Antiarthritic and antioxidant effects of the leaf extract of Ficus exasperata P. Beauv. (Moraceae)

Pharmacognosy Research

Volumn 2, Issue 2, 2010, Pages 89-97

  Abotsi, Wonder M K ^a   Woode, Eric ^a   Ainooson, George K ^a   Amo Barimah, Ama K ^a   Boakye Gyasi, Eric ^a  

^a KWAME NKRUMAH UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Ghana)

Author keywords

DPPH; Ficus exasperata; Freund s adjuvant induced arthritis; Lipid peroxidation; Total phenol

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; ANTIRHEUMATIC AGENT; DEXAMETHASONE; FREUND ADJUVANT; HERBACEOUS AGENT; METHOTREXATE;

ADJUVANT ARTHRITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN HOMOGENATE; CONTROLLED STUDY; DRUG ISOLATION; FEMALE; FICUS; FICUS EXASPERATA; IC 50; LIPID PEROXIDATION; MALE; NONHUMAN; PLANT LEAF; RAT;

EID: 77953403531     PISSN: None     EISSN: 09748490     Source Type: Journal    
DOI: 10.4103/0974-8490.62958     Document Type: Article

References (48)

1. Berg CC. Classification and distribution of Ficus. Experientia 1989;45:605-611
2. Berg CC, Wiebes JT. African fig trees and fig wasps. 1 ed. Amsterdam: Koninklijke Nederlandse Akademie van Wetenschappen; 1992.
3. Irvine FR. Woody plants of Ghana. 1 ed. London: Oxford University Press; 1961.
4. Chhabra SC, Mahunnah RL, Mshiu EN. Plants used in traditional medicine in eastern Tanzania. IV. Angiosperms (Mimosaceae to Papilionaceae). J Ethnopharmacol 1990;29:295-323.
5. Ayinde BA, Omogbai EK, Amaechina FC. Pharmacognosy and hypotensive evaluation of Ficus exasperata Vahl (Moraceae) leaf. Acta Pol Pharm 2007;64:543-546
6. Akah PA, Orisakwe OE, Gamaniel KS, Shittu A. Evaluation of Nigerian traditional medicines: II. Effects of some Nigerian folk remedies on peptic ulcer. J Ethnopharmacol 1998;62:123-127
7. Macfoy CA, Cline EI. In vitro antibacterial activities of three plants used in traditional medicine in Sierra Leone. J Ethnopharmacol 1990;28:323-327
8. Woode E, Poku RA, Ainooson GK, Boakye-Gyasi E, Abotsi WKM, Mensah TL, et al. An evaluation of the anti-inflammatory, antipyretic and antinociceptive effects of Ficus exasperata (Vahl) leaf extract. J Pharmaco Toxicol 2009;4:138-151
9. Pearson CM, Wood FD. Studies of polyarthritis and other lesions induced in rats by injection of mycobacterial adjuvant. I. General clinical and pathologic characteristics and some modifying factors. Arthritis Rheum 1959;2:440-459
10. Li H, Zhang YY, Tan HW, Jia YF, Li D. Therapeutic effect of tripterine on adjuvant arthritis in rats. J Ethnopharmacol 2008;118:479-484
11. Greenwald RA. Animal models for evaluation of arthritis drugs. Methods Find Exp Clin Pharmacol 1991;13:75-83.
12. Andersen ML, Santos EH, Seabra Mde L, da Silva AA, Tufik S. Evaluation of acute and chronic treatments with Harpagophytum procumbens on Freund's adjuvant-induced arthritis in rats. J Ethnopharmacol 2004;91:325-330
13. Biemond P, Swaak AJ, Koster JF. Protective factors against oxygen free radicals and hydrogen peroxide in rheumatoid arthritis synovial fluid. Arthritis Rheum 1984;27:760-765
14. Lunec J, Halloran SP, White AG, Dormandy TL. Free-radical oxidation (peroxidation) products in serum and synovial fluid in rheumatoid arthritis. J Rheumatol 1981;8:233-245
15. Hadjigogos K. The role of free radicals in the pathogenesis of rheumatoid arthritis. Panminerva Med 2003;45:7-13.
16. Ostrakhovitch EA, Afanas'ev IB. Oxidative stress in rheumatoid arthritis leukocytes: suppression by rutin and other antioxidants and chelators. Biochem Pharmacol 2001;62:743-746
17. Campo GM, Avenoso A, Campo S, Ferlazzo AM, Altavilla D, Calatroni A. Efficacy of treatment with glycosaminoglycans on experimental collagen-induced arthritis in rats. Arthritis Res Ther 2003;5:122-131
18. Cui K, Luo X, Xu K, Ven Murthy MR. Role of oxidative stress in neurodegeneration: Recent developments in assay methods for oxidative stress and nutraceutical antioxidants. Prog Neuropsychopharmacol Biol Psychiatry 2004;28:771-799
19. Pearson CM. Development of arthritis, periarthritis and periostitis in rats given adjuvants. Proc Soc Exp Biol Med 1956;91:95-101.
20. Fereidoni M, Ahmadiani A, Semnanian S, Javan M. An accurate and simple method for measurement of paw edema. J Pharmacol Toxicol Methods 2000;43:11-14
21. Woode E, Ainooson G, Boakye-Gyasi E, Ansah C, Obiri D, Koffour G, et al. Anti-arthritic and antioxidant properties of the ethanolic stem bark extract of Newbouldia laevis (P. Beauv.) Seaman ex Bureau (Bignoniaceae). J Med Plants Res 2008;2:180-188
22. Woode E, Boakye-Gyasi E, Danquah C, Ansah C, Duwiejua M. Anti-arthritic effects of palisota hirsuta. Schum. Leaf extract in Freund's adjuvant-induced arthritis in rats. Int J Pharmacol 2009;5:181-190
23. Kinne RW, Schmidt-Weber CB, Hoppe R, Buchner E, Palombo-Kinne E, Nürnberg E, et al. Long-term amelioration of rat adjuvant arthritis following systemic elimination of macrophages by clodronate-containing liposomes. Arthritis Rheum 1995;38:1777-1790
24. Zhao H, Shuto T, Hirata G, Iwamoto Y. Aminobisphosphonate (YM175) inhibits bone destruction in rat adjuvant arthritis. J Orthop Sci 2000;5:397-403.
25. Hoffmann JC, Herklotz C, Zeidler H, Bayer B, Rosenthal H, Westermann J. Initiation and perpetuation of rat adjuvant arthritis is inhibited by the anti-CD2 monoclonal antibody (mAb) OX34. Ann Rheum Dis 1997;56:716-722
26. Singleton VL, Rossi JA Jr. Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am J Enol Vitic 1965;16:144-158
27. Slinkard K, Singleton VL. Total phenol analyses: Automation and comparison with manual methods. Am J Enol Vitic 1977;28:49-55.
28. Oyaizu M. Studies on products of browning reaction: Antioxidative activities of products of browning reaction prepared from glucosamine. Jpn J Nutr 1986;44:307-315
29. Woode E, Ansah C, Ainooson GK, Abotsi WM, Mensah AY, Duwiejua M. Anti-inflammatory and antioxidant properties of the root extract of Carissa edulis (Forsk.) Vahl (Apocynaceae). J Sci Tech 2007;27:6-15.
30. Blois MS. Antioxidant determinations by the use of a stable free radical. Nature 1958;181:1199-1200
31. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979;95:351-358
32. Motulsky HJ, Christopoulos A. Fitting model to biological data using linear and nonlinear regression. A practical guide to curve fitting. San Diego, CA.: GraphPad Software Inc.; 2003.
33. Miller JR. GraphPad Version 4.0. Step-by-step examples. San Diego, CA: GraphPad Software Inc; 2003.
34. Aota S, Nakamura T, Suzuki K, Tanaka Y, Okazaki Y, Segawa Y, et al. Effects of indomethacin administration on bone turnover and bone mass in adjuvant-induced arthritis in rats. Calcif Tissue Int 1996;59:385-391
35. Findlay DM, Haynes DR. Mechanisms of bone loss in rheumatoid arthritis. Mod Rheumatol 2005;15:232-240
36. Ijeh II, Ukwemi AI. Acute effect of administration of ethanol extracts of Ficus exasperata vahl on kidney function in albino rats. J Med Plants Res 2007;1:27-29
37. Woode E, Poku R, Ainooson G, Boakye-Gyasi E, Abotsi W, Mensah T, et al. An evaluation of the anti-inflammatory, antipyretic and antinociceptive effects of Ficus exasperata (Vahl) leaf extract. J Pharmaco Toxicol 2009;4:138-151
38. Guardia T, Rotelli AE, Juarez AO, Pelzer LE. Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat. Farmaco 2001;56:683-687
39. Rotelli AE, Guardia T, Juarez AO, de la Rocha NE, Pelzer LE. Comparative study of flavonoids in experimental models of inflammation. Pharmacol Res 2003;48:601-606
40. Barbosa-Filho J, Piuvezam M, Moura M, Silva M, Lima K, da-Cunha E, et al. Anti-inflammatory activity of alkaloids: A twenty-century review. Rev Bras Farmacogn 2006;16:109-139
41. Clavin M, Gorzalczany S, Macho A, Munoz E, Ferraro G, Acevedo C, et al. Anti-inflammatory activity of flavonoids from Eupatorium arnottianum. J Ethnopharmacol 2007;112:585-589
42. Whitehouse M, Fairlie D, Thong Y. Anti-inflammatory activity of the isoquinoline alkaloid, tetrandrine, against established adjuvant arthritis in rats. Inflamm Res 1994;42:123-127
43. Bauerova K, Bezek A. Role of reactive oxygen and nitrogen species in etiopathogenesis of rheumatoid arthritis. Gen Physiol Biophys 1999;18:15-20.
44. Fahim AT, Abd-el Fattah AA, Agha AM, Gad MZ. Effect of pumpkin-seed oil on the level of free radical scavengers induced during adjuvant-arthritis in rats. Pharmacol Res 1995;31:73-79
45. Jung HJ, Nam JH, Choi J, Lee KT, Park HJ. Antiinflammatory effects of chiisanoside and chiisanogenin obtained from the leaves of Acanthopanax chiisanensis in the carrageenan- and Freund's complete adjuvant-induced rats. J Ethnopharmacol 2005;97:359-367
46. Shahidi F, Wanasundara PK. Phenolic antioxidants. Crit Rev Food Sci Nutr 1992;32:67-103.
47. Sawa T, Nakao M, Akaike T, Ono K, Maeda H. Alkylperoxyl radical-scavenging activity of various flavonoids and other phenolic compounds: implications for the anti-tumor-promoter effect of vegetables. J Agric Food Chem 1999;47:397-402.
48. Narendhirakannan RT, Subramanian S, Kandaswamy M. Free radical scavenging activity of Cleome gynandra L. leaves on adjuvant induced arthritis in rats. Mol Cell Biochem 2005;276:71-80.