Diagnostic value of protein induced by vitamin K absence (PIVKAII) and hepatoma-specific band of serum gamma-glutamyl transferase (GGTII) as hepatocellular carcinoma markers complementary to α-fetoprotein

British Journal of Cancer

Volumn 88, Issue 12, 2003, Pages 1878-1882

  Cui, R ^a,d   He, J ^b   Zhang, F ^a   Wang, B ^a   Ding, H ^c   Shen, H ^a   Li, Y ^a   Chen, X ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b LANZHOU MEDICAL COLLEGE   (China)

^c CAPITAL MEDICAL UNIVERSITY   (China)

^d INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

Author keywords

fetoprotein; Diagnosis; Hepatocellular carcinoma; Hepatoma specific band of serum gamma glutamyl transferase; Protein induced by vitamin K absence or antagonist II

Indexed keywords

ALPHA FETOPROTEIN; GAMMA GLUTAMYLTRANSFERASE; PROTEIN INDUCED BY VITAMIN K ABSENCE OR ANTAGONIST II; TUMOR MARKER; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BLOOD LEVEL; CANCER DIAGNOSIS; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST; DIAGNOSTIC VALUE; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HUMAN; HUMAN TISSUE; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

ADULT; AGED; ALPHA-FETOPROTEINS; BIOLOGICAL MARKERS; CARCINOMA, HEPATOCELLULAR; GAMMA-GLUTAMYLTRANSFERASE; HUMANS; LIVER CIRRHOSIS; LIVER NEOPLASMS; MIDDLE AGED; PROTEIN PRECURSORS; PROTHROMBIN; SENSITIVITY AND SPECIFICITY; TUMOR MARKERS, BIOLOGICAL;

EID: 0038236531     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6601018     Document Type: Article

References (29)

1. Aoyagi Y, Oguro M, Yanagi M, Mita Y, Suda T, Suzuki Y, Hata K, Ichii K, Asakura H (1996) Clinical significance of simultaneous determinations of alpha-fetoprotein and des-gamma-carboxy prothrombin in monitoring recurrence in patients with hepatocellular carcinoma. Cancer 77: 1781-1786
2. Cui R, Wang B, Ding H, Shen H, Li Y, Chen X (2002) Usefulness of determining a protein induced by vitamin K absence in detection of hepatocellular carcinoma. Chin Med J (Engl) 115: 42-45
3. Fujiyama S, Morishita T, Hashiguchi O, Sato T (1988) Plasma abnormal prothrombin (des-gamma-carboxy prothrombin) as a marker of hepatocellular carcinoma. Cancer 61: 1621-1628
4. Hattori N, Ohmizo R, Unoura M, Tanaka N, Kobayashi K (1988) PIVKA II Collaboration working group. J Tumor Marker Oncol 3: 207-216
5. Hetland O, Anderson TR, Gerner T (1975) The heterogeneity of the serum activity of γ-glutamyl transpeptidase in hepatobiliary disease as studied by agarose gel electrophoresis. Clin Chim Acta 62: 425-431
6. Hitoi A, Yamashita K, Ohkawa J, Kobata A (1984) Application of a Phaseolus vulgaris erythroagglutinating lectin agarose column for the specific detection of human hepatoma gamma-glutamyl transpeptidase in serum. Jap J of Cancer Res (Gann) 75: 301-304
7. Ishii M, Gama H, Chida N, Ueno Y, Shinzawa H, Takagi T, Toyota T, Takahashi T, Kasukawa R (2000) Simultaneous measurements of serum α-fetoprotein and protein induced by vitamin K absence for detecting hepatocellular carcinoma. Am J Gastroenterol 95: 1036-1040
8. Kew MC, Wolf P, Whittaker D, Rowe P (1984) Tumour-associated isoenzymes of gamma-glutamyl transferase in the serum of patients with hepatocellular carcinoma. Br J Cancer 50: 451-455
9. Kojima J, Kanatani M, Nakamura N, Kashiwagi T, Tohjoh F, Akiyama M (1980) Electrophoretic fractionation of serum gamma-glutamyl transpeptidase in human hepatic cancer. Clin Chim Acta 106: 165-172
10. Kokot F, Kuska M (1965) Uber die bedetum der isoenzyme der γ-glutamyl transpeptidase der klinischen diagnostik. Clin Chim Acta 11: 118-121
11. Kuromatsu R, Tanaka M, Shimauchi Y, Shimada M, Tanikawa K, Watanabe K, Yokoo T (1997) Usefulness of ED036 kit for measuring serum PIVKA II levels in small hepatocellular carcinoma. J Gastroenterol 32: 507-512
12. Liebman H, Furie BC, Tong MJ, Blanchard RA, Lo K-J, Lee S-D, Coleman MS, Furie B (1984) Des-gamma-carboxy prothrombin (abnormal) prothrombin as a serum marker of primary hepatocellular carcinoma. N Engl J Med 310: 1427-1431
13. Mita Y, Aoyagi Y, Yanagi M, Suda T, Suzuki Y, Asakura H (1998) The usefulness of determining des-γ-carboxy prothrombin by sensitive enzyme immunoassay in the early diagnosis of patients with hepatocellular carcinoma. Cancer 82: 1643-1648
14. Nakao A, Iwaki Y, Virji MA, Kita Y, Demetris AJ, Iwatsuki S, Starzl TE (1995) Normotest and abnormal prothrombin in liver transplantation. Liver 15: 260-264
15. Nomura F, Ishijima M, Kuwa K, Tanaka N, Nakai T, Ohnishi K (1999) Serum des-gamma-carboxy prothrombin levels determined by a new generation of sensitive immunoassays in patients with small-sized hepatocellular carcinoma. Am J Gastroenterol 94: 650-654
16. Okuda K (1986) Early recognition of hepatocellular carcinoma. Hepatology 6: 729-738
17. Okuda H, Nakanishi T, Takatsu K, Saito A, Hayashi N, Watanabe K, Magario N, Yokoo T, Naraki T (1999) Measurement of serum levels of des-γ-carboxy prothrombin in patients with hepatocellular carcinoma by a revised enzyme immunoassy kit with increased sensitivity. Cancer 85: 812-818
18. Okuda H, Obata H, Nakanishi T, Furukawa R, Hashimoto E (1987) Production of abnormal prothrombin (des-gamma-carboxy prothrombin) by hepatocellular carcinoma; a clinical and experimental study. J Hepatol 4: 357-363
19. Orlowski M, Szczeklik A (1967) Heterogeneity of serum γ-glutamyl transpeptidase in hepatobiliary disease. Clin Chim Acta 15: 387-391
20. Saitoh S, Ikeda K, Koida I, Tsubota A, Arase Y, Chayama K, Kumada H (1994) Serum des-gamma-carboxyprothrombin concentration determined by the avidin-biotin complex method in small hepatocellular carcinomas. Cancer 32: 2918-2923
21. Sato Y, Nakata K, Kato Y, Shima M, Ishii N, Koji T, Taketa K, Endo Y, Nagataki S (1993) Early recognition of hepatocellular carcinoma bases on altered profiles of alpha-fetoprotein. N Engl J Med 328: 1802-1806
22. Sawabu N, Nakagen M, Ozaki K, Wakabayashi T, Toya D, Hattori N, Ishii M (1983) Clinical evaluation of specific gamma-GTP isoenzyme in patients with hepatocellular carcinoma. Cancer 51: 327-331
23. Suehiro T, Boros P, Emre S, Sheiner P-A, Guy S, Schwartz M-E, Miller CM (1998) Donor des-gamma-carboxy prothrombin positivity is a risk factor for poor early graft function in liver transplantation. Transplant Int 11: 143-146
24. Suzuki H (1981) Clinical significance of appearance of serum gamma-glutamyl transpeptidase isozyme. Gastroenterol Jpn 16: 122-128
25. Taketa K, Sekiya C, Namiki M, Akamatsu K, Ohta Y, Endo Y, Kosaka K (1990) Lectin-reactive profiles of alpha-fetoprotein and its usefulness in the early diagnosis of hepatocellular carcinoma and related conditions. Gastroenterology 99: 508-518
26. Taketoshi S, Keizo S, Takashi M, Hidetoshi I, Akinobu T, Takashi M (1995) Protein induced by vitamin K absence or antagonist II as a prognostic marker in hepatocellular carcinoma. Cancer 73: 2464-2471
27. Xu KC, Meng XY, Shi YC, Ge ZJ, Ye L, Yu ZJ, Yang DM (1985) The diagnostic value of a hepatoma-specific band of serum gamma-glutamyl transferase. Int J Cancer 36: 667-669
28. Xu K, Meng XY, Wu JW, Shen B, Shi YC, Wei Q (1992) Diagnostic value of serum gamma-glutamyl transferase isoenzyme for hepatocellular carcinoma: a 10-year study. Am J Gastroenterol 87: 991-995
29. Yao DF, Huang ZW, Chen SZ, Huang JF, Lu JX, Xiao MB, Meng XY (1998) Diagnosis of hepatocellular carcinoma by quantitative detection of hepatoma-specific bands of serum gamma-glutamyltransferase. Am J Clin Pathol 110: 743-749