A2A adenosine receptor deficiency leads to impaired tracheal relaxation via NADPH oxidase pathway in allergic mice

Journal of Pharmacology and Experimental Therapeutics

Volumn 330, Issue 1, 2009, Pages 99-108

  Nadeem, Ahmed ^a   Ponnoth, D S ^a   Ansari, H R ^a   Batchelor, T P ^b   Dey, R D ^b   Ledent, C ^c   Mustafa, S J ^a  

^a WEST VIRGINIA UNIVERSITY   (United States)

^b WEST VIRGINIA UNIVERSITY   (United States)

^c UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A2A RECEPTOR; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; DIPHENYLIODONIUM SALT; KT 5720; OVALBUMIN; PHOSPHOPROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; ADENOSINE; DRUG DERIVATIVE; PHENETHYLAMINE DERIVATIVE;

AEROSOL; ALLERGY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOOTH MUSCLE RELAXATION; TRACHEA MUSCLE; WILD TYPE; ANIMAL; ASTHMA; C57BL MOUSE; COMPARATIVE STUDY; DISEASE MODEL; DRUG EFFECT; DRUG POTENTIATION; ENZYMOLOGY; FEMALE; GENETICS; IN VITRO STUDY; MALE; METABOLISM; MOUSE MUTANT; MUSCLE RELAXATION; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; SMOOTH MUSCLE; TRACHEA;

ADENOSINE; ANIMALS; ASTHMA; DISEASE MODELS, ANIMAL; FEMALE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE RELAXATION; MUSCLE, SMOOTH; NADPH OXIDASE; PHENETHYLAMINES; REACTIVE OXYGEN SPECIES; RECEPTOR, ADENOSINE A2A; SIGNAL TRANSDUCTION; TRACHEA;

EID: 67649873066     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.151613     Document Type: Article

References (41)

1. Ansari HR, Nadeem A, Talukder MA, Sakhalkar S, and Mustafa SJ (2007) Evidence for the involvement of nitric oxide in A2B receptor-mediated vasorelaxation of mouse aorta. Am J Physiol Heart Circ Physiol 292:H719-H725. (Pubitemid 46105235)
2. 2+ influx in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 290:L278-L283.
3. Barnes PJ and Drazen JM (2002) Pathophysiology of asthma, in Asthma and COPD (Barnes PJ, Drazen JM, Rennard S eds) pp 343-359, Academic Press, London.
4. Bengis-Garber C and Gruener N (1996) Protein kinase A downregulates the phosphorylation of p47 phox in human neutrophils: a possible pathway for inhibition of the respiratory burst. Cell Signal 8:291-296.
5. Bubolz AH, Li H, Wu Q, and Liu Y (2005) Enhanced oxidative stress impairs cAMP-mediated dilation by reducing Kv channel function in small coronary arteries of diabetic rats. Am J Physiol Heart Circ Physiol 289:H1873-H1880. (Pubitemid 41507335)
6. Busse WW and Lemanske RF Jr (2001) Asthma. N Engl J Med 344:350-362.
7. Cushing DJ, Brown GL, Sabouni MH, and Mustafa SJ (1991) Adenosine receptormediated coronary artery relaxation and cyclic nucleotide production. Am J Physiol 261:H343-H348.
8. Erdös B, Simandle SA, Snipes JA, Miller AW, and Busija DW (2004) Potassium channel dysfunction in cerebral arteries of insulin-resistant rats is mediated by reactive oxygen species. Stroke 35:964-969. (Pubitemid 38419811)
9. Fredholm BB, IJzerman AP, Jacobson KA, Klotz KN, and Linden J (2001) International union of pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev 53:527-552.
10. Gopalakrishnan SM, Buckner SA, Milicic I, Groebe DR, Whiteaker KL, Burns DJ, Warrior U, and Gopalakrishnan M (2002) Functional characterization of adenosine receptors and coupling to ATP-sensitive K+ channels in Guinea pig urinary bladder smooth muscle. J Pharmacol Exp Ther 300:910-917. (Pubitemid 34164995)
11. Green SA and Liggett SB (1996) G protein coupled receptor signalling in the lung, in The Genetics of Asthma (Liggett S and Meyers D eds) pp 67-90, Marcel Dekker Inc., New York.
12. (2A) adenosine receptor mediated potassium channel activation in rat epididymal smooth muscle. Br J Pharmacol 130:685-691. (Pubitemid 30332989)
13. 2+-activated K+ channels in endothelium-independent relaxation by urocortin in the rat coronary artery. Cardiovasc Res 57:824-833. (Pubitemid 36254876)
14. Kim JS, Diebold BA, Babior BM, Knaus UG, and Bokoch GM (2007) Regulation of Nox1 activity via protein kinase A-mediated phosphorylation of NoxA1 and 14-3-3 binding. J Biol Chem 282:34787-34800. (Pubitemid 350232473)
15. 2A agonists in development for the treatment of inflammation. Expert Opin Investig Drugs 14:797-806. (Pubitemid 41030948)
16. 2A receptor. Nature 388:674-678. (Pubitemid 27366438)
17. Liu Y and Gutterman DD (2002) The coronary circulation in diabetes: influence of reactive oxygen species on K+ channel-mediated vasodilation. Vascul Pharmacol 38:43-49.
18. Livak KJ and Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402-408.
19. 2A receptors in human and porcine cardiovascular tissues. J Pharmacol Exp Ther 286:1051-1057.
20. Miura M, Belvisi MG, Stretton CD, Yacoub MH, and Barnes PJ (1992) Role of potassium channels in bronchodilator responses in human airways. Am Rev Respir Dis 146:132-136.
21. Motojima S, Yukawa T, Fukuda T, and Makino S (1989) Changes in airway responsiveness and beta- and alpha-1-adrenergic receptors in the lungs of guinea pigs with experimental asthma. Allergy 44:66-74. (Pubitemid 19053038)
22. Mustafa SJ, Nadeem A, Fan M, Zhong H, Belardinelli L, and Zeng D (2007) Effect of a specific and selective A(2B) adenosine receptor antagonist on adenosine agonist AMP and allergen-induced airway responsiveness and cellular influx in a mouse model of asthma. J Pharmacol Exp Ther 320:1246-1251. (Pubitemid 46294058)
23. 2A adenosine receptor-deficient allergic mice. Am J Physiol Lung Cell Mol Physiol 292:L1335-L1344. (Pubitemid 47077350)
24. Nadeem A, Masood A, and Siddiqui N (2008) Oxidant-antioxidant imbalance in asthma: scientific evidence, epidemiological data and possible therapeutic options. Ther Adv Respir Dis 2:215-235.
25. Nadeem A and Mustafa SJ (2006) Adenosine receptor antagonists and asthma. Drug Discov Today Ther Strat 3:269-275.
26. Obiefuna PC, Batra VK, Nadeem A, Borron P, Wilson CN, and Mustafa SJ (2005) A novel A1 adenosine receptor antagonist, L-97-1 [3-[2-(4-aminophenyl)- ethyl]-8-benzyl-7-{2-ethyl-(2-hydroxyethyl)-amino]-ethyl}-1-propyl-3, 7-dihydro-purine-2,6-dione], reduces allergic responses to house dust mite in an allergic rabbit model of asthma. J Pharmacol Exp Ther 315:329-336. (Pubitemid 41380528)
27. Oldenburg P and Mustafa SJ (2004) Involvement of A1 adenosine receptors in adenosine induced bronchoconstriction in an allergic mouse model [Abstract]. Am J Respir Crit Care Med 169:A197.
28. Peshavariya HM, Dusting GJ, and Selemidis S (2007) Analysis of dihydroethidium fluorescence for the detection of intracellular and extracellular superoxide produced by NADPH oxidase. Free Radic Res 41:699-712. (Pubitemid 46845591)
29. Ponnoth DS, Nadeem A, and Mustafa SJ (2008) Adenosine-mediated alteration of vascular reactivity and inflammation in a murine model of asthma. Am J Physiol Heart Circ Physiol 294:H2158-H165.
30. Radenkoviæ M, Grboviæ L, Pesiæ S, and Stojiæ D (2005) Isolated rat inferior mesenteric artery response to adenosine: possible participation of Na+/K+- ATPase and potassium channels. Pharmacol Rep 57:824-832.
31. Sato T, Bewtra AK, Hopp RJ, Nair N, and Townley RG (1990) Alpha- and betaadrenergic-receptor systems in bronchial asthma and in subjects without asthma: reduced mononuclear cell beta-receptors in bronchial asthma. J Allergy Clin Immunol 86:839-850.
32. Shore SA and Moore PE (2003) Regulation of beta-adrenergic responses in airway smooth muscle. Respir Physiol Neurobiol 137:179-195.
33. Song P, Milanese M, Crimi E, Rehder K, and Brusasco V (1997) Allergen challenge of passively sensitized human bronchi alters M2 and beta2 receptor function. Am J Respir Crit Care Med 155:1230-1234.
34. Sturrock A, Huecksteadt TP, Norman K, Sanders K, Murphy TM, Chitano P, Wilson K, Hoidal JR, and Kennedy TP (2007) Nox4 mediates TGF-beta1-induced retinoblastoma protein phosphorylation, proliferation, and hypertrophy in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 292:L1543-L1555. (Pubitemid 47078930)
35. (2A) receptor agonists. Br J Pharmacol 132: 1017-1026. (Pubitemid 32238907)
36. Thabut G, El-Benna J, Samb A, Corda S, Megret J, Leseche G, Vicaut E, Aubier M, and Boczkowski J (2002) Tumor necrosis factor-alpha increases airway smooth muscle oxidants production through a NADPH oxidase-like system to enhance myosin light chain phosphorylation and contractility. J Biol Chem 277:22814-22821. (Pubitemid 34967262)
37. van der Vliet A (2008) NADPH oxidases in lung biology and pathology: host defense enzymes, and more. Free Radic Biol Med 44:938-955.
38. 2A adenosine receptors in human neutrophils. Br J Pharmacol 136:57-66. (Pubitemid 34499316)
39. 2A adenosine receptors. Cell Mol Life Sci 62: 2350-2358. (Pubitemid 41500550)
40. (2A) subtype adenosine receptor in the anti-inflammatory interactions of CGS 21680, cyclopentyladenosine, and IB-MECA with human neutrophils. Biochem Pharmacol 60:993-999. (Pubitemid 30676311)
41. Wang H and Joseph JA (1999) Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader. Free Radic Biol Med 27:612-616.