메뉴 건너뛰기




Volumn 31, Issue 1, 2011, Pages 22-35

Clinical and molecular insights into the hepatocellular carcinoma tumour marker des-γ-carboxyprothrombin

Author keywords

Angiogenesis; Cancer cell growth; Des carboxyprothrombin; Diagnosis; Drug discovery; Hepatocellular carcinoma; Prognosis; Tumor marker

Indexed keywords

ALPHA FETOPROTEIN; DECARBOXYPROTHROMBIN; FARNOQUINONE; TUMOR MARKER;

EID: 78650088633     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2010.02348.x     Document Type: Review
Times cited : (102)

References (104)
  • 1
    • 0037698789 scopus 로고    scopus 로고
    • Des-gamma carboxyprothrombin can differentiate hepatocellular carcinoma from nonmalignant chronic liver disease in American patients
    • Marrero JA, Su GL, Wei W, et al. Des-gamma carboxyprothrombin can differentiate hepatocellular carcinoma from nonmalignant chronic liver disease in American patients. Hepatology 2003; 37: 1114-21.
    • (2003) Hepatology , vol.37 , pp. 1114-21
    • Marrero, J.A.1    Su, G.L.2    Wei, W.3
  • 2
    • 30644467109 scopus 로고    scopus 로고
    • Usefulness of serum des-gamma-carboxy prothrombin in detection of hepatocellular carcinoma
    • Wang CS, Lin CL, Lee HC, et al. Usefulness of serum des-gamma-carboxy prothrombin in detection of hepatocellular carcinoma. World J Gastroenterol 2005; 11: 6115-9.
    • (2005) World J Gastroenterol , vol.11 , pp. 6115-9
    • Wang, C.S.1    Lin, C.L.2    Lee, H.C.3
  • 3
    • 37149003890 scopus 로고    scopus 로고
    • PIVKA-II is a useful tumor marker for recurrent hepatocellular carcinoma after surgical resection
    • Kim do Y, Paik YH, Ahn SH, et al. PIVKA-II is a useful tumor marker for recurrent hepatocellular carcinoma after surgical resection. Oncology 2007; 72: 52-7.
    • (2007) Oncology , vol.72 , pp. 52-7
    • Kim do, Y.1    Paik, Y.H.2    Ahn, S.H.3
  • 4
    • 0017275076 scopus 로고
    • Prothrombin
    • Mann KG. Prothrombin. Methods Enzymol 1976; 45: 123-56.
    • (1976) Methods Enzymol , vol.45 , pp. 123-56
    • Mann, K.G.1
  • 5
    • 0021891883 scopus 로고
    • Vitamin K-dependent carboxylase
    • Suttie JW. Vitamin K-dependent carboxylase. Annu Rev Biochem 1985; 54: 459-77.
    • (1985) Annu Rev Biochem , vol.54 , pp. 459-77
    • Suttie, J.W.1
  • 6
    • 0025272678 scopus 로고
    • Molecular basis of vitamin K-dependent gamma-carboxylation
    • Furie B, Furie BC. Molecular basis of vitamin K-dependent gamma-carboxylation. Blood 1990; 75: 1753-62.
    • (1990) Blood , vol.75 , pp. 1753-62
    • Furie, B.1    Furie, B.C.2
  • 7
    • 0037165762 scopus 로고    scopus 로고
    • Gamma-carboxyglutamic acid content of hepatocellular carcinoma-associated des-gamma-carboxy prothrombin
    • Naraki T, Kohno N, Saito H, et al. Gamma-carboxyglutamic acid content of hepatocellular carcinoma-associated des-gamma-carboxy prothrombin. Biochim Biophys Acta 2002; 1586: 287-98.
    • (2002) Biochim Biophys Acta , vol.1586 , pp. 287-98
    • Naraki, T.1    Kohno, N.2    Saito, H.3
  • 8
    • 0023124431 scopus 로고
    • Abnormal prothrombin in the plasma of rats carrying hepatic tumors
    • Shah DV, Engelke JA, Suttie JW. Abnormal prothrombin in the plasma of rats carrying hepatic tumors. Blood 1987; 69: 850-4.
    • (1987) Blood , vol.69 , pp. 850-4
    • Shah, D.V.1    Engelke, J.A.2    Suttie, J.W.3
  • 9
    • 0027299491 scopus 로고
    • Vitamin K-dependent carboxylase activity, prothrombin mRNA, and prothrombin production in two cultured rat hepatoma cell lines
    • Shah DV, Zhang P, Engelke JA, Bach AU, Suttie JW. Vitamin K-dependent carboxylase activity, prothrombin mRNA, and prothrombin production in two cultured rat hepatoma cell lines. Thromb Res 1993; 70: 365-73.
    • (1993) Thromb Res , vol.70 , pp. 365-73
    • Shah, D.V.1    Zhang, P.2    Engelke, J.A.3    Bach, A.U.4    Suttie, J.W.5
  • 10
    • 51249109057 scopus 로고    scopus 로고
    • Exon 2 deletion splice variant of gamma-glutamyl carboxylase causes des-gamma-carboxy prothrombin production in hepatocellular carcinoma cell lines
    • Ueda N, Shiraha H, Fujikawa T, et al. Exon 2 deletion splice variant of gamma-glutamyl carboxylase causes des-gamma-carboxy prothrombin production in hepatocellular carcinoma cell lines. Mol Oncol 2008; 2: 241-9.
    • (2008) Mol Oncol , vol.2 , pp. 241-9
    • Ueda, N.1    Shiraha, H.2    Fujikawa, T.3
  • 11
    • 0023243522 scopus 로고
    • Production of abnormal prothrombin (des-gamma-carboxy prothrombin) by hepatocellular carcinoma. A clinical and experimental study
    • Okuda H, Obata H, Nakanishi T, Furukawa R, Hashimoto E. Production of abnormal prothrombin (des-gamma-carboxy prothrombin) by hepatocellular carcinoma. A clinical and experimental study. J Hepatol 1987; 4: 357-63.
    • (1987) J Hepatol , vol.4 , pp. 357-63
    • Okuda, H.1    Obata, H.2    Nakanishi, T.3    Furukawa, R.4    Hashimoto, E.5
  • 12
    • 0025853695 scopus 로고
    • The effects of vitamin K on the generation of des-gamma-carboxy prothrombin (PIVKA-II) in patients with hepatocellular carcinoma
    • Sakon M, Monden M, Gotoh M, et al. The effects of vitamin K on the generation of des-gamma-carboxy prothrombin (PIVKA-II) in patients with hepatocellular carcinoma. Am J Gastroenterol 1991; 86: 339-45.
    • (1991) Am J Gastroenterol , vol.86 , pp. 339-45
    • Sakon, M.1    Monden, M.2    Gotoh, M.3
  • 14
    • 70449579247 scopus 로고    scopus 로고
    • Cytoskeletal changes during epithelial-to-fibroblastoid conversion as a crucial mechanism of des-gamma-carboxy prothrombin production in hepatocellular carcinoma
    • Murata K, Suzuki H, Okano H, et al. Cytoskeletal changes during epithelial-to-fibroblastoid conversion as a crucial mechanism of des-gamma-carboxy prothrombin production in hepatocellular carcinoma. Int J Oncol 2009; 35: 1005-14.
    • (2009) Int J Oncol , vol.35 , pp. 1005-14
    • Murata, K.1    Suzuki, H.2    Okano, H.3
  • 15
    • 74549217434 scopus 로고    scopus 로고
    • Hypoxia-induced des-gamma-carboxy prothrombin production in hepatocellular carcinoma
    • Murata K, Suzuki H, Okano H, et al. Hypoxia-induced des-gamma-carboxy prothrombin production in hepatocellular carcinoma. Int J Oncol 2010; 36: 161-70.
    • (2010) Int J Oncol , vol.36 , pp. 161-70
    • Murata, K.1    Suzuki, H.2    Okano, H.3
  • 17
    • 0028925322 scopus 로고
    • Levels of vitamin K, immunoreactive prothrombin, des-gamma-carboxy prothrombin and gamma-glutamyl carboxylase activity in hepatocellular carcinoma tissue
    • Yamagata H, Nakanishi T, Furukawa M, Okuda H, Obata H. Levels of vitamin K, immunoreactive prothrombin, des-gamma-carboxy prothrombin and gamma-glutamyl carboxylase activity in hepatocellular carcinoma tissue. J Gastroenterol Hepatol 1995; 10: 8-13.
    • (1995) J Gastroenterol Hepatol , vol.10 , pp. 8-13
    • Yamagata, H.1    Nakanishi, T.2    Furukawa, M.3    Okuda, H.4    Obata, H.5
  • 18
    • 0021273094 scopus 로고
    • Des-gamma-carboxy (abnormal) prothrombin as a serum marker of primary hepatocellular carcinoma
    • Liebman HA, Furie BC, Tong MJ, et al. Des-gamma-carboxy (abnormal) prothrombin as a serum marker of primary hepatocellular carcinoma. N Engl J Med 1984; 310: 1427-31.
    • (1984) N Engl J Med , vol.310 , pp. 1427-31
    • Liebman, H.A.1    Furie, B.C.2    Tong, M.J.3
  • 19
    • 0023882166 scopus 로고
    • Plasma abnormal prothrombin (des-gamma-carboxy prothrombin) as a marker of hepatocellular carcinoma
    • Fujiyama S, Morishita T, Hashiguchi O, Sato T. Plasma abnormal prothrombin (des-gamma-carboxy prothrombin) as a marker of hepatocellular carcinoma. Cancer 1988; 61: 1621-8.
    • (1988) Cancer , vol.61 , pp. 1621-8
    • Fujiyama, S.1    Morishita, T.2    Hashiguchi, O.3    Sato, T.4
  • 20
    • 0009641250 scopus 로고    scopus 로고
    • Clinical evaluation of PIVKA-II kit (ED-036)
    • Suzuki H, Akahane Y, Tanaka M, et al. Clinical evaluation of PIVKA-II kit (ED-036). Kan Tan Sui 1996; 33: 1069-76.
    • (1996) Kan Tan Sui , vol.33 , pp. 1069-76
    • Suzuki, H.1    Akahane, Y.2    Tanaka, M.3
  • 21
    • 0009641251 scopus 로고    scopus 로고
    • Development and performance of an assay kit for PIVKA-II (ED-038) by ECL technique
    • Takatsu K, Nakanishi T, Watanabe K, et al. Development and performance of an assay kit for PIVKA-II (ED-038) by ECL technique. Jpn J Clin Exp Med 1996; 73: 2656-64.
    • (1996) Jpn J Clin Exp Med , vol.73 , pp. 2656-64
    • Takatsu, K.1    Nakanishi, T.2    Watanabe, K.3
  • 22
    • 0032080912 scopus 로고    scopus 로고
    • The usefulness of determining des-gamma-carboxy prothrombin by sensitive enzyme immunoassay in the early diagnosis of patients with hepatocellular carcinoma
    • Mita Y, Aoyagi Y, Yanagi M, et al. The usefulness of determining des-gamma-carboxy prothrombin by sensitive enzyme immunoassay in the early diagnosis of patients with hepatocellular carcinoma. Cancer 1998; 82: 1643-8.
    • (1998) Cancer , vol.82 , pp. 1643-8
    • Mita, Y.1    Aoyagi, Y.2    Yanagi, M.3
  • 23
    • 0033048769 scopus 로고    scopus 로고
    • Serum des-gamma-carboxy prothrombin levels determined by a new generation of sensitive immunoassays in patients with small-sized hepatocellular carcinoma
    • Nomura F, Ishijima M, Kuwa K, et al. Serum des-gamma-carboxy prothrombin levels determined by a new generation of sensitive immunoassays in patients with small-sized hepatocellular carcinoma. Am J Gastroenterol 1999; 94: 650-4.
    • (1999) Am J Gastroenterol , vol.94 , pp. 650-4
    • Nomura, F.1    Ishijima, M.2    Kuwa, K.3
  • 24
    • 0033457907 scopus 로고    scopus 로고
    • Clinical utility of simultaneous measurement of serum high-sensitivity des-gamma-carboxy prothrombin and Lens culinaris agglutinin A-reactive alpha-fetoprotein in patients with small hepatocellular carcinoma
    • Sassa T, Kumada T, Nakano S, Uematsu T. Clinical utility of simultaneous measurement of serum high-sensitivity des-gamma-carboxy prothrombin and Lens culinaris agglutinin A-reactive alpha-fetoprotein in patients with small hepatocellular carcinoma. Eur J Gastroenterol Hepatol 1999; 11: 1387-92.
    • (1999) Eur J Gastroenterol Hepatol , vol.11 , pp. 1387-92
    • Sassa, T.1    Kumada, T.2    Nakano, S.3    Uematsu, T.4
  • 25
    • 0031736039 scopus 로고    scopus 로고
    • Serum des-gamma-carboxyprothrombin level by a modified enzyme immunoassay method in hepatocellular carcinoma
    • Hepatogastroenterology
    • Soga K, Watanabe T, Aikawa K, et al. Serum des-gamma-carboxyprothrombin level by a modified enzyme immunoassay method in hepatocellular carcinoma: clinical significance in small hepatocellular carcinoma. Hepatogastroenterology 1998; 45: 1737-41.
    • (1998) clinical significance in small hepatocellular carcinoma , vol.45 , pp. 1737-41
    • Soga, K.1    Watanabe, T.2    Aikawa, K.3
  • 26
    • 0036215258 scopus 로고    scopus 로고
    • Early diagnosis of hepatocellular carcinoma using a sensitive assay for serum des-gamma-carboxy prothrombin
    • Hepatogastroenterology
    • Ikoma J, Kaito M, Ishihara T, et al. Early diagnosis of hepatocellular carcinoma using a sensitive assay for serum des-gamma-carboxy prothrombin: a prospective study. Hepatogastroenterology 2002; 49: 235-8.
    • (2002) a prospective study , vol.49 , pp. 235-8
    • Ikoma, J.1    Kaito, M.2    Ishihara, T.3
  • 27
    • 0030863067 scopus 로고    scopus 로고
    • Usefulness of ED036 kit for measuring serum PIVKA-II levels in small hepatocellular carcinoma
    • Kuromatsu R, Tanaka M, Shimauchi Y, et al. Usefulness of ED036 kit for measuring serum PIVKA-II levels in small hepatocellular carcinoma. J Gastroenterol 1997; 32: 507-12.
    • (1997) J Gastroenterol , vol.32 , pp. 507-12
    • Kuromatsu, R.1    Tanaka, M.2    Shimauchi, Y.3
  • 28
    • 0033557988 scopus 로고    scopus 로고
    • Measurement of serum levels of des-gamma-carboxy prothrombin in patients with hepatocellular carcinoma by a revised enzyme immunoassay kit with increased sensitivity
    • Okuda H, Nakanishi T, Takatsu K, et al. Measurement of serum levels of des-gamma-carboxy prothrombin in patients with hepatocellular carcinoma by a revised enzyme immunoassay kit with increased sensitivity. Cancer 1999; 85: 812-8.
    • (1999) Cancer , vol.85 , pp. 812-8
    • Okuda, H.1    Nakanishi, T.2    Takatsu, K.3
  • 29
    • 0032830462 scopus 로고    scopus 로고
    • Sensitive measurement of serum abnormal prothrombin (PIVKA-II) as a marker of hepatocellular carcinoma
    • Tanaka Y, Kashiwagi T, Tsutsumi H, et al. Sensitive measurement of serum abnormal prothrombin (PIVKA-II) as a marker of hepatocellular carcinoma. Hepatogastroenterology 1999; 46: 2464-8.
    • (1999) Hepatogastroenterology , vol.46 , pp. 2464-8
    • Tanaka, Y.1    Kashiwagi, T.2    Tsutsumi, H.3
  • 30
    • 0038236531 scopus 로고    scopus 로고
    • Diagnostic value of protein induced by vitamin K absence (PIVKAII) and hepatoma-specific band of serum gamma-glutamyl transferase (GGTII) as hepatocellular carcinoma markers complementary to alpha-fetoprotein
    • Cui R, He J, Zhang F, et al. Diagnostic value of protein induced by vitamin K absence (PIVKAII) and hepatoma-specific band of serum gamma-glutamyl transferase (GGTII) as hepatocellular carcinoma markers complementary to alpha-fetoprotein. Br J Cancer 2003; 88: 1878-82.
    • (2003) Br J Cancer , vol.88 , pp. 1878-82
    • Cui, R.1    He, J.2    Zhang, F.3
  • 31
    • 0034033231 scopus 로고    scopus 로고
    • Simultaneous measurements of serum alpha-fetoprotein and protein induced by vitamin K absence for detecting hepatocellular carcinoma. South Tohoku district study group
    • Ishii M, Gama H, Chida N, et al. Simultaneous measurements of serum alpha-fetoprotein and protein induced by vitamin K absence for detecting hepatocellular carcinoma. South Tohoku district study group. Am J Gastroenterol 2000; 95: 1036-40.
    • (2000) Am J Gastroenterol , vol.95 , pp. 1036-40
    • Ishii, M.1    Gama, H.2    Chida, N.3
  • 32
    • 51849127949 scopus 로고    scopus 로고
    • Des-gamma-carboxyprothrombin, alpha-fetoprotein and AFP-L3 in patients with chronic hepatitis, cirrhosis and hepatocellular carcinoma
    • Durazo FA, Blatt LM, Corey WG, et al. Des-gamma-carboxyprothrombin, alpha-fetoprotein and AFP-L3 in patients with chronic hepatitis, cirrhosis and hepatocellular carcinoma. J Gastroenterol Hepatol 2008; 23: 1541-8.
    • (2008) J Gastroenterol Hepatol , vol.23 , pp. 1541-8
    • Durazo, F.A.1    Blatt, L.M.2    Corey, W.G.3
  • 33
    • 0032781041 scopus 로고    scopus 로고
    • Use of serum PIVKA-II (DCP) determination for differentiation between benign and malignant liver diseases
    • Lamerz R, Runge M, Stieber P, Meissner E. Use of serum PIVKA-II (DCP) determination for differentiation between benign and malignant liver diseases. Anticancer Res 1999; 19: 2489-93.
    • (1999) Anticancer Res , vol.19 , pp. 2489-93
    • Lamerz, R.1    Runge, M.2    Stieber, P.3    Meissner, E.4
  • 34
    • 0025342730 scopus 로고
    • Plasma des-gamma-carboxyprothrombin in the early stage of hepatocellular carcinoma
    • Tsai SL, Huang GT, Yang PM, et al. Plasma des-gamma-carboxyprothrombin in the early stage of hepatocellular carcinoma. Hepatology 1990; 11: 481-8.
    • (1990) Hepatology , vol.11 , pp. 481-8
    • Tsai, S.L.1    Huang, G.T.2    Yang, P.M.3
  • 35
    • 0026082855 scopus 로고
    • Clinical evaluation of plasma abnormal prothrombin (des-gamma-carboxy prothrombin) in hepatobiliary malignancies and other diseases
    • Nakao A, Suzuki Y, Isshiki K, et al. Clinical evaluation of plasma abnormal prothrombin (des-gamma-carboxy prothrombin) in hepatobiliary malignancies and other diseases. Am J Gastroenterol 1991; 86: 62-6.
    • (1991) Am J Gastroenterol , vol.86 , pp. 62-6
    • Nakao, A.1    Suzuki, Y.2    Isshiki, K.3
  • 36
    • 0027130291 scopus 로고
    • Clinical evaluation of plasma des-gamma-carboxy prothrombin as a marker protein of hepatocellular carcinoma in patients with tumors of various sizes
    • Kasahara A, Hayashi N, Fusamoto H, et al. Clinical evaluation of plasma des-gamma-carboxy prothrombin as a marker protein of hepatocellular carcinoma in patients with tumors of various sizes. Dig Dis Sci 1993; 38: 2170-6.
    • (1993) Dig Dis Sci , vol.38 , pp. 2170-6
    • Kasahara, A.1    Hayashi, N.2    Fusamoto, H.3
  • 37
    • 0029099151 scopus 로고
    • A clinical study of lectin-reactive alpha-fetoprotein as an early indicator of hepatocellular carcinoma in the follow-up of cirrhotic patients
    • Shiraki K, Takase K, Tameda Y, et al. A clinical study of lectin-reactive alpha-fetoprotein as an early indicator of hepatocellular carcinoma in the follow-up of cirrhotic patients. Hepatology 1995; 22: 802-7.
    • (1995) Hepatology , vol.22 , pp. 802-7
    • Shiraki, K.1    Takase, K.2    Tameda, Y.3
  • 38
    • 0028291568 scopus 로고
    • Protein induced by vitamin K absence or antagonist II as a prognostic marker in hepatocellular carcinoma. Comparison with alpha-fetoprotein
    • Suehiro T, Sugimachi K, Matsumata T, et al. Protein induced by vitamin K absence or antagonist II as a prognostic marker in hepatocellular carcinoma. Comparison with alpha-fetoprotein. Cancer 1994; 73: 2464-71.
    • (1994) Cancer , vol.73 , pp. 2464-71
    • Suehiro, T.1    Sugimachi, K.2    Matsumata, T.3
  • 39
    • 67649305155 scopus 로고    scopus 로고
    • Alpha-fetoprotein, des-gamma carboxyprothrombin, and lectin-bound alpha-fetoprotein in early hepatocellular carcinoma
    • Marrero JA, Feng Z, Wang Y, et al. Alpha-fetoprotein, des-gamma carboxyprothrombin, and lectin-bound alpha-fetoprotein in early hepatocellular carcinoma. Gastroenterology 2009; 137: 110-8.
    • (2009) Gastroenterology , vol.137 , pp. 110-8
    • Marrero, J.A.1    Feng, Z.2    Wang, Y.3
  • 40
    • 48549106668 scopus 로고    scopus 로고
    • AFP, PIVKAII, GP3, SCCA-1 and follisatin as surveillance biomarkers for hepatocellular cancer in non-alcoholic and alcoholic fatty liver disease
    • Beale G, Chattopadhyay D, Gray J, et al. AFP, PIVKAII, GP3, SCCA-1 and follisatin as surveillance biomarkers for hepatocellular cancer in non-alcoholic and alcoholic fatty liver disease. BMC Cancer 2008; 8: 200-7.
    • (2008) BMC Cancer , vol.8 , pp. 200-7
    • Beale, G.1    Chattopadhyay, D.2    Gray, J.3
  • 41
    • 0024803386 scopus 로고
    • Evaluation of des-gamma-carboxy prothrombin as a marker protein of hepatocellular carcinoma
    • Deyashiki Y, Nishioka Y, Takahashi K, Kosaka Y, Suzuki K. Evaluation of des-gamma-carboxy prothrombin as a marker protein of hepatocellular carcinoma. Cancer 1989; 64: 2546-51.
    • (1989) Cancer , vol.64 , pp. 2546-51
    • Deyashiki, Y.1    Nishioka, Y.2    Takahashi, K.3    Kosaka, Y.4    Suzuki, K.5
  • 42
    • 0024217002 scopus 로고
    • Plasma abnormal prothrombin levels in patients with small hepatocellular carcinoma
    • Tanabe Y, Ohnishi K, Nomura F, Iida S. Plasma abnormal prothrombin levels in patients with small hepatocellular carcinoma. Am J Gastroenterol 1988; 83: 1386-9.
    • (1988) Am J Gastroenterol , vol.83 , pp. 1386-9
    • Tanabe, Y.1    Ohnishi, K.2    Nomura, F.3    Iida, S.4
  • 44
    • 0034146463 scopus 로고    scopus 로고
    • A simultaneous monitoring of Lens culinaris agglutinin A-reactive alpha-fetoprotein and des-gamma-carboxy prothrombin as an early diagnosis of hepatocellular carcinoma in the follow-up of cirrhotic patients
    • Shimauchi Y, Tanaka M, Kuromatsu R, et al. A simultaneous monitoring of Lens culinaris agglutinin A-reactive alpha-fetoprotein and des-gamma-carboxy prothrombin as an early diagnosis of hepatocellular carcinoma in the follow-up of cirrhotic patients. Oncol Rep 2000; 7: 249-56.
    • (2000) Oncol Rep , vol.7 , pp. 249-56
    • Shimauchi, Y.1    Tanaka, M.2    Kuromatsu, R.3
  • 45
    • 0028037521 scopus 로고
    • Serum des-gamma-carboxyprothrombin concentration determined by the avidin-biotin complex method in small hepatocellular carcinomas
    • Saitoh S, Ikeda K, Koida I, et al. Serum des-gamma-carboxyprothrombin concentration determined by the avidin-biotin complex method in small hepatocellular carcinomas. Cancer 1994; 74: 2918-23.
    • (1994) Cancer , vol.74 , pp. 2918-23
    • Saitoh, S.1    Ikeda, K.2    Koida, I.3
  • 46
    • 79960702622 scopus 로고    scopus 로고
    • The Japan society of hepatology 2009 update
    • Clinical Practice Guidelines for Hepatocellular Carcinoma.
    • Clinical Practice Guidelines for Hepatocellular Carcinoma. The Japan society of hepatology 2009 update. Hepatol Res 2010; 40 (Suppl. 1): 2-144.
    • (2010) Hepatol Res , vol.40 , Issue.SUPPL. 1 , pp. 2-144
  • 47
    • 73349113221 scopus 로고    scopus 로고
    • Significance of alpha-fetoprotein and des-gamma-carboxy prothrombin in patients with hepatocellular carcinoma undergoing hepatectomy
    • Yamamoto K, Imamura H, Matsuyama Y, et al. Significance of alpha-fetoprotein and des-gamma-carboxy prothrombin in patients with hepatocellular carcinoma undergoing hepatectomy. Ann Surg Oncol 2009; 16: 2795-804.
    • (2009) Ann Surg Oncol , vol.16 , pp. 2795-804
    • Yamamoto, K.1    Imamura, H.2    Matsuyama, Y.3
  • 48
    • 40149087561 scopus 로고    scopus 로고
    • Intrahepatic distant recurrence after radiofrequency ablation for a single small hepatocellular carcinoma
    • J Gastroenterol
    • Okuwaki Y, Nakazawa T, Shibuya A, et al. Intrahepatic distant recurrence after radiofrequency ablation for a single small hepatocellular carcinoma: risk factors and patterns. J Gastroenterol 2008; 43: 71-8.
    • (2008) risk factors and patterns , vol.43 , pp. 71-8
    • Okuwaki, Y.1    Nakazawa, T.2    Shibuya, A.3
  • 49
    • 0038546404 scopus 로고    scopus 로고
    • Des-gamma-carboxy prothrombin (DCP) ratio, a novel parameter measured by monoclonal antibodies MU-3 and 19B7, as a new prognostic indicator for hepatocellular carcinoma
    • Sugimoto H, Takeda S, Inoue S, et al. Des-gamma-carboxy prothrombin (DCP) ratio, a novel parameter measured by monoclonal antibodies MU-3 and 19B7, as a new prognostic indicator for hepatocellular carcinoma. Liver Int 2003; 23: 38-44.
    • (2003) Liver Int , vol.23 , pp. 38-44
    • Sugimoto, H.1    Takeda, S.2    Inoue, S.3
  • 50
    • 41549107119 scopus 로고    scopus 로고
    • Des-gamma-carboxy prothrombin (DCP) ratio is a useful prognostic tumor marker for single nodule hepatocellular carcinoma (HCC)
    • Murakami N, Tamano M, Yoneda M, Sugaya H, Hiraishi H. Des-gamma-carboxy prothrombin (DCP) ratio is a useful prognostic tumor marker for single nodule hepatocellular carcinoma (HCC). Hepatogastroenterology 2008; 55: 197-201.
    • (2008) Hepatogastroenterology , vol.55 , pp. 197-201
    • Murakami, N.1    Tamano, M.2    Yoneda, M.3    Sugaya, H.4    Hiraishi, H.5
  • 51
    • 41149128806 scopus 로고    scopus 로고
    • Des-gamma-carboxy prothrombin as an important prognostic indicator in patients with small hepatocellular carcinoma
    • Hakamada K, Kimura N, Miura T, et al. Des-gamma-carboxy prothrombin as an important prognostic indicator in patients with small hepatocellular carcinoma. World J Gastroenterol 2008; 14: 1370-7.
    • (2008) World J Gastroenterol , vol.14 , pp. 1370-7
    • Hakamada, K.1    Kimura, N.2    Miura, T.3
  • 52
    • 0347525816 scopus 로고    scopus 로고
    • Studies on the correlation among the fucosylation index, concentration of alpha-fetoprotein and des-gamma-carboxy prothrombin as prognostic indicators in hepatocellular carcinoma
    • Igarashi H, Aoyagi Y, Suda T, Mita Y, Kawai K. Studies on the correlation among the fucosylation index, concentration of alpha-fetoprotein and des-gamma-carboxy prothrombin as prognostic indicators in hepatocellular carcinoma. Hepatol Res 2003; 27: 280-8.
    • (2003) Hepatol Res , vol.27 , pp. 280-8
    • Igarashi, H.1    Aoyagi, Y.2    Suda, T.3    Mita, Y.4    Kawai, K.5
  • 53
    • 0027939329 scopus 로고
    • Clinical significance of abnormal prothrombin (DCP) in relation to postoperative survival and prognosis in patients with hepatocellular carcinoma
    • Inoue S, Nakao A, Harada A, Nonami T, Takagi H. Clinical significance of abnormal prothrombin (DCP) in relation to postoperative survival and prognosis in patients with hepatocellular carcinoma. Am J Gastroenterol 1994; 89: 2222-6.
    • (1994) Am J Gastroenterol , vol.89 , pp. 2222-6
    • Inoue, S.1    Nakao, A.2    Harada, A.3    Nonami, T.4    Takagi, H.5
  • 54
    • 58149091328 scopus 로고    scopus 로고
    • PIVKA-II is the best prognostic predictor in patients with hepatocellular carcinoma after radiofrequency ablation therapy
    • Takahashi S, Kudo M, Chung H, et al. PIVKA-II is the best prognostic predictor in patients with hepatocellular carcinoma after radiofrequency ablation therapy. Oncology 2008; 75 (Suppl. 1): 91-8.
    • (2008) Oncology , vol.75 , Issue.SUPPL. 1 , pp. 91-8
    • Takahashi, S.1    Kudo, M.2    Chung, H.3
  • 55
    • 46149115142 scopus 로고    scopus 로고
    • Prognostic value of pretreatment levels of tumor markers for hepatocellular carcinoma on survival after curative treatment of patients with HCC
    • Toyoda H, Kumada T, Kaneoka Y, et al. Prognostic value of pretreatment levels of tumor markers for hepatocellular carcinoma on survival after curative treatment of patients with HCC. J Hepatol 2008; 49: 223-32.
    • (2008) J Hepatol , vol.49 , pp. 223-32
    • Toyoda, H.1    Kumada, T.2    Kaneoka, Y.3
  • 56
    • 60049099362 scopus 로고    scopus 로고
    • High serum des-gamma-carboxy prothrombin level predicts poor prognosis after radiofrequency ablation of hepatocellular carcinoma
    • Kobayashi M, Ikeda K, Kawamura Y, et al. High serum des-gamma-carboxy prothrombin level predicts poor prognosis after radiofrequency ablation of hepatocellular carcinoma. Cancer 2009; 115: 571-80.
    • (2009) Cancer , vol.115 , pp. 571-80
    • Kobayashi, M.1    Ikeda, K.2    Kawamura, Y.3
  • 58
    • 65649113571 scopus 로고    scopus 로고
    • Impact of des-gamma-carboxy prothrombin and tumor size on the recurrence of hepatocellular carcinoma after living donor liver transplantation
    • Taketomi A, Sanefuji K, Soejima Y, et al. Impact of des-gamma-carboxy prothrombin and tumor size on the recurrence of hepatocellular carcinoma after living donor liver transplantation. Transplantation 2009; 87: 531-7.
    • (2009) Transplantation , vol.87 , pp. 531-7
    • Taketomi, A.1    Sanefuji, K.2    Soejima, Y.3
  • 59
    • 70349213817 scopus 로고    scopus 로고
    • Significance of des-gamma-carboxy prothrombin in selection criteria for living donor liver transplantation for hepatocellular carcinoma
    • Fujiki M, Takada Y, Ogura Y, et al. Significance of des-gamma-carboxy prothrombin in selection criteria for living donor liver transplantation for hepatocellular carcinoma. Am J Transplant 2009; 9: 2362-71.
    • (2009) Am J Transplant , vol.9 , pp. 2362-71
    • Fujiki, M.1    Takada, Y.2    Ogura, Y.3
  • 60
    • 67651097586 scopus 로고    scopus 로고
    • Prognostic values of alpha-fetoprotein and protein induced by vitamin K absence or antagonist-II in hepatitis B virus-related hepatocellular carcinoma
    • J Clin Gastroenterol
    • Kim HS, Park JW, Jang JS, et al. Prognostic values of alpha-fetoprotein and protein induced by vitamin K absence or antagonist-II in hepatitis B virus-related hepatocellular carcinoma: a prospective study. J Clin Gastroenterol 2009; 43: 482-8.
    • (2009) a prospective study , vol.43 , pp. 482-8
    • Kim, H.S.1    Park, J.W.2    Jang, J.S.3
  • 61
    • 0035253469 scopus 로고    scopus 로고
    • Des-gamma-carboxy prothrombin as a useful predisposing factor for the development of portal venous invasion in patients with hepatocellular carcinoma
    • Cancer
    • Koike Y, Shiratori Y, Sato S, et al. Des-gamma-carboxy prothrombin as a useful predisposing factor for the development of portal venous invasion in patients with hepatocellular carcinoma: a prospective analysis of 227 patients. Cancer 2001; 91: 561-9.
    • (2001) a prospective analysis of 227 patients , vol.91 , pp. 561-9
    • Koike, Y.1    Shiratori, Y.2    Sato, S.3
  • 62
    • 33947575209 scopus 로고    scopus 로고
    • Prognostic factors for portal venous invasion in patients with hepatocellular carcinoma
    • Hagiwara S, Kudo M, Kawasaki T, et al. Prognostic factors for portal venous invasion in patients with hepatocellular carcinoma. J Gastroenterol 2006; 41: 1214-9.
    • (2006) J Gastroenterol , vol.41 , pp. 1214-9
    • Hagiwara, S.1    Kudo, M.2    Kawasaki, T.3
  • 63
    • 33847209203 scopus 로고    scopus 로고
    • The predictors of microvascular invasion in candidates for liver transplantation with hepatocellular carcinoma-with special reference to the serum levels of des-gamma-carboxy prothrombin
    • Shirabe K, Itoh S, Yoshizumi T, et al. The predictors of microvascular invasion in candidates for liver transplantation with hepatocellular carcinoma-with special reference to the serum levels of des-gamma-carboxy prothrombin. J Surg Oncol 2007; 95: 235-40.
    • (2007) J Surg Oncol , vol.95 , pp. 235-40
    • Shirabe, K.1    Itoh, S.2    Yoshizumi, T.3
  • 64
    • 0033953406 scopus 로고    scopus 로고
    • Prospective analysis of risk factors for early intrahepatic recurrence of hepatocellular carcinoma following ethanol injection
    • Khan KN, Yatsuhashi H, Yamasaki K, et al. Prospective analysis of risk factors for early intrahepatic recurrence of hepatocellular carcinoma following ethanol injection. J Hepatol 2000; 32: 269-78.
    • (2000) J Hepatol , vol.32 , pp. 269-78
    • Khan, K.N.1    Yatsuhashi, H.2    Yamasaki, K.3
  • 65
    • 0029073320 scopus 로고
    • Des-gamma-carboxy prothrombin and proliferative activity of hepatocellular carcinoma
    • Suehiro T, Matsumata T, Itasaka H, et al. Des-gamma-carboxy prothrombin and proliferative activity of hepatocellular carcinoma. Surgery 1995; 117: 682-91.
    • (1995) Surgery , vol.117 , pp. 682-91
    • Suehiro, T.1    Matsumata, T.2    Itasaka, H.3
  • 66
    • 0032784523 scopus 로고    scopus 로고
    • Prognostic significance of anatomical resection and des-gamma-carboxy prothrombin in patients with hepatocellular carcinoma
    • Imamura H, Matsuyama Y, Miyagawa Y, et al. Prognostic significance of anatomical resection and des-gamma-carboxy prothrombin in patients with hepatocellular carcinoma. Br J Surg 1999; 86: 1032-8.
    • (1999) Br J Surg , vol.86 , pp. 1032-8
    • Imamura, H.1    Matsuyama, Y.2    Miyagawa, Y.3
  • 67
    • 0344235194 scopus 로고    scopus 로고
    • The des-gamma-carboxy prothrombin index is a new prognostic indicator for hepatocellular carcinoma
    • Nagaoka S, Yatsuhashi H, Hamada H, et al. The des-gamma-carboxy prothrombin index is a new prognostic indicator for hepatocellular carcinoma. Cancer 2003; 98: 2671-7.
    • (2003) Cancer , vol.98 , pp. 2671-7
    • Nagaoka, S.1    Yatsuhashi, H.2    Hamada, H.3
  • 68
    • 0344961316 scopus 로고    scopus 로고
    • Clinical characteristics among patients with hepatocellular carcinoma according to the serum levels of alpha-fetoprotein and des-y-carboxy prothrombin
    • Dohmen K, Shigematsu H, Irie K, Ishibashi H. Clinical characteristics among patients with hepatocellular carcinoma according to the serum levels of alpha-fetoprotein and des-y-carboxy prothrombin. Hepatogastroenterology 2003; 50: 2072-8.
    • (2003) Hepatogastroenterology , vol.50 , pp. 2072-8
    • Dohmen, K.1    Shigematsu, H.2    Irie, K.3    Ishibashi, H.4
  • 69
    • 0029913526 scopus 로고    scopus 로고
    • Des-gamma-carboxy prothrombin and alpha-fetoprotein positive status as a new prognostic indicator after hepatic resection for hepatocellular carcinoma
    • Shimada M, Takenaka K, Fujiwara Y, et al. Des-gamma-carboxy prothrombin and alpha-fetoprotein positive status as a new prognostic indicator after hepatic resection for hepatocellular carcinoma. Cancer 1996; 78: 2094-100.
    • (1996) Cancer , vol.78 , pp. 2094-100
    • Shimada, M.1    Takenaka, K.2    Fujiwara, Y.3
  • 72
    • 31144478870 scopus 로고    scopus 로고
    • Prognostic significance of simultaneous measurement of three tumor markers in patients with hepatocellular carcinoma
    • Toyoda H, Kumada T, Kiriyama S, et al. Prognostic significance of simultaneous measurement of three tumor markers in patients with hepatocellular carcinoma. Clin Gastroenterol Hepatol 2006; 4: 111-7.
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 111-7
    • Toyoda, H.1    Kumada, T.2    Kiriyama, S.3
  • 73
  • 74
    • 0035722291 scopus 로고    scopus 로고
    • Histological study of PIVKA-II expression in hepatocellular carcinoma and adenomatous hyperplasia
    • Miskad UA, Yano Y, Nakaji M, et al. Histological study of PIVKA-II expression in hepatocellular carcinoma and adenomatous hyperplasia. Pathol Int 2001; 51: 916-22.
    • (2001) Pathol Int , vol.51 , pp. 916-22
    • Miskad, U.A.1    Yano, Y.2    Nakaji, M.3
  • 75
    • 0036256533 scopus 로고    scopus 로고
    • Serum and tissue PIVKA-II expression reflect the biological malignant potential of small hepatocellular carcinoma
    • Tamano M, Sugaya H, Oguma M, et al. Serum and tissue PIVKA-II expression reflect the biological malignant potential of small hepatocellular carcinoma. Hepatol Res 2002; 22: 261-9.
    • (2002) Hepatol Res , vol.22 , pp. 261-9
    • Tamano, M.1    Sugaya, H.2    Oguma, M.3
  • 76
    • 0041627705 scopus 로고    scopus 로고
    • Des-gamma-carboxy prothrombin in cancer and non-cancer liver tissue of patients with hepatocellular carcinoma
    • Tang W, Miki K, Kokudo N, et al. Des-gamma-carboxy prothrombin in cancer and non-cancer liver tissue of patients with hepatocellular carcinoma. Int J Oncol 2003; 22: 969-75.
    • (2003) Int J Oncol , vol.22 , pp. 969-75
    • Tang, W.1    Miki, K.2    Kokudo, N.3
  • 78
    • 49049122240 scopus 로고    scopus 로고
    • Measurement of serum and tissue des-gamma-carboxyprothrombin in resectable hepatocellular carcinoma
    • Xiang CH, Zhang W, Inagaki Y, et al. Measurement of serum and tissue des-gamma-carboxyprothrombin in resectable hepatocellular carcinoma. Anticancer Res 2008; 28: 2219-24.
    • (2008) Anticancer Res , vol.28 , pp. 2219-24
    • Xiang, C.H.1    Zhang, W.2    Inagaki, Y.3
  • 79
    • 0345299824 scopus 로고    scopus 로고
    • Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis
    • Mazzaferro V, Regalia E, Doci R, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med 1996; 334: 693-9.
    • (1996) N Engl J Med , vol.334 , pp. 693-9
    • Mazzaferro, V.1    Regalia, E.2    Doci, R.3
  • 82
    • 42449090636 scopus 로고    scopus 로고
    • Inclusion of tumor markers improves the correlation of the Milan criteria with vascular invasion and tumor cell differentiation in patients with hepatocellular carcinoma undergoing liver resection (#JGSU-D-07-00462)
    • Hasegawa K, Imamura H, Ijichi M, et al. Inclusion of tumor markers improves the correlation of the Milan criteria with vascular invasion and tumor cell differentiation in patients with hepatocellular carcinoma undergoing liver resection (#JGSU-D-07-00462). J Gastrointest Surg 2008; 12: 858-66.
    • (2008) J Gastrointest Surg , vol.12 , pp. 858-66
    • Hasegawa, K.1    Imamura, H.2    Ijichi, M.3
  • 83
    • 58149394928 scopus 로고    scopus 로고
    • The role of des-gamma-carboxyprothrombin expression in hepatocellular carcinoma
    • Harino Y, Fujii M, Imura S, et al. The role of des-gamma-carboxyprothrombin expression in hepatocellular carcinoma. Hepatogastroenterology 2008; 55: 1385-9.
    • (2008) Hepatogastroenterology , vol.55 , pp. 1385-9
    • Harino, Y.1    Fujii, M.2    Imura, S.3
  • 84
    • 0034676237 scopus 로고    scopus 로고
    • The role of des-gamma-carboxy prothrombin levels in hepatocellular carcinoma and liver tissues
    • Shimada M, Yamashita Y, Hamatsu T, et al. The role of des-gamma-carboxy prothrombin levels in hepatocellular carcinoma and liver tissues. Cancer Lett 2000; 159: 87-94.
    • (2000) Cancer Lett , vol.159 , pp. 87-94
    • Shimada, M.1    Yamashita, Y.2    Hamatsu, T.3
  • 85
    • 16544368331 scopus 로고    scopus 로고
    • Measurement of des-gamma-carboxy prothrombin levels in cancer and non-cancer tissue in patients with hepatocellular carcinoma
    • Yuan LW, Tang W, Kokudo N, et al. Measurement of des-gamma-carboxy prothrombin levels in cancer and non-cancer tissue in patients with hepatocellular carcinoma. Oncol Rep 2004; 12: 269-73.
    • (2004) Oncol Rep , vol.12 , pp. 269-73
    • Yuan, L.W.1    Tang, W.2    Kokudo, N.3
  • 86
    • 0024427178 scopus 로고
    • Molecular cloning and expression of human hepatocyte growth factor
    • Nakamura T, Nishizawa T, Hagiya M, et al. Molecular cloning and expression of human hepatocyte growth factor. Nature 1989; 342: 440-3.
    • (1989) Nature , vol.342 , pp. 440-3
    • Nakamura, T.1    Nishizawa, T.2    Hagiya, M.3
  • 87
    • 14844290900 scopus 로고    scopus 로고
    • Des-gamma-carboxy prothrombin is a potential autologous growth factor for hepatocellular carcinoma
    • Suzuki M, Shiraha H, Fujikawa T, et al. Des-gamma-carboxy prothrombin is a potential autologous growth factor for hepatocellular carcinoma. J Biol Chem 2005; 280: 6409-15.
    • (2005) J Biol Chem , vol.280 , pp. 6409-15
    • Suzuki, M.1    Shiraha, H.2    Fujikawa, T.3
  • 88
    • 54949111321 scopus 로고    scopus 로고
    • Vitamin K2 inhibits the growth of hepatocellular carcinoma via decrease of des-gamma-carboxy prothrombin
    • Ma M, Qu XJ, Mu GY, et al. Vitamin K2 inhibits the growth of hepatocellular carcinoma via decrease of des-gamma-carboxy prothrombin. Chemotherapy 2009; 55: 28-35.
    • (2009) Chemotherapy , vol.55 , pp. 28-35
    • Ma, M.1    Qu, X.J.2    Mu, G.Y.3
  • 89
    • 34247874803 scopus 로고    scopus 로고
    • Des-gamma-carboxyl prothrombin-promoted vascular endothelial cell proliferation and migration
    • Fujikawa T, Shiraha H, Ueda N, et al. Des-gamma-carboxyl prothrombin-promoted vascular endothelial cell proliferation and migration. J Biol Chem 2007; 282: 8741-8.
    • (2007) J Biol Chem , vol.282 , pp. 8741-8
    • Fujikawa, T.1    Shiraha, H.2    Ueda, N.3
  • 90
    • 67349183382 scopus 로고    scopus 로고
    • Des-gamma-carboxy prothrombin stimulates human vascular endothelial cell growth and migration
    • Wang SB, Cheng YN, Cui SX, et al. Des-gamma-carboxy prothrombin stimulates human vascular endothelial cell growth and migration. Clin Exp Metastasis 2009; 26: 469-77.
    • (2009) Clin Exp Metastasis , vol.26 , pp. 469-77
    • Wang, S.B.1    Cheng, Y.N.2    Cui, S.X.3
  • 91
    • 55749106742 scopus 로고    scopus 로고
    • Des-gamma-carboxy prothrombin increases the expression of angiogenic factors in human hepatocellular carcinoma cells
    • Gao FJ, Cui SX, Chen MH, et al. Des-gamma-carboxy prothrombin increases the expression of angiogenic factors in human hepatocellular carcinoma cells. Life Sci 2008; 83: 815-20.
    • (2008) Life Sci , vol.83 , pp. 815-20
    • Gao, F.J.1    Cui, S.X.2    Chen, M.H.3
  • 92
    • 0036534375 scopus 로고    scopus 로고
    • Tumor microvessel density as a predictor of recurrence after resection of hepatocellular carcinoma
    • J Clin Oncol
    • Poon RT, Ng IO, Lau C, et al. Tumor microvessel density as a predictor of recurrence after resection of hepatocellular carcinoma: a prospective study. J Clin Oncol 2002; 20: 1775-85.
    • (2002) a prospective study , vol.20 , pp. 1775-85
    • Poon, R.T.1    Ng, I.O.2    Lau, C.3
  • 94
    • 34447333098 scopus 로고    scopus 로고
    • Complete remission of hepatocellular carcinoma with portal vein tumor thrombus and lymph node metastases by arterial infusion of 5-fluorouracil and interferon-alpha combination therapy following hepatic resection
    • Wada H, Nagano H, Noda T, et al. Complete remission of hepatocellular carcinoma with portal vein tumor thrombus and lymph node metastases by arterial infusion of 5-fluorouracil and interferon-alpha combination therapy following hepatic resection. J Gastroenterol 2007; 42: 501-6.
    • (2007) J Gastroenterol , vol.42 , pp. 501-6
    • Wada, H.1    Nagano, H.2    Noda, T.3
  • 95
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • Llovet JM, Ricci S, Mazzaferro V, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008; 359: 378-90.
    • (2008) N Engl J Med , vol.359 , pp. 378-90
    • Llovet, J.M.1    Ricci, S.2    Mazzaferro, V.3
  • 96
    • 57749189578 scopus 로고    scopus 로고
    • Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma
    • Lancet Oncol
    • Cheng AL, Kang YK, Chen Z, et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol 2009; 10: 25-34.
    • (2009) a phase III randomised, double-blind, placebo-controlled trial , vol.10 , pp. 25-34
    • Cheng, A.L.1    Kang, Y.K.2    Chen, Z.3
  • 98
    • 32544446614 scopus 로고    scopus 로고
    • The effect of menatetrenone, a vitamin K2 analog, on disease recurrence and survival in patients with hepatocellular carcinoma after curative treatment
    • Cancer
    • Mizuta T, Ozaki I, Eguchi Y, et al. The effect of menatetrenone, a vitamin K2 analog, on disease recurrence and survival in patients with hepatocellular carcinoma after curative treatment: a pilot study. Cancer 2006; 106: 867-72.
    • (2006) a pilot study , vol.106 , pp. 867-72
    • Mizuta, T.1    Ozaki, I.2    Eguchi, Y.3
  • 99
    • 3042697863 scopus 로고    scopus 로고
    • Vitamin K2 inhibits the growth and invasiveness of hepatocellular carcinoma cells via protein kinase A activation
    • Otsuka M, Kato N, Shao RX, et al. Vitamin K2 inhibits the growth and invasiveness of hepatocellular carcinoma cells via protein kinase A activation. Hepatology 2004; 40: 243-51.
    • (2004) Hepatology , vol.40 , pp. 243-51
    • Otsuka, M.1    Kato, N.2    Shao, R.X.3
  • 100
    • 34247537075 scopus 로고    scopus 로고
    • Menatetrenone, a vitamin K2 analogue, inhibits hepatocellular carcinoma cell growth by suppressing cyclin D1 expression through inhibition of nuclear factor kappaB activation
    • Ozaki I, Zhang H, Mizuta T, et al. Menatetrenone, a vitamin K2 analogue, inhibits hepatocellular carcinoma cell growth by suppressing cyclin D1 expression through inhibition of nuclear factor kappaB activation. Clin Cancer Res 2007; 13: 2236-45.
    • (2007) Clin Cancer Res , vol.13 , pp. 2236-45
    • Ozaki, I.1    Zhang, H.2    Mizuta, T.3
  • 101
    • 60449107113 scopus 로고    scopus 로고
    • Involvement of hepatoma-derived growth factor in the growth inhibition of hepatocellular carcinoma cells by vitamin K(2)
    • Yamamoto T, Nakamura H, Liu W, et al. Involvement of hepatoma-derived growth factor in the growth inhibition of hepatocellular carcinoma cells by vitamin K(2). J Gastroenterol 2009; 44: 228-35.
    • (2009) J Gastroenterol , vol.44 , pp. 228-35
    • Yamamoto, T.1    Nakamura, H.2    Liu, W.3
  • 102
    • 37749011807 scopus 로고    scopus 로고
    • Effect of vitamin K2 on the recurrence in patients with hepatocellular carcinoma
    • Hotta N, Ayada M, Sato K, et al. Effect of vitamin K2 on the recurrence in patients with hepatocellular carcinoma. Hepatogastroenterology 2007; 54: 2073-7.
    • (2007) Hepatogastroenterology , vol.54 , pp. 2073-7
    • Hotta, N.1    Ayada, M.2    Sato, K.3
  • 103
    • 67649158636 scopus 로고    scopus 로고
    • Combination of vitamin K2 and angiotensin-converting enzyme inhibitor ameliorates cumulative recurrence of hepatocellular carcinoma
    • Yoshiji H, Noguchi R, Toyohara M, et al. Combination of vitamin K2 and angiotensin-converting enzyme inhibitor ameliorates cumulative recurrence of hepatocellular carcinoma. J Hepatol 2009; 51: 315-21.
    • (2009) J Hepatol , vol.51 , pp. 315-21
    • Yoshiji, H.1    Noguchi, R.2    Toyohara, M.3
  • 104
    • 20144389070 scopus 로고    scopus 로고
    • Combination of vitamin K2 and the angiotensin-converting enzyme inhibitor, perindopril, attenuates the liver enzyme-altered preneoplastic lesions in rats via angiogenesis suppression
    • Yoshiji H, Kuriyama S, Noguchi R, et al. Combination of vitamin K2 and the angiotensin-converting enzyme inhibitor, perindopril, attenuates the liver enzyme-altered preneoplastic lesions in rats via angiogenesis suppression. J Hepatol 2005; 42: 687-93.
    • (2005) J Hepatol , vol.42 , pp. 687-93
    • Yoshiji, H.1    Kuriyama, S.2    Noguchi, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.