메뉴 건너뛰기




Volumn 50, Issue 54, 2003, Pages 2072-2078

Clinical Characteristics among Patients with Hepatocellular Carcinoma According to the Serum Levels of α-fetoprotein and Des-γ-carboxy Prothrombin

Author keywords

Alpha fetoprotein; Des carboxy prothrombin; Hepatocellular carcinoma; PIVKA II; Platelet; Portal thrombosis

Indexed keywords

ALPHA FETOPROTEIN; PROTHROMBIN; TUMOR MARKER;

EID: 0344961316     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (11)

References (36)
  • 1
    • 0033545541 scopus 로고    scopus 로고
    • Rising incidence of hepatocellular carcinoma in the United States
    • El-Serag HB, Mason AC: Rising incidence of hepatocellular carcinoma in the United States. N Eng J Med 1999; 340:745-750.
    • (1999) N Eng J Med , vol.340 , pp. 745-750
    • El-Serag, H.B.1    Mason, A.C.2
  • 2
    • 0023950388 scopus 로고
    • Ultrasonography and alpha-fetoprotein in diagnosis of hepatocellular carcinoma in cirrhosis
    • Maringhini A, Cottone M, Sciarrino E, et al: Ultrasonography and alpha-fetoprotein in diagnosis of hepatocellular carcinoma in cirrhosis. Dig Dis Sci 1988; 33:47-51.
    • (1988) Dig Dis Sci , vol.33 , pp. 47-51
    • Maringhini, A.1    Cottone, M.2    Sciarrino, E.3
  • 3
    • 0025364993 scopus 로고
    • Lectin-reactive profiles of alpha-fetoprotein characterizing hepatocellular carcinoma and related conditions
    • Taketa K, Sekiya C, Namiki M, et al: Lectin-reactive profiles of alpha-fetoprotein characterizing hepatocellular carcinoma and related conditions. Gastroenterology 1990; 99:506-518.
    • (1990) Gastroenterology , vol.99 , pp. 506-518
    • Taketa, K.1    Sekiya, C.2    Namiki, M.3
  • 4
    • 0028983840 scopus 로고
    • Monitoring of lectin-reactive α-fetoprotein in patients with hepatocellular carcinoma treated using transcatheter arterial embolization
    • Yamashita F, Tanaka M, Satomura S, et al: Monitoring of lectin-reactive α-fetoprotein in patients with hepatocellular carcinoma treated using transcatheter arterial embolization. Eur J Gastroenterol Hepatol 1995; 7:627-633.
    • (1995) Eur J Gastroenterol Hepatol , vol.7 , pp. 627-633
    • Yamashita, F.1    Tanaka, M.2    Satomura, S.3
  • 5
    • 0025824756 scopus 로고
    • Clinical usefulness of des-gamma-carboxy prothrombin assay in early diagnosis of hepatocellular carcinoma
    • Fujiyama S, Izuno K, Gohshi K, et al: Clinical usefulness of des-gamma-carboxy prothrombin assay in early diagnosis of hepatocellular carcinoma. Dig Dis Sci 1991; 36:1787-1792.
    • (1991) Dig Dis Sci , vol.36 , pp. 1787-1792
    • Fujiyama, S.1    Izuno, K.2    Gohshi, K.3
  • 6
    • 0027130291 scopus 로고
    • Clinical evaluation of plasma des-γ-carboxy prothrombin as a marker protein of hepatocellular carcinoma in patients with tumors of various sizes
    • Kasahara A, Hayashi N, Fusamoto H, et al: Clinical evaluation of plasma des-γ-carboxy prothrombin as a marker protein of hepatocellular carcinoma in patients with tumors of various sizes. Dig Dis Sci 1993; 38:2170-2176.
    • (1993) Dig Dis Sci , vol.38 , pp. 2170-2176
    • Kasahara, A.1    Hayashi, N.2    Fusamoto, H.3
  • 7
    • 0030863067 scopus 로고    scopus 로고
    • Usefuness of ED036 kit for measuring serum PIVKA-II levels in small hepatocellular carcinoma
    • Kuromatsu R, Tanaka M, Shimauchi Y, et al: Usefuness of ED036 kit for measuring serum PIVKA-II levels in small hepatocellular carcinoma. J Gastroenterol 1997; 32:507-512.
    • (1997) J Gastroenterol , vol.32 , pp. 507-512
    • Kuromatsu, R.1    Tanaka, M.2    Shimauchi, Y.3
  • 8
    • 0032830462 scopus 로고    scopus 로고
    • Sensitive measurement of serum abnormal prothrombin (PIVKA-II) as a marker of hepatocellular carcinoma
    • Tanaka Y, Kashiwagi T, Tsutsumi H, et al: Sensitive measurement of serum abnormal prothrombin (PIVKA-II) as a marker of hepatocellular carcinoma. Hepatogastroenterology 1999; 46:2464-2468.
    • (1999) Hepatogastroenterology , vol.46 , pp. 2464-2468
    • Tanaka, Y.1    Kashiwagi, T.2    Tsutsumi, H.3
  • 9
    • 0032080912 scopus 로고    scopus 로고
    • The usefulness of determing des-γ-carboxy prothrombin by sensitive enzyme immunoassay in the early diagnosis of patients with hepatocellular carcinoma
    • Mita Y, Aoyagi Y, Yanagi M, et al: The usefulness of determing des-γ-carboxy prothrombin by sensitive enzyme immunoassay in the early diagnosis of patients with hepatocellular carcinoma. Cancer 1998; 82:1643-1648.
    • (1998) Cancer , vol.82 , pp. 1643-1648
    • Mita, Y.1    Aoyagi, Y.2    Yanagi, M.3
  • 10
    • 0033557988 scopus 로고    scopus 로고
    • Measurement of serum levels of des-γ-carboxy prothrombin inpatients with hepatocellular carcinoma by a revised enzyme immunoassay kit with increased sensitivity
    • Okuda H, Nakanishi T, Takatsu K, et al: Measurement of serum levels of des-γ-carboxy prothrombin inpatients with hepatocellular carcinoma by a revised enzyme immunoassay kit with increased sensitivity. Cancer 1999; 85:812-818.
    • (1999) Cancer , vol.85 , pp. 812-818
    • Okuda, H.1    Nakanishi, T.2    Takatsu, K.3
  • 11
    • 0034141402 scopus 로고    scopus 로고
    • Serum levels of des-γ-carboxy prothrombin measured using the revised enzyme immunoassay kit with increased sensitivity in relation to clinicopathologic features of solitary hepatocellular carcinoma
    • Okuda H, Nakanishi T, Takatsu K, et al: Serum levels of des-γ-carboxy prothrombin measured using the revised enzyme immunoassay kit with increased sensitivity in relation to clinicopathologic features of solitary hepatocellular carcinoma. Cancer 2000; 88:544-549.
    • (2000) Cancer , vol.88 , pp. 544-549
    • Okuda, H.1    Nakanishi, T.2    Takatsu, K.3
  • 12
    • 0035253469 scopus 로고    scopus 로고
    • Des-gamma-carboxy prothrombin as a useful predisposing factor for the development of portal venous invasion in patients with hepatocellular carcinoma: A prospective analysis of 227 patients
    • Koike Y, Shiratori Y, Sato S, et al: Des-gamma-carboxy prothrombin as a useful predisposing factor for the development of portal venous invasion in patients with hepatocellular carcinoma: a prospective analysis of 227 patients. Cancer 2001; 91:561-569.
    • (2001) Cancer , vol.91 , pp. 561-569
    • Koike, Y.1    Shiratori, Y.2    Sato, S.3
  • 13
    • 0028291568 scopus 로고
    • Protein induced by vitamin K absence or antagonist II as a prognostic marker in hepatocellular carcinoma - Comparison with alpha-fetoprotein
    • Suehiro T, Sugimachi K, Matsumata T, et al: Protein induced by vitamin K absence or antagonist II as a prognostic marker in hepatocellular carcinoma - comparison with alpha-fetoprotein. Cancer 1994; 73:2464-2471.
    • (1994) Cancer , vol.73 , pp. 2464-2471
    • Suehiro, T.1    Sugimachi, K.2    Matsumata, T.3
  • 14
    • 0029966485 scopus 로고    scopus 로고
    • Clinical significance of simultaneous determination of alpha-fetoprotein and desgammma-carboxy prothrombin in monitoring recurrence in patients with hepatocellular carcinoma
    • Aoyagi Y, Oguro M, Yanagi M, et al: Clinical significance of simultaneous determination of alpha-fetoprotein and desgammma-carboxy prothrombin in monitoring recurrence in patients with hepatocellular carcinoma. Cancer 1996; 77:1781-1786.
    • (1996) Cancer , vol.77 , pp. 1781-1786
    • Aoyagi, Y.1    Oguro, M.2    Yanagi, M.3
  • 15
    • 0023243522 scopus 로고
    • Production of abnormal prothrombin (des-γ-carboxy prothrombin) by hepatocellular carcinoma: A clinical and experimental study
    • Okuda H, Obata H, Nakanishi T, et al: Production of abnormal prothrombin (des-γ-carboxy prothrombin) by hepatocellular carcinoma: a clinical and experimental study. J Hepatol 1987; 4:357-363.
    • (1987) J Hepatol , vol.4 , pp. 357-363
    • Okuda, H.1    Obata, H.2    Nakanishi, T.3
  • 16
    • 0025772427 scopus 로고
    • Vitamin K-dependent proteins and hepatocellular carcinoma
    • Okuda H, Nakanishi T, Furukawa M, et al: Vitamin K-dependent proteins and hepatocellular carcinoma. J Gastroenteol Hepatol 1991; 6:392-399.
    • (1991) J Gastroenteol Hepatol , vol.6 , pp. 392-399
    • Okuda, H.1    Nakanishi, T.2    Furukawa, M.3
  • 17
    • 0028925322 scopus 로고
    • Levels of vitamin K, immunoreactive prothrombin, des-γ-carboxy prothrombin and y-glutamyl carboxylase activity in hepatocellular carcinoma tissue
    • Yamagata H, Nakanishi T, Furukawa M, et al: Levels of vitamin K, immunoreactive prothrombin, des-γ-carboxy prothrombin and y-glutamyl carboxylase activity in hepatocellular carcinoma tissue. J Gastroenterol Hepatol 1995; 10:8-13.
    • (1995) J Gastroenterol Hepatol , vol.10 , pp. 8-13
    • Yamagata, H.1    Nakanishi, T.2    Furukawa, M.3
  • 18
    • 0033074462 scopus 로고    scopus 로고
    • Clinicopathologic significance of protein induced vitamin K absence or antagonist II and α-fetoprotein in hepatocellular carcinoma
    • Nakagawa T, Seki T, Shiro T, et al: Clinicopathologic significance of protein induced vitamin K absence or antagonist II and α-fetoprotein in hepatocellular carcinoma. Int J Oncol 1999; 14:281-286.
    • (1999) Int J Oncol , vol.14 , pp. 281-286
    • Nakagawa, T.1    Seki, T.2    Shiro, T.3
  • 19
    • 0019809628 scopus 로고
    • Relationship between serum alpha-fetoprotein, cirrhosis, and survival in hepatocellular carcinoma
    • Johnson PJ, Melia WM, Palmer MK, et al: Relationship between serum alpha-fetoprotein, cirrhosis, and survival in hepatocellular carcinoma. Br J Cancer 1981; 44:502-505.
    • (1981) Br J Cancer , vol.44 , pp. 502-505
    • Johnson, P.J.1    Melia, W.M.2    Palmer, M.K.3
  • 20
    • 0031017944 scopus 로고    scopus 로고
    • Significance of alpha-fetoprotein levels for detection of early recurrence of hepatocellular carcinoma after hepatic resection
    • Shirabe K, Takenaka K, Gion T, et al: Significance of alpha-fetoprotein levels for detection of early recurrence of hepatocellular carcinoma after hepatic resection. J Surg Oncol 1997; 64:143-146.
    • (1997) J Surg Oncol , vol.64 , pp. 143-146
    • Shirabe, K.1    Takenaka, K.2    Gion, T.3
  • 21
    • 0029913526 scopus 로고    scopus 로고
    • Des-γ-carboxy prothrombin and alpha-fetoprotein AFP/DCP status as a new prognostic indicator after hepatic resection for hepatocellular carcinoma
    • Shimada M, Takenaka K, Fujiwara Y, et al: Des-γ-carboxy prothrombin and alpha-fetoprotein AFP/DCP status as a new prognostic indicator after hepatic resection for hepatocellular carcinoma. Cancer 1996; 78:2094-2100.
    • (1996) Cancer , vol.78 , pp. 2094-2100
    • Shimada, M.1    Takenaka, K.2    Fujiwara, Y.3
  • 22
    • 0034177223 scopus 로고    scopus 로고
    • Unique clinical characteristics of patients with hepatocellular carcinoma who present with high plasma des-γ-carboxy prothrombin and low serum α-fetoprotein
    • Hamamura K, Shiratori Y, Shiina S, et al: Unique clinical characteristics of patients with hepatocellular carcinoma who present with high plasma des-γ-carboxy prothrombin and low serum α-fetoprotein. Cancer 2000; 88:1557-1564.
    • (2000) Cancer , vol.88 , pp. 1557-1564
    • Hamamura, K.1    Shiratori, Y.2    Shiina, S.3
  • 23
    • 0035698289 scopus 로고    scopus 로고
    • Comparison of clinicopathological features of patients with hepatocellular carcinoma seropositive for α-fetoprotein alone and these seropositive for des-γ-carboxy prothrombin alone
    • Okuda H, Nakanishi T, Takatsu K, et al: Comparison of clinicopathological features of patients with hepatocellular carcinoma seropositive for α-fetoprotein alone and these seropositive for des-γ-carboxy prothrombin alone. J Gastoenterol Hepatol 2001; 16:1290-1296.
    • (2001) J Gastoenterol Hepatol , vol.16 , pp. 1290-1296
    • Okuda, H.1    Nakanishi, T.2    Takatsu, K.3
  • 24
    • 78651053628 scopus 로고
    • Primary carcinoma of the liver: A study of 100 cases among 48,900 necropsies
    • Edmondson HA, Steiner PE: Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. Cancer 1954; 7:462-503.
    • (1954) Cancer , vol.7 , pp. 462-503
    • Edmondson, H.A.1    Steiner, P.E.2
  • 25
    • 33845382806 scopus 로고
    • Nonparametric estimation for incomplete observations
    • Kaplan EL, Meier P: Nonparametric estimation for incomplete observations. J Am Stat Assoc 1958; 53:457-481.
    • (1958) J Am Stat Assoc , vol.53 , pp. 457-481
    • Kaplan, E.L.1    Meier, P.2
  • 26
    • 0035403236 scopus 로고    scopus 로고
    • Increased expression of platelet-derived endothelial cell growth factor in human hepatocellular carcinomas correlated with high Edmondson grades and portal vein tumor thrombosis
    • Guo L, Kuroda N, Toi M, et al: Increased expression of platelet-derived endothelial cell growth factor in human hepatocellular carcinomas correlated with high Edmondson grades and portal vein tumor thrombosis. Oncology Rep 2001; 8:871-876.
    • (2001) Oncology Rep , vol.8 , pp. 871-876
    • Guo, L.1    Kuroda, N.2    Toi, M.3
  • 27
    • 0027409404 scopus 로고
    • A player of many parts: The spotlight falls on thrombin structure
    • Stubbs MT, Bode W: A player of many parts: the spotlight falls on thrombin structure. Thromb Res 1993; 69:1-58.
    • (1993) Thromb Res , vol.69 , pp. 1-58
    • Stubbs, M.T.1    Bode, W.2
  • 28
    • 0022978846 scopus 로고
    • Biologic activities of nonenzymatic thrombin: Elucidation of a macrophage interactive domain
    • Bar-Sharit R, Wilner GD: Biologic activities of nonenzymatic thrombin: elucidation of a macrophage interactive domain. Sem Thromb Hemost 1986; 12:244-249.
    • (1986) Sem Thromb Hemost , vol.12 , pp. 244-249
    • Bar-Sharit, R.1    Wilner, G.D.2
  • 29
    • 0029073320 scopus 로고
    • Des-gamma-carboxy prothrombin and proliferative activity of hepatocel-lular carcinoma
    • Suehiro T, Matsumata T, Itasaka H, et al: Des-gamma-carboxy prothrombin and proliferative activity of hepatocel-lular carcinoma. Surgery 1995; 117:682-691.
    • (1995) Surgery , vol.117 , pp. 682-691
    • Suehiro, T.1    Matsumata, T.2    Itasaka, H.3
  • 32
    • 0034781301 scopus 로고    scopus 로고
    • Transcatheter arterial chemoembolization therapy combined with percutaneous ethanol injection for unresectable large hepatocellular carcinoma: An evaluation of the local therapeutic effect and survival rate
    • Dohmen K, Shirahama M, Shigematsu H, et al: Transcatheter arterial chemoembolization therapy combined with percutaneous ethanol injection for unresectable large hepatocellular carcinoma: An evaluation of the local therapeutic effect and survival rate. Hepatogastroenterology 2001; 48:1409-1415.
    • (2001) Hepatogastroenterology , vol.48 , pp. 1409-1415
    • Dohmen, K.1    Shirahama, M.2    Shigematsu, H.3
  • 33
    • 0029079899 scopus 로고
    • Hepatocellular carcinoma and cirrhosis in 746 patients; Long-term results of percutaneous ethanol injection
    • Livraghi T, Giorgio A, Martin G, et al: Hepatocellular carcinoma and cirrhosis in 746 patients; Long-term results of percutaneous ethanol injection. Radiology 1995; 197:101-108.
    • (1995) Radiology , vol.197 , pp. 101-108
    • Livraghi, T.1    Giorgio, A.2    Martin, G.3
  • 34
    • 0028871580 scopus 로고
    • Treatment of small hepatocellular carcinoma with percutaneous ethanol injection. Analysis of prognostic factors in 105 Western patients
    • Lencioni R, Bartolozzi C, Caramella D, et al: Treatment of small hepatocellular carcinoma with percutaneous ethanol injection. Analysis of prognostic factors in 105 Western patients. Cancer 1995; 76:1737-1746.
    • (1995) Cancer , vol.76 , pp. 1737-1746
    • Lencioni, R.1    Bartolozzi, C.2    Caramella, D.3
  • 35
    • 0242638309 scopus 로고    scopus 로고
    • Trends in clinical characteristics, treatment and prognosis of hepatocellular carcinoma
    • Dohmen K, Shigematsu H, Ishibashi H: Trends in clinical characteristics, treatment and prognosis of hepatocellular carcinoma. Hepatogastroenterology 2003; 50:1872-1877.
    • (2003) Hepatogastroenterology , vol.50 , pp. 1872-1877
    • Dohmen, K.1    Shigematsu, H.2    Ishibashi, H.3
  • 36
    • 0027055456 scopus 로고
    • Relationship between pathologic factors and abnormal levels of des-γ-carboxy prothrombin and α-fetoprotein in hepatocellular carcinoma
    • Sakon M, Monden M, Gotoh M, et al: Relationship between pathologic factors and abnormal levels of des-γ-carboxy prothrombin and α-fetoprotein in hepatocellular carcinoma. Am J Surg 1992; 163:251-256.
    • (1992) Am J Surg , vol.163 , pp. 251-256
    • Sakon, M.1    Monden, M.2    Gotoh, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.