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3, and NaOAc were added in the model reaction using 13a and catalyst 3 at room temperature in chlorobenzene. Conversion and enantioselectivity were not improved. Basic additives were previously reported to have beneficial effects in the asymmetric Pudovik reaction mediated by cinchona alkaloids, see
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3, and NaOAc were added in the model reaction using 13a and catalyst 3 at room temperature in chlorobenzene. Conversion and enantioselectivity were not improved. Basic additives were previously reported to have beneficial effects in the asymmetric Pudovik reaction mediated by cinchona alkaloids, see:, S. Nakamura, M. Hayashi, Y. Hiramatsu, N. Shibata, Y. Funahashi, T. Toru, J. Am. Chem. Soc. 2009, 131, 18240.
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[9]
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[9]
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Characterisation data of all new compounds 14 are reported in the Supporting Information
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Characterisation data of all new compounds 14 are reported in the Supporting Information.
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