Biodegradable nanofibers-reinforced microfibrous composite scaffolds for bone tissue engineering

Tissue Engineering - Part A

Volumn 16, Issue 12, 2010, Pages 3599-3609

  Martins, Albino ^a   Pinho, Elisabete D ^a   Correlo, Vítor M ^a   Faria, Susana ^a   Marques, Alexandra P ^a   Reis, Rui L ^a   Neves, Nuno M ^a  

^a UNIVERSITY OF MINHO   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

BIODEGRADABLE POLYMERS; BUTENES; CALCIUM PHOSPHATE; CELL CULTURE; ENZYME ACTIVITY; NANOFIBERS; PHOSPHATASES; PHOSPHATES; SCAFFOLDS; STEM CELLS; STRUCTURE (COMPOSITION); TISSUE ENGINEERING; TRANSCRIPTION; TRANSCRIPTION FACTORS;

ALKALINE PHOSPHATASE; BONE SIALOPROTEINS; BONE TISSUE ENGINEERING; COLLAGEN FIBRILS; COMPOSITE SCAFFOLDS; ELECTROSPUNS; EXTRACELLULAR MATRICES; FEASIBLE SOLUTION; FIBER MESHES; HUMAN BONE MARROW MESENCHYMAL STEM CELLS; LENGTH SCALE; MICROFIBERS; MICROFIBROUS; NANO SCALE; OSTEOBLASTIC GENES; OSTEOCALCIN; OSTEOGENESIS; OSTEOGENIC; OSTEOGENIC DIFFERENTIATION; OSTEOPONTIN; OSTERIX; POLY (BUTYLENE SUCCINATE); RATIONAL DESIGN; REINFORCED COMPOSITES;

BONE;

BIOMATERIAL; NANOFIBER; TISSUE SCAFFOLD;

ARTICLE; BONE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CYTOLOGY; EXTRACELLULAR MATRIX; HUMAN; MESENCHYMAL STEM CELL; METABOLISM; METHODOLOGY; PHYSIOLOGY; SCANNING ELECTRON MICROSCOPY; TISSUE ENGINEERING; ULTRASTRUCTURE;

BIOCOMPATIBLE MATERIALS; BONE AND BONES; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; EXTRACELLULAR MATRIX; HUMANS; MESENCHYMAL STEM CELLS; MICROSCOPY, ELECTRON, SCANNING; NANOFIBERS; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 78650055735     PISSN: 19373341     EISSN: 1937335X     Source Type: Journal    
DOI: 10.1089/ten.tea.2009.0779     Document Type: Article

References (44)

1. Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., and Walter, P. Molecular Biology of the Cell. London, UK: Garland Science, 2002.
2. Weiner, S., and Wagner, H.D. The material bone: structure-mechanical function relations. Annu Rev Mater Sci 28, 271, 1998.
3. Teo, W.E., and Ramakrishna, S. Electrospun nanofibers as a platform for multifunctional, hierarchically organized na-nocomposite. Comp Sci Technol 69, 1804, 2009.
4. Martins, A., Araujo, J.V., Reis, R.L., and Neves, N.M. Elec-trospun nanostructured scaffolds for tissue engineering applications. Nanomedicine 2, 929, 2007.
5. Martins, A., Pinho, E.D., Faria, S., Pashkuleva, I., Marques, A.P., Reis, R.L., and Neves, N.M. Surface modification of elec-trospun polycaprolactone nanofiber meshes by plasma treatment to enhance biological performance. Small 5, 1195, 2009.
6. Bergshoef, M.M., and Vancso, G.J. Transparent nano-composites with ultrathin, electrospun nylon-4,6 fiber reinforcement. Adv Mater 11, 1362, 1999.
7. Fong, H. Electrospun nylon 6 nanofiber reinforced BIS-GMA/TEGDMA dental restorative composite resins. Polymer 45, 2427, 2004.
8. Pinho, E.D., Martins, A., Araujo, J.V., Reis, R.L., and Neves, N.M. Degradable particulate composite reinforced with nano-fibres for biomedical applications. Acta Biomater 5, 1104, 2009.
9. Pinho, E.D., Martins, A., Araujo, J.V., Reis, R.L., and Neves, N.M. Size also matters in biodegradable composite micro-fibre reinforced by chitosan nanofibres. Submitted, 2010.
10. Tian, M., Gao, Y., Liu, Y., Liao, Y., Xu, R., Hedin, N.E., and Fong, H. Bis-GMA/TEGDMA dental composites reinforced with electrospun nylon 6 nanocomposite nanofibers containing highly aligned fibrillar silicate single crystals. Polymer 48, 2720, 2007.
11. Gao, Y., Sagi, S., Zhang, L., Liao, Y., Cowles, D.M., Sun, Y., and Fong, H. Electrospun nano-scaled glass fiber reinforcement of bis-GMA/TEGDMA dental composites. J Appl Polym Sci 110, 2063, 2008.
12. Chen, G., and Liu, H. Electrospun cellulose nanofiber reinforced soybean protein isolate compositefilm.JAppl Polym Sci 110, 641, 2008.
13. Dodiuk-Kenig, H., Lizenboim, K., Roth, S., Zalsman, B., McHale, W.A., Jaffe, M., and Griswold, K. Performance enhancement of dental composites using electrospun nanofi-bers. J Nanomater 2008. doi: 10.1155/2008/840254
14. Lin, S., Cai, Q., Ji, J., Sui, G., Yu, Y., Yang, X., Ma, Q., Wei, Y., and Deng, X. Electrospun nanofiber reinforced and toughened composites through in situ nano-interface formation. Compos Sci Technol 68, 3322, 2008.
15. Kim, J.S., and Reneker, D.H. Mechanical properties of composites using ultrafine electrospun fibers. Polym Compos 20, 124, 1999.
16. Sihn, S., Kim, R.Y., Huh, W., Lee, K.H., and Roy, A.K. Improvement of damage resistance in laminated composites with electrospun nano-interlayers. Compos Sci Technol 68, 673, 2008.
17. Tian, M., Gao, Y., Liu, Y., Liao, Y., Hedin, N.E., and Fong, H. Fabrication and evaluation of Bis-GMA/TEGDMA dental resins/composites containing nano fibrillar silicate. Dental Mater 24, 235, 2008.
18. Norman, J.J., and Desai, T.A. Methods for fabrication of nanoscale topography for tissue engineering scaffolds. Ann Biomed Eng 34, 89, 2006.
19. Dzenis, Y.A. Hierarchical nano-/micromaterials based on electrospun polymer fibers: predictive models for thermo-mechanical behavior. J Comp Aid Mater Des 3, 403, 1996.
20. Park, S.H., Kim, T.G., Kim, H.C., Yang, D.Y., and Park, T.G. Development of dual scale scaffolds via direct polymer melt deposition and electrospinning for applications in tissue regeneration. Acta Biomater 4, 1198, 2008.
21. Santos, M.I., Fuchs, S., Gomes, M.E., Unger, R.E., Reis, R.L., and Kirkpatrick, C.J. Response of micro- and macrovascular endothelial cells to starch-based fiber meshes for bone tissue engineering. Biomaterials 28, 240, 2007.
22. Santos, M.I., Tuzlakoglu, K., Fuchs, S., Gomes, M.E., Peters, K., Unger, R.E., Piskin, E., Reis, R.L., and Kirkpatrick, C.J. Endothelial cell colonization and angiogenic potential of combined nano- and micro-fibrous scaffolds for bone tissue engineering. Biomaterials 29, 4306, 2008.
23. Tuzlakoglu, K., Bolgen, N., Salgado, A.J., Gomes, M.E., Piskin, E., and Reis, R.L. Nano- and micro-fiber combined scaffolds: a new architecture for bone tissue engineering. J Mater Sci Mater Med 16, 1099, 2005.
24. Martins, A., Chung, S., Pedro, A.J., Sousa, R.A., Marques, A.P., Reis, R.L., and Neves, N.M. Hierarchical starch-based fibrous scaffold for bone tissue engineering applications. J Tissue Eng Regen Med 3, 37, 2009.
25. Moroni, L., Schotel, R., Hamann, D., De Wijn, J.R., and Van Blitterswijk, C.A. 3D fiber-deposited electrospun integrated scaffolds enhance cartilage tissue formation. Adv Funct Mater 18, 53, 2008.
26. Delorme, B., and Charbord, P. Culture and characterization of human bone marrow mesenchymal stem cells. Methods Mol Med 140, 67, 2007.
27. Hofmann, S., Kaplan, D., Vunjak-Novakovic, G., and Mei-nel, L. Tissue engineering of bone. In: Vunjak-Novakovic, G., and Freshney, R.I., eds. Culture of Cells for Tissue Engineering. New Jersey: John Wiley & Sons, Inc., 2006, pp. 323-373.
28. Schaefer, D.W., and Justice, R.S. How nano are nano-composites? Macromolecules 40, 8501, 2007.
29. Coleman, J.N., Khan, U., and Gun'ko, Y.K. Mechanical reinforcement of polymers using carbon nanotubes. Adv Mater 18, 689, 2006.
30. Lutolf, M.P., and Hubbell, J.A. Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. Nat Biotech 23, 47, 2005.
31. Agrawal, C.M., and Ray, R.B. Biodegradable polymeric scaffolds for musculoskeletal tissue engineering. J Biomed Mater Res 55, 141, 2001.
32. Gomes, M.E., and Reis, R.L. Biodegradable polymers and composites in biomedical applications: from catgut to tissue engineering part 1: available systems and their properties. Int Mater Rev 49, 261, 2004.
33. Gan, Z., Abe, H., Kurokawa, H., and Doi, Y. Solid-state microstructures, thermal properties, and crystallization of biodegradable poly(butylene succinate) (PBS) and its copo-lyesters. Biomacromolecules 2, 605, 2001.
34. Ray, S.S., Okamoto, K., Maiti, P., and Okamoto, M. New poly(butylene succinate)/layered silicate nanocomposites: preparation and mechanical properties. J Nanosci Nano-technol 2, 171, 2002.
35. Correlo, V.M., Boesel, L.F., Bhattacharya, M., Mano, J.F., Neves, N.M., and Reis, R.L. Properties of melt processed chitosan and aliphatic polyester blends. Mater Sci Eng A 403, 57, 2005.
36. Correlo, V.M., Boesel, L.F., Pinho, E., Costa-Pinto, A.R., Alves da Silva, M.L., Bhattacharya, M., Mano, J.F., Neves, N.M., and Reis, R.L. Melt-based compression-molded scaffolds from chitosan-polyester blends and composites: morphology and mechanical properties. J Biomed Mater Res A 91, 489, 2009.
37. Costa-Pinto, A.R., Salgado, A.J., Correlo, V.M., Sol, P., Bhattacharya, M., Charbord, P., Reis, R.L., and Neves, N.M. Adhesion, proliferation, and osteogenic differentiation of a mouse mesenchymal stem cell line (BMC9) seeded on novel melt-based chitosan/polyester 3D porous scaffolds. Tissue Eng Part A 14, 1049, 2008.
38. Coutinho, D.F., Pashkuleva, I.H., Alves, C.M., Marques, A.P., Neves, N.M., and Reis, R.L. The effect of chitosan on the in vitro biological performance of chitosan-poly(butylene succinate) blends. Biomacromolecules 9, 1139, 2008.
39. Oliveira, J.T., Correlo, V.M., Sol, P.C., Costa-Pinto, A.R., Malafaya, P.B., Salgado, A.J., Bhattacharya, M., Charbord, P., Neves, N.M., and Reis, R.L. Assessment of the suitability of chitosan/polybutylene succinate scaffolds seeded with mouse mesenchymal progenitor cells for a cartilage tissue engineering approach. Tissue Eng Part A 14, 1651, 2008.
40. Correlo, V.M., Pinho, E.D., Pashkuleva, I., Bhattacharya, M., Neves, N.M., and Reis, R.L. Water absorption and degradation characteristics of chitosan-based polyesters and hydroxyapatite composites. Macromol Biosci 7, 354, 2007.
41. Sarasam, A., and Madihally, S.V. Characterization of chitosan- polycaprolactone blends for tissue engineering applications. Biomaterials 26, 5500, 2005.
42. Lahiji, A., Sohrabi, A., Hungerford, D.S., and Frondoza, C.G. Chitosan supports the expression of extracellular matrix proteins in human osteoblasts and chondrocytes. J Biomed Mater Res 51, 586, 2000.
43. Mohammadi, Y., Soleimani, M., Fallahi-Sichani, M., Gazme, A., Haddadi-Asl, V., Arefian, E., Kiani, J., Moradi, R., Atashi, A., and Ahmadbeigi, N. Nanofibrous poly(epsilon-capro-lactone)/poly(vinyl alcohol)/chitosan hybrid scaffolds for bone tissue engineering using mesenchymal stem cells. Int J Artif Organs 30, 204, 2007.
44. Yang, X., Chen, X., and Wang, H. Acceleration of osteo-genic differentiation of preosteoblastic cells by chitosan containing nanofibrous scaffolds. Biomacromolecules 10, 2772, 2009.