Melt-based compression-molded scaffolds from chitosan-polyester blends and composites: Morphology and mechanical properties

Journal of Biomedical Materials Research - Part A

Volumn 91, Issue 2, 2009, Pages 489-504

  Correlo, V M ^a   Boesel, L F ^a   Pinho, E ^a   Costa Pinto, A R ^a   Alves Da Silva, M L ^a   Bhattacharya, M ^b   Mano, J F ^a   Neves, N M ^a   Reis, R L ^a  

^a UNIVERSITY OF MINHO   (Portugal)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Biodegradable blends; Chitosan; Polyesters; Scaffolds; Tissue engineering

Indexed keywords

ADIPATES; ALIPHATIC POLYESTER; AVERAGE PARTICLE SIZE; BIODEGRADABLE BLENDS; CRYSTALLINE ORIENTATIONS; INTERCONNECTIVITY; LINEAR ELASTICITY; MELTING TEMPERATURES; METABOLIC ACTIVITY; MICROCOMPUTED TOMOGRAPHY; MINERAL FILLER; MORPHOLOGY AND MECHANICAL PROPERTIES; NEGATIVE CONTROL; OSTEOCONDUCTION; POLYBUTYLENE SUCCINATE; POLYBUTYLENE TEREPTHALATES; POLYESTER BLENDS; POLYMER COMPOSITION; POROSITY LEVEL; POROUS SCAFFOLD; SALT CONTENT; SCAFFOLD MORPHOLOGY; SMALL ANGLE X-RAY SCATTERING; STANDARD TESTS; STRAIN AT BREAK; WIDE ANGLE X-RAY SCATTERING;

APATITE; BIOMECHANICS; CHITIN; CHITOSAN; COMPRESSION TESTING; COMPUTERIZED TOMOGRAPHY; DIFFERENTIAL SCANNING CALORIMETRY; ESTERS; HYDROXYAPATITE; LEACHING; MECHANICAL PROPERTIES; MELTING POINT; MORPHOLOGY; PARTICLE SIZE; POLYCAPROLACTONE; POLYPROPYLENES; SCANNING ELECTRON MICROSCOPY; SCATTERING; SODIUM CHLORIDE; STRESS-STRAIN CURVES; TISSUE ENGINEERING; TOMOGRAPHY; X RAY SCATTERING; YIELD STRESS;

SCAFFOLDS;

CHITOSAN; HYDROXYAPATITE; POLYBUTYLENE SUCCINATE; POLYBUTYLENE SUCCINATE ADIPATE; POLYBUTYLENE TEREPHTHALATE ADIPATE; POLYCAPROLACTONE; POLYESTER; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHEMICAL COMPOSITION; COMPOSITE MATERIAL; COMPRESSION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY; DIFFERENTIAL SCANNING CALORIMETRY; ELASTICITY; FOAM; LEACHING; MELTING POINT; MICRO-COMPUTED TOMOGRAPHY; NONHUMAN; PARTICLE SIZE; POROSITY; RAT; SCANNING ELECTRON MICROSCOPY; STRESS STRAIN RELATIONSHIP; X RAY CRYSTALLOGRAPHY;

ANIMALS; CALORIMETRY, DIFFERENTIAL SCANNING; CELL LINE; CELL SURVIVAL; CHITOSAN; CRYSTALLIZATION; FIBROBLASTS; MATERIALS TESTING; POLYESTERS; POROSITY; RATS; STRESS, MECHANICAL; TENSILE STRENGTH; TISSUE SCAFFOLDS;

EID: 70349451980     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.32221     Document Type: Article

References (41)

1. Langer R, Vacanti JP. Tissue engineering. Science 1993;260:920-926.
2. Hutmacher DW. Scaffold design and fabrication technologies for engineering tissues - State of the art and future perspectives. J Biomater Sci Polym Ed 2001;12:107-124.
3. Muzzarelli RAA. Chitin. New York: Pergamon; 1977.
4. Klokkevold PR, Vandemark L, Kenney EB, Bernard GW. Osteogenesis enhanced by chitosan (poly-N-acetyl glucosaminoglycan) in vitro. J Periodontal 1996;67:1170-1175. (Pubitemid 26413008)
5. Peluso G, Petillo O, Ranieri M, Santin M, Ambrosio L, Calabro D, Avallone B, Balsamo G. Chitosan-mediated stimulation of macrophage function. Biomaterials 1994;15:1215-1220.
6. Baran ET, Reis RL. Use of chemically modified chitosan and other natural-origin polymers in tissue engineering and drug delivery. In: Reis RL, Roman JS, editors. Biodegradable Systems in Tissue Engineering and Regenerative Medicine. Boca Raton: CRC Press; 2005. p 325-335.
7. Sarasam A, Madihally SV. Characterization of chitosan-polycaprolactone blends for tissue engineering applications. Biomaterials 2005;26:5500-5508. (Pubitemid 40592138)
8. Zhang J, Wu L, Jing D, Ding J. A comparative study of porous scaffolds with cubic and spherical macropores. Polymer 2005;46:4979-4985. (Pubitemid 40688499)
9. McGlohorn JB, Holder WD Jr, Grimes LW, Thomas CB, Burg KJL. Evaluation of smooth muscle cell response using two types of porous polylactide scaffolds with differing pore topography. Tissue Eng 2004;10:505-514.
10. Lee WK, Ichi T, Ooya T, Yamamoto T, Katoh M, Yui N. Novel poly(ethylene glycol) scaffolds crosslinked by hydrolyzable polyrotaxane for cartilage tissue engineering. J Biomed Mater Res A 2003;67:1087-1092. (Pubitemid 37522720)
11. Kim SS, Sun Park M, Jeon O, Yong Choi C, Kim BS. Poly(lactide-co- glycolide)/hydroxyapatite composite scaffolds for bone tissue engineering. Biomaterials 2006;7:1399-1409. (Pubitemid 41739565)
12. Riddle KW, Mooney DJ. Role of poly(lactide-co-glycolide) particle size on gas-foamed scaffolds. J Biomater Sci Polym Ed 2004;15:1561-1570. (Pubitemid 40045382)
13. Hou Q, Grijpma DW, Feijen J. Preparation of interconnected highly porous polymeric structures by a replication and freeze-drying process. J Biomed Mater Res B 2003;67:732-740.
14. Wu L, Jing D, Ding J. A room-temperature injection moulding/particulate leaching approach for fabrication of biodegradable three-dimensional porous scaffolds. Biomaterials 2006;27:185-191. (Pubitemid 41278519)
15. Jeong SI, Kim SH, Kim YH, Jung Y, Kwon JH, Kim BS, Lee YM. Manufacture of elastic biodegradable PLCL scaffolds for mechano-active vascular tissue engineering. J Biomater Sci Polym Ed 2004;15:645-660. (Pubitemid 38842405)
16. Wu L, Zhang H, Zhang J, Ding J. Fabrication of three-dimensional porous scaffolds of complicated shape for tissue engineering. I. Compression molding based on flexible-rigid combined mold. Tissue Eng 2005;11:1105-1114.
17. Malda J, Woodfield TBF, Van Der Vloodt F, Wilson C, Martens DE, Tramper J, Van Blitterswijk CA, Riesle J. The effect of PEGT/PBT scaffold architecture on the composition of tissue engineered cartilage. Biomaterials 2005;26:63-72. (Pubitemid 38759472)
18. Lee SH, Kim BS, Kim SH, Kang SW, Kim YH. Thermally produced biodegradable scaffolds for cartilage tissue engineering. Macromol Biosci 2004;4:802-810. (Pubitemid 39257144)
19. Jung Y, Kim SS, Young HK, Kim SH, Kim BS, Kim S, Cha YC, Soo HK. A poly(lactic acid)/calcium metaphosphate composite for bone tissue engineering. Biomaterials 2005;26:6314-6322. (Pubitemid 40828387)
20. Sun J, Wu J, Li H, Chang J. Macroporous poly(3-hydroxybutyrate-co-3- hydroxyvalerate) matrices for cartilage tissue engineering. Eur Polym J 2005;41:2443-2449. (Pubitemid 41101357)
21. Gomes ME, Godinho JS, Tchalamov D, Cunha AM, Reis RL. Alternative tissue engineering scaffolds based on starch: Processing methodologies, morphology, degradation and mechanical properties. Mater Sci Eng C 2002;20:19-26. (Pubitemid 34718474)
22. Correlo VM, Boesel LF, Bhattacharya M, Mano JF, Neves NM, Reis RL. Properties of melt processed chitosan and aliphatic polyester blends. Mater Sci Eng A 2005;403:57-68. (Pubitemid 41110235)
23. Correlo VM, Boesel LF, Bhattacharya M, Mano JF, Neves NM, Reis RL. Hydroxyapatite reinforced chitosan and polyester blends for biomedical applications. Macromol Mater Eng 2005;290:1157-1165. (Pubitemid 43036219)
24. Ho ST, Hutmacher DW. Comparison of micro CT with other techniques used in the characterization of scaffolds. Biomaterials 2006;27:1362-2376.
25. Koza E, Leonowicz M, Wojciechowski S, Simancik F. Compressive strength of aluminium foams. Mater Lett 2003;58:132-135.
26. Gibson LJ. Mechanical behavior of metallic foams. Annu Rev Mater Sci 2000;30:191-227.
27. Banhart J, Baumeister J. Deformation characteristics of metal foams. J Mater Sci 1998;33:1431-1440.
28. Beals JT, Thompson MS. Density gradient effects on aluminium foam compression behavior. J Mater Sci 1997;32:3595-3600.
29. Gibson LJ, Ashby MF. Cellular Solids Structure and Properties, 2nd ed. Cambridge, UK: Cambridge University Press; 1997.
30. Burdick JA, Frankel D, Dernell WS, Anseth KS. An initial investigation of photocurable three-dimensional lactic acid based scaffolds in a critical-sized cranial defect. Biomaterials 2003;24:1613-1620. (Pubitemid 36143698)
31. Ma PX, Choi JW. Biodegradable polymer scaffolds with well-defined interconnected spherical pore network. Tissue Eng 2001;7:23-33.
32. Landers R, Pfister A, Hubner U, John H, Schmelzeisen R, Mulhaupt R. Fabrication of soft tissue engineering scaffolds by means of rapid prototyping techniques. J Mater Sci 2002;37:3107-3116. (Pubitemid 34950203)
33. Huang JS, Chou CY. Survival probability for brittle isotropic foams under multiaxial loading. J Mater Sci 2000;35:3881-3887.
34. Grenestedt JL. Influence of wavy imperfections in cell walls on elastic stiffness of cellular solids. J Mech Phys Solids 1998;46:29-50. (Pubitemid 128392896)
35. Simone AE, Gibson LJ. Aluminum foams produced by liquid-state processes. Acta Mater 46, 1998, 3109-3123.
36. Van Krevelen DW. Properties of Polymers. Amsterdam: Elsevier; 1990.
37. 1r CRAMPS. J Appl Polym Sci 2002;86:1253-1258.
38. Ihn KJ, Yoo ES, Inn SS. Structure and morphology of poly (tetramethylene succinate) crystals. Macromolecules 1995;28:2460-2464.
39. Alexander LE. X-ray Diffraction Methods in Polymer Science. New York: Wiley Interscience; 1969. p 137.
40. Costa-Pinto AR, Salgado AJ, Correlo V, Sol P, Bhattacharya M, Charbord P, Reis RL, Neves NM. Adhesion, proliferation and osteogenic differentiation of a mouse mesenchymal stem cell line (bmc9) seeded on novel melt based chitosan/polyester 3D porous scaffolds. Tissue Eng Part A 2008;94:1049-1057. (Pubitemid 351862218)
41. Oliveira JT, Correlo VM, Sol PC, Costa-Pinto AR, Salgado AJ, Bhattacharya M, Charbord P, Neves NM, Reis RL. Assessment of the suitability of chitosan/polybutylene succinate scaffolds seeded with mouse mesenchymal progenitor cells for a cartilage tissue engineering approach. Tissue Eng Part A 2008;14:1651-1661.