Inactivation of adenosine A2A receptor attenuates basal and angiotensin II-induced ROS production by Nox2 in endothelial cells

Journal of Biological Chemistry

Volumn 285, Issue 51, 2010, Pages 40104-40113

  Thakur, Sapna ^a   Du, Junjie ^a   Hourani, Susanna ^a   Ledent, Catherine ^b   Li, Jian Mei ^a  

^a UNIVERSITY OF SURREY   (United Kingdom)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DEAMINASES; AKT PHOSPHORYLATION; ANGIOTENSIN II; CONTROL LEVEL; ENDOTHELIAL DYSFUNCTION; KNOCK OUTS; MEMBRANE TRANSLOCATION; P38 MAPK; REACTIVE OXYGEN SPECIES; REDOX SIGNALING; WESTERN BLOTTING; WILD TYPES;

OXYGEN; PHOSPHORYLATION; SELF ASSEMBLY; SIGNALING;

ENDOTHELIAL CELLS;

5 AMINO 2 (2 FURYL) 7 (2 PHENYLETHYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; ACETYLCHOLINE; ADENOSINE A2A RECEPTOR; ADENOSINE DEAMINASE; ANGIOTENSIN II; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; PROTEIN P47; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; SMALL INTERFERING RNA; 5 AMINO 7 (2 PHENYLETHYL) 2 (2 FURYL)PYRAZOLO(4,3 E) 1,2,4 TRIAZOLO(1,5 C)PYRIMIDINE; 5-AMINO-7-(2-PHENYLETHYL)-2-(2-FURYL)PYRAZOLO(4,3-E)-1,2,4-TRIAZOLO(1,5-C)PYRIMIDINE; ADENOSINE A2 RECEPTOR ANTAGONIST; CYBB PROTEIN, MOUSE; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 3; NEUTROPHIL CYTOSOLIC FACTOR 1; PYRIMIDINE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TRIAZOLE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASAL CELL; CELL MEMBRANE TRANSPORT; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INACTIVATION; GENE SILENCING; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; THORACIC AORTA; VASCULAR ENDOTHELIUM; VASODILATATION; WESTERN BLOTTING; WILD TYPE; ANIMAL; BIOSYNTHESIS; CELL CULTURE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOUSE MUTANT; PHOSPHORYLATION; PHYSIOLOGY;

MUS;

ADENOSINE A2 RECEPTOR ANTAGONISTS; ANGIOTENSIN II; ANIMALS; CELLS, CULTURED; ENDOTHELIAL CELLS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 3; NADPH OXIDASE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PYRIMIDINES; REACTIVE OXYGEN SPECIES; RECEPTOR, ADENOSINE A2A; SIGNAL TRANSDUCTION; TRIAZOLES;

EID: 78650044035     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.184606     Document Type: Article

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