Discovery of novel cyclophilin a ligands using an H/D exchange- and mass spectrometry-based strategy

Journal of Biomolecular Screening

Volumn 15, Issue 9, 2010, Pages 1051-1062

  Dearmond, Patrick D ^a   West, Graham M ^a   Anbalagan, Victor ^a   Campa, Michael J ^b   Patz Jr , Edward F ^b   Fitzgerald, Michael C ^a  

^a DUKE UNIVERSITY   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

amide H D exchange; cyclophilin A; high throughput screening; matrix assisted laser desorption ionization

Indexed keywords

1 (3,5 DICHLOROPHENYL) 1H PYRROLE 2,5 DIONE; 1 [2 (3,4 DIMETHOXYPHENYL)ETHYL] 1H PYRROLE 2,5 DIONE; 2 (ALPHA NAPHTHOYL)ETHYLTRIMETHYLAMMONIUM IODIDE; 3 (4 TERT BUTYLPHENYLSULFONYL) 2 PROPENENITRILE; 3 (N BENZYL N ISOPROPYL)AMINO 1 (NAPHTHALEN 2 YL)PROPAN 1 ONE; 4 (2 METHOXY 4 NITROPHENYL) 1 METHYL 10 OXA 4 AZATRICYCLO[5.2.1.0 2,6]DEC 8 ENE 3,5 DIONE; CISPLATIN; CYCLOPHILIN A; CYCLOPHILIN INHIBITOR; CYCLOSPORIN A; LIGAND; MOLECULAR SCAFFOLD; N (3 CHLORO 1,4 DIOXO 1,4 DIHYDRO 2 NAPHTHALENYL) N CYCLOHEXYLACETAMIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DEUTERIUM HYDROGEN EXCHANGE; DIAGNOSTIC IMAGING; FALSE NEGATIVE RESULT; FALSE POSITIVE RESULT; GENE OVEREXPRESSION; HIGH THROUGHPUT SCREENING; INHIBITION KINETICS; LIGAND BINDING; LUNG CANCER; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR LIBRARY; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION;

CYCLOPHILIN A; DEUTERIUM EXCHANGE MEASUREMENT; DRUG DISCOVERY; HUMANS; LIGANDS; MASS SPECTROMETRY; SMALL MOLECULE LIBRARIES;

EID: 78650097593     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057110382775     Document Type: Article

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