Role of adhesion molecules in synovial inflammation. Curr. Opm. Rheumatol., 18: 268-276.
5. Akaogi, J., T. Nozaki, M. Satoh and H. Yamada, 2006. Role of PGE2 and EP receptors in the pathogenesis of rheumatoid arthritis and as a novel therapeutic strategy. Endocr. Metab. Immune Disord. Drug Targets, 6: 383-394.
6. Aota, S., T. Nakamura, K. Suzuki, Y. Tanaka, Y. Okazaki, Y. Segawa, M. Miura and S. Kikuchi, 1996. Effects of indomethacin administration on bone turnover and bone mass in adjuvant-induced arthritis in rats. Calcif. Tissue Int., 59: 385-391.
7. Atzeni, F. and P. Sarzi-Puttini, 2007. Early rheumatoid arthritis. Reumatismo, 59: 100-117.
8. Balunas, M.J. and A.D. Kinghorn, 2005. Drug discovery from medicinal plants. Life Sci., 78:431-441.
9. Bonnet, J., E. Zerath, N. Picaud, C. Lesur and A. Mattio et al., 1993. Bone morphometric changes in adjuvant-induced polyarthritic osteopenia in rats: evidence for an early bone formation defect. J. Bone Miner Res., 8: 659-668.
10. Bradbeer, J.N., R.D. Kapadia, S.K. Sarkar, H. Zhao and GB. Stroup et al, 1996. Disease-modifying activity of SK&F 106615 in rat adjuvant-induced arthritis. Multiparameter analysis of disease magnetic resonance imaging and bone mineral density measurements. Arthritis Rheum., 39: 504-514.
11. Brown, A.K., M.A. Quinn, Z. Karim, P.G. Conaghan and C.G. Peterfy et al., 2006. Presence of significant synovitis in rheumatoid arthritis patients with disease-modifying antirheumatic drug-induced clinical remission: evidence from an imaging study may explain structural progression. Arth. Rheum., 54: 3761-3773.
12. Campo, G.M., A. Avenoso, S. Campo, A.M. Ferlazzo, D. Altavilla and A. Calatroni, 2003. Efficacy of treatment with glycosaminoglycans on experimental collagen-induced arthritis in rats. Arthritis Res. Ther, 5: R122-R131.
13. Capell, H.A., R. Madhok, D.R. Porter, R.A.L. Munro, LB. Mclnnes and J.A. Hunter et al, 2007. Combination therapy with sufasalazine and methotrexate is more effective than either drug alone in patients rheumatoid arthritis with a suboptimal response to sulfasalazine: Results from the double-blind placebo-controlled MASCOT study. Ann. Rheum. Dis., 66: 235-241.
14. Caspi, D., M. Anouk, I. Golan, D. Paran and I. Kaufman et al., 2006. Synovial fluid levels of anti-cyclic citrullinated peptide antibodies and IgA rheumatoid factor in rheumatoid arthritis, psoriatic arthritis and osteoarthritis. Arthritis Rheum., 55: 53-56.
15. Escandell, J.M., M.C. Recio, S. Manez, R.M. Gmer, M. Cerda-Nicolas and J.L. Rios, 2007. Cucurbitacin R reduces the inflammation and bone damage associated with adjuvant arthritis in lewis rats by suppression of tumor necrosis factor-alpha in T lymphocytes and macrophages. J. Pharmacol. Exp. Ther, 320: 581-590.
16. Fairhurst, A.M., P.K. Wallace, A.S. Jawad and N.J. Goulding, 2007. Rheumatoid peripheral blood phagocytes are primed for activation but have impaired Fc-mediated generation of reactive oxygen species. Arthritis Res. Ther, 9: R29-R29.
17. Feldmann, M, F.M. Brennan, B.M. Foxwell, P.C. Taylor, R.O. Williams and R.N. Maim, 2005. Anti-TNF therapy: Where have we got to in 2005. J. Autoimmun, 25: 26-28.
18. Fereidoni, M, A. Ahmadiani, S. Semnanian and M. Javan, 2000. An accurate and simple method for measurement of paw edema. J. Pharmacol. Toxicol. Methods, 43: 11-14.
19. Findlay, D.M. and D.R. Haynes, 2005. Mechanisms of bone loss in rheumatoid arthritis. Mod. Rheumatol, 15: 232-240.
20. Hisadome, M, T. Fukuda, K. Adachi and H. Komatsu, 2004. Combination benefit of a pyrimidylpiperazine derivative (Y-40138) and methotrexate in arthritic rats. Eur. J. Pharmacol, 497: 351-359.
21. Hoffmann, J.C., C. Herklotz, H. Zeidler, B. Bayer, H. Rosenthal and J. Westermann, 1997. Initiation and perpetuation of rat adjuvant arthritis is inhibited by the anti-CD2 monoclonal antibody (mAb) 0X34. Ann. Rheum. Dis, 56: 716-722.
22. Hurley, J.V. and D.A. Willoughby, 1973. Acute inflammation: A combined topographical and electron microscopic study of the mode of action of carrageenan. Pathology, 5: 9-21.
23. Irvine, F.R., 1961. Woody Plants of Ghana. 1st Edn., Oxford University Press, London.
24. Issekutz, A.C. and T.B. Issekutz, 1991. Quantitation andkinetics of polymorp ho nuclear leukocyte and lymphocyte accumulation in joints during adjuvant arthritis in the rat. Lab. Invest., 64: 656-663.
25. Kapoor, M., O. Shaw and I. Appleton, 2005. Possible anti-inflammatory role of COX-2-derived prostaglandins: Implications for inflammation research. Curr. Opin. Invest. Drugs, 6: 461-466.
26. Kimel, M., M. Cifaldi, N. Chen and D. Revicki, 2008. Adalimumab plus methotrexate improved sf-36 scores and reduced the effect of Rheumatoid Arthritis (RA) on work activity for patients with early RA. J. Rheumatol., 35: 206-215.
27. Kinne, R.W., C.B. Schmidt-Weber, R. Hoppe, E. Buchner, E. Palombo-Kinne, E. Nurnberg and F. Emmrich, 1995. Long-term amelioration of rat adjuvant arthritis following systemic elimination of macrophages by clodronate-containing liposomes. Arth. Rheum., 38: 1777-1790.
28. Kweifio-Okai, G, D. Bird, B. Field, R. Ambrose, A.R. Carroll, P. Smith and R. Valdes, 1995. Antiinflammatory activity of a Ghanaian antiarthritic herbal preparation: III. J. Ethnopharmacol., 46: 7-15.
29. Liu, L., E. Buchner, D. Beitze, C.B.S. Weber, V. Kaever, F. Emmrich and R.W. Kinne, 1996. Amelioration of rat experimental arthritides by treatment with the alkaloid sinomenine. Int. J. Immunopharmacol., 18: 529-543.
30. Makinen, H., H. Kautiainen, P. Hannonen, T. Mottonen and M. Leirisalo-Repo et al., 2007. Sustained remission and reduced radiographic progression with combination disease modifying antirheumatic drugs in early rheumatoid arthritis. J. Rheumatol., 34: 316-321.
31. Malaviya, A.M., 2006. Cytokine network and its manipulation in rheumatoid arthritis. J. Assoc. Physicians India, 54: 15-18.
32. Mbagwu, H.O., R.A. Anene and 0.0 Adeyemi, 2007. Analgesic, antipyretic and anti-inflammatory properties of Mezoneuron benthamianum Baill. Nig. Q. J. Hosp. Med., 17: 35-41.
33. Meyer, L.H., L. Franssen and T. Pap, 2006. The role of mesenchymal cells in the pathophysiology of inflammatory arthritis. Best Pract Res. Clin. Rheumatol., 20: 969-981.
34. Miller, J.R., 2003. GraphPad: Version 4.0. Step-by-Step Examples. 1st Edn., GraphPad Software Inc., San Diego, CA.
35. Mottonen, T., P. Hannonen, M. Leirisalo-Repo, M. Korpela, M. Hakala and H. Kautiainen, 2006. Efficacy of combination therapy in rheumatoid arthritis: Comment on the review by Smolen et al. Arth. Rheum., 54: 2032-2034.
36. Motulsky, H.J. and A. Christopoulos, 2003. Fitting Model to Biological Data using Linear and Nonlinear Regression a Practical Guide to Curve Fitting. 1st Edn., GraphPad Software Inc., San Diego, CA.
37. Mshana, N.R., D.K. Abbiw, I. Addae-Mensah, E. Adjanohoun and M.R.A. Ahyi et al., 2000. Traditional Medicine and Pharmacopoeia: Contribution to the Revision of Ethnobotanical and Floristic Studies in Ghana. Organization of African Unity/Scientific, Technical and Research Commision, Nairobi, Kenya, ISBN: 978-2453-66-2.
38. Mullazehi, M., L. Mathsson, J. Lampa and J. Ronnelid, 2007. High anti-collagen type-II antibody levels and induction of proinflammatory cytokines by anti-collagen antibody-containing immune complexes in vitro characterise a distinct rheumatoid arthritis phenotype associated with acute inflammation at the time of disease onset. Ann. Rheum. Dis., 66: 537-541.
39. Narendhirakannan, R.T., S. Subramanian and M. Kandaswamy, 2007. Anti-inflammatory and lysosomal stability actions of Cleome gynandra L. studied in adjuvant induced arthritic rats. Food Chem. Toxicol, 45: 1001-1012.
40. Ochaion, A., S. Bar-Yehuda, S. Cohn, L. del Valle and G. Perez-Liz et al., 2006. Methotrexate enhances the anti-inflammatory effect of CF101 via up-regulation of the A3 adenosine receptor expression. Arthritis Res. Ther., 8: R169-R169.
41. Pakozdi, A., M.A. Amm, C.S. Haas, R.J. Martinez and G.K. Hames 3rd et al, 2006. Macrophage migration inhibitory factor: A mediator of matrix metalloproteinase-2 production in rheumatoid arthritis. Arthritis Res. Ther., 8: R132-R132.
42. Pearson, CM., 1956. Development of arthritis, periarthritis and periostitis in rats given adjuvants. Proc. Soc. Exp. Biol. Med, 91: 95-101.
43. Pine, P.R., B. Chang, N. Schoettler, M.L. Banquerigo and S. Wang et al., 2007. Inflammation and bone erosion are suppressed in models of rheumatoid arthritis following treatment with a novel Syk inhibitor. Clin. Immunol., 124: 244-257.
44. Pohlers, D., A. Beyer, D. Koczan, T. Wilhelm, H.J. Thiesen and R.W. Kinne, 2007. Constitutive upregulation of the transforming growth factor-beta pathway in rheumatoid arthritis synovial fibroblasts. Arth. Res. Ther, 9: R59-R59.
45. Pulichino, A.M., S. Rowland, T. Wu, P. Clark and D. Xu et al., 2006. Prostacyclin antagonism reduces pain and inflammation in rodent models of hyperalgesia and chronic arthritis. J. Pharmacol. Exp. Ther, 319: 1043-1050.
46. Reinhart, W.H, 2006. Erythrocyte sedimentation rate-more than an old fashion. Ther. Umsch, 63: 108-112.
47. Singh, B, P.M. Sahu and M.K. Sharma, 2002. An ti-inflammatory and antimicrobial activities of triterpenoids from Strobilanthes callosus nees. Phytomedicine, 9: 355-359.
48. Smolen, J.S, K. Redlich, J. Zwerina, D. Aletaha, G. Steiner and G. Schett, 2005. Pro-inflammatory cytokines in rheumatoid arthritis: Pathogenetic and therapeutic aspects. Clin. Rev. Allergy Immunol, 28: 239-248.
49. Sofowara, A, 1993. Medicinal Plants and Traditional Medicine in Africa. Spectrum Books Ltd, Ibadan, Nigeria, pp: 289.
50. Sokka, T, P. Hannonen and T. Mottonen, 2005. Conventional disease-modifying antirheumatic drugs in early arthritis. Rheum. Dis. Clin. North Am, 31: 729-744.
51. Swierkot, J. and J. Szechinski, 2006. Methotrexate in rheumatoid arthritis. Pharmacol. Rep, 58: 473-492.
52. Trease, E. and W.C. Evans, 1989. A Text Book of Pharmacognosy. 13th Edn, Billiare Tindall, London, pp: 61-62.
53. Weissmann, G, 2006. The pathogenesis of rheumatoid arthritis. Bull. NYU Hosp. J. Dis, 64: 12-15.
54. Whitehouse, M.W, 2007. Adjuvant arthritis 50 years on: The impact of the 1956 article by CM. Pearson, Development of arthritis, periarthritis and periostitis in rats given adjuvants. Inflamm. Res, 56: 133-138.
55. Willoughby, D.A, E. Coote and J.L. Turk, 1969. Complement in acute inflammation. J. Pathol, 97: 295-305.
56. Woode, E., G.K. Ainooson, E. Boakye-Gyasi, C. Ansah and D.D. Obiri et al., 2008. Anti-arthritic and antioxidant properties of the ethanolic stembark extract of Newbouldia laevis (P. Beauv.) Seaman ex Bureau (Bignoniaceae). J. Med. Plants Res., 2: 180-188.
57. Woode, E., C.A. Danquah, E. Boakye-Gyasi, C. Ansah and G. Ainooson, 2009. Antinociceptive effects of an ethanolic extract of Capparis erythrocarpos Isert roots in the mice formalin test. Int. J.Pharmacol, 5:354-361.
58. Woode, E, E. Boakye-Gyasi, C.A. Danquah, C. Ansah and M. Duwiejua, 2009. Anti-arthritic effects of Palisota hirsuta K. Schum. leaf extract in freund's adjuvant-induced arthritis in rats. Int. J. Pharmacol, 5: 181-190.
59. Wu, J.F, Y.H. Yang, L.C. Wang, J.H. Lee, E.Y. Shen and B.L. Chiang, 2007. Comparative usefulness of C-reactive protein and erythrocyte sedimentation rate in juvenile rheumatoid arthritis. Clm. Exp. Rheumatol, 25: 782-785.
60. Zhao, H, S. Liu, D. Huang, Q. Xu, T. Shuto and Y. Iwamoto, 2006. The protective effects of incadronate on inflammation and joint destruction in established rat adjuvant arthritis. Rheumatol. Int., 26: 732-740.