Hsp90 (Heat Shock Protein 90) inhibitor occupancy is a direct determinant of client protein degradation and tumor growth arrest in vivo

Journal of Biological Chemistry

Volumn 285, Issue 51, 2010, Pages 39835-39843

  Tillotson, Bonnie ^a   Slocum, Kelly ^a   Coco, John ^a   Whitebread, Nigel ^a   Thomas, Brian ^a   West, Kip A ^a   MacDougall, John ^a   Ge, Jie ^a   Ali, Janid A ^a   Palombella, Vito J ^a   Normant, Emmanuel ^a   Adams, Julian ^a   Fritz, Christian C ^a  

^a Infinity Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFTER-TREATMENT; ANTI-CANCER AGENTS; BINDING ASSAYS; CANCER CELL GROWTH; CELLULAR EFFECTS; CLINICAL EVALUATION; DOWNSTREAM EFFECTS; GROWTH INHIBITION; HEAT SHOCK PROTEIN; HUMAN CANCER; HUMAN EPIDERMAL GROWTH FACTOR; IN-CELL; IN-VITRO; IN-VIVO; LINEAR CORRELATION; LIVING CELL; MOLECULAR LEVELS; NON SMALL CELL LUNG CANCER; PROTEIN DEGRADATION; PROTEIN LEVEL; TIME POINTS; TUMOR GROWTH; TUMOR XENOGRAFTS;

ASTATINE; BIOLOGICAL MATERIALS; CELL GROWTH; DEGRADATION; GROWTH KINETICS; PHARMACODYNAMICS; TUMORS;

PROTEINS;

EPIDERMAL GROWTH FACTOR RECEPTOR 2; HEAT SHOCK PROTEIN 90; TANESPIMYCIN HYDROQUINONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EXPOSURE; GROWTH INHIBITION; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; LUNG NON SMALL CELL CANCER; MALE; MOUSE; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DEGRADATION; PROTEIN SYNTHESIS INHIBITION; TEMPERATURE DEPENDENCE; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZOQUINONES; CARCINOMA, NON-SMALL-CELL LUNG; HELA CELLS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; LUNG NEOPLASMS; MICE; MICE, NUDE; NEOPLASM PROTEINS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 78650057776     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.141580     Document Type: Article

References (42)

1. Neckers, L. (2007) J. Biosci. 32, 517-530
2. Workman, P., Burrows, F., Neckers, L., and Rosen, N. (2007) Ann. N.Y. Acad. Sci. 1113, 202-216
3. Mahalingam, D., Swords, R., Carew, J. S., Nawrocki, S. T., Bhalla, K., and Giles, F. J. (2009) Br. J. Cancer 100, 1523-1529
4. Neckers, L. (2003) Curr. Med. Chem. 10, 733-739
5. Pearl, L. H., and Prodromou, C. (2006) Annu. Rev. Biochem. 75, 271-294
6. Aherne, W., Maloney, A., Prodromou, C., Rowlands, M. G., Hardcastle, A., Boxall, K., Clarke, P., Walton, M. I., Pearl, L., and Workman, P. (2003) Methods Mol. Med. 85, 149-161
7. Ge, J., Normant, E., Porter, J. R., Ali, J. A., Dembski, M. S., Gao, Y., Georges, A. T., Grenier, L., Pak, R. H., Patterson, J., Sydor, J. R., Tibbitts, T. T., Tong, J. K., Adams, J., and Palombella, V. J. (2006) J. Med. Chem. 49, 4606-4615
8. Douglas, M., Lim, A. R., Porter, J. R., West, K., Pink, M. M., Ge, J., Wylie, A. A., Tibbits, T. T., Biggs, K., Curtis, M., Palombella, V. J., Adams, J., Fritz, C. C., and Normant, E. (2009) Mol. Cancer Ther. 8, 3369-3378
9. Maroney, A. C., Marugan, J. J., Mezzasalma, T. M., Barnakov, A. N., Garrabrant, T. A., Weaner, L. E., Jones, W. J., Barnakova, L. A., Koblish, H. K., Todd, M. J., Masucci, J. A., Deckman, I. C., Galemmo, R. A., Jr., and Johnson, D. L. (2006) Biochemistry 45, 5678-5685
10. Bauer, S., Yu, L. K., Demetri, G. D., and Fletcher, J. A. (2006) Cancer Res. 66, 9153-9161
11. Dewaele, B., Wasag, B., Cools, J., Sciot, R., Prenen, H., Vandenberghe, P., Wozniak, A., Schöffski, P., Marynen, P., and Debiec-Rychter, M. (2008) Clin. Cancer Res. 14, 5749-5758
12. Peng, C., Brain, J., Hu, Y., Goodrich, A., Kong, L., Grayzel, D., Pak, R., Read, M., and Li, S. (2007) Blood 110, 678-685
13. Abramson, J. S., Chen, W., Juszczynski, P., Takahashi, H., Neuberg, D., Kutok, J. L., Takeyama, K., and Shipp, M. A. (2009) Br. J. Haematol. 144, 358-366
14. Song, D., Chaerkady, R., Tan, A. C., García-García, E., Nalli, A., Suárez-Gauthier, A., López-Ríos, F., Zhang, X. F., Solomon, A., Tong, J., Read, M., Fritz, C., Jimeno, A., Pandey, A., and Hidalgo, M. (2008) Mol. Cancer Ther. 7, 3275-3284
15. Avila, C., Hadden, M. K., Ma, Z., Kornilayev, B. A., Ye, Q. Z., and Blagg, B. S. (2006) Bioorg. Med. Chem. Lett. 16, 3005-3008
16. Park, H., Kim, Y. J., and Hahn, J. S. (2007) Bioorg. Med. Chem. Lett. 17, 6345-6349
17. Rowlands, M. G., Newbatt, Y. M., Prodromou, C., Pearl, L. H., Workman, P., and Aherne, W. (2004) Anal. Biochem. 327, 176-183
18. Schumacher, R. J., Hurst, R., Sullivan, W. P., McMahon, N. J., Toft, D. O., and Matts, R. L. (1994) J. Biol. Chem. 269, 9493-9499
19. Howes, R., Barril, X., Dymock, B. W., Grant, K., Northfield, C. J., Robertson, A. G., Surgenor, A., Wayne, J., Wright, L., James, K., Matthews, T., Cheung, K. M., McDonald, E., Workman, P., and Drysdale, M. J. (2006) Anal. Biochem. 350, 202-213
20. Chan, C. T., Paulmurugan, R., Gheysens, O. S., Kim, J., Chiosis, G., and Gambhir, S. S. (2008) Cancer Res. 68, 216-226
21. Galam, L., Hadden, M. K., Ma, Z., Ye, Q. Z., Yun, B. G., Blagg, B. S., and Matts, R. L. (2007) Bioorg. Med. Chem. 15, 1939-1946
22. Schneider, C., Sepp-Lorenzino, L., Nimmesgern, E., Ouerfelli, O., Danishefsky, S., Rosen, N., and Hartl, F. U. (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 14536-14541
23. Goetz, M. P., Toft, D., Reid, J., Ames, M., Stensgard, B., Safgren, S., Adjei, A. A., Sloan, J., Atherton, P., Vasile, V., Salazaar, S., Adjei, A., Croghan, G., and Erlichman, C. (2005) J. Clin. Oncol. 23, 1078-1087
24. Grem, J. L., Morrison, G., Guo, X. D., Agnew, E., Takimoto, C. H., Thomas, R., Szabo, E., Grochow, L., Grollman, F., Hamilton, J. M., Neckers, L., and Wilson, R. H. (2005) J. Clin. Oncol. 23, 1885-1893
25. Ramanathan, R. K., Trump, D. L., Eiseman, J. L., Belani, C. P., Agarwala, S. S., Zuhowski, E. G., Lan, J., Potter, D. M., Ivy, S. P., Ramalingam, S., Brufsky, A. M., Wong, M. K., Tutchko, S., and Egorin, M. J. (2005) Clin. Cancer Res. 11, 3385-3391
26. Kamal, A., Thao, L., Sensintaffar, J., Zhang, L., Boehm, M. F., Fritz, L. C., and Burrows, F. J. (2003) Nature 425, 407-410
27. Sydor, J. R., Normant, E., Pien, C. S., Porter, J. R., Ge, J., Grenier, L., Pak, R. H., Ali, J. A., Dembski, M. S., Hudak, J., Patterson, J., Penders, C., Pink, M., Read, M. A., Sang, J., Woodward, C., Zhang, Y., Grayzel, D. S., Wright, J., Barrett, J. A., Palombella, V. J., Adams, J., and Tong, J. K. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 17408-17413
28. Carreras, C. W., Schirmer, A., Zhong, Z., and Santi, D. V. (2003) Anal. Biochem. 317, 40-46
29. Gooljarsingh, L. T., Fernandes, C., Yan, K., Zhang, H., Grooms, M., Johanson, K., Sinnamon, R. H., Kirkpatrick, R. B., Kerrigan, J., Lewis, T., Arnone, M., King, A. J., Lai, Z., Copeland, R. A., and Tummino, P. J. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 7625-7630
30. Guo, W., Reigan, P., Siegel, D., Zirrolli, J., Gustafson, D., and Ross, D. (2005) Cancer Res. 65, 10006-10015
31. Basso, A. D., Solit, D. B., Chiosis, G., Giri, B., Tsichlis, P., and Rosen, N. (2002) J. Biol. Chem. 277, 39858-39866
32. Citri, A., Harari, D., Shohat, G., Ramakrishnan, P., Gan, J., Lavi, S., Eisenstein, M., Kimchi, A., Wallach, D., Pietrokovski, S., and Yarden, Y. (2006) J. Biol. Chem. 281, 14361-14369
33. Guo, A., Villén, J., Kornhauser, J., Lee, K. A., Stokes, M. P., Rikova, K., Possemato, A., Nardone, J., Innocenti, G., Wetzel, R., Wang, Y., Mac- Neill, J., Mitchell, J., Gygi, S. P., Rush, J., Polakiewicz, R. D., and Comb, M. J. (2008) Proc. Natl. Acad. Sci. U.S.A. 105, 692-697
34. Sawai, A., Chandarlapaty, S., Greulich, H., Gonen, M., Ye, Q., Arteaga, C. L., Sellers, W., Rosen, N., and Solit, D. B. (2008) Cancer Res. 68, 589-596
35. Banerji, U., O'Donnell, A., Scurr, M., Pacey, S., Stapleton, S., Asad, Y., Simmons, L., Maloney, A., Raynaud, F., Campbell, M., Walton, M., Lakhani, S., Kaye, S., Workman, P., and Judson, I. (2005) J. Clin. Oncol. 23, 4152-4161
36. Smith-Jones, P. M., Solit, D. B., Akhurst, T., Afroze, F., Rosen, N., and Larson, S. M. (2004) Nat. Biotechnol. 22, 701-706
37. Grammatikakis, N., Lin, J. H., Grammatikakis, A., Tsichlis, P. N., and Cochran, B. H. (1999) Mol. Cell. Biol. 19, 1661-1672
38. Whitesell, L., Mimnaugh, E. G., De Costa, B., Myers, C. E., and Neckers, L. M. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 8324-8328
39. Dittmar, K. D., Demady, D. R., Stancato, L. F., Krishna, P., and Pratt, W. B. (1997) J. Biol. Chem. 272, 21213-21220
40. Stancato, L. F., Silverstein, A. M., Owens-Grillo, J. K., Chow, Y. H., Jove, R., and Pratt, W. B. (1997) J. Biol. Chem. 272, 4013-4020
41. Xu, W., Mimnaugh, E., Rosser, M. F., Nicchitta, C., Marcu, M., Yarden, Y., and Neckers, L. (2001) J. Biol. Chem. 276, 3702-3708
42. Xu, L., Eiseman, J. L., Egorin, M. J., and D'Argenio, D. Z. (2003) J Pharmacokinet Pharmacodyn. 30, 185-219